Published in Neuropsychopharmacology on March 21, 2007
How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology (2008) 1.56
Multiple rare SAPAP3 missense variants in trichotillomania and OCD. Mol Psychiatry (2009) 1.37
Pharmacogenetics of antidepressant response. J Psychiatry Neurosci (2011) 1.28
A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry (2009) 1.16
BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology (2009) 1.11
Genetics of early-onset obsessive-compulsive disorder. Eur Child Adolesc Psychiatry (2010) 0.97
The genetics of obsessive-compulsive disorder: a review. Dialogues Clin Neurosci (2010) 0.95
Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity. Philos Trans R Soc Lond B Biol Sci (2013) 0.94
Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis. Front Integr Neurosci (2013) 0.94
Association of serotonin transporter gene polymorphisms with obsessive-compulsive disorder (OCD) in a south Indian population. Indian J Med Res (2010) 0.90
Dopamine D4 receptor and serotonin transporter gene effects on the longitudinal development of infant temperament. Genes Brain Behav (2011) 0.88
Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder. Mov Disord (2013) 0.83
Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes. Eur J Hum Genet (2013) 0.81
AVPR1A and SLC6A4 polymorphisms in choral singers and non-musicians: a gene association study. PLoS One (2012) 0.81
Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder. Neurosci Lett (2014) 0.79
Consideration of the BDNF gene in relation to two phenotypes: hoarding and obesity. J Abnorm Psychol (2011) 0.79
A review of the serotonin transporter and prenatal cortisol in the development of autism spectrum disorders. Mol Autism (2013) 0.78
The Genetics of Obsessive-Compulsive Disorder. Curr Psychiatry Rev (2010) 0.77
Network Modules of the Cross-Species Genotype-Phenotype Map Reflect the Clinical Severity of Human Diseases. PLoS One (2015) 0.75
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet (2005) 3.24
Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Am J Psychiatry (2007) 2.84
Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet (2003) 2.55
A human serotonin transporter mutation causes constitutive activation of transport activity. Mol Pharmacol (2003) 2.15
Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33. Am J Psychiatry (2007) 1.85
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68
Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Methods (2004) 1.59
Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry (2003) 1.58
Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest (2008) 1.57
Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories. Psychiatry Res (2008) 1.54
Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. Cereb Cortex (2009) 1.48
Psychiatric symptoms associated with focal hand dystonia. Mov Disord (2010) 1.47
Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Behav Res Ther (2006) 1.41
Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology (2004) 1.41
A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet (2007) 1.39
Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology (2002) 1.39
Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology (2003) 1.36
Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity. Psychiatry Res (2005) 1.31
Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice. Am J Physiol Gastrointest Liver Physiol (2008) 1.31
Discomfort intolerance: evaluation of a potential risk factor for anxiety psychopathology. Behav Ther (2007) 1.26
Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. Behav Pharmacol (2008) 1.23
Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene. Endocrinology (2002) 1.23
Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study. Biol Psychiatry (2006) 1.22
Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism. J Neurosci (2006) 1.21
Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology (2005) 1.20
Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome. Brain (2012) 1.19
Analyzing grooming microstructure in neurobehavioral experiments. Nat Protoc (2007) 1.18
Ethanol-related behaviors in serotonin transporter knockout mice. Alcohol Clin Exp Res (2006) 1.18
A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry (2009) 1.16
Involvement of insula and cingulate cortices in control and suppression of natural urges. Cereb Cortex (2008) 1.14
Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees. Biol Psychiatry (2004) 1.13
Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice. Behav Genet (2007) 1.10
Social anxiety and insomnia: the mediating role of depressive symptoms. Depress Anxiety (2008) 1.10
Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies. Cell Mol Neurobiol (2006) 1.09
Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter. Am J Physiol Gastrointest Liver Physiol (2002) 1.08
Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain Res (2002) 1.08
The OCD collaborative genetics study: methods and sample description. Am J Med Genet B Neuropsychiatr Genet (2006) 1.08
Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice. Proc Natl Acad Sci U S A (2005) 1.08
Reduced aggression in mice lacking the serotonin transporter. Psychopharmacology (Berl) (2002) 1.08
Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice. J Neurochem (2003) 1.07
Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. J Neurochem (2003) 1.07
Absence of thermal hyperalgesia in serotonin transporter-deficient mice. J Neurosci (2003) 1.05
Vulnerability to mild predator stress in serotonin transporter knockout mice. Behav Brain Res (2006) 1.05
5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter. Psychopharmacology (Berl) (2005) 1.03
Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. Psychopharmacology (Berl) (2008) 1.02
The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch (2013) 1.02
Exploration of anxiety sensitivity and distress tolerance as vulnerability factors for hoarding behaviors. Depress Anxiety (2009) 1.01
Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Eur J Pharmacol (2007) 1.00
Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction. J Immunol (2009) 1.00
Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice. Neuropharmacology (2007) 0.98
Do traumatic events influence the clinical expression of compulsive hoarding? Behav Res Ther (2007) 0.98
The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology (Berl) (2009) 0.98
Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder. Psychiatr Genet (2008) 0.97
Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. J Neurosci Res (2005) 0.97
The developing use of heterozygous mutant mouse models in brain monoamine transporter research. Trends Pharmacol Sci (2007) 0.96
miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells. Int J Neuropsychopharmacol (2012) 0.94
A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacology (Berl) (2007) 0.94
An investigation of traumatic life events and obsessive-compulsive disorder. Behav Res Ther (2006) 0.94
Locomotory patterns, spatiotemporal organization of exploration and spatial memory in serotonin transporter knockout mice. Brain Res (2007) 0.93
Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences. J Neurosci (2004) 0.93
Diagnostic interview assessed neuropsychiatric disorder comorbidity in 334 individuals with obsessive-compulsive disorder. Depress Anxiety (2004) 0.93
Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet (2011) 0.93
Domain interplay concept in animal models of neuropsychiatric disorders: a new strategy for high-throughput neurophenotyping research. Behav Brain Res (2007) 0.91
SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder. Psychiatr Genet (2008) 0.91
Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters. Synapse (2005) 0.90
Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nat Genet (2004) 0.90
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Am J Psychiatry (2014) 0.90
17beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection. FASEB J (2003) 0.89
The importance of cognitive phenotypes in experimental modeling of animal anxiety and depression. Neural Plast (2007) 0.89
Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism. Am J Med Genet B Neuropsychiatr Genet (2006) 0.89
Effects of metergoline on symptoms in women with premenstrual dysphoric disorder. Am J Psychiatry (2002) 0.89
The hoarding dimension of OCD: psychological comorbidity and the five-factor personality model. Behav Res Ther (2006) 0.88
Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT). Br J Pharmacol (2010) 0.87
Are serotonin transporter knockout mice 'depressed'?: hypoactivity but no anhedonia. Neuroreport (2006) 0.87
Sex-specific clinical correlates of hoarding in obsessive-compulsive disorder. Behav Res Ther (2008) 0.87
Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice. Neuropsychopharmacology (2009) 0.87
Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC Pharmacol (2011) 0.87
Increased gene expression of diacylglycerol kinase η in bipolar disorder. Int J Neuropsychopharmacol (2010) 0.86
Using individual items to clarify OCD symptom structure: the case for five factors. Am J Psychiatry (2009) 0.86
BDNF in anxiety and depression. Science (2006) 0.86
Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress. Ann N Y Acad Sci (2004) 0.85
Cerebrospinal fluid monoamine metabolite levels in human newborn infants born in winter differ from those born in summer. Psychiatry Res (2006) 0.83
Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder. Mov Disord (2013) 0.83
An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice. Psychopharmacology (Berl) (2013) 0.83
Serotonergic-like progenitor cells propagated from neural stem cells in vitro: survival with SERT protein expression following implantation into brains of mice lacking SERT. FASEB J (2005) 0.82
Reduced programmed cell death in brains of serotonin transporter knockout mice. Neuroreport (2003) 0.82
Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20. Psychiatr Genet (2008) 0.82
Role of the redox protein thioredoxin in cytoprotective mechanism evoked by (-)-deprenyl. Mol Pharmacol (2005) 0.82
Phenomenological features and clinical impact of affective disorders in OCD: a focus on the bipolar disorder and OCD connection. Depress Anxiety (2011) 0.82
The regular and light-dark Suok tests of anxiety and sensorimotor integration: utility for behavioral characterization in laboratory rodents. Nat Protoc (2008) 0.81
Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset. Brain Imaging Behav (2009) 0.81
(+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter. J Pharmacol Exp Ther (2005) 0.79
Consideration of the BDNF gene in relation to two phenotypes: hoarding and obesity. J Abnorm Psychol (2011) 0.79
Characterization of SLITRK1 variation in obsessive-compulsive disorder. PLoS One (2013) 0.79