Published in J Cell Biol on March 01, 1993
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol Cell Biol (1995) 7.23
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol (1996) 5.41
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J (1996) 5.09
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J (1997) 5.03
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol (1997) 4.27
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol (1996) 4.06
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol (2003) 3.85
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J Cell Biol (1999) 3.77
An ECT2-centralspindlin complex regulates the localization and function of RhoA. J Cell Biol (2005) 3.74
Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev (1999) 3.61
A role for Rho in Ras transformation. Proc Natl Acad Sci U S A (1995) 3.59
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis. J Cell Biol (2000) 3.55
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol (2002) 3.51
Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J Cell Biol (1998) 3.44
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol (1999) 3.43
A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev (1999) 3.25
A microtubule-dependent zone of active RhoA during cleavage plane specification. J Cell Biol (2005) 3.15
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J (1995) 2.99
Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.87
Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. J Cell Biol (1994) 2.74
Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cells. J Cell Biol (1998) 2.64
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell (2007) 2.52
Regulation of cytokinesis by Rho GTPase flux. Nat Cell Biol (2008) 2.50
Cytokinesis in eukaryotes. Microbiol Mol Biol Rev (2002) 2.43
RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J Cell Biol (2003) 2.34
Dissecting the role of Rho-mediated signaling in contractile ring formation. Mol Biol Cell (2005) 2.33
Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24. Mol Cell Biol (1995) 2.31
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol (1999) 2.17
rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. Mol Cell Biol (1994) 2.12
The small GTP-binding protein rho regulates cortical activities in cultured cells during division. J Cell Biol (1999) 2.09
Myosin phosphatase target subunit: Many roles in cell function. Biochem Biophys Res Commun (2007) 2.08
Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase. J Cell Biol (1998) 1.85
Rho GTPase activity zones and transient contractile arrays. Bioessays (2006) 1.79
A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis. J Cell Biol (1996) 1.76
Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments. J Cell Biol (1998) 1.69
Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. J Cell Biol (1996) 1.63
RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. Mol Biol Cell (1998) 1.62
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. J Cell Biol (2005) 1.62
The Aspergillus nidulans sepA gene encodes an FH1/2 protein involved in cytokinesis and the maintenance of cellular polarity. EMBO J (1997) 1.57
Polo-like kinase controls vertebrate spindle elongation and cytokinesis. PLoS One (2007) 1.53
A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities. EMBO J (1995) 1.53
Phosphoinositide signaling plays a key role in cytokinesis. J Cell Biol (2006) 1.51
A role for Dictyostelium racE in cortical tension and cleavage furrow progression. J Cell Biol (1998) 1.49
A novel type of myosin implicated in signalling by rho family GTPases. EMBO J (1995) 1.48
The Rho family G proteins play a critical role in muscle differentiation. Mol Cell Biol (1998) 1.47
p160ROCK mediates RhoA activation of Na-H exchange. EMBO J (1998) 1.45
Stable and dynamic microtubules coordinately shape the myosin activation zone during cytokinetic furrow formation. J Cell Biol (2008) 1.43
Dictyostelium IQGAP-related protein specifically involved in the completion of cytokinesis. J Cell Biol (1997) 1.42
A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis. J Cell Biol (1996) 1.36
Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulators. J Cell Biol (2000) 1.36
Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes. J Cell Biol (1995) 1.36
Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK. J Cell Biol (1999) 1.29
Effect of cytolethal distending toxin on F-actin assembly and cell division in Chinese hamster ovary cells. Infect Immun (1997) 1.27
Rho and Rab small G proteins coordinately reorganize stress fibers and focal adhesions in MDCK cells. Mol Biol Cell (1998) 1.25
Role of Dictyostelium racE in cytokinesis: mutational analysis and localization studies by use of green fluorescent protein. Mol Biol Cell (1997) 1.23
p190RhoGAP is cell cycle regulated and affects cytokinesis. J Cell Biol (2003) 1.18
Taxol-stabilized microtubules can position the cytokinetic furrow in mammalian cells. Mol Biol Cell (2005) 1.14
Conditional lethality of a yeast strain expressing human RHOA in place of RHO1. Proc Natl Acad Sci U S A (1994) 1.13
The RhoGAP domain of CYK-4 has an essential role in RhoA activation. Curr Biol (2012) 1.13
A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2001) 1.12
Inhibition of cytokinesis by a lipid metabolite, psychosine. J Cell Biol (2000) 1.12
Rac1 is required for cell proliferation and G2/M progression. Biochem J (1997) 1.11
Rho GTPases in animal cell cytokinesis: an occupation by the one percent. Cytoskeleton (Hoboken) (2012) 1.11
Understanding cytokinesis failure. Adv Exp Med Biol (2010) 1.06
Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. Mol Cell Biol (2002) 1.05
Redundant mechanisms recruit actin into the contractile ring in silkworm spermatocytes. PLoS Biol (2008) 1.00
Inside view of cell locomotion through single-molecule: fast F-/G-actin cycle and G-actin regulation of polymer restoration. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.00
Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells. Small GTPases (2014) 1.00
Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells. Clin Exp Metastasis (2002) 1.00
Guanine nucleotide-dependent translocation of RhoA from cytosol to high affinity membrane binding sites in human erythrocytes. Biochem J (1998) 0.96
p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells. Exp Cell Res (2009) 0.95
Novel functions of Ect2 in polar lamellipodia formation and polarity maintenance during "contractile ring-independent" cytokinesis in adherent cells. Mol Biol Cell (2007) 0.95
Opposing roles of p190RhoGAP and Ect2 RhoGEF in regulating cytokinesis. Cell Cycle (2008) 0.93
Diaphanous-related formin 2 and profilin I are required for gastrulation cell movements. PLoS One (2008) 0.93
Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane. Dev Cell (2015) 0.92
Small GTPase RhoA regulates cytoskeleton dynamics during porcine oocyte maturation and early embryo development. Cell Cycle (2014) 0.91
Cytoskeleton responses in wound repair. Cell Mol Life Sci (2012) 0.91
Mitotic down-regulation of p190RhoGAP is required for the successful completion of cytokinesis. J Biol Chem (2010) 0.91
Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901. World J Gastroenterol (2008) 0.91
The protein tyrosine phosphatase PTP-BL associates with the midbody and is involved in the regulation of cytokinesis. Mol Biol Cell (2003) 0.90
Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage. J Cell Biol (2016) 0.88
PKN delays mitotic timing by inhibition of Cdc25C: possible involvement of PKN in the regulation of cell division. Proc Natl Acad Sci U S A (2001) 0.87
Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs. J Cell Biol (1996) 0.86
Rho-guanine nucleotide exchange factors during development: Force is nothing without control. Small GTPases (2010) 0.85
Translocation of PKN from the cytosol to the nucleus induced by stresses. Proc Natl Acad Sci U S A (1996) 0.84
ADP-ribosylation of the GTP-binding protein RhoA blocks cytoplasmic division in human myelomonocytic cells. Biochem J (1995) 0.83
Rho GTPase-independent regulation of mitotic progression by the RhoGEF Net1. Mol Biol Cell (2013) 0.82
Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma × glioma hybrid NG108-15 cells. Cell Mol Neurobiol (2011) 0.81
The Tumor Suppressor, p190RhoGAP, Differentially Initiates Apoptosis and Confers Docetaxel Sensitivity to Breast Cancer Cells. Genes Cancer (2011) 0.81
Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during cytokinesis in adherent mammalian cells. Exp Cell Res (2011) 0.80
Controlling the switches: Rho GTPase regulation during animal cell mitosis. Cell Signal (2014) 0.80
Ect2, an ortholog of Drosophila Pebble, regulates formation of growth cones in primary cortical neurons. Neurochem Int (2012) 0.79
Increased cytoplasmic localization of p27(kip1) and its modulation of RhoA activity during progression of chronic myeloid leukemia. PLoS One (2013) 0.79
Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro. Clin Exp Immunol (2014) 0.78
Localized calcium signals along the cleavage furrow of the Xenopus egg are not involved in cytokinesis. Mol Biol Cell (2002) 0.77
A novel role of Rho-kinase in the regulation of ligand-induced phosphorylated EGFR endocytosis via the early/late endocytic pathway in human fibrosarcoma cells. J Mol Histol (2011) 0.76
Implications of mechanical stretch on wound repair of gastric smooth muscle cells in vitro. Dig Dis Sci (2000) 0.75
C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene (1988) 52.71
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell (1992) 30.02
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell (1992) 28.36
Measurement of molecular weights by electrophoresis on SDS-acrylamide gel. Methods Enzymol (1972) 14.68
Actin and actin-binding proteins. A critical evaluation of mechanisms and functions. Annu Rev Biochem (1986) 9.17
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. Cell (1982) 9.11
Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J Cell Biol (1990) 6.29
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature (1991) 5.16
Microinjection of recombinant p21rho induces rapid changes in cell morphology. J Cell Biol (1990) 4.83
Actin in dividing cells: contractile ring filaments bind heavy meromyosin. Proc Natl Acad Sci U S A (1973) 4.61
The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J (1989) 4.21
The contractile ring. I. Fine structure of dividing mammalian (HeLa) cells and the effects of cytochalasin B. Z Zellforsch Mikrosk Anat (1970) 4.15
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science (1991) 3.87
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature (1991) 3.68
Actin-like filaments in the cleavage furrow of newt egg. Exp Cell Res (1971) 3.53
Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase. J Biol Chem (1989) 3.47
ras proteins can induce meiosis in Xenopus oocytes. Cell (1985) 3.23
rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem (1989) 3.21
Establishment of the mechanism of cytokinesis in animal cells. Int Rev Cytol (1986) 3.16
Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum. Mol Cell Biol (1988) 3.11
Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem (1992) 2.90
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene (1990) 2.89
Receptor-coupled, permeabilized smooth muscle. Role of the phosphatidylinositol cascade, G-proteins, and modulation of the contractile response to Ca2+. J Biol Chem (1989) 2.81
Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity. Biochemistry (1986) 2.77
Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Mol Cell Biol (1993) 2.71
Interconversion of metaphase and interphase microtubule arrays, as studied by the injection of centrosomes and nuclei into Xenopus eggs. J Cell Biol (1984) 2.61
Norepinephrine and GTP-gamma-S increase myofilament Ca2+ sensitivity in alpha-toxin permeabilized arterial smooth muscle. Biochem Biophys Res Commun (1988) 2.57
Cytokinesis: filaments in the cleavage furrow. Exp Cell Res (1968) 2.50
Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor. J Biol Chem (1990) 2.47
Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol (1990) 2.25
A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc Natl Acad Sci U S A (1991) 2.22
Small GTP-binding proteins. Int Rev Cytol (1992) 2.19
Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein. J Biol Chem (1990) 2.09
Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins. Oncogene (1991) 1.93
Botulinum ADP-ribosyltransferase C3. Purification of the enzyme and characterization of the ADP-ribosylation reaction in platelet membranes. Eur J Biochem (1988) 1.90
The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins. J Biol Chem (1992) 1.84
Biochemical aspects of cytokinesis. Int Rev Cytol (1986) 1.80
A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr. New Biol (1991) 1.74
Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes. Mol Cell Biol (1992) 1.66
Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product. J Biol Chem (1988) 1.64
Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins. J Biol Chem (1990) 1.62
Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins. Biochem Biophys Res Commun (1992) 1.55
Epidermal cell differentiation inhibitor ADP-ribosylates small GTP-binding proteins and induces hyperplasia of epidermis. J Biol Chem (1992) 1.52
Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins. J Biol Chem (1992) 1.45
ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility. Biochem Biophys Res Commun (1991) 1.44
ADP-ribosylation of the bovine brain rho protein by botulinum toxin type C1. J Biol Chem (1988) 1.41
ADP-ribosylation of the rho/rac proteins induces growth inhibition, neurite outgrowth and acetylcholine esterase in cultured PC-12 cells. Biochem Biophys Res Commun (1990) 1.38
Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein. Mol Cell Biol (1991) 1.36
Cleavage furrow isolated from newt eggs: contraction, organization of the actin filaments, and protein components of the furrow. Proc Natl Acad Sci U S A (1988) 1.25
Effects of guanosine nucleotides on skinned smooth muscle tissue of the rabbit mesenteric artery. J Physiol (1989) 1.19
Rabbit intestine contains a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein. Biochem Biophys Res Commun (1989) 1.18
A novel epidermal cell differentiation inhibitor (EDIN): purification and characterization from Staphylococcus aureus. Biochem Biophys Res Commun (1990) 1.16
The posttranslationally modified C-terminal structure of bovine aortic smooth muscle rhoA p21. J Biol Chem (1991) 1.10
A geranylgeranyltransferase for rhoA p21 distinct from the farnesyltransferase for ras p21S. Biochem Biophys Res Commun (1991) 1.09
Partial purification and characterization of GDP dissociation stimulator (GDS) for the rho proteins from bovine brain cytosol. Biochem Biophys Res Commun (1990) 1.08
Functional interactions of stimulatory and inhibitory GDP/GTP exchange proteins and their common substrate small GTP-binding protein. J Biol Chem (1992) 1.08
Effects of phalloidin microinjection and localization of fluorescein-labeled phalloidin in living sand dollar eggs. Cell Motil (1982) 1.03
Morphological alterations of Xenopus oocytes induced by valine-14 p21rho depend on isoprenylation and are inhibited by Clostridium botulinum C3 ADP-ribosyltransferase. FEBS Lett (1990) 1.00
Cooperative function of rho GDS and rho GDI to regulate rho p21 activation in smooth muscle. Biochem Biophys Res Commun (1992) 0.94
Purification and characterization of ADP-ribosyltransferases (exoenzyme C3) of Clostridium botulinum type C and D strains. J Bacteriol (1991) 0.86
Cleavage furrow formation and actin-modulating proteins. Ann N Y Acad Sci (1990) 0.85
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity. Proc Natl Acad Sci U S A (1977) 18.37
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem (1982) 16.71
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell (1998) 13.98
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol (2000) 13.29
A physical map of the human genome. Nature (2001) 12.39
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. Proc Natl Acad Sci U S A (1976) 12.30
The DNA sequence of human chromosome 21. Nature (2000) 10.66
Small GTP-binding proteins. Physiol Rev (2001) 9.52
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93
Hd1, a major photoperiod sensitivity quantitative trait locus in rice, is closely related to the Arabidopsis flowering time gene CONSTANS. Plant Cell (2000) 6.93
A high-density rice genetic linkage map with 2275 markers using a single F2 population. Genetics (1998) 6.82
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol (1998) 6.38
Formation of an RNA primer for initiation of replication of ColE1 DNA by ribonuclease H. Proc Natl Acad Sci U S A (1980) 6.04
Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. N Engl J Med (1999) 5.61
Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J Biol Chem (1980) 5.08
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (2001) 5.07
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature (1998) 4.95
T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity (2001) 4.62
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat Genet (2001) 4.54
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell (2000) 4.53
Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem (1999) 4.53
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A (1990) 4.40
Osteoblastic cells are involved in osteoclast formation. Endocrinology (1988) 4.37
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol (1997) 4.27
Inhibition of ColE1 RNA primer formation by a plasmid-specified small RNA. Proc Natl Acad Sci U S A (1981) 4.14
Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. J Biol Chem (1979) 4.12
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature (2000) 4.08
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol (1996) 4.06
Binding of neuroligins to PSD-95. Science (1997) 3.88
A simple method for determining the modulation transfer function in digital radiography. IEEE Trans Med Imaging (1992) 3.79
Plasmid ColE1 incompatibility determined by interaction of RNA I with primer transcript. Proc Natl Acad Sci U S A (1981) 3.77
Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science (1997) 3.70
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J Biol Chem (1983) 3.69
Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties. J Biol Chem (1982) 3.64
Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. J Biol Chem (1983) 3.60
Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. J Cell Biol (1999) 3.47
Rho1p, a yeast protein at the interface between cell polarization and morphogenesis. Science (1996) 3.42
Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes. EMBO J (2000) 3.32
The origin of replication of plasmid p15A and comparative studies on the nucleotide sequences around the origin of related plasmids. Cell (1983) 3.18
Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J Biol Chem (1997) 3.08
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. J Biol Chem (1977) 3.02
Rice gibberellin-insensitive dwarf mutant gene Dwarf 1 encodes the alpha-subunit of GTP-binding protein. Proc Natl Acad Sci U S A (1999) 2.97
Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. Biochem Biophys Res Commun (1979) 2.96
Excitation--contraction coupling in smooth muscle cells of the guinea-pig mesenteric artery. J Physiol (1981) 2.92
Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem (1992) 2.90
Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke (1985) 2.89
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene (1990) 2.89
Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.87
The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology (1989) 2.83
cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol (2000) 2.83
Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice. J Immunol (1996) 2.83
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol (1997) 2.82
Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae. EMBO J (1997) 2.80
Large-scale EST sequencing in rice. Plant Mol Biol (1997) 2.80
Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein. J Biol Chem (1990) 2.77
Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.76
Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. J Cell Biol (1994) 2.74
Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Mol Cell Biol (1993) 2.71
Factors modifying contraction-relaxation cycle in vascular smooth muscles. Am J Physiol (1982) 2.63
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins. J Biol Chem (1993) 2.62
Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol Cell Biol (1998) 2.59
Rapid reorganization of resistance gene homologues in cereal genomes. Proc Natl Acad Sci U S A (1998) 2.53
Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. Microbiol Immunol (2001) 2.52
Rho as a regulator of the cytoskeleton. Trends Biochem Sci (1995) 2.52
Expression of Xa1, a bacterial blight-resistance gene in rice, is induced by bacterial inoculation. Proc Natl Acad Sci U S A (1998) 2.49
Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin. Mol Cell Biol (1993) 2.48
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature (2001) 2.47
Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor. J Biol Chem (1990) 2.47
Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Mol Cell Biol (1999) 2.37
Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron (1998) 2.36
Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows. Oncogene (1995) 2.32
SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev (1999) 2.31
Genome plasticity as a paradigm of eubacteria evolution. J Mol Evol (1997) 2.29
Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding. EMBO J (1999) 2.28
Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae. Oncogene (1998) 2.27
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol (1998) 2.26
Differences and similarities in the noradrenaline- and caffeine-induced mechanical responses in the rabbit mesenteric artery. J Physiol (1983) 2.26
Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily. J Biol Chem (1995) 2.26
SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. J Biol Chem (1997) 2.23
CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus. Neuron (2001) 2.22
A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc Natl Acad Sci U S A (1991) 2.22
Hd6, a rice quantitative trait locus involved in photoperiod sensitivity, encodes the alpha subunit of protein kinase CK2. Proc Natl Acad Sci U S A (2001) 2.22
Inositol 1,4,5-trisphosphate activates pharmacomechanical coupling in smooth muscle of the rabbit mesenteric artery. J Physiol (1986) 2.20
Risk factors for primary dysfunction after liver transplantation--a multivariate analysis. Transplantation (1993) 2.20
The Pib gene for rice blast resistance belongs to the nucleotide binding and leucine-rich repeat class of plant disease resistance genes. Plant J (1999) 2.18