Published in J Biol Chem on April 03, 2008
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol (2009) 2.90
Cortactin branches out: roles in regulating protrusive actin dynamics. Cell Motil Cytoskeleton (2008) 2.26
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics (2008) 1.46
Cortactin: a multifunctional regulator of cellular invasiveness. Cell Adh Migr (2011) 1.36
Cortactin in cell migration and cancer at a glance. J Cell Sci (2012) 1.34
Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2. Biochemistry (2011) 1.13
Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity. Invest Ophthalmol Vis Sci (2008) 1.10
Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation. J Cell Sci (2010) 1.02
Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia. J Cell Sci (2012) 0.98
PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J Biol Chem (2010) 0.95
Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. J Biol Chem (2013) 0.90
Podocyte Protein, Nephrin, Is a Substrate of Protein Tyrosine Phosphatase 1B. J Signal Transduct (2011) 0.87
Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation. PLoS One (2012) 0.84
A highly scalable peptide-based assay system for proteomics. PLoS One (2012) 0.83
Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B. Cell Commun Signal (2013) 0.83
Protein-tyrosine phosphatase 1B substrates and metabolic regulation. Semin Cell Dev Biol (2014) 0.82
pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1). PLoS One (2014) 0.78
Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects β-cell function. Endocrinology (2014) 0.78
Protein tyrosine phosphatase PTP1B in cell adhesion and migration. Cell Adh Migr (2013) 0.78
A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 protein insolubility and filament organization. J Biol Chem (2013) 0.78
Nitropropenyl benzodioxole, an anti-infective agent with action as a protein tyrosine phosphatase inhibitor. Open Med Chem J (2014) 0.75
Mena(INV) dysregulates cortactin phosphorylation to promote invadopodium maturation. Sci Rep (2016) 0.75
Novel role of cortactin in G protein-coupled receptor agonist-induced nuclear export and degradation of p21Cip1. Sci Rep (2016) 0.75
Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1. Nat Commun (2017) 0.75
Protein tyrosine phosphatases in the human genome. Cell (2004) 8.09
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (1999) 7.84
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol (2004) 7.69
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc Natl Acad Sci U S A (2007) 4.80
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol Cell Proteomics (2005) 4.33
Identification and characterization of a novel cytoskeleton-associated pp60src substrate. Mol Cell Biol (1991) 3.83
Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med (2006) 3.66
The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell (1992) 3.59
Cellular response to hyperosmotic stresses. Physiol Rev (2007) 3.58
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol Syst Biol (2006) 3.01
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell (2002) 2.99
The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J Biol Chem (1998) 2.39
Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines. J Biol Chem (2000) 2.02
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol (2002) 2.02
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nat Genet (2007) 1.98
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol Biol Cell (2003) 1.90
Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer. Cancer Res (2007) 1.82
Substrate-trapping techniques in the identification of cellular PTP targets. Methods (2005) 1.60
The role of protein tyrosine phosphatase 1B in Ras signaling. Proc Natl Acad Sci U S A (2004) 1.43
Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control. FEBS Lett (2005) 1.37
PTP-1B is an essential positive regulator of platelet integrin signaling. J Cell Biol (2005) 1.34
Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase. Biochem J (2004) 1.31
Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases. J Biol Chem (2000) 1.31
Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC). J Proteome Res (2005) 1.29
Alternative splicing of the actin binding domain of human cortactin affects cell migration. J Biol Chem (2003) 1.23
Attenuation of adhesion-dependent signaling and cell spreading in transformed fibroblasts lacking protein tyrosine phosphatase-1B. J Biol Chem (2001) 1.23
Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. EMBO J (2006) 1.22
Osmotic stress-induced remodeling of the cortical cytoskeleton. Am J Physiol Cell Physiol (2002) 1.21
Roles of cortactin in tumor pathogenesis. Biochim Biophys Acta (2007) 1.18
Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens. Trends Microbiol (2005) 1.09
Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry. Mol Cell Proteomics (2003) 1.08
Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration. J Biol Chem (2005) 1.06
Preferential phosphorylation of focal adhesion kinase tyrosine 861 is critical for mediating an anti-apoptotic response to hyperosmotic stress. J Biol Chem (2007) 0.97
Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives. Chembiochem (2007) 0.91
Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding. J Biol Chem (2005) 0.88
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell (2002) 2.99
Rap1: a key regulator in cell-cell junction formation. J Cell Sci (2007) 2.44
Inside the human cancer tyrosine phosphatome. Nat Rev Cancer (2011) 2.38
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS One (2009) 2.11
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol (2002) 2.02
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nat Genet (2007) 1.98
Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle (2011) 1.79
Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. Circulation (2009) 1.70
Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP. Curr Opin Cell Biol (2005) 1.61
Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice. Diabetologia (2014) 1.49
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J Biol Chem (2004) 1.49
Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat Immunol (2005) 1.49
Problems with co-funding in Canada. Science (2005) 1.48
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell (2009) 1.47
T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice. Arthritis Rheum (2012) 1.46
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics (2008) 1.46
Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genet (2005) 1.44
The role of protein tyrosine phosphatase 1B in Ras signaling. Proc Natl Acad Sci U S A (2004) 1.43
Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases. Biochem Cell Biol (2004) 1.38
LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol (2012) 1.37
Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. J Exp Med (2003) 1.37
PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP. J Biol Chem (2001) 1.37
Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice. Glia (2010) 1.36
Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta. J Neurosci (2006) 1.33
Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling. Mol Cell Biol (2003) 1.32
Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases. Sci Signal (2009) 1.32
The two faces of PTP1B in cancer. Biochim Biophys Acta (2009) 1.31
Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol Cell Biol (2002) 1.27
T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease. Immunol Rev (2009) 1.25
The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation. J Biol Chem (2008) 1.22
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. J Clin Invest (2011) 1.20
Redox regulation of interleukin-4 signaling. Immunity (2008) 1.20
Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS. Mol Cell Neurosci (2005) 1.20
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood (2004) 1.20
Phosphatases in cell-matrix adhesion and migration. Nat Rev Mol Cell Biol (2003) 1.19
Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer. Biochim Biophys Acta (2005) 1.19
Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J Biol Chem (2008) 1.15
PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP. J Biol Chem (2006) 1.14
Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone. Circ Res (2009) 1.13
PTP1B and TC-PTP: novel roles in immune-cell signaling. Can J Physiol Pharmacol (2006) 1.11
Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. Cancer Res (2005) 1.11
PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Cancer Res (2012) 1.10
Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Mech Dev (2006) 1.08
Coordinated action of protein tyrosine phosphatases in insulin signal transduction. Eur J Biochem (2002) 1.08
PTP1B and TC-PTP: regulators of transformation and tumorigenesis. Cancer Metastasis Rev (2008) 1.07
Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models. J Endocrinol (2010) 1.07
In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis. Trends Cell Biol (2010) 1.06
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol (2004) 1.06
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. J Cell Sci (2005) 1.05
Localization, function and regulation of the two intestinal fatty acid-binding protein types. Histochem Cell Biol (2009) 1.04
T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis. Diabetes (2010) 1.03
Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PLoS One (2010) 1.03
Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling. Proc Natl Acad Sci U S A (2006) 1.02
Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure. J Biol Chem (2005) 1.02
T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. Mol Cell Biol (2006) 1.02
Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse. PLoS One (2010) 1.01
Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases. J Clin Invest (2009) 1.01
The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase. J Biol Chem (2006) 1.00
A sulfated carbohydrate epitope inhibits axon regeneration after injury. Proc Natl Acad Sci U S A (2012) 1.00
Modulation of leptin resistance by protein tyrosine phosphatases. Cell Metab (2012) 0.99
Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. Cancer Res (2010) 0.98
Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia. J Cell Sci (2012) 0.98
Organization of the Sec61 translocon, studied by high resolution native electrophoresis. J Proteome Res (2010) 0.97
Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins. Mol Endocrinol (2006) 0.96
Identification of PTPsigma as an autophagic phosphatase. J Cell Sci (2011) 0.95
PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J Biol Chem (2010) 0.95
The DNA damage response pathway regulates the alternative splicing of the apoptotic mediator Bcl-x. J Biol Chem (2010) 0.95
Protein tyrosine phosphatases: emerging regulators of apoptosis. Cell Cycle (2007) 0.94
TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}. Blood (2007) 0.93
Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors. J Biol Chem (2011) 0.92
HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. PLoS One (2009) 0.92
Beyond the metabolic function of PTP1B. Cell Cycle (2004) 0.92
Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives. Chembiochem (2007) 0.91
PTP1B: a simple enzyme for a complex world. Crit Rev Biochem Mol Biol (2013) 0.91
Increasing peripheral insulin sensitivity by protein tyrosine phosphatase 1B deletion improves control of blood pressure in obesity. Hypertension (2012) 0.89
Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma. Can J Physiol Pharmacol (2006) 0.89
Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity. J Neurochem (2012) 0.89
Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-gamma signaling. Proc Natl Acad Sci U S A (2009) 0.88
Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response. Mol Cell Biol (2006) 0.88
Protein tyrosine phosphatases in cancer: friends and foes! Prog Mol Biol Transl Sci (2012) 0.88
Protein tyrosine phosphatase 1B is a regulator of the interleukin-10-induced transcriptional program in macrophages. Sci Signal (2014) 0.88
NRAMP-1 expression modulates protein-tyrosine phosphatase activity in macrophages: impact on host cell signaling and functions. J Biol Chem (2007) 0.86
Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence. Development (2013) 0.86
PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo. J Immunol (2011) 0.85
Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo. Mol Pharmacol (2014) 0.83
Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival. Cancer Res (2011) 0.83
Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors. Mol Cancer Res (2013) 0.83
Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice. PLoS One (2012) 0.83