Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases.

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ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation. J Biol Chem (2009) 1.31

Thyroid hormone drives fetal cardiomyocyte maturation. FASEB J (2011) 1.09

Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity. J Biol Chem (2010) 1.03

Calcium regulates ERK signaling by modulating its protein-protein interactions. Commun Integr Biol (2008) 0.99

Fluid shear stress induces renal epithelial gene expression through polycystin-2-dependent trafficking of extracellular regulated kinase. Nephron Physiol (2010) 0.97

Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions. J Cell Sci (2010) 0.92

The N-terminal domain of ERK1 accounts for the functional differences with ERK2. PLoS One (2008) 0.88

Stimulated nuclear import by β-like importins. F1000Prime Rep (2013) 0.85

Anti-inflammatory cannabinoids in diet: Towards a better understanding of CB(2) receptor action? Commun Integr Biol (2008) 0.84

HLA class I-mediated stress fiber formation requires ERK1/2 activation in the absence of an increase in intracellular Ca2+ in human aortic endothelial cells. Am J Physiol Cell Physiol (2012) 0.84

The role of intracellular calcium for the development and treatment of neuroblastoma. Cancers (Basel) (2015) 0.80

Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction. PLoS One (2010) 0.80

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Pulsatile hormonal signaling to extracellular signal-regulated kinase: exploring system sensitivity to gonadotropin-releasing hormone pulse frequency and width. J Biol Chem (2014) 0.79

NOA1, a novel ClpXP substrate, takes an unexpected nuclear detour prior to mitochondrial import. PLoS One (2014) 0.78

Second messengers mediating the proliferation and collagen synthesis of tenocytes induced by low-level laser irradiation. Lasers Med Sci (2014) 0.78

Monomeric and dimeric models of ERK2 in conjunction with studies on cellular localization, nuclear translocation, and in vitro analysis. Mol Cells (2012) 0.77

Specialized Functional Diversity and Interactions of the Na,K-ATPase. Front Physiol (2016) 0.76

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors (2006) 5.58

The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta (2006) 4.06

Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron (2005) 3.09

The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions. Methods Mol Biol (2010) 2.72

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene (2002) 2.50

DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation. Mol Cell (2007) 2.48

The ERK cascade: a prototype of MAPK signaling. Mol Biotechnol (2005) 2.45

CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions. Nat Immunol (2011) 2.05

The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Biochim Biophys Acta (2010) 1.85

The ERK Cascade: Distinct Functions within Various Subcellular Organelles. Genes Cancer (2011) 1.74

Identification and characterization of a general nuclear translocation signal in signaling proteins. Mol Cell (2008) 1.73

Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol (2006) 1.59

Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase. J Mol Biol (2006) 1.57

The mitogen-activated protein kinase signaling cascade: from bench to bedside. Isr Med Assoc J (2002) 1.44

Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. J Biol Chem (2002) 1.37

MAPK kinases as nucleo-cytoplasmic shuttles for PPARgamma. Cell Cycle (2007) 1.37

The subcellular localization of MEK and ERK--a novel nuclear translocation signal (NTS) paves a way to the nucleus. Mol Cell Endocrinol (2009) 1.37

Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. J Clin Invest (2005) 1.36

Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. Mol Cell (2004) 1.34

Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells. J Biol Chem (2007) 1.32

ERK1c regulates Golgi fragmentation during mitosis. J Cell Biol (2006) 1.28

Protein-protein interactions in the regulation of the extracellular signal-regulated kinase. Mol Biotechnol (2005) 1.28

Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy. Biol Chem (2008) 1.25

Activation of MAPK cascades by GnRH: ERK and Jun N-terminal kinase are involved in basal and GnRH-stimulated activity of the glycoprotein hormone LHbeta-subunit promoter. Endocrinology (2002) 1.20

Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci U S A (2007) 1.18

Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation. Mol Cell Biol (2011) 1.17

Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies. Biochem J (2007) 1.16

BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development (2010) 1.14

A positive role of the PI3-K/Akt signaling pathway in PC12 cell differentiation. Mol Cells (2004) 1.11

The ERK signaling cascade--views from different subcellular compartments. Biofactors (2009) 1.11

Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function. Mol Cell Biol (2004) 1.07

Extracellular signal-regulated kinase, Jun N-terminal kinase, p38, and c-Src are involved in gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone follicle-stimulating hormone beta-subunit promoter. Endocrinology (2004) 1.07

Acetylation of the chemotaxis response regulator CheY by acetyl-CoA synthetase purified from Escherichia coli. J Mol Biol (2004) 1.07

Retracted Regulation of p53: intricate loops and delicate balances. Biochem Pharmacol (2002) 1.05

PPARgamma and MEK Interactions in Cancer. PPAR Res (2008) 1.02

Regulation of p53: intricate loops and delicate balances. Ann N Y Acad Sci (2002) 1.01

Glycolysis and glucose transporter 1 as markers of response to hormonal therapy in breast cancer. Int J Cancer (2003) 1.00

Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits. Eur J Biochem (2002) 1.00

Calcium regulates ERK signaling by modulating its protein-protein interactions. Commun Integr Biol (2008) 0.99

Phosphomimetic mutants of pigment epithelium-derived factor with enhanced antiangiogenic activity as potent anticancer agents. Cancer Res (2010) 0.98

Manipulation of redox signaling in mammalian cells enabled by controlled photogeneration of reactive oxygen species. J Cell Sci (2005) 0.97

The chemotaxis response regulator CheY can catalyze its own acetylation. J Mol Biol (2006) 0.96

Acetylation represses the binding of CheY to its target proteins. Mol Microbiol (2010) 0.96

Purification of Na+,K+-ATPase expressed in Pichia pastoris reveals an essential role of phospholipid-protein interactions. J Biol Chem (2005) 0.95

Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1. J Clin Endocrinol Metab (2003) 0.94

Activation of mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent. Mol Cell Endocrinol (2006) 0.94

The ERK cascade as a prototype of MAPK signaling pathways. Methods Mol Biol (2004) 0.94

Distribution and function of new bacterial intein-like protein domains. Mol Microbiol (2003) 0.94

ERK as a model for systems biology of enzyme kinetics in cells. Curr Biol (2013) 0.94

Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality. J Biol Chem (2008) 0.93

In vivo acetylation of CheY, a response regulator in chemotaxis of Escherichia coli. J Mol Biol (2008) 0.93

MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. J Cell Sci (2004) 0.93

Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor. Blood (2004) 0.92

Retracted Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and p38-mediated migration arrest. J Biol Chem (2010) 0.91

Retracted c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells. J Biol Chem (2003) 0.91

Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade. Genes Dev (2009) 0.90

The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain. Mol Cell Biol (2011) 0.89

A preformed signaling complex mediates GnRH-activated ERK phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells. Mol Endocrinol (2009) 0.89

Covalent cross-links between the gamma subunit (FXYD2) and alpha and beta subunits of Na,K-ATPase: modeling the alpha-gamma interaction. J Biol Chem (2005) 0.88

The ATP-Mg2+ binding site and cytoplasmic domain interactions of Na+,K+-ATPase investigated with Fe2+-catalyzed oxidative cleavage and molecular modeling. Biochemistry (2002) 0.88

Extracellular signal-regulated kinase and c-Src, but not Jun N-terminal kinase, are involved in basal and gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone alpha-subunit promoter. Endocrinology (2003) 0.87

Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells. J Biol Chem (2012) 0.87

Differential role of PKC isoforms in GnRH and phorbol 12-myristate 13-acetate activation of extracellular signal-regulated kinase and Jun N-terminal kinase. Endocrinology (2010) 0.87

Retracted Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation. J Biol Chem (2011) 0.85

Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF. FEBS J (2008) 0.85

Stimulated nuclear import by β-like importins. F1000Prime Rep (2013) 0.85

Variable phosphorylation states of pigment-epithelium-derived factor differentially regulate its function. Blood (2005) 0.84

Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinases. Mol Cell Biol (2013) 0.84

Gonadotropin-releasing hormone in apoptosis of prostate cancer cells. Cancer Lett (2005) 0.84

Determination of ERK activity: anti-phospho-ERK antibodies and in vitro phosphorylation. Methods Mol Biol (2010) 0.81

ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage. Oncogene (2002) 0.80

Fe2+ -catalyzed oxidative cleavages of Ca2+ -ATPase reveal novel features of its pumping mechanism. J Biol Chem (2004) 0.80

Mxi2 sustains ERK1/2 phosphorylation in the nucleus by preventing ERK1/2 binding to phosphatases. Biochem J (2012) 0.80

ERK signaling in colorectal cancer: a preliminary report on the expression of phosphorylated ERK and the effects of radiation therapy. Am J Clin Oncol (2008) 0.80

Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction. PLoS One (2010) 0.80

Use of inhibitors in the study of MAPK signaling. Methods Mol Biol (2004) 0.79

Gonadotropin-releasing hormone induces apoptosis of prostate cancer cells: role of c-Jun NH2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways. Cancer Res (2004) 0.79

Mechanisms of gonadotropin desensitization. Mol Cell Endocrinol (2002) 0.79

Ligand interaction scan (LIScan) in the study of ERK8. Biochem Biophys Res Commun (2010) 0.79

Maturation-promoting factor governs mitogen-activated protein kinase activation and interphase suppression during meiosis of rat oocytes. Biol Reprod (2002) 0.79

Deletion of alloreactive T cells by veto cytotoxic T lymphocytes is mediated through extracellular signal-regulated kinase phosphorylation. Transplantation (2010) 0.78

Differential signaling of the GnRH receptor in pituitary gonadotrope cell lines and prostate cancer cell lines. Mol Cell Endocrinol (2013) 0.78

Gender and sexual behavior modulate the composition of serum lipocalins in Nile tilapia (Oreochromis niloticus). Gene (2012) 0.77

Determination of ERK activity: antiphospho-ERK antibodies, in vitro phosphorylation, and in-gel kinase assay. Methods Mol Biol (2004) 0.77

Nuclear localization of phosphorylated ERK1 and ERK2 as markers for the progression of ovarian cancer. Int J Oncol (2011) 0.77

Role of non-phosphorylated activation loop residues in determining ERK2 dephosphorylation, activity, and subcellular localization. J Biol Chem (2007) 0.77

SB203580 induces prolonged B-Raf activation and promotes neuronal differentiation upon EGF treatment of PC12 cells. Biochemistry (Mosc) (2004) 0.76

The detection of MAPK signaling. Curr Protoc Mol Biol (2006) 0.76

A 50-kDa ERK-like protein is up-regulated by a dual altered peptide ligand that suppresses myasthenia gravis-associated responses. Proc Natl Acad Sci U S A (2006) 0.76

Conjugates of gonadotropin releasing hormone (GnRH) with carminic acid: Synthesis, generation of reactive oxygen species (ROS) and biological evaluation. Bioorg Med Chem (2008) 0.76

Ecto- and exo-protein kinases in Schistosoma mansoni: regulation of surface phosphorylation by acetylcholine and identification of the alpha subunit of CKII as a major secreted protein kinase. J Parasitol (2005) 0.76

Isolation and characterization of porins from Desulfovibrio piger and Bilophila wadsworthia: structure and gene sequencing. Arch Microbiol (2008) 0.76

Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs. J Biol Chem (2017) 0.75

Two initiation sites of early detection of colon cancer revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of the tumor cells. Acta Histochem (2013) 0.75

c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells. J Biol Chem (2017) 0.75

Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases. J Biol Chem (2017) 0.75

Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone. J Biol Chem (2017) 0.75