The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans.

PubWeight™: 1.38‹?› | Rank: Top 10%

🔗 View Article (PMC 1073676)

Published in Mol Biol Cell on January 26, 2005

Authors

Mykola M Maidan1, Larissa De Rop, Joke Serneels, Simone Exler, Steffen Rupp, Hélène Tournu, Johan M Thevelein, Patrick Van Dijck

Author Affiliations

1: Department of Molecular Microbiology, Flanders Interuniversity Institute for Biotechnology (VIB) and Laboratory of Molecular Cell Biology, Katholieke Universiteit Leuven, Flanders, Belgium.

Articles citing this

Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans. Microbiol Mol Biol Rev (2007) 2.71

Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nat Rev Microbiol (2011) 2.70

Morphogenesis in Candida albicans. Annu Rev Microbiol (2007) 2.39

Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance. PLoS Biol (2011) 2.21

Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05

Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiol Mol Biol Rev (2011) 1.90

Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. Eukaryot Cell (2008) 1.73

The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans. Mol Biol Cell (2005) 1.70

Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. Mol Microbiol (2008) 1.61

The myriad roles of cyclic AMP in microbial pathogens: from signal to sword. Nat Rev Microbiol (2011) 1.58

G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Mol Biol Cell (2005) 1.50

Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. FEMS Microbiol Rev (2008) 1.33

Identification of an N-acetylglucosamine transporter that mediates hyphal induction in Candida albicans. Mol Biol Cell (2006) 1.32

Molecular mechanisms of mechanosensing and their roles in fungal contact sensing. Nat Rev Microbiol (2008) 1.27

A glucose sensor in Candida albicans. Eukaryot Cell (2006) 1.24

G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans. Mol Biol Cell (2007) 1.24

Barrier activity in Candida albicans mediates pheromone degradation and promotes mating. Eukaryot Cell (2007) 1.06

The predicted G-protein-coupled receptor GPR-1 is required for female sexual development in the multicellular fungus Neurospora crassa. Eukaryot Cell (2006) 1.00

GPR-4 is a predicted G-protein-coupled receptor required for carbon source-dependent asexual growth and development in Neurospora crassa. Eukaryot Cell (2006) 1.00

The Yak1 kinase is involved in the initiation and maintenance of hyphal growth in Candida albicans. Mol Biol Cell (2008) 0.98

Glucose sensing network in Candida albicans: a sweet spot for fungal morphogenesis. Eukaryot Cell (2009) 0.97

Roles of Ras1 membrane localization during Candida albicans hyphal growth and farnesol response. Eukaryot Cell (2011) 0.97

Temporal and spatial control of HGC1 expression results in Hgc1 localization to the apical cells of hyphae in Candida albicans. Eukaryot Cell (2006) 0.94

Candida albicans: A Model Organism for Studying Fungal Pathogens. ISRN Microbiol (2012) 0.91

Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans. Eukaryot Cell (2012) 0.91

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One (2011) 0.89

In vitro and in vivo activities of pterostilbene against Candida albicans biofilms. Antimicrob Agents Chemother (2014) 0.88

Inhibitors of cellular signalling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicans. J Med Microbiol (2009) 0.86

Tight control of trehalose content is required for efficient heat-induced cell elongation in Candida albicans. J Biol Chem (2012) 0.85

Protein kinase A and fungal virulence: a sinister side to a conserved nutrient sensing pathway. Virulence (2012) 0.83

Global survey of canonical Aspergillus flavus G protein-coupled receptors. MBio (2014) 0.83

Fungal adenylyl cyclase acts as a signal sensor and integrator and plays a central role in interaction with bacteria. PLoS Pathog (2013) 0.83

Combined inactivation of the Candida albicans GPR1 and TPS2 genes results in avirulence in a mouse model for systemic infection. Infect Immun (2008) 0.82

Candida albicans cell-type switching and functional plasticity in the mammalian host. Nat Rev Microbiol (2016) 0.81

Regulated proteolysis of Candida albicans Ras1 is involved in morphogenesis and quorum sensing regulation. Mol Microbiol (2013) 0.81

Candida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death. Eukaryot Cell (2013) 0.80

The late endosomal HOPS complex anchors active G-protein signaling essential for pathogenesis in magnaporthe oryzae. PLoS Pathog (2013) 0.79

The yeast Sks1p kinase signaling network regulates pseudohyphal growth and glucose response. PLoS Genet (2014) 0.79

The cAMP pathway is important for controlling the morphological switch to the pathogenic yeast form of Paracoccidioides brasiliensis. Mol Microbiol (2007) 0.79

GPR11, a putative seven-transmembrane G protein-coupled receptor, controls zoospore development and virulence of Phytophthora sojae. Eukaryot Cell (2009) 0.78

Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development. Microbiol Mol Biol Rev (2017) 0.77

Ribosomal protein S6 phosphorylation is controlled by TOR and modulated by PKA in Candida albicans. Mol Microbiol (2015) 0.77

Regulation of copper toxicity by Candida albicans GPA2. Eukaryot Cell (2013) 0.77

Phosphorylation of phosducin-like protein BDM-1 by protein kinase 2 (CK2) is required for virulence and G beta subunit stability in the fungal plant pathogen Cryphonectria parasitica. Mol Microbiol (2010) 0.77

cAMP-independent signal pathways stimulate hyphal morphogenesis in Candida albicans. Mol Microbiol (2016) 0.76

Identification of factors involved in dimorphism and pathogenicity of Zymoseptoria tritici. PLoS One (2017) 0.75

Magnesium Ion Acts as a Signal for Capsule Induction in Cryptococcus neoformans. Front Microbiol (2016) 0.75

Fungal morphogenesis. Cold Spring Harb Perspect Med (2014) 0.75

Characterization of gprK Encoding a Putative Hybrid G-Protein-Coupled Receptor in Aspergillus fumigatus. PLoS One (2016) 0.75

Activity of Sanguinarine against Candida albicans Biofilms. Antimicrob Agents Chemother (2017) 0.75

A Bimolecular Fluorescence Complementation Tool for Identification of Protein-Protein Interactions in Candida albicans. G3 (Bethesda) (2017) 0.75

Schizosaccharomyces pombe rsv1 Transcription Factor and its Putative Homologues Preserved their Functional Homology and are Evolutionarily Conserved. Curr Microbiol (2017) 0.75

In vitro Antibiofilm Activity of Eucarobustol E against Candida albicans. Antimicrob Agents Chemother (2017) 0.75

Articles cited by this

Isogenic strain construction and gene mapping in Candida albicans. Genetics (1993) 17.18

Nonfilamentous C. albicans mutants are avirulent. Cell (1997) 13.83

An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida Albicans. Sabouraudia (1975) 11.53

Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J Bacteriol (1999) 10.31

Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science (1994) 8.59

Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science (1997) 6.60

Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J (1997) 4.82

Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot Cell (2003) 4.71

Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol (1999) 3.98

The distinct morphogenic states of Candida albicans. Trends Microbiol (2004) 3.86

Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development. Proc Natl Acad Sci U S A (1996) 3.65

Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc Natl Acad Sci U S A (1996) 3.50

NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO J (2001) 3.48

Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. EMBO J (1997) 3.41

Ras signaling is required for serum-induced hyphal differentiation in Candida albicans. J Bacteriol (1999) 3.09

The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. EMBO J (1998) 3.09

Regulatory networks controlling Candida albicans morphogenesis. Trends Microbiol (1999) 3.06

Candida albicans RIM101 pH response pathway is required for host-pathogen interactions. Infect Immun (2000) 3.03

Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans. Mol Biol Cell (2001) 2.99

Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis. Infect Immun (1998) 2.98

NRG1, a repressor of filamentous growth in C.albicans, is down-regulated during filament induction. EMBO J (2001) 2.76

Filamentous growth of Candida albicans in response to physical environmental cues and its regulation by the unique CZF1 gene. Mol Microbiol (1999) 2.74

The MET3 promoter: a new tool for Candida albicans molecular genetics. Mol Microbiol (1999) 2.66

Gpa2p, a G-protein alpha-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism. J Biol Chem (1997) 2.63

Pichia pastoris as a host system for transformations. Mol Cell Biol (1985) 2.60

A single-transformation gene function test in diploid Candida albicans. J Bacteriol (2000) 2.47

GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway. EMBO J (1998) 2.37

Cassettes for PCR-mediated construction of green, yellow, and cyan fluorescent protein fusions in Candida albicans. Yeast (2001) 2.37

The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics (2000) 2.35

Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p. Curr Biol (1997) 2.33

Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans. Mol Microbiol (2001) 2.32

A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol Microbiol (1999) 2.23

Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryot Cell (2002) 2.21

Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae. EMBO J (1998) 2.14

Cloning and expression of Candida albicans ADE2 and proteinase genes on a replicative plasmid in C. albicans and in Saccharomyces cerevisiae. Mol Gen Genet (1992) 2.02

cAMP signalling in pathogenic fungi: control of dimorphic switching and pathogenicity. Trends Microbiol (2000) 2.02

Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans. Mol Microbiol (2000) 2.00

Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acids. Mol Cell Biol (1999) 1.83

Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans. Mol Microbiol (2001) 1.79

CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans. J Bacteriol (2001) 1.75

APSES proteins regulate morphogenesis and metabolism in Candida albicans. Mol Biol Cell (2004) 1.74

The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling out of an early endosome in Saccharomyces cerevisiae. J Cell Biol (2000) 1.70

Inorganic phosphate is sensed by specific phosphate carriers and acts in concert with glucose as a nutrient signal for activation of the protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol (2003) 1.69

The eukaryotic plasma membrane as a nutrient-sensing device. Trends Biochem Sci (2004) 1.63

Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. Curr Opin Microbiol (2000) 1.60

Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae. Mol Cell (2004) 1.58

A potential phosphorylation site for an A-type kinase in the Efg1 regulator protein contributes to hyphal morphogenesis of Candida albicans. Genetics (2001) 1.54

Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans. Mol Biol Cell (1997) 1.45

Requirement of one functional RAS gene and inability of an oncogenic ras variant to mediate the glucose-induced cyclic AMP signal in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1988) 1.45

Sequence and promoter regulation of the PCK1 gene encoding phosphoenolpyruvate carboxykinase of the fungal pathogen Candida albicans. Gene (1997) 1.45

The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae. Mol Microbiol (2003) 1.44

In vitro reconstructed human epithelia reveal contributions of Candida albicans EFG1 and CPH1 to adhesion and invasion. Microbiology (2002) 1.42

Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans. Eukaryot Cell (2004) 1.40

Glucose-induced cAMP signalling in yeast requires both a G-protein coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process. Mol Microbiol (2000) 1.37

The sensing of nutritional status and the relationship to filamentous growth in Saccharomyces cerevisiae. FEMS Yeast Res (2002) 1.36

Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation. Infect Immun (2002) 1.33

Efficient transition to growth on fermentable carbon sources in Saccharomyces cerevisiae requires signaling through the Ras pathway. EMBO J (1998) 1.31

Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae. J Biol Chem (2004) 1.22

G-protein coupled receptor from yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun (1997) 1.19

Studies on the mechanism of the glucose-induced cAMP signal in glycolysis and glucose repression mutants of the yeast Saccharomyces cerevisiae. Eur J Biochem (1988) 1.18

Sex and sugar in yeast: two distinct GPCR systems. EMBO Rep (2001) 1.16

Gpr1p, a putative G-protein coupled receptor, regulates glucose-dependent cellular cAMP level in yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun (1998) 1.15

Candida albicans lacking the gene encoding the regulatory subunit of protein kinase A displays a defect in hyphal formation and an altered localization of the catalytic subunit. Eukaryot Cell (2004) 1.14

Identification of the dialysable serum inducer of germ-tube formation in Candida albicans. Microbiology (2004) 1.12

Glucose-induced cAMP signaling in Saccharomyces cerevisiae is mediated by the CDC25 protein. FEBS Lett (1989) 1.10

The C-terminal part of the CDC25 gene product plays a key role in signal transduction in the glucose-induced modulation of cAMP level in Saccharomyces cerevisiae. Eur J Biochem (1990) 1.04

Epidemiological shifts in opportunistic and nosocomial Candida infections: mycological aspects. Int J Antimicrob Agents (1996) 0.97

Candida albicans Csy1p is a nutrient sensor important for activation of amino acid uptake and hyphal morphogenesis. Eukaryot Cell (2004) 0.97

Gpa2, a G-protein alpha subunit required for hyphal development in Candida albicans. Eukaryot Cell (2002) 0.94

Regulation of dimorphism in Candida albicans. Contrib Microbiol (2000) 0.93

A Candida albicans homolog of CDC25 is functional in Saccharomyces cerevisiae. Eur J Biochem (1993) 0.83

Articles by these authors

A central integrator of transcription networks in plant stress and energy signalling. Nature (2007) 5.05

Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet (2006) 3.04

Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans. Microbiol Mol Biol Rev (2007) 2.71

Glucose-sensing and -signalling mechanisms in yeast. FEMS Yeast Res (2002) 2.50

The value of CMV IgG avidity and immunoblot for timing the onset of primary CMV infection in pregnancy. J Clin Virol (2012) 2.12

Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia. Nat Genet (2012) 1.85

The Arabidopsis trehalose-6-P synthase AtTPS1 gene is a regulator of glucose, abscisic acid, and stress signaling. Plant Physiol (2004) 1.71

Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome. Nat Genet (2012) 1.70

Inorganic phosphate is sensed by specific phosphate carriers and acts in concert with glucose as a nutrient signal for activation of the protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol (2003) 1.69

PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability. Mol Microbiol (2005) 1.69

The eukaryotic plasma membrane as a nutrient-sensing device. Trends Biochem Sci (2004) 1.63

Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev (2014) 1.59

Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae. Mol Cell (2004) 1.58

Expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters. Appl Environ Microbiol (2003) 1.56

Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I. Am J Hum Genet (2010) 1.52

Identification of novel causative genes determining the complex trait of high ethanol tolerance in yeast using pooled-segregant whole-genome sequence analysis. Genome Res (2012) 1.46

Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways. J Biol Chem (2001) 1.46

The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae. Mol Microbiol (2003) 1.44

Aquaporin expression correlates with freeze tolerance in baker's yeast, and overexpression improves freeze tolerance in industrial strains. Appl Environ Microbiol (2002) 1.42

Flavor-active esters: adding fruitiness to beer. J Biosci Bioeng (2003) 1.39

Trehalose metabolism in plants. Plant J (2014) 1.39

The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. J Biol Chem (2005) 1.34

Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast. Mol Microbiol (2006) 1.33

Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation. Infect Immun (2002) 1.33

Intrauterine transmission and clinical outcome of 248 pregnancies with primary cytomegalovirus infection in relation to gestational age. J Clin Virol (2011) 1.22

Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae. J Biol Chem (2004) 1.22

Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. Proc Natl Acad Sci U S A (2009) 1.21

Recent insights into Candida albicans biofilm resistance mechanisms. Curr Genet (2013) 1.20

Candida albicans biofilm formation in a new in vivo rat model. Microbiology (2009) 1.20

A short regulatory domain restricts glycerol transport through yeast Fps1p. J Biol Chem (2002) 1.17

Identification of novel enzymes with different hydrolytic activities by metagenome expression cloning. J Biotechnol (2006) 1.16

Candida albicans Sun41p, a putative glycosidase, is involved in morphogenesis, cell wall biogenesis, and biofilm formation. Eukaryot Cell (2007) 1.16

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nat Chem Biol (2008) 1.16

Expansive evolution of the trehalose-6-phosphate phosphatase gene family in Arabidopsis. Plant Physiol (2012) 1.16

Why do microorganisms have aquaporins? Trends Microbiol (2006) 1.15

Production and biological function of volatile esters in Saccharomyces cerevisiae. Microb Biotechnol (2009) 1.15

Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor. Proc Natl Acad Sci U S A (2010) 1.14

Improved drought tolerance without undesired side effects in transgenic plants producing trehalose. Plant Mol Biol (2007) 1.14

Molecular mechanisms controlling the localisation of protein kinase A. Curr Genet (2002) 1.14

Multi-level response of the yeast genome to glucose. Genome Biol (2003) 1.12

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco. Proc Natl Acad Sci U S A (2011) 1.12

A single active trehalose-6-P synthase (TPS) and a family of putative regulatory TPS-like proteins in Arabidopsis. Mol Plant (2010) 1.11

Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A (2006) 1.11

Diversity in genetic in vivo methods for protein-protein interaction studies: from the yeast two-hybrid system to the mammalian split-luciferase system. Microbiol Mol Biol Rev (2012) 1.11

From transporter to transceptor: signaling from transporters provokes re-evaluation of complex trafficking and regulatory controls: endocytic internalization and intracellular trafficking of nutrient transceptors may, at least in part, be governed by their signaling function. Bioessays (2011) 1.09

Truncation of Arabidopsis thaliana and Selaginella lepidophylla trehalose-6-phosphate synthase unlocks high catalytic activity and supports high trehalose levels on expression in yeast. Biochem J (2002) 1.08

Single-molecule imaging and functional analysis of Als adhesins and mannans during Candida albicans morphogenesis. ACS Nano (2012) 1.08

QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing. PLoS Genet (2013) 1.08

Overexpression of the trehalase gene AtTRE1 leads to increased drought stress tolerance in Arabidopsis and is involved in abscisic acid-induced stomatal closure. Plant Physiol (2013) 1.08

Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein. Mol Immunol (2009) 1.07

ABI4 mediates the effects of exogenous trehalose on Arabidopsis growth and starch breakdown. Plant Mol Biol (2006) 1.05

Protein phosphatase 2A on track for nutrient-induced signalling in yeast. Mol Microbiol (2002) 1.05

In vivo efficacy of anidulafungin against mature Candida albicans biofilms in a novel rat model of catheter-associated Candidiasis. Antimicrob Agents Chemother (2010) 1.05

Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Cell Res (2012) 1.04

Extensive expression regulation and lack of heterologous enzymatic activity of the Class II trehalose metabolism proteins from Arabidopsis thaliana. Plant Cell Environ (2009) 1.04

Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10. Eukaryot Cell (2010) 1.03

Uncoupling of the glucose growth defect and the deregulation of glycolysis in Saccharomyces cerevisiae Tps1 mutants expressing trehalose-6-phosphate-insensitive hexokinase from Schizosaccharomyces pombe. Biochim Biophys Acta (2003) 1.03

Isolation and characterization of a freeze-tolerant diploid derivative of an industrial baker's yeast strain and its use in frozen doughs. Appl Environ Microbiol (2002) 1.03

Genetic mapping of quantitative phenotypic traits in Saccharomyces cerevisiae. FEMS Yeast Res (2012) 1.03

Functional screening of a cDNA library from the desiccation-tolerant plant Selaginella lepidophylla in yeast mutants identifies trehalose biosynthesis genes of plant and microbial origin. J Plant Res (2014) 1.03

Cyclic AMP mediates the cell cycle dynamics of energy metabolism in Saccharomyces cerevisiae. Yeast (2003) 1.01

Comparative polygenic analysis of maximal ethanol accumulation capacity and tolerance to high ethanol levels of cell proliferation in yeast. PLoS Genet (2013) 1.01

Saccharomyces cerevisiae plasma membrane nutrient sensors and their role in PKA signaling. FEMS Yeast Res (2009) 1.00

Cytomegalovirus (CMV) seroprevalence in pregnant women, bone marrow donors and adolescents in Germany, 1996-2010. Med Microbiol Immunol (2012) 1.00

The moonlighting protein Tsa1p is implicated in oxidative stress response and in cell wall biogenesis in Candida albicans. Mol Microbiol (2005) 1.00

RBR1, a novel pH-regulated cell wall gene of Candida albicans, is repressed by RIM101 and activated by NRG1. Eukaryot Cell (2004) 1.00

Feedback inhibition on cell wall integrity signaling by Zds1 involves Gsk3 phosphorylation of a cAMP-dependent protein kinase regulatory subunit. J Biol Chem (2003) 1.00

Real-time PCR expression profiling of genes encoding potential virulence factors in Candida albicans biofilms: identification of model-dependent and -independent gene expression. BMC Microbiol (2010) 0.99

The protein quality control system manages plant defence compound synthesis. Nature (2013) 0.99

Deletion of the high-affinity cAMP phosphodiesterase encoded by PDE2 affects stress responses and virulence in Candida albicans. Mol Microbiol (2007) 0.99

Isolation and characterization of brewer's yeast variants with improved fermentation performance under high-gravity conditions. Appl Environ Microbiol (2006) 0.99

Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia. Proc Natl Acad Sci U S A (2012) 0.97

Disentangling information flow in the Ras-cAMP signaling network. Genome Res (2006) 0.97

Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum. Proc Natl Acad Sci U S A (2014) 0.96

Detailed comparison of Candida albicans and Candida glabrata biofilms under different conditions and their susceptibility to caspofungin and anidulafungin. J Med Microbiol (2011) 0.96

A bifunctional TPS-TPP enzyme from yeast confers tolerance to multiple and extreme abiotic-stress conditions in transgenic Arabidopsis. Planta (2007) 0.96

Molecular mechanisms of feedback inhibition of protein kinase A on intracellular cAMP accumulation. Cell Signal (2012) 0.96

Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro. New Phytol (2013) 0.95

The Saccharomyces cerevisiae alcohol acetyl transferase Atf1p is localized in lipid particles. Yeast (2004) 0.95

The Cytophaga hutchinsonii ChTPSP: First characterized bifunctional TPS-TPP protein as putative ancestor of all eukaryotic trehalose biosynthesis proteins. Mol Biol Evol (2009) 0.95

Combining inhibitor tolerance and D-xylose fermentation in industrial Saccharomyces cerevisiae for efficient lignocellulose-based bioethanol production. Biotechnol Biofuels (2013) 0.95

Molecular mechanisms controlling phosphate-induced downregulation of the yeast Pho84 phosphate transporter. Biochemistry (2009) 0.94