Negative regulation of the deacetylase SIRT1 by DBC1.

Modes of p53 regulation. Cell (2009) 9.31

Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55

Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11

Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol (2012) 4.86

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol (2009) 4.09

How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17

SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci (2009) 2.80

p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46

Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. Nat Cell Biol (2010) 2.25

The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Cell (2014) 2.22

Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99

Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest (2010) 1.97

Mechanisms and molecular probes of sirtuins. Chem Biol (2008) 1.90

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci U S A (2011) 1.90

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc Natl Acad Sci U S A (2009) 1.89

Energy metabolism in the liver. Compr Physiol (2014) 1.88

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell (2011) 1.86

Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85

Energy balance, host-related factors, and cancer progression. J Clin Oncol (2010) 1.85

Brain SIRT1: anatomical distribution and regulation by energy availability. J Neurosci (2008) 1.75

Epigenetic mechanisms in neurological disease. Nat Med (2012) 1.74

The impact of acetylation and deacetylation on the p53 pathway. Protein Cell (2011) 1.66

Sirtuin 1 in lipid metabolism and obesity. Ann Med (2011) 1.65

The tumor suppressor p53: from structures to drug discovery. Cold Spring Harb Perspect Biol (2010) 1.64

The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol (2013) 1.63

p53-based cancer therapy. Cold Spring Harb Perspect Biol (2010) 1.62

The role of sirtuins in the control of metabolic homeostasis. Ann N Y Acad Sci (2009) 1.62

Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid Redox Signal (2012) 1.60

A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell (2011) 1.55

A continuous microplate assay for sirtuins and nicotinamide-producing enzymes. Anal Biochem (2009) 1.54

Sorting out functions of sirtuins in cancer. Oncogene (2013) 1.47

Turning enzymes ON with small molecules. Nat Chem Biol (2010) 1.47

SIRT1 and p53, effect on cancer, senescence and beyond. Biochim Biophys Acta (2010) 1.46

The dual role of sirtuins in cancer. Genes Cancer (2011) 1.45

CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One (2009) 1.43

SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. PLoS Genet (2011) 1.41

Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. PLoS One (2008) 1.41

Sirtuins at a glance. J Cell Sci (2011) 1.41

SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41

Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochim Biophys Acta (2009) 1.39

Sirtuin catalysis and regulation. J Biol Chem (2012) 1.35

Identification of DBC1 as a transcriptional repressor for BRCA1. Br J Cancer (2010) 1.31

Inhibition of SUV39H1 methyltransferase activity by DBC1. J Biol Chem (2009) 1.31

HDAC3 is negatively regulated by the nuclear protein DBC1. J Biol Chem (2010) 1.30

Central administration of resveratrol improves diet-induced diabetes. Endocrinology (2009) 1.30

Deleted in breast cancer 1, a novel androgen receptor (AR) coactivator that promotes AR DNA-binding activity. J Biol Chem (2009) 1.30

Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. J Biol Chem (2009) 1.28

Peptide switch is essential for Sirt1 deacetylase activity. Mol Cell (2011) 1.26

SIRT1 and energy metabolism. Acta Biochim Biophys Sin (Shanghai) (2013) 1.25

Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. Neoplasia (2009) 1.25

Histone acetylation in drug addiction. Semin Cell Dev Biol (2009) 1.24

SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. PLoS One (2012) 1.23

Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation. Cell Metab (2011) 1.23

Regulation of SIRT1 activity by genotoxic stress. Genes Dev (2012) 1.22

MicroRNA Regulation of SIRT1. Front Physiol (2012) 1.21

SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer. Cancer Res (2011) 1.21

Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J Biol Chem (2012) 1.19

Erasers of histone acetylation: the histone deacetylase enzymes. Cold Spring Harb Perspect Biol (2014) 1.18

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17

Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17

The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb Exp Pharmacol (2011) 1.16

Biochemical effects of SIRT1 activators. Biochim Biophys Acta (2009) 1.16

Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol (2011) 1.14

A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. FASEB J (2012) 1.11

RNA content in the nucleolus alters p53 acetylation via MYBBP1A. EMBO J (2011) 1.11

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. Nature (2012) 1.11

SIRT1 stabilizes PML promoting its sumoylation. Cell Death Differ (2010) 1.10

A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2. Mol Cell (2011) 1.09

Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy. Nucleic Acids Res (2011) 1.09

Sirtuin-1 regulation of mammalian metabolism. Trends Mol Med (2011) 1.07

SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1. Br J Cancer (2013) 1.06

hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage. Mol Cell Biol (2009) 1.06

The Roles of SIRT1 in Cancer. Genes Cancer (2013) 1.04

The multifaceted functions of sirtuins in cancer. Nat Rev Cancer (2015) 1.04

Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J Pineal Res (2010) 1.02

The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metab (2013) 1.01

Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites. Cell Cycle (2008) 1.01

Structural and functional analysis of human SIRT1. J Mol Biol (2013) 1.01

Calorie restriction and cancer prevention: a mechanistic perspective. Cancer Metab (2013) 1.01

SIRT1: Regulator of p53 Deacetylation. Genes Cancer (2013) 1.01

Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cell Mol Life Sci (2010) 1.00

A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8). J Biol Chem (2008) 0.99

Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model. J Pineal Res (2010) 0.99

DBC1 is over-expressed and associated with poor prognosis in colorectal cancer. Int J Clin Oncol (2013) 0.99

The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status. Sci Rep (2012) 0.98

Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer. Biosci Rep (2013) 0.98

Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem (2011) 0.98

Mammalian Sirt1: insights on its biological functions. Cell Commun Signal (2011) 0.98

Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med (2015) 0.97

Emerging Roles of SIRT1 in Cancer Drug Resistance. Genes Cancer (2013) 0.97

p53 Acetylation: Regulation and Consequences. Cancers (Basel) (2014) 0.97

Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma. Korean J Pathol (2012) 0.96

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol Cell Biol (2013) 0.96

Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell (1997) 16.79

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97

Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05

Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14

Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J (2002) 6.37

Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol (2005) 6.34

Substrate-specific activation of sirtuins by resveratrol. J Biol Chem (2005) 5.28

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04

Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature (2000) 4.93

Mechanism of human SIRT1 activation by resveratrol. J Biol Chem (2005) 4.86

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell (2005) 4.16

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell (2004) 3.73

Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol (2004) 3.00

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res (2006) 2.92

DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proc Natl Acad Sci U S A (2002) 2.58

Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling. Oncogene (2005) 1.51

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem (2005) 1.40

Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer. Cancer Lett (2004) 1.23

Regulation of NF-kappaB action by reversible acetylation. Novartis Found Symp (2004) 1.20

The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet (2005) 1.12

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell (2006) 10.50

MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (2008) 10.11

Modes of p53 regulation. Cell (2009) 9.31

Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64

p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46

SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23

Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Cell (2002) 4.57

Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol (2008) 4.30

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14

A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev (2002) 3.83

Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J (2003) 3.72

The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. Proc Natl Acad Sci U S A (2003) 3.52

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev (2002) 3.49

Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol (2005) 3.40

Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35

PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol (2004) 3.33

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J Biol Chem (2005) 3.19

How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17

Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11

Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09

The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell (2006) 3.09

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06

Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06

Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell (2008) 3.01

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity (2011) 3.01

Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00

Analysis of the human endogenous coregulator complexome. Cell (2011) 2.97

Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell (2004) 2.95

Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J Cell Biol (2008) 2.88

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem (2004) 2.76

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72

ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation. Mol Cell Biol (2007) 2.69

Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68

A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64

The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev (2002) 2.60

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59

Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58

p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54

Structural basis for the autoinhibition of talin in regulating integrin activation. Mol Cell (2008) 2.53

Mechanism of magnesium activation of calcium-activated potassium channels. Nature (2002) 2.50

N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol Cell (2003) 2.47

The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell (2004) 2.46

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46

Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol (2002) 2.45

Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35

The lipid whisker model of the structure of oxidized cell membranes. J Biol Chem (2007) 2.31

Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30

Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 2.25

Cohesin acetylation speeds the replication fork. Nature (2009) 2.23

The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility. J Biol Chem (2007) 2.20

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem (2007) 2.09

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06

Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00

Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A (2009) 2.00

A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92

Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A (2003) 1.90

Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87

A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87

Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood (2011) 1.86

Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol (2002) 1.86

VEGF-integrin interplay controls tumor growth and vascularization. Proc Natl Acad Sci U S A (2005) 1.84