PubRank

Dennis L Murphy

Author PubWeight™ 120.22‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 2006 6.27
2 Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet 2005 3.24
3 Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Am J Psychiatry 2007 2.84
4 Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet 2003 2.55
5 A human serotonin transporter mutation causes constitutive activation of transport activity. Mol Pharmacol 2003 2.15
6 Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33. Am J Psychiatry 2007 1.85
7 Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet 2013 1.68
8 Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Methods 2004 1.59
9 Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry 2003 1.58
10 Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest 2008 1.57
11 Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories. Psychiatry Res 2008 1.54
12 Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. Cereb Cortex 2009 1.48
13 Psychiatric symptoms associated with focal hand dystonia. Mov Disord 2010 1.47
14 Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Behav Res Ther 2006 1.41
15 Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology 2004 1.41
16 A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet 2007 1.39
17 Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology 2002 1.39
18 Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology 2003 1.36
19 Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity. Psychiatry Res 2005 1.31
20 Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice. Am J Physiol Gastrointest Liver Physiol 2008 1.31
21 Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. Behav Pharmacol 2008 1.23
22 Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene. Endocrinology 2002 1.23
23 Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study. Biol Psychiatry 2006 1.22
24 Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism. J Neurosci 2006 1.21
25 Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology 2005 1.20
26 Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome. Brain 2012 1.19
27 Analyzing grooming microstructure in neurobehavioral experiments. Nat Protoc 2007 1.18
28 Ethanol-related behaviors in serotonin transporter knockout mice. Alcohol Clin Exp Res 2006 1.18
29 A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry 2009 1.16
30 Involvement of insula and cingulate cortices in control and suppression of natural urges. Cereb Cortex 2008 1.14
31 Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees. Biol Psychiatry 2004 1.13
32 Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice. Behav Genet 2007 1.10
33 Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies. Cell Mol Neurobiol 2006 1.09
34 Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter. Am J Physiol Gastrointest Liver Physiol 2002 1.08
35 Reduced aggression in mice lacking the serotonin transporter. Psychopharmacology (Berl) 2002 1.08
36 The OCD collaborative genetics study: methods and sample description. Am J Med Genet B Neuropsychiatr Genet 2006 1.08
37 Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice. Proc Natl Acad Sci U S A 2005 1.08
38 Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain Res 2002 1.08
39 A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder. Neuropsychopharmacology 2007 1.07
40 Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. J Neurochem 2003 1.07
41 Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice. J Neurochem 2003 1.07
42 Absence of thermal hyperalgesia in serotonin transporter-deficient mice. J Neurosci 2003 1.05
43 Vulnerability to mild predator stress in serotonin transporter knockout mice. Behav Brain Res 2006 1.05
44 5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter. Psychopharmacology (Berl) 2005 1.03
45 Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. Psychopharmacology (Berl) 2008 1.02
46 The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch 2013 1.02
47 Exploration of anxiety sensitivity and distress tolerance as vulnerability factors for hoarding behaviors. Depress Anxiety 2009 1.01
48 Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction. J Immunol 2009 1.00
49 Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Eur J Pharmacol 2007 1.00
50 Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice. Neuropharmacology 2007 0.98
51 Do traumatic events influence the clinical expression of compulsive hoarding? Behav Res Ther 2007 0.98
52 The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology (Berl) 2009 0.98
53 Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. J Neurosci Res 2005 0.97
54 Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder. Psychiatr Genet 2008 0.97
55 The developing use of heterozygous mutant mouse models in brain monoamine transporter research. Trends Pharmacol Sci 2007 0.96
56 miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells. Int J Neuropsychopharmacol 2012 0.94
57 A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacology (Berl) 2007 0.94
58 An investigation of traumatic life events and obsessive-compulsive disorder. Behav Res Ther 2006 0.94
59 Diagnostic interview assessed neuropsychiatric disorder comorbidity in 334 individuals with obsessive-compulsive disorder. Depress Anxiety 2004 0.93
60 Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences. J Neurosci 2004 0.93
61 Locomotory patterns, spatiotemporal organization of exploration and spatial memory in serotonin transporter knockout mice. Brain Res 2007 0.93
62 Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2011 0.93
63 Domain interplay concept in animal models of neuropsychiatric disorders: a new strategy for high-throughput neurophenotyping research. Behav Brain Res 2007 0.91
64 SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder. Psychiatr Genet 2008 0.91
65 Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Am J Psychiatry 2014 0.90
66 Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nat Genet 2004 0.90
67 Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters. Synapse 2005 0.90
68 17beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection. FASEB J 2003 0.89
69 Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism. Am J Med Genet B Neuropsychiatr Genet 2006 0.89
70 Effects of metergoline on symptoms in women with premenstrual dysphoric disorder. Am J Psychiatry 2002 0.89
71 The importance of cognitive phenotypes in experimental modeling of animal anxiety and depression. Neural Plast 2007 0.89
72 The hoarding dimension of OCD: psychological comorbidity and the five-factor personality model. Behav Res Ther 2006 0.88
73 Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT). Br J Pharmacol 2010 0.87
74 Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice. Neuropsychopharmacology 2009 0.87
75 Are serotonin transporter knockout mice 'depressed'?: hypoactivity but no anhedonia. Neuroreport 2006 0.87
76 Sex-specific clinical correlates of hoarding in obsessive-compulsive disorder. Behav Res Ther 2008 0.87
77 Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC Pharmacol 2011 0.87
78 Increased gene expression of diacylglycerol kinase η in bipolar disorder. Int J Neuropsychopharmacol 2010 0.86
79 Using individual items to clarify OCD symptom structure: the case for five factors. Am J Psychiatry 2009 0.86
80 BDNF in anxiety and depression. Science 2006 0.86
81 Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress. Ann N Y Acad Sci 2004 0.85
82 Cerebrospinal fluid monoamine metabolite levels in human newborn infants born in winter differ from those born in summer. Psychiatry Res 2006 0.83
83 An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice. Psychopharmacology (Berl) 2013 0.83
84 Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder. Mov Disord 2013 0.83
85 Role of the redox protein thioredoxin in cytoprotective mechanism evoked by (-)-deprenyl. Mol Pharmacol 2005 0.82
86 Reduced programmed cell death in brains of serotonin transporter knockout mice. Neuroreport 2003 0.82
87 Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20. Psychiatr Genet 2008 0.82
88 Serotonergic-like progenitor cells propagated from neural stem cells in vitro: survival with SERT protein expression following implantation into brains of mice lacking SERT. FASEB J 2005 0.82
89 Phenomenological features and clinical impact of affective disorders in OCD: a focus on the bipolar disorder and OCD connection. Depress Anxiety 2011 0.82
90 Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset. Brain Imaging Behav 2009 0.81
91 The regular and light-dark Suok tests of anxiety and sensorimotor integration: utility for behavioral characterization in laboratory rodents. Nat Protoc 2008 0.81
92 (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter. J Pharmacol Exp Ther 2005 0.79
93 Characterization of SLITRK1 variation in obsessive-compulsive disorder. PLoS One 2013 0.79
94 Consideration of the BDNF gene in relation to two phenotypes: hoarding and obesity. J Abnorm Psychol 2011 0.79
95 Predicting genetic loading from symptom patterns in obsessive- compulsive disorder: a latent variable analysis. Depress Anxiety 2008 0.79
96 Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. Behav Pharmacol 2015 0.78
97 The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-chlorophenylpiperazine in leuprolide-induced hypogonadism in women and men. Neuropsychopharmacology 2002 0.77
98 Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB). J Pharmacol Exp Ther 2003 0.77
99 Hybridizing behavioral models: a possible solution to some problems in neurophenotyping research? Prog Neuropsychopharmacol Biol Psychiatry 2007 0.77
100 Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive-compulsive disorder: Results from the OCD Collaborative Genetics Study. Am J Med Genet B Neuropsychiatr Genet 2014 0.77
101 Separation anxiety disorder in OCD. Depress Anxiety 2011 0.77
102 Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder. Depress Anxiety 2008 0.77
103 Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. Int J Neuropsychopharmacol 2009 0.77
104 Developmental alterations in anxiety and cognitive behavior in serotonin transporter mutant mice. Psychopharmacology (Berl) 2014 0.76
105 Perspectives on genetic animal models of serotonin toxicity. Neurochem Int 2007 0.76
106 Neuronal and astroglial responses to the serotonin and norepinephrine neurotoxin: 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine. J Pharmacol Exp Ther 2003 0.76
107 Refining psychiatric genetics: from 'mouse psychiatry' to understanding complex human disorders. Behav Pharmacol 2008 0.76
108 Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse. Eur J Pharmacol 2008 0.76
109 Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Behav Pharmacol 2015 0.75
110 2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: a comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine]. J Pharmacol Exp Ther 2002 0.75