Published in Proc Natl Acad Sci U S A on January 13, 2014
De novo production of the plant-derived alkaloid strictosidine in yeast. Proc Natl Acad Sci U S A (2015) 1.10
Engineering strategies for the fermentative production of plant alkaloids in yeast. Metab Eng (2015) 0.91
OSC2 and CYP716A14v2 catalyze the biosynthesis of triterpenoids for the cuticle of aerial organs of Artemisia annua. Plant Cell (2015) 0.90
Recent advances in combinatorial biosynthesis for drug discovery. Drug Des Devel Ther (2015) 0.90
GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway. Nat Commun (2016) 0.86
Designer microbes for biosynthesis. Curr Opin Biotechnol (2014) 0.80
Expression patterns, molecular markers and genetic diversity of insect-susceptible and resistant Barbarea genotypes by comparative transcriptome analysis. BMC Genomics (2015) 0.77
Candidate Genes Involved in the Biosynthesis of Triterpenoid Saponins in Platycodon grandiflorum Identified by Transcriptome Analysis. Front Plant Sci (2016) 0.75
Cloning and Functional Characterization of Cycloartenol Synthase from the Red Seaweed Laurencia dendroidea. PLoS One (2016) 0.75
Transcriptomic Comparison Reveals Candidate Genes for Triterpenoid Biosynthesis in Two Closely Related Ilex Species. Front Plant Sci (2017) 0.75
Elucidation of terpenoid metabolism in Scoparia dulcis by RNA-seq analysis. Sci Rep (2017) 0.75
Transcriptome profiling shows gene regulation patterns in ginsenoside pathway in response to methyl jasmonate in Panax Quinquefolium adventitious root. Sci Rep (2016) 0.75
Functional Characterization of CYP716 Family P450 Enzymes in Triterpenoid Biosynthesis in Tomato. Front Plant Sci (2017) 0.75
The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis. Nat Commun (2017) 0.75
β-Amyrin synthase from Conyza blinii expressed in Saccharomyces cerevisiae. FEBS Open Bio (2017) 0.75
Use of cyclodextrins for manipulating cellular cholesterol content. J Lipid Res (1997) 4.44
High-level semi-synthetic production of the potent antimalarial artemisinin. Nature (2013) 3.80
E unum pluribus: multiple proteins from a self-processing polyprotein. Trends Biotechnol (2005) 2.73
Cyclodextrins. Toxicol Pathol (2008) 2.11
New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. J Nat Prod (2011) 1.90
Quantitative cDNA-AFLP analysis for genome-wide expression studies. Mol Genet Genomics (2003) 1.67
Biosynthetic diversity in plant triterpene cyclization. Curr Opin Plant Biol (2006) 1.62
A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula. Plant J (2002) 1.57
A metabolic gene cluster in Lotus japonicus discloses novel enzyme functions and products in triterpene biosynthesis. New Phytol (2013) 1.49
Molecular activities, biosynthesis and evolution of triterpenoid saponins. Phytochemistry (2011) 1.43
The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol (2011) 1.37
Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proc Natl Acad Sci U S A (2008) 1.37
Identification of beta-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay. FEBS J (2006) 1.22
Oleanolic acid. Phytochemistry (2012) 1.18
Enzymatic synthesis of cyclic triterpenes. Nat Prod Rep (2007) 1.18
Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins. Plant Cell (2011) 1.15
CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. Plant Cell Physiol (2011) 1.14
Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol (2012) 1.13
Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action. J Pharm Pharmacol (2010) 1.13
Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell (2011) 1.11
Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. Planta (2012) 1.11
Conformational changes of the NADPH-dependent cytochrome P450 reductase in the course of electron transfer to cytochromes P450. Biochim Biophys Acta (2010) 1.08
Engineering triterpene production in Saccharomyces cerevisiae-beta-amyrin synthase from Artemisia annua. FEBS J (2008) 1.07
Cloning and characterization of a cDNA encoding beta-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice. Biol Pharm Bull (2001) 1.06
Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants. Proc Natl Acad Sci U S A (2013) 1.03
Formation of P450 · P450 complexes and their effect on P450 function. Pharmacol Ther (2011) 1.03
The saponins: polar isoprenoids with important and diverse biological activities. Nat Prod Rep (2011) 0.98
Transcriptome analysis of Bupleurum chinense focusing on genes involved in the biosynthesis of saikosaponins. BMC Genomics (2011) 0.98
The involvement of β-amyrin 28-oxidase (CYP716A52v2) in oleanane-type ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol (2013) 0.98
Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene. Phytochemistry (1998) 0.96
UDP-glycosyltransferases from the UGT73C subfamily in Barbarea vulgaris catalyze sapogenin 3-O-glucosylation in saponin-mediated insect resistance. Plant Physiol (2012) 0.95
Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro. New Phytol (2013) 0.95
Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers. PLoS One (2011) 0.94
Combinatorial biosynthesis in plants: a (p)review on its potential and future exploitation. Nat Prod Rep (2011) 0.92
Combinatorial biosynthesis of legume natural and rare triterpenoids in engineered yeast. Plant Cell Physiol (2013) 0.89
Purification, properties, and characterization of recombinant Streptomyces sp. strain C5 DoxA, a cytochrome P-450 catalyzing multiple steps in doxorubicin biosynthesis. J Bacteriol (1999) 0.87
Gene regulation patterns in triterpene biosynthetic pathway driven by overexpression of squalene synthase and methyl jasmonate elicitation in Bupleurum falcatum. Planta (2010) 0.86
Characterization of a dammarenediol synthase in Centella asiatica (L.) Urban. Plant Physiol Biochem (2009) 0.84
Challenges and pitfalls of P450-dependent (+)-valencene bioconversion by Saccharomyces cerevisiae. Metab Eng (2013) 0.82
Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs. Nat Prod Rep (2012) 0.82
An integrated PCR colony hybridization approach to screen cDNA libraries for full-length coding sequences. PLoS One (2011) 0.79
Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization. Org Lett (2006) 0.79
A central integrator of transcription networks in plant stress and energy signalling. Nature (2007) 5.05
Modeling gene and genome duplications in eukaryotes. Proc Natl Acad Sci U S A (2005) 5.00
NINJA connects the co-repressor TOPLESS to jasmonate signalling. Nature (2010) 3.23
Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet (2006) 3.04
The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses. Plant Cell (2011) 3.03
Glucose-sensing and -signalling mechanisms in yeast. FEMS Yeast Res (2002) 2.50
Small heat shock proteins and stress tolerance in plants. Biochim Biophys Acta (2002) 2.22
Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells. Proc Natl Acad Sci U S A (2008) 2.17
The JAZ proteins: a crucial interface in the jasmonate signaling cascade. Plant Cell (2011) 2.17
A comprehensive analysis of hydrogen peroxide-induced gene expression in tobacco. Proc Natl Acad Sci U S A (2003) 1.92
GDP-mannose 3',5'-epimerase forms GDP-L-gulose, a putative intermediate for the de novo biosynthesis of vitamin C in plants. J Biol Chem (2003) 1.75
The Arabidopsis trehalose-6-P synthase AtTPS1 gene is a regulator of glucose, abscisic acid, and stress signaling. Plant Physiol (2004) 1.71
Catalase deficiency drastically affects gene expression induced by high light in Arabidopsis thaliana. Plant J (2004) 1.71
Nitric oxide production by the differentiating xylem of Zinnia elegans. New Phytol (2005) 1.70
Inorganic phosphate is sensed by specific phosphate carriers and acts in concert with glucose as a nutrient signal for activation of the protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol (2003) 1.69
PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability. Mol Microbiol (2005) 1.69
The eukaryotic plasma membrane as a nutrient-sensing device. Trends Biochem Sci (2004) 1.63
The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. J Biol Chem (2008) 1.62
Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev (2014) 1.59
Transcriptional machineries in jasmonate-elicited plant secondary metabolism. Trends Plant Sci (2012) 1.58
Transcript profiling of early lateral root initiation. Proc Natl Acad Sci U S A (2004) 1.58
Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae. Mol Cell (2004) 1.58
Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum. Proc Natl Acad Sci U S A (2009) 1.58
Expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters. Appl Environ Microbiol (2003) 1.56
NMR-based characterization of metabolic alterations in hypertension using an adaptive, intelligent binning algorithm. Anal Chem (2008) 1.53
Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells. Proc Natl Acad Sci U S A (2006) 1.53
Exploration of jasmonate signalling via automated and standardized transient expression assays in tobacco cells. Plant J (2005) 1.51
Jasmonate-inducible gene: What does it mean? Trends Plant Sci (2009) 1.51
Expression of the Arabidopsis jasmonate signalling repressor JAZ1/TIFY10A is stimulated by auxin. EMBO Rep (2009) 1.48
PtABI3 impinges on the growth and differentiation of embryonic leaves during bud set in poplar. Plant Cell (2002) 1.47
Identification of novel causative genes determining the complex trait of high ethanol tolerance in yeast using pooled-segregant whole-genome sequence analysis. Genome Res (2012) 1.46
The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae. Mol Microbiol (2003) 1.44
Secretions of plant-parasitic nematodes: a molecular update. Gene (2004) 1.43
Aquaporin expression correlates with freeze tolerance in baker's yeast, and overexpression improves freeze tolerance in industrial strains. Appl Environ Microbiol (2002) 1.42
Chromosomal locus that affects pathogenicity of Rhodococcus fascians. J Bacteriol (2002) 1.41
Salicylic acid suppresses jasmonic acid signaling downstream of SCFCOI1-JAZ by targeting GCC promoter motifs via transcription factor ORA59. Plant Cell (2013) 1.41
Flavor-active esters: adding fruitiness to beer. J Biosci Bioeng (2003) 1.39
The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans. Mol Biol Cell (2005) 1.38
The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity. J Biol Chem (2005) 1.34
Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast. Mol Microbiol (2006) 1.33
Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation. Infect Immun (2002) 1.33
The metabolic blueprint of Phaeodactylum tricornutum reveals a eukaryotic Entner-Doudoroff glycolytic pathway. Plant J (2012) 1.32
Size-dependent optical properties of colloidal PbS quantum dots. ACS Nano (2009) 1.31
The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth. Proc Natl Acad Sci U S A (2005) 1.26
Methyl jasmonate stimulates the de novo biosynthesis of vitamin C in plant cell suspensions. J Exp Bot (2005) 1.26
Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae. J Biol Chem (2004) 1.22
Altered levels of proline dehydrogenase cause hypersensitivity to proline and its analogs in Arabidopsis. Plant Physiol (2002) 1.20
Fluorescent castasterone reveals BRI1 signaling from the plasma membrane. Nat Chem Biol (2012) 1.19
Oleanolic acid. Phytochemistry (2012) 1.18
CathaCyc, a metabolic pathway database built from Catharanthus roseus RNA-Seq data. Plant Cell Physiol (2013) 1.18
A short regulatory domain restricts glycerol transport through yeast Fps1p. J Biol Chem (2002) 1.17
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nat Chem Biol (2008) 1.16
Comprehensive analysis of gene expression in Nicotiana tabacum leaves acclimated to oxidative stress. Proc Natl Acad Sci U S A (2002) 1.15
Surface chemistry of colloidal PbSe nanocrystals. J Am Chem Soc (2008) 1.15
Why do microorganisms have aquaporins? Trends Microbiol (2006) 1.15
Production and biological function of volatile esters in Saccharomyces cerevisiae. Microb Biotechnol (2009) 1.15
Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants. New Phytol (2010) 1.14
Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor. Proc Natl Acad Sci U S A (2010) 1.14
Molecular mechanisms controlling the localisation of protein kinase A. Curr Genet (2002) 1.14
A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2004) 1.13
All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade. Proc Natl Acad Sci U S A (2002) 1.12
Multi-level response of the yeast genome to glucose. Genome Biol (2003) 1.12
Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds. Proc Natl Acad Sci U S A (2007) 1.12
How thioredoxin can reduce a buried disulphide bond. J Mol Biol (2004) 1.12
Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco. Proc Natl Acad Sci U S A (2011) 1.12
Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A (2006) 1.11
Synergistic effect of methyljasmonate and cyclodextrin on stilbene biosynthesis pathway gene expression and resveratrol production in Monastrell grapevine cell cultures. BMC Res Notes (2008) 1.09
Functional specialization of the TRANSPARENT TESTA GLABRA1 network allows differential hormonal control of laminal and marginal trichome initiation in Arabidopsis rosette leaves. Plant Physiol (2008) 1.09
Truncation of Arabidopsis thaliana and Selaginella lepidophylla trehalose-6-phosphate synthase unlocks high catalytic activity and supports high trehalose levels on expression in yeast. Biochem J (2002) 1.08
Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis. Proc Natl Acad Sci U S A (2008) 1.08
QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing. PLoS Genet (2013) 1.08
Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements. Protein Sci (2004) 1.05
ABI4 mediates the effects of exogenous trehalose on Arabidopsis growth and starch breakdown. Plant Mol Biol (2006) 1.05
APETALA2/ETHYLENE RESPONSE FACTOR and basic helix-loop-helix tobacco transcription factors cooperatively mediate jasmonate-elicited nicotine biosynthesis. Plant J (2011) 1.05
Protein phosphatase 2A on track for nutrient-induced signalling in yeast. Mol Microbiol (2002) 1.05
The VTC2 cycle and the de novo biosynthesis pathways for vitamin C in plants: an opinion. Phytochemistry (2007) 1.05
Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. J Mol Biol (2007) 1.04
Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Cell Res (2012) 1.04
Extensive expression regulation and lack of heterologous enzymatic activity of the Class II trehalose metabolism proteins from Arabidopsis thaliana. Plant Cell Environ (2009) 1.04
Isolation and characterization of a freeze-tolerant diploid derivative of an industrial baker's yeast strain and its use in frozen doughs. Appl Environ Microbiol (2002) 1.03
Uncoupling of the glucose growth defect and the deregulation of glycolysis in Saccharomyces cerevisiae Tps1 mutants expressing trehalose-6-phosphate-insensitive hexokinase from Schizosaccharomyces pombe. Biochim Biophys Acta (2003) 1.03
Genetic mapping of quantitative phenotypic traits in Saccharomyces cerevisiae. FEMS Yeast Res (2012) 1.03
Differential transcriptome analysis of glandular and filamentous trichomes in Artemisia annua. BMC Plant Biol (2013) 1.03
Boosting heterologous protein production in transgenic dicotyledonous seeds using Phaseolus vulgaris regulatory sequences. Nat Biotechnol (2002) 1.02
Comparative polygenic analysis of maximal ethanol accumulation capacity and tolerance to high ethanol levels of cell proliferation in yeast. PLoS Genet (2013) 1.01
Saccharomyces cerevisiae plasma membrane nutrient sensors and their role in PKA signaling. FEMS Yeast Res (2009) 1.00
Feedback inhibition on cell wall integrity signaling by Zds1 involves Gsk3 phosphorylation of a cAMP-dependent protein kinase regulatory subunit. J Biol Chem (2003) 1.00
Lipopolysaccharides as a communication signal for progression of legume endosymbiosis. Proc Natl Acad Sci U S A (2005) 1.00
The protein quality control system manages plant defence compound synthesis. Nature (2013) 0.99
Isolation and characterization of brewer's yeast variants with improved fermentation performance under high-gravity conditions. Appl Environ Microbiol (2006) 0.99
Gamma-glutamyl transpeptidase in transgenic tobacco plants. Cellular localization, processing, and biochemical properties. Plant Physiol (2002) 0.98
Functional characterisation of genes involved in pyridine alkaloid biosynthesis in tobacco. Phytochemistry (2007) 0.98
The antimicrobial compound xantholysin defines a new group of Pseudomonas cyclic lipopeptides. PLoS One (2013) 0.97
A bifunctional TPS-TPP enzyme from yeast confers tolerance to multiple and extreme abiotic-stress conditions in transgenic Arabidopsis. Planta (2007) 0.96