Published in J Biol Chem on January 18, 2005
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Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase. J Am Chem Soc (2009) 1.41
Isolation of anti-CD22 Fv with high affinity by Fv display on human cells. Proc Natl Acad Sci U S A (2006) 1.30
Development of a novel mammalian cell surface antibody display platform. MAbs (2010) 0.94
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A Novel Two-Tag System for Monitoring Transport and Cleavage through the Classical Secretory Pathway - Adaptation to HIV Envelope Processing. PLoS One (2013) 0.79
The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif. PLoS One (2013) 0.79
In Vitro Selection of Cancer Cell-Specific Molecular Recognition Elements from Amino Acid Libraries. J Immunol Res (2015) 0.75
Causal protein-signaling networks derived from multiparameter single-cell data. Science (2005) 34.28
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science (2011) 15.45
Computational solutions to large-scale data management and analysis. Nat Rev Genet (2010) 6.58
Single cell profiling of potentiated phospho-protein networks in cancer cells. Cell (2004) 6.24
Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE. Nat Biotechnol (2011) 5.46
Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity (2012) 5.26
Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling. Nat Methods (2006) 5.25
viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat Biotechnol (2013) 4.88
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry A (2003) 4.45
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell (2008) 4.06
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nat Biotechnol (2012) 3.65
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood (2010) 3.41
Mapping normal and cancer cell signalling networks: towards single-cell proteomics. Nat Rev Cancer (2006) 3.24
A deep profiler's guide to cytometry. Trends Immunol (2012) 3.14
Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications. Clin Immunol (2004) 2.69
Normalization of mass cytometry data with bead standards. Cytometry A (2013) 2.63
Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. Nat Immunol (2003) 2.58
High-content single-cell drug screening with phosphospecific flow cytometry. Nat Chem Biol (2007) 2.54
Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry. Nat Biotechnol (2002) 2.43
Chemical combination effects predict connectivity in biological systems. Mol Syst Biol (2007) 2.42
Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 2.39
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci Signal (2010) 2.36
Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells. Blood (2006) 2.32
From single cells to deep phenotypes in cancer. Nat Biotechnol (2012) 2.12
B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression. Proc Natl Acad Sci U S A (2010) 2.10
Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity (2010) 2.05
Chemical labeling strategies for cell biology. Nat Methods (2006) 2.05
Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race. Hepatology (2006) 2.03
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood (2006) 1.93
Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry. J Immunol (2005) 1.93
The initial phase of an immune response functions to activate regulatory T cells. J Immunol (2009) 1.88
Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry. J Immunol (2006) 1.72
Decoupling of tumor-initiating activity from stable immunophenotype in HoxA9-Meis1-driven AML. Cell Stem Cell (2012) 1.71
A platinum-based covalent viability reagent for single-cell mass cytometry. Cytometry A (2012) 1.69
Characterization of the murine immunological signaling network with phosphospecific flow cytometry. J Immunol (2005) 1.65
The transcriptional landscape of αβ T cell differentiation. Nat Immunol (2013) 1.61
Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. Cancer Res (2008) 1.58
Luminescent imaging of beta-galactosidase activity in living subjects using sequential reporter-enzyme luminescence. Nat Methods (2006) 1.40
Single-cell phospho-protein analysis by flow cytometry. Curr Protoc Immunol (2007) 1.38
Flow cytometric analysis of kinase signaling cascades. Methods Mol Biol (2004) 1.38
Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell level. Immunol Rev (2006) 1.38
Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A (2010) 1.36
Single-cell mass cytometry for analysis of immune system functional states. Curr Opin Immunol (2013) 1.35
In vivo targeting of organic calcium sensors via genetically selected peptides. Chem Biol (2004) 1.35
Single-cell mass cytometry adapted to measurements of the cell cycle. Cytometry A (2012) 1.33
Activation of the PKB/AKT pathway by ICAM-2. Immunity (2002) 1.31
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. Blood (2007) 1.27
A novel method for detection of phosphorylation in single cells by surface enhanced Raman scattering (SERS) using composite organic-inorganic nanoparticles (COINs). PLoS One (2009) 1.24
Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53. Blood (2006) 1.23
A general approach for chemical labeling and rapid, spatially controlled protein inactivation. Proc Natl Acad Sci U S A (2004) 1.21
Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci U S A (2013) 1.19
T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infection. J Virol (2005) 1.19
Transient partial permeabilization with saponin enables cellular barcoding prior to surface marker staining. Cytometry A (2014) 1.18
Fluorescent cell barcoding for multiplex flow cytometry. Curr Protoc Cytom (2011) 1.16
The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity. J Virol (2006) 1.15
The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals. J Immunol (2009) 1.11
Distinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemia. PLoS One (2010) 1.08
Phospho flow cytometry methods for the analysis of kinase signaling in cell lines and primary human blood samples. Methods Mol Biol (2011) 1.07
Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A (2010) 1.05
CytoSPADE: high-performance analysis and visualization of high-dimensional cytometry data. Bioinformatics (2012) 1.04
Phospho-specific flow cytometry: intersection of immunology and biochemistry at the single-cell level. Curr Opin Mol Ther (2006) 1.00
Tyramide signal amplification for analysis of kinase activity by intracellular flow cytometry. Cytometry A (2010) 0.99
Cloud and heterogeneous computing solutions exist today for the emerging big data problems in biology. Nat Rev Genet (2011) 0.99
Electron microscopy localization and characterization of functionalized composite organic-inorganic SERS nanoparticles on leukemia cells. Ultramicroscopy (2008) 0.99
LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells. Blood (2004) 0.99
Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus. PLoS One (2009) 0.98
Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells. Oncogene (2005) 0.98
Alternate mechanisms of initial pattern recognition drive differential immune responses to related poxviruses. Cell Host Microbe (2010) 0.97
Patient-specific Immune States before Surgery Are Strong Correlates of Surgical Recovery. Anesthesiology (2015) 0.96
Learning signaling network structures with sparsely distributed data. J Comput Biol (2009) 0.95
Transcending the biomarker mindset: deciphering disease mechanisms at the single cell level. Curr Opin Chem Biol (2006) 0.94
Association of reactive oxygen species-mediated signal transduction with in vitro apoptosis sensitivity in chronic lymphocytic leukemia B cells. PLoS One (2011) 0.94
Multiparameter analysis of intracellular phosphoepitopes in immunophenotyped cell populations by flow cytometry. Curr Protoc Cytom (2005) 0.92
Prolonged liver-specific transgene expression by a non-primate lentiviral vector. Biochem Biophys Res Commun (2004) 0.91
Single-cell phospho-protein analysis by flow cytometry. Curr Protoc Immunol (2012) 0.90
A regression model approach to enable cell morphology correction in high-throughput flow cytometry. Mol Syst Biol (2011) 0.90
Lentiviral vectors for the delivery of DNA into mammalian cells. Methods Mol Biol (2004) 0.88
Treatment of autoimmune disease by adoptive cellular gene therapy. Ann N Y Acad Sci (2003) 0.88
Expression from second-generation feline immunodeficiency virus vectors is impaired in human hematopoietic cells. Mol Ther (2002) 0.86
New technologies for autoimmune disease monitoring. Curr Opin Endocrinol Diabetes Obes (2010) 0.85
Retroviral technology--applications for expressed peptide libraries. Front Biosci (2003) 0.84
Characterization of patient specific signaling via augmentation of Bayesian networks with disease and patient state nodes. Conf Proc IEEE Eng Med Biol Soc (2009) 0.84
Antigen-dependent integration of opposing proximal TCR-signaling cascades determines the functional fate of T lymphocytes. J Immunol (2014) 0.83
WebFlow: a software package for high-throughput analysis of flow cytometry data. Assay Drug Dev Technol (2009) 0.82
Conditional protein stabilization via the small molecules Shld-1 and rapamycin increases the signal-to-noise ratio with tet-inducible gene expression. Biotechniques (2009) 0.78
Efficient transduction of pancreatic islets by feline immunodeficiency virus vectors1. Transplantation (2002) 0.78
COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication. PLoS One (2012) 0.78
Mass cytometry to decipher the mechanism of nongenetic drug resistance in cancer. Curr Top Microbiol Immunol (2014) 0.78
A novel splice donor mutation in the thrombopoietin gene leads to exon 2 skipping in a Filipino family with hereditary thrombocythemia. Blood (2011) 0.77
Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events. Stem Cells (2011) 0.77
Differential role of ICAM ligands in determination of human memory T cell differentiation. BMC Immunol (2007) 0.77
Tadpoles by the tail. Nat Methods (2005) 0.77
Snapin, positive regulator of stimulation- induced Ca²⁺ release through RyR, is necessary for HIV-1 replication in T cells. PLoS One (2013) 0.76
T-cell STAT3 is required for the maintenance of humoral immunity to LCMV. Eur J Immunol (2014) 0.76
Recombinant feline immunodeficiency virus vectors. Preparation and use. Methods Mol Med (2002) 0.76
In Reply. Anesthesiology (2016) 0.75