Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis.

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Published in Antimicrob Agents Chemother on February 01, 2005

Authors

Ashraf S Ibrahim1, Joel C Bowman, Valentina Avanessian, Keturah Brown, Brad Spellberg, John E Edwards, Cameron M Douglas

Author Affiliations

1: Division of Infectious Diseases, St. John's Cardiovascular Research Center, Los Angeles Biomedical Research Institute at Harbor-University of Californa, Los Angeles Medical Center, Torrance, CA 90502, USA. ibrahim@labiomed.org

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