Published in Diabetologia on December 30, 2011
AMPK and Exercise: Glucose Uptake and Insulin Sensitivity. Diabetes Metab J (2013) 1.03
Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway. Br J Pharmacol (2015) 0.95
Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging. J Gerontol A Biol Sci Med Sci (2013) 0.87
ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Mol Cell (2015) 0.85
Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases. J Med Chem (2014) 0.84
Artemisia scoparia enhances adipocyte development and endocrine function in vitro and enhances insulin action in vivo. PLoS One (2014) 0.83
Influence of diet on visceral adipose remodeling in NONcNZO10 mice with polygenic susceptibility for type 2 diabetes. Obesity (Silver Spring) (2012) 0.82
Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes. Cell Physiol Biochem (2015) 0.80
The PI3K pathway in B cell metabolism. Crit Rev Biochem Mol Biol (2016) 0.78
Regulation of a truncated isoform of AMP-activated protein kinase α (AMPKα) in response to hypoxia in the muscle of Pacific oyster Crassostrea gigas. J Comp Physiol B (2013) 0.77
Glucose deprivation promotes activation of mTOR signaling pathway and protein synthesis in rat skeletal muscle cells. Pflugers Arch (2014) 0.76
GnRH Regulates Gonadotropin Gene Expression Through NADPH/Dual Oxidase-Derived Reactive Oxygen Species. Endocrinology (2015) 0.75
Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity. PLoS One (2014) 0.75
Role of free fatty acids in endothelial dysfunction. J Biomed Sci (2017) 0.75
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65
AMPK in Health and Disease. Physiol Rev (2009) 6.38
AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res (2007) 6.36
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab (2006) 4.98
AMP-activated protein kinase--development of the energy sensor concept. J Physiol (2006) 4.93
AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab (2009) 4.30
Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem Sci (2005) 3.77
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem (2005) 3.74
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie (2005) 3.20
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res (2004) 2.91
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest (1995) 2.66
Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Proc Natl Acad Sci U S A (2002) 2.62
AMP-activated protein kinase in the heart: role during health and disease. Circ Res (2007) 2.27
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem (2005) 2.24
Role of glycogen synthase kinase-3beta in cardioprotection. Circ Res (2009) 2.10
Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE (2005) 2.04
5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside. J Biol Chem (2001) 1.97
AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. Mol Endocrinol (2010) 1.75
Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation. J Biol Chem (2003) 1.75
Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Res Treat (2010) 1.67
Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol (2004) 1.65
Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. J Biol Chem (2003) 1.62
Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells. Endocrinology (2001) 1.56
Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. J Biol Chem (2003) 1.47
TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat Cell Biol (2002) 1.42
Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity. Proc Natl Acad Sci U S A (1986) 1.40
Glucose transport in the heart. Front Biosci (2004) 1.40
AKT signaling in physiology and disease. Curr Top Microbiol Immunol (2010) 1.35
Insulin resistance in obesity as the underlying cause for the metabolic syndrome. Mt Sinai J Med (2010) 1.29
Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes (2003) 1.14
Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells. Mol Endocrinol (2008) 1.12
Glucose transport activity in L6 muscle cells is regulated by the coordinate control of subcellular glucose transporter distribution, biosynthesis, and mRNA transcription. J Biol Chem (1990) 1.12
Phosphorylation of purified insulin receptor by cAMP kinase. Diabetes (1987) 1.11
Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. J Cell Biol (2004) 1.10
Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223. Endocrinology (2005) 1.09
Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr Diabetes Rev (2005) 1.06
In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents. J Biol Chem (2002) 1.04
Hypoxia regulates the adenosine transporter, mENT1, in the murine cardiomyocyte cell line, HL-1. Cardiovasc Res (2004) 0.98
Dephosphorylation of insulin-receptor autophosphorylation sites by particulate and soluble phosphotyrosyl-protein phosphatases. Biochem J (1990) 0.97
Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with beta isoenzymes and interaction with the catalytic domain of betaII. Cell Signal (2004) 0.92
Murine muscle cell models for Pompe disease and their use in studying therapeutic approaches. Mol Genet Metab (2009) 0.92
Substrate autoregulation of glucose transport: hexose 6-phosphate mediates the cellular distribution of glucose transporters. Diabetologia (1997) 0.87
Activation of the Cbl insulin signaling pathway in cardiac muscle; dysregulation in obesity and diabetes. Biochem Biophys Res Commun (2006) 0.84
Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation. J Biol Chem (1991) 0.83
Differential role of insulin receptor autophosphorylation sites 1162 and 1163 in the long-term insulin stimulation of glucose transport, glycogenesis, and protein synthesis. J Biol Chem (1992) 0.80
Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation. Diabetes (2000) 0.79
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest (2001) 7.20
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol (1997) 6.61
Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med (1999) 6.27
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science (1997) 6.10
Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A (1996) 6.00
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell (1996) 5.45
HMG-1 as a mediator of acute lung inflammation. J Immunol (2000) 4.78
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci U S A (2001) 4.62
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science (1999) 4.61
Evolutionary analyses of the human genome. Nature (2001) 4.13
Gene expression profiles during the initial phase of salt stress in rice. Plant Cell (2001) 4.11
Quantum ground state and single-phonon control of a mechanical resonator. Nature (2010) 3.71
Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1. Genes Dev (1990) 3.62
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med (1999) 3.57
Requirement for math5 in the development of retinal ganglion cells. Genes Dev (2001) 3.26
A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature (1997) 3.26
Alternative gene form discovery and candidate gene selection from gene indexing projects. Genome Res (1998) 3.26
Hyperexpression of mitogen-activated protein kinase in human breast cancer. J Clin Invest (1997) 3.26
Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron (1998) 3.18
An association between renal cell carcinoma and lymphoid malignancies. A case series of eight patients. Cancer (1996) 3.12
A floral transmitting tissue-specific glycoprotein attracts pollen tubes and stimulates their growth. Cell (1995) 2.85
Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol (2001) 2.85
Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J (2012) 2.81
Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J Virol (2001) 2.79
MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene (2007) 2.79
Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol (2000) 2.78
Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution. Acta Crystallogr D Biol Crystallogr (1999) 2.77
Ecology. Giant pandas in a changing landscape. Science (2001) 2.73
Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem (2000) 2.71
Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth (2013) 2.70
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68
Effect of peer led programme for asthma education in adolescents: cluster randomised controlled trial. BMJ (2001) 2.67
Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66
Strongly enhanced current densities in superconducting coated conductors of YBa2Cu3O7-x + BaZrO3. Nat Mater (2004) 2.61
Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res (2001) 2.53
Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature (2000) 2.51
Integrin activation by R-ras. Cell (1996) 2.50
High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum (2002) 2.45
Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations. Curr Genet (1987) 2.42
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A (1999) 2.42
A theoretical solution for the frictionless rolling contact of cylindrical biphasic articular cartilage layers. J Biomech (1995) 2.42
On sample size calculation in bioequivalence trials. J Pharmacokinet Pharmacodyn (2001) 2.40
GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development (1997) 2.38
Fire and flood management of coastal swamp enabled first rice paddy cultivation in east China. Nature (2007) 2.36
Discovering molecular pathways from protein interaction and gene expression data. Bioinformatics (2003) 2.32
Phylogeny of the Simbu serogroup of the genus Bunyavirus. J Gen Virol (2001) 2.30
Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet Genome Res (2004) 2.26
A PhoP-regulated outer membrane protease of Salmonella enterica serovar typhimurium promotes resistance to alpha-helical antimicrobial peptides. J Bacteriol (2000) 2.26
Single-molecule recognition imaging microscopy. Proc Natl Acad Sci U S A (2004) 2.25
Validation of the functional assessment of multiple sclerosis quality of life instrument. Neurology (1996) 2.20
Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT. Phys Med Biol (1994) 2.19
NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP. Nature (1999) 2.18
Quality of life for children with fecal incontinence after surgically corrected anorectal malformation. J Pediatr Surg (2000) 2.17
Energy transduction in ATP synthase. Nature (1998) 2.15
Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem (1998) 2.15
Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol (2010) 2.15
TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res (2010) 2.14
A pollen tube growth stimulatory glycoprotein is deglycosylated by pollen tubes and displays a glycosylation gradient in the flower. Cell (1995) 2.14
Materials science challenges for high-temperature superconducting wire. Nat Mater (2007) 2.13
The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia (2009) 2.11
CORG: a database for COmparative Regulatory Genomics. Nucleic Acids Res (2003) 2.06
Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Mol Cell Biol (1997) 2.04
Synthesizing arbitrary quantum states in a superconducting resonator. Nature (2009) 2.03
Regional hippocampal atrophy in multiple sclerosis. Brain (2008) 2.02
In vitro Arabidopsis pollen germination and characterization of the inward potassium currents in Arabidopsis pollen grain protoplasts. J Exp Bot (2001) 2.01
Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest (1997) 2.00
Expression of ethylene biosynthetic pathway transcripts in senescing carnation flowers. Plant Physiol (1992) 1.99
Three-dimensional evaluation of upper airway in patients with different anteroposterior skeletal patterns. Orthod Craniofac Res (2013) 1.97
Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. J Biol Chem (2001) 1.96
Identification of two factors required for transcription of the ovalbumin gene. Mol Cell Biol (1986) 1.96
Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II). Cell (1987) 1.95
Violation of Bell's inequality in Josephson phase qubits. Nature (2009) 1.92
Building a root: the control of patterning and morphogenesis during root development. Plant Cell (1997) 1.89
The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem (1997) 1.87
Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Hum Mol Genet (2000) 1.87
Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity. Kidney Int (2008) 1.86
Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49. J Biol Chem (1997) 1.83
Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circ Res (2001) 1.83
Polymer-assisted deposition of metal-oxide films. Nat Mater (2004) 1.83
Effects of the renin-angiotensin system on the current I(to) in epicardial and endocardial ventricular myocytes from the canine heart. Circ Res (2000) 1.81
Generation of three-qubit entangled states using superconducting phase qubits. Nature (2010) 1.81
Protein kinase CK2 signal in neoplasia. Histol Histopathol (2001) 1.79
MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circ Res (2001) 1.78
Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem Biophys Res Commun (1998) 1.77
Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat Med (1998) 1.76
Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent. Diabetologia (2007) 1.73
Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock. Lancet (1999) 1.71
Reverse engineering a protein: the mechanochemistry of ATP synthase. Biochim Biophys Acta (2000) 1.71
Genetic variation in the 3' non-coding region of dengue viruses. Virology (2001) 1.71
Nucleotide sequences and phylogeny of the nucleocapsid gene of Oropouche virus. J Gen Virol (2000) 1.70
Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes. Circ Res (2000) 1.70
Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. Neuroscience (2010) 1.70
Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response. J Exp Med (1997) 1.70
Implementing the quantum von Neumann architecture with superconducting circuits. Science (2011) 1.68
Predicting antibody hypervariable loop conformations. II: Minimization and molecular dynamics studies of MCPC603 from many randomly generated loop conformations. Proteins (1986) 1.67
NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio. Cell (1998) 1.67