Published in J Cell Biol on January 10, 2005
An ECT2-centralspindlin complex regulates the localization and function of RhoA. J Cell Biol (2005) 3.74
Dissecting the role of Rho-mediated signaling in contractile ring formation. Mol Biol Cell (2005) 2.33
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
KIF14 and citron kinase act together to promote efficient cytokinesis. J Cell Biol (2006) 2.06
MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. Proc Natl Acad Sci U S A (2005) 2.00
mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells. Mol Biol Cell (2008) 1.78
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol (2008) 1.57
A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A. Nat Cell Biol (2010) 1.49
Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. J Exp Med (2007) 1.49
The constitutive centromere component CENP-50 is required for recovery from spindle damage. Mol Cell Biol (2005) 1.44
The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals. PLoS One (2011) 1.43
The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer. Adv Enzyme Regul (2009) 1.28
The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis. Proc Natl Acad Sci U S A (2005) 1.28
A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis. EMBO J (2006) 1.24
GM130-dependent control of Cdc42 activity at the Golgi regulates centrosome organization. Mol Biol Cell (2008) 1.23
Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis. EMBO J (2007) 1.19
Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells. Mol Biol Cell (2007) 1.16
Rho GTPases modulate malignant transformation of tumor cells. Small GTPases (2014) 1.12
Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells. Mol Cancer Res (2012) 1.08
Understanding cytokinesis failure. Adv Exp Med Biol (2010) 1.06
Polarized Cdc42 activation promotes polar body protrusion and asymmetric division in mouse oocytes. Dev Biol (2013) 1.00
Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells. Small GTPases (2014) 1.00
Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. J Cell Sci (2013) 0.97
Quantitative proteome analysis of pluripotent cells by iTRAQ mass tagging reveals post-transcriptional regulation of proteins required for ES cell self-renewal. Mol Cell Proteomics (2010) 0.96
JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun (2015) 0.93
Gene expression profiling of chemically induced rat bladder tumors. Neoplasia (2007) 0.87
The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration. Genes Cancer (2011) 0.85
The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation. Genes Cancer (2013) 0.85
Ect2/Pbl acts via Rho and polarity proteins to direct the assembly of an isotropic actomyosin cortex upon mitotic entry. Dev Cell (2015) 0.83
Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes. Mol Biol Cell (2013) 0.83
Rho GTPase-independent regulation of mitotic progression by the RhoGEF Net1. Mol Biol Cell (2013) 0.82
IQGAP1 is a key node within the small GTPase network. Small GTPases (2013) 0.82
APC(CDH1) targets MgcRacGAP for destruction in the late M phase. PLoS One (2013) 0.80
Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during cytokinesis in adherent mammalian cells. Exp Cell Res (2011) 0.80
Controlling the switches: Rho GTPase regulation during animal cell mitosis. Cell Signal (2014) 0.80
Nonparametric Bayesian evaluation of differential protein quantification. J Proteome Res (2013) 0.79
Coupling changes in cell shape to chromosome segregation. Nat Rev Mol Cell Biol (2016) 0.79
Cellular contractility requires ubiquitin mediated proteolysis. PLoS One (2009) 0.78
Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis. Cell Cycle (2014) 0.78
Activation of the human FP prostanoid receptor disrupts mitosis progression and generates aneuploidy and polyploidy. Cell Mol Life Sci (2006) 0.75
The dynamic behavior of Ect2 in response to DNA damage. Sci Rep (2016) 0.75
The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion. Nat Commun (2014) 0.75
Rho GTPases in cell biology. Nature (2002) 22.81
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell (2003) 9.90
The BRCT domain is a phospho-protein binding domain. Science (2003) 7.42
Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell (2001) 7.07
Fluorescence microscopy in three dimensions. Methods Cell Biol (1989) 6.70
Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI). J Cell Biol (1993) 3.87
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J Cell Biol (1999) 3.77
The spindle: a dynamic assembly of microtubules and motors. Nat Cell Biol (2001) 3.74
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis. J Cell Biol (2000) 3.55
Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science (2004) 3.48
Rho GTPase-activating proteins in cell regulation. Trends Cell Biol (2003) 3.44
A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis. Dev Cell (2003) 3.43
A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev (1999) 3.25
Dbl family guanine nucleotide exchange factors. Trends Biochem Sci (2001) 2.94
A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs. Zygote (1993) 2.71
Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell (2003) 2.54
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem (2000) 2.51
Oncogene ect2 is related to regulators of small GTP-binding proteins. Nature (1993) 2.34
Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol (2000) 2.19
Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment. J Cell Biol (1998) 2.16
Cdc42 and mDia3 regulate microtubule attachment to kinetochores. Nature (2004) 2.15
Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. J Biol Chem (2000) 2.04
MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J Biol Chem (2000) 1.99
An evaluation of the double thymidine block for synchronizing mammalian cells at the G1-S border. Exp Cell Res (1971) 1.83
Rho GTPases as targets of bacterial protein toxins. Biol Chem (2000) 1.68
MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. J Biol Chem (1998) 1.56
Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. J Biol Chem (2004) 1.41
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep (2002) 1.30
Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth. J Biol Chem (2001) 1.21
MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood (2000) 1.17
A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins. Mol Cell Biol (1992) 1.08
The mechanism of cytokinesis: reconsideration and reconciliation. Cell Struct Funct (2001) 1.04
Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development. Mech Dev (2001) 0.99
Potential roles of the nucleotide exchange factor ECT2 and Cdc42 GTPase in spindle assembly in Xenopus egg cell-free extracts. J Cell Biochem (2003) 0.90
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet (2004) 8.62
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Identification of Tim4 as a phosphatidylserine receptor. Nature (2007) 6.06
ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat Biotechnol (2006) 5.46
Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41
Prostaglandin E receptors. J Biol Chem (2007) 5.29
Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science (2003) 4.40
Autophagosomes form at ER-mitochondria contact sites. Nature (2013) 4.32
Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes. Cell (2006) 3.67
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab (2005) 3.49
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest (2008) 3.25
Aneuploidy drives genomic instability in yeast. Science (2011) 3.22
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest (2002) 3.21
Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell (2010) 3.05
Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors. JAMA (2007) 3.00
Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. EMBO J (2002) 2.82
Actin polymerization-driven molecular movement of mDia1 in living cells. Science (2004) 2.80
Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells. J Cell Sci (2003) 2.78
Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in children. Clin Infect Dis (2006) 2.72
Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med (2009) 2.68
Selective elimination of messenger RNA prevents an incidence of untimely meiosis. Nature (2006) 2.64
Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell (2003) 2.54
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol (2005) 2.50
Human placenta-derived cells have mesenchymal stem/progenitor cell potential. Stem Cells (2004) 2.38
Meiosis-specific noncoding RNA mediates robust pairing of homologous chromosomes in meiosis. Science (2012) 2.26
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nat Immunol (2005) 2.24
Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II. Mol Biol Cell (2003) 2.17
Cdc42 and mDia3 regulate microtubule attachment to kinetochores. Nature (2004) 2.15
Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J Clin Invest (2004) 2.12
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
Dynamics of homologous chromosome pairing during meiotic prophase in fission yeast. Dev Cell (2004) 2.11
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol (2003) 2.07
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts. J Cell Biol (2002) 2.05
AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood (2008) 2.03
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. Cancer Res (2002) 2.02
Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res (2002) 2.00
Monopolar spindle attachment of sister chromatids is ensured by two distinct mechanisms at the first meiotic division in fission yeast. EMBO J (2003) 1.95
CENP-I is essential for centromere function in vertebrate cells. Dev Cell (2002) 1.94
Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain (2005) 1.94
Heterochromatin integrity affects chromosome reorganization after centromere dysfunction. Science (2008) 1.88
Rotational movement of the formin mDia1 along the double helical strand of an actin filament. Science (2010) 1.87
The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol Cell (2004) 1.85
Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Nat Med (2003) 1.78
Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue. Diabetes (2005) 1.78
Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. Blood (2009) 1.78
mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells. Mol Biol Cell (2008) 1.78
The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. Mol Cell (2004) 1.74
Induction of human cardiomyocyte-like cells from fibroblasts by defined factors. Proc Natl Acad Sci U S A (2013) 1.74
Identity of the elusive IgM Fc receptor (FcmuR) in humans. J Exp Med (2009) 1.72
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis. J Exp Med (2005) 1.72
Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing. J Cell Biol (2006) 1.70
Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res (2002) 1.70
Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J Neurosci Res (2008) 1.70
Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med (2003) 1.69
ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo. Genes Cells (2005) 1.69
The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. Kidney Int (2012) 1.66
Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One (2011) 1.65
The Rho-associated protein kinase p160ROCK is required for centrosome positioning. J Cell Biol (2002) 1.65
Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. J Exp Med (2007) 1.64
Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis. J Biol Chem (2005) 1.63
Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process. Blood (2010) 1.63
The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model. Int Immunol (2004) 1.63
Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation. Am J Physiol Endocrinol Metab (2005) 1.62
Physiological roles of Rho and Rho effectors in mammals. Eur J Cell Biol (2013) 1.62
Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J Biol Chem (2002) 1.61
LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. J Cell Sci (2004) 1.61
Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors. J Physiol (2003) 1.59
Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Plant Cell (2010) 1.59
Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. J Cell Biol (2003) 1.58
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics. Hum Mol Genet (2003) 1.58
The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed. J Immunol (2005) 1.57
Survival and death signals can predict tumor response to therapy after oncogene inactivation. Sci Transl Med (2011) 1.56
Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling. Arterioscler Thromb Vasc Biol (2009) 1.55
Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation. Curr Biol (2012) 1.53
Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly. J Cell Sci (2008) 1.53
Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J Exp Med (2007) 1.52
Rho GTPases in animal cell mitosis. Curr Opin Cell Biol (2006) 1.52
Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation. Proc Natl Acad Sci U S A (2002) 1.51
Virtual breakdown of the nuclear envelope in fission yeast meiosis. Curr Biol (2010) 1.50
Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis. J Exp Med (2006) 1.49
Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase. J Cell Sci (2003) 1.49
Semi-quantitative analysis of Streptococcus pneumoniae urinary antigen: kinetics of antigen titers and severity of diseases. Scand J Infect Dis (2006) 1.48
Cellular stresses induce the nuclear accumulation of importin alpha and cause a conventional nuclear import block. J Cell Biol (2004) 1.46