Neuropathic pain: a maladaptive response of the nervous system to damage.

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Published in Annu Rev Neurosci on January 01, 2009

Authors

Michael Costigan1, Joachim Scholz, Clifford J Woolf

Author Affiliations

1: Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA. mcostigan@partners.org

Associated clinical trials:

Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain (CT-Pain) | NCT04798573

Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy | NCT04920097

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Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. J Neurosci (2005) 1.29

Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. Hum Mol Genet (2005) 1.29

Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. Eur J Neurosci (2004) 1.27

Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats. Mol Pain (2005) 1.26

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype. Eur J Pain (2008) 1.26

The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor. Gastroenterology (2004) 1.25

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci (2013) 1.25

COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest (2009) 1.18

TrpA1 regulates thermal nociception in Drosophila. PLoS One (2011) 1.15

Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol (2013) 1.14

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. J Am Coll Cardiol (2008) 1.13

Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. J Neurosci (2008) 1.13

The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models. Pain (2002) 1.12

Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. J Neurosci (2005) 1.10

Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol (2013) 1.09

A classification of chronic pain for ICD-11. Pain (2015) 1.09

Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing. J Neurosci (2013) 1.06

Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain (2013) 1.06

Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats. Pain (2008) 1.04

Selective up-regulation of the growth arrest DNA damage-inducible gene Gadd45 alpha in sensory and motor neurons after peripheral nerve injury. Eur J Neurosci (2003) 1.03

5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. J Neurosci (2012) 1.03

GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord. Mol Cell Neurosci (2007) 1.01

Bradykinin and peripheral sensitization. Biol Chem (2006) 0.95

Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. Endocrinology (2005) 0.93

The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans. Gastroenterology (2003) 0.92

Future directions in neuropathic pain therapy: closing the translational loop. Oncologist (2010) 0.92

Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve. Anesthesiology (2008) 0.92

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Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats. Eur J Neurosci (2008) 0.91

Exploiting microarrays to reveal differential gene expression in the nervous system. Genome Biol (2003) 0.90

The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. J Neurosci (2011) 0.90

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Patients with chest pain and occult gastroesophageal reflux demonstrate visceral pain hypersensitivity which may be partially responsive to acid suppression. Am J Gastroenterol (2004) 0.89