Published in Biochem Cell Biol on December 01, 2004
A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet (2010) 3.25
PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science (2009) 2.84
Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors. J Neurosci (2011) 1.52
DEPDC1B coordinates de-adhesion events and cell-cycle progression at mitosis. Dev Cell (2014) 1.43
RNA sequencing of the human milk fat layer transcriptome reveals distinct gene expression profiles at three stages of lactation. PLoS One (2013) 1.42
Structural genomics of protein phosphatases. J Struct Funct Genomics (2007) 1.40
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet (2013) 1.32
Synaptic cell adhesion. Cold Spring Harb Perspect Biol (2012) 1.30
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mol Psychiatry (2014) 1.29
Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases. Proc Natl Acad Sci U S A (2013) 1.22
Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective. Nat Rev Neurosci (2014) 1.19
Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization. Trends Neurosci (2013) 1.16
Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret. Proc Natl Acad Sci U S A (2010) 1.08
N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth. Mol Cell Biol (2006) 1.01
LAR receptor tyrosine phosphatases and HSPGs guide peripheral sensory axons to the skin. Curr Biol (2012) 0.97
Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-sigma. FEBS J (2006) 0.92
The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche. Development (2012) 0.90
Receptor type protein tyrosine phosphatases (RPTPs) - roles in signal transduction and human disease. J Cell Commun Signal (2012) 0.88
Receptor protein tyrosine phosphatases are novel components of a polycystin complex. Biochim Biophys Acta (2010) 0.87
PPAR-γ2 and PTPRD gene polymorphisms influence type 2 diabetes patients' response to pioglitazone in China. Acta Pharmacol Sin (2012) 0.84
Intercellular protein-protein interactions at synapses. Protein Cell (2014) 0.83
PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission. Proc Natl Acad Sci U S A (2015) 0.82
Tumor-derived extracellular fragments of receptor protein tyrosine phosphatases (RPTPs) as cancer molecular diagnostic tools. Anticancer Agents Med Chem (2011) 0.81
Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population. J Diabetes Investig (2012) 0.80
Phosphatase regulation of intercellular junctions. Tissue Barriers (2013) 0.80
Low-resolution structure and fluorescence anisotropy analysis of protein tyrosine phosphatase eta catalytic domain. Biophys J (2007) 0.78
Variants of insulin-signaling inhibitor genes in type 2 diabetes and related metabolic abnormalities. Int J Genomics (2013) 0.77
Identification of novel, less toxic PTP-LAR inhibitors using in silico strategies: pharmacophore modeling, SADMET-based virtual screening and docking. J Mol Model (2011) 0.76
The physiological concentration of ferrous iron (II) alters the inhibitory effect of hydrogen peroxide on CD45, LAR and PTP1B phosphatases. Biometals (2015) 0.76
Regulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study. Mol Cell Proteomics (2016) 0.76
Receptor protein tyrosine phosphatase σ binds to neurons in the adult mouse brain. Exp Neurol (2014) 0.75
Traffic lights for axon growth: proteoglycans and their neuronal receptors. Neural Regen Res (2014) 0.75
Genetic variants in PTPRD and risk of gestational diabetes mellitus. Oncotarget (2016) 0.75
Genetic Determinants of Type 2 Diabetes in Asians. Int J Diabetol Vasc Dis Res (2015) 0.75
Crystallization and preliminary X-ray diffraction analysis of rat protein tyrosine phosphatase eta. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.75
Catalytic and substrate promiscuity: distinct multiple chemistries catalysed by the phosphatase domain of receptor protein tyrosine phosphatase. Biochem J (2016) 0.75
Classification of 27 Tumor-Associated Antigens by Histochemical Analysis of 36 Freshly Resected Lung Cancer Tissues. Int J Mol Sci (2016) 0.75
Glioma Cell Invasion is Significantly Enhanced in Composite Hydrogel Matrices Composed of Chondroitin 4- and 4,6-Sulfated Glycosaminoglycans. J Mater Chem B Mater Biol Med (2016) 0.75
Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex. Dev Cell (2016) 0.75
In utero exposure to diesel exhaust particulates is associated with an altered cardiac transcriptional response to transverse aortic constriction and altered DNA methylation. FASEB J (2017) 0.75
Fat-like cadherins in cell migration-leading from both the front and the back. Curr Opin Cell Biol (2017) 0.75
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell (2002) 2.99
Inside the human cancer tyrosine phosphatome. Nat Rev Cancer (2011) 2.38
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS One (2009) 2.11
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol (2002) 2.02
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nat Genet (2007) 1.98
Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle (2011) 1.79
Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. Circulation (2009) 1.70
Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP. Curr Opin Cell Biol (2005) 1.61
Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice. Diabetologia (2014) 1.49
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J Biol Chem (2004) 1.49
Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat Immunol (2005) 1.49
Problems with co-funding in Canada. Science (2005) 1.48
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell (2009) 1.47
T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice. Arthritis Rheum (2012) 1.46
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics (2008) 1.46
Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genet (2005) 1.44
The role of protein tyrosine phosphatase 1B in Ras signaling. Proc Natl Acad Sci U S A (2004) 1.43
LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol (2012) 1.37
Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. J Exp Med (2003) 1.37
PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP. J Biol Chem (2001) 1.37
Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice. Glia (2010) 1.36
Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta. J Neurosci (2006) 1.33
Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling. Mol Cell Biol (2003) 1.32
Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases. Sci Signal (2009) 1.32
The two faces of PTP1B in cancer. Biochim Biophys Acta (2009) 1.31
Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol Cell Biol (2002) 1.27
T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease. Immunol Rev (2009) 1.25
The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation. J Biol Chem (2008) 1.22
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. J Clin Invest (2011) 1.20
Redox regulation of interleukin-4 signaling. Immunity (2008) 1.20
Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS. Mol Cell Neurosci (2005) 1.20
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood (2004) 1.20
Phosphatases in cell-matrix adhesion and migration. Nat Rev Mol Cell Biol (2003) 1.19
Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer. Biochim Biophys Acta (2005) 1.19
Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J Biol Chem (2008) 1.15
PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP. J Biol Chem (2006) 1.14
Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone. Circ Res (2009) 1.13
PTP1B and TC-PTP: novel roles in immune-cell signaling. Can J Physiol Pharmacol (2006) 1.11
Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. Cancer Res (2005) 1.11
PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Cancer Res (2012) 1.10
Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Mech Dev (2006) 1.08
Coordinated action of protein tyrosine phosphatases in insulin signal transduction. Eur J Biochem (2002) 1.08
PTP1B and TC-PTP: regulators of transformation and tumorigenesis. Cancer Metastasis Rev (2008) 1.07
Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models. J Endocrinol (2010) 1.07
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol (2004) 1.06
In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis. Trends Cell Biol (2010) 1.06
PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446. J Biol Chem (2008) 1.06
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. J Cell Sci (2005) 1.05
T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis. Diabetes (2010) 1.03
Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PLoS One (2010) 1.03
Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling. Proc Natl Acad Sci U S A (2006) 1.02
Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure. J Biol Chem (2005) 1.02
T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. Mol Cell Biol (2006) 1.02
Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse. PLoS One (2010) 1.01
Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases. J Clin Invest (2009) 1.01
The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase. J Biol Chem (2006) 1.00
A sulfated carbohydrate epitope inhibits axon regeneration after injury. Proc Natl Acad Sci U S A (2012) 1.00
Modulation of leptin resistance by protein tyrosine phosphatases. Cell Metab (2012) 0.99
Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. Cancer Res (2010) 0.98
Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia. J Cell Sci (2012) 0.98
Organization of the Sec61 translocon, studied by high resolution native electrophoresis. J Proteome Res (2010) 0.97
Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins. Mol Endocrinol (2006) 0.96
ERK-FosB signaling in dorsal MPOA neurons plays a major role in the initiation of parental behavior in mice. Mol Cell Neurosci (2007) 0.96
Identification of PTPsigma as an autophagic phosphatase. J Cell Sci (2011) 0.95
The DNA damage response pathway regulates the alternative splicing of the apoptotic mediator Bcl-x. J Biol Chem (2010) 0.95
PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J Biol Chem (2010) 0.95
Protein tyrosine phosphatases: emerging regulators of apoptosis. Cell Cycle (2007) 0.94
TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}. Blood (2007) 0.93
Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors. J Biol Chem (2011) 0.92
Beyond the metabolic function of PTP1B. Cell Cycle (2004) 0.92
HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. PLoS One (2009) 0.92
Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives. Chembiochem (2007) 0.91
PTP1B: a simple enzyme for a complex world. Crit Rev Biochem Mol Biol (2013) 0.91
Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma. Can J Physiol Pharmacol (2006) 0.89
Increasing peripheral insulin sensitivity by protein tyrosine phosphatase 1B deletion improves control of blood pressure in obesity. Hypertension (2012) 0.89
Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity. J Neurochem (2012) 0.89
Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-gamma signaling. Proc Natl Acad Sci U S A (2009) 0.88
Protein tyrosine phosphatase 1B is a regulator of the interleukin-10-induced transcriptional program in macrophages. Sci Signal (2014) 0.88
Protein tyrosine phosphatases in cancer: friends and foes! Prog Mol Biol Transl Sci (2012) 0.88
Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response. Mol Cell Biol (2006) 0.88
NRAMP-1 expression modulates protein-tyrosine phosphatase activity in macrophages: impact on host cell signaling and functions. J Biol Chem (2007) 0.86
Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence. Development (2013) 0.86
PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo. J Immunol (2011) 0.85
Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo. Mol Pharmacol (2014) 0.83
Impact of oncogenic protein tyrosine phosphatases in cancer. Anticancer Agents Med Chem (2012) 0.83
Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice. PLoS One (2012) 0.83
Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors. Mol Cancer Res (2013) 0.83
Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival. Cancer Res (2011) 0.83
Receptor tyrosine phosphatase sigma (RPTPσ) regulates, p250GAP, a novel substrate that attenuates Rac signaling. Cell Signal (2010) 0.81
Neurobehavioral basis of the impaired nurturing in mice lacking the immediate early gene FosB. Brain Res (2008) 0.80