Published in Ann Neurol on January 01, 2005
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci U S A (2009) 2.47
Cancer stem cells as mediators of treatment resistance in brain tumors: status and controversies. Neoplasia (2007) 1.62
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Iron labeling and pre-clinical MRI visualization of therapeutic human neural stem cells in a murine glioma model. PLoS One (2009) 1.36
Molecular optical imaging: applications leading to the development of present day therapeutics. NeuroRx (2005) 1.36
Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model. J Neurosci (2008) 1.36
Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL. Neoplasia (2007) 1.33
Fluorescent nanoparticle uptake for brain tumor visualization. Neoplasia (2006) 1.33
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Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal. Oncotarget (2013) 1.22
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Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide. Mol Cancer Ther (2008) 1.16
Genetically engineered microvesicles carrying suicide mRNA/protein inhibit schwannoma tumor growth. Mol Ther (2012) 1.10
Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. Curr Top Med Chem (2005) 1.09
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Therapeutic efficacy and fate of bimodal engineered stem cells in malignant brain tumors. Stem Cells (2013) 1.03
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A novel molecule integrating therapeutic and diagnostic activities reveals multiple aspects of stem cell-based therapy. Stem Cells (2010) 1.00
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Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol (2011) 0.96
Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors. Oncogene (2012) 0.95
Migration and fate of therapeutic stem cells in different brain disease models. Neuroscience (2011) 0.92
Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesenchymal stem cells requires their substantial intratumoral presence. J Cell Mol Med (2010) 0.92
Migration of human neural stem cells toward an intracranial glioma. Exp Mol Med (2008) 0.92
In vitro validation of bioluminescent monitoring of disease progression and therapeutic response in leukaemia model animals. Eur J Nucl Med Mol Imaging (2006) 0.89
Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors. Oncogene (2010) 0.89
Strategies in gene therapy for glioblastoma. Cancers (Basel) (2013) 0.87
Chemokine CXC receptor 4--mediated glioma tumor tracking by bone marrow--derived neural progenitor/stem cells. Mol Cancer Ther (2009) 0.86
Gliomagenesis and the use of neural stem cells in brain tumor treatment. Anticancer Agents Med Chem (2010) 0.86
A first-generation multi-functional cytokine for simultaneous optical tracking and tumor therapy. PLoS One (2012) 0.86
Antiangiogenic variant of TSP-1 targets tumor cells in glioblastomas. Mol Ther (2014) 0.84
Selective migration of neuralized embryonic stem cells to stem cell factor and media conditioned by glioma cell lines. Cancer Cell Int (2006) 0.83
Encapsulated stem cells loaded with hyaluronidase-expressing oncolytic virus for brain tumor therapy. Mol Ther (2014) 0.82
Stem cells as delivery vehicles for oncolytic adenoviral virotherapy. Curr Gene Ther (2009) 0.82
Bioluminescence imaging: a shining future for cardiac regeneration. J Cell Mol Med (2013) 0.82
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Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells. Brain (2015) 0.80
Combination of systemic chemotherapy with local stem cell delivered S-TRAIL in resected brain tumors. Stem Cells (2015) 0.79
Evaluating the effect of therapeutic stem cells on TRAIL resistant and sensitive medulloblastomas. PLoS One (2012) 0.78
Targeting c-Met receptor overcomes TRAIL-resistance in brain tumors. PLoS One (2014) 0.78
Stem cell-based therapies for tumors in the brain: are we there yet? Neuro Oncol (2016) 0.77
Human gene therapy and imaging in neurological diseases. Eur J Nucl Med Mol Imaging (2005) 0.77
MMP14 as a novel downstream target of VEGFR2 in migratory glioma-tropic neural stem cells. Stem Cell Res (2015) 0.77
The Expanding Toolbox of In Vivo Bioluminescent Imaging. Front Oncol (2016) 0.77
Probe-Based Confocal Laser Endomicroscopy for Imaging TRAIL-Expressing Mesenchymal Stem Cells to Monitor Colon Xenograft Tumors In Vivo. PLoS One (2016) 0.75
Neural stem cell therapy for cancer. Methods (2015) 0.75
Aligned Nanotopography Promotes a Migratory State in Glioblastoma Multiforme Tumor Cells. Sci Rep (2016) 0.75
Potential of neural stem cells for the treatment of brain tumors. Clin Med Oncol (2008) 0.75
Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas. Cytotherapy (2017) 0.75
Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas. Proc Natl Acad Sci U S A (2017) 0.75
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol (2008) 19.86
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med (2008) 14.47
Restoration of p53 function leads to tumour regression in vivo. Nature (2007) 12.62
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med (2007) 11.51
Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science (2009) 10.47
Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotechnol (2005) 9.57
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med (2003) 9.09
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest (2007) 8.65
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36
Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur Radiol (2002) 6.06
Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo. Mol Ther (2005) 6.04
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A (2006) 5.90
Fluorescence molecular tomography resolves protease activity in vivo. Nat Med (2002) 5.53
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell (2006) 5.34
Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11
Myocardial infarction accelerates atherosclerosis. Nature (2012) 4.48
Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov (2013) 4.35
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
Chip-NMR biosensor for detection and molecular analysis of cells. Nat Med (2008) 4.29
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation (2007) 4.20
Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med (2013) 4.14
Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol (2002) 4.13
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A (2004) 4.12
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nat Med (2012) 4.11
Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat Commun (2011) 4.07
A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96
Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol (2011) 3.95
Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem (2008) 3.93
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity (2006) 3.92
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation (2007) 3.85
Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl (2009) 3.63
Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation (2006) 3.57
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation (2007) 3.51
Molecular imaging in drug discovery and development. Nat Rev Drug Discov (2003) 3.44
Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol (2005) 3.40
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A (2006) 3.38
Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv Drug Deliv Rev (2008) 3.34
A secreted luciferase for ex vivo monitoring of in vivo processes. Nat Methods (2008) 3.31
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24
Intravital imaging. Cell (2011) 3.18
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med (2010) 2.98
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med (2012) 2.92
Multivalent effects of RGD peptides obtained by nanoparticle display. J Med Chem (2006) 2.91
MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res (2007) 2.90
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol (2010) 2.90
Near-infrared fluorescence: application to in vivo molecular imaging. Curr Opin Chem Biol (2009) 2.89
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater (2006) 2.84
Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Sci Transl Med (2012) 2.82
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell (2012) 2.78
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res (2007) 2.77
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci U S A (2004) 2.77
Rapid detection and profiling of cancer cells in fine-needle aspirates. Proc Natl Acad Sci U S A (2009) 2.75
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A (2006) 2.72
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle. Circ Res (2005) 2.67
Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology (2002) 2.64
A highly sensitive assay for monitoring the secretory pathway and ER stress. PLoS One (2007) 2.63
In vivo imaging of proteolytic activity in atherosclerosis. Circulation (2002) 2.62
Molecular imaging in the clinical arena. JAMA (2005) 2.59
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Phys (2003) 2.58
Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. J Neurosurg (2006) 2.58
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell (2008) 2.57
Bioorthogonal turn-on probes for imaging small molecules inside living cells. Angew Chem Int Ed Engl (2010) 2.57
Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation (2006) 2.56
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res (2003) 2.55
Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation (2008) 2.52
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol (2010) 2.49
One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes. Tetrahedron Lett (2007) 2.49
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci U S A (2009) 2.47
Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy. J Natl Cancer Inst (2007) 2.46
Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction. Circulation (2005) 2.45
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45
Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation (2011) 2.45
Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A (2012) 2.42
PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol (2012) 2.39
Identification of the target self-antigens in reperfusion injury. J Exp Med (2006) 2.38
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. Cancer Res (2006) 2.35
Molecular imaging of cardiovascular disease. Circulation (2007) 2.33
Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30
Colonic adenocarcinomas: near-infrared microcatheter imaging of smart probes for early detection--study in mice. Radiology (2007) 2.29
PepBank--a database of peptides based on sequence text mining and public peptide data sources. BMC Bioinformatics (2007) 2.27
Quantitative real-time catheter-based fluorescence molecular imaging in mice. Radiology (2007) 2.26
Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor. Circulation (2007) 2.20
Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation (2007) 2.19
18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis. JACC Cardiovasc Imaging (2009) 2.17
Hybrid PET-optical imaging using targeted probes. Proc Natl Acad Sci U S A (2010) 2.17