Published in Sci Signal on September 29, 2009
Leishmaniasis: complexity at the host-pathogen interface. Nat Rev Microbiol (2011) 2.93
Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. Genome Res (2011) 1.90
PTP1B: a double agent in metabolism and oncogenesis. Trends Biochem Sci (2010) 1.44
Macrophage cytokines: involvement in immunity and infectious diseases. Front Immunol (2014) 1.44
Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species. Nucleic Acids Res (2011) 1.23
Circulating microparticles: square the circle. BMC Cell Biol (2013) 1.14
Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function. J Immunol (2013) 1.14
Host cell signalling and leishmania mechanisms of evasion. J Trop Med (2011) 1.13
Leishmania-induced inactivation of the macrophage transcription factor AP-1 is mediated by the parasite metalloprotease GP63. PLoS Pathog (2010) 1.12
Linking in vitro and in vivo survival of clinical Leishmania donovani strains. PLoS One (2010) 1.12
The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response. Front Cell Infect Microbiol (2012) 1.08
Restoration of IFNγR subunit assembly, IFNγ signaling and parasite clearance in Leishmania donovani infected macrophages: role of membrane cholesterol. PLoS Pathog (2011) 0.99
Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis. Semin Immunopathol (2012) 0.98
Impact of Leishmania metalloprotease GP63 on macrophage signaling. Front Cell Infect Microbiol (2012) 0.98
Proteinases as virulence factors in Leishmania spp. infection in mammals. Parasit Vectors (2012) 0.98
Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis. PLoS Negl Trop Dis (2013) 0.96
Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival. PLoS Negl Trop Dis (2011) 0.95
The role of extracellular vesicles in Plasmodium and other protozoan parasites. Cell Microbiol (2014) 0.95
Temperature-induced protein secretion by Leishmania mexicana modulates macrophage signalling and function. PLoS One (2011) 0.93
Exosomes and Other Extracellular Vesicles: The New Communicators in Parasite Infections. Trends Parasitol (2015) 0.93
Leishmania donovani amastigotes impair gamma interferon-induced STAT1alpha nuclear translocation by blocking the interaction between STAT1alpha and importin-alpha5. Infect Immun (2010) 0.91
Leishmania exosomes deliver preemptive strikes to create an environment permissive for early infection. Front Cell Infect Microbiol (2012) 0.91
Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions. Infect Immun (2010) 0.90
Absence of metalloprotease GP63 alters the protein content of Leishmania exosomes. PLoS One (2014) 0.87
Genome evolution in trypanosomatid parasites. Parasitology (2014) 0.85
The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids. Front Microbiol (2016) 0.80
PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection. PLoS Negl Trop Dis (2015) 0.80
Impact of Leishmania mexicana infection on dendritic cell signaling and functions. PLoS Negl Trop Dis (2014) 0.80
Drug delivery by tattooing to treat cutaneous leishmaniasis. Sci Rep (2014) 0.78
Impact of Leishmania infection on host macrophage nuclear physiology and nucleopore complex integrity. PLoS Pathog (2015) 0.78
A perspective on the emergence of sialic acids as potent determinants affecting leishmania biology. Mol Biol Int (2011) 0.78
Infection with Leishmania major induces a cellular stress response in macrophages. PLoS One (2014) 0.78
Mapping the genes for susceptibility and response to Leishmania tropica in mouse. PLoS Negl Trop Dis (2013) 0.78
Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. Mol Microbiol (2013) 0.78
Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63. PLoS Pathog (2016) 0.78
Immunomodulatory Effects of Four Leishmania infantum Potentially Excreted/Secreted Proteins on Human Dendritic Cells Differentiation and Maturation. PLoS One (2015) 0.78
The genetics of Leishmania virulence. Med Microbiol Immunol (2015) 0.77
Impact of neutrophil-secreted myeloid related proteins 8 and 14 (MRP 8/14) on leishmaniasis progression. PLoS Negl Trop Dis (2013) 0.77
Identification of protease m1 zinc metalloprotease conferring resistance to deltamethrin by characterization of an AFLP marker in Culex pipiens pallens. Parasit Vectors (2016) 0.76
The Leishmania metaphylome: a comprehensive survey of Leishmania protein phylogenetic relationships. BMC Genomics (2015) 0.75
Functional impairment of murine dendritic cell subsets following infection with infective larval stage 3 of Brugia malayi. Infect Immun (2016) 0.75
The gp63 Gene Cluster Is Highly Polymorphic in Natural Leishmania (Viannia) braziliensis Populations, but Functional Sites Are Conserved. PLoS One (2016) 0.75
Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression. PLoS Pathog (2016) 0.75
The Dialogue of the Host-Parasite Relationship: Leishmania spp. and Trypanosoma cruzi Infection. Biomed Res Int (2015) 0.75
Shp1 function in myeloid cells. J Leukoc Biol (2017) 0.75
The role of PD-1 in regulation of macrophage apoptosis and its subversion by Leishmania donovani. Clin Transl Immunology (2017) 0.75
Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway. Infect Immun (2017) 0.75
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. Proc Natl Acad Sci U S A (2007) 3.41
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell (2002) 2.99
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology. Proc Natl Acad Sci U S A (2013) 2.45
Inside the human cancer tyrosine phosphatome. Nat Rev Cancer (2011) 2.38
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS One (2009) 2.11
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog (2009) 2.07
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol (2002) 2.02
Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host Microbe (2011) 2.01
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nat Genet (2007) 1.98
Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle (2011) 1.79
Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. Circulation (2009) 1.70
Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP. Curr Opin Cell Biol (2005) 1.61
Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice. Diabetologia (2014) 1.49
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J Biol Chem (2004) 1.49
Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat Immunol (2005) 1.49
Problems with co-funding in Canada. Science (2005) 1.48
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell (2009) 1.47
Hemozoin-inducible proinflammatory events in vivo: potential role in malaria infection. J Immunol (2004) 1.46
T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice. Arthritis Rheum (2012) 1.46
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics (2008) 1.46
Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genet (2005) 1.44
The role of protein tyrosine phosphatase 1B in Ras signaling. Proc Natl Acad Sci U S A (2004) 1.43
Leishmania-induced cellular recruitment during the early inflammatory response: modulation of proinflammatory mediators. J Infect Dis (2002) 1.42
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med (2006) 1.42
Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases. Biochem Cell Biol (2004) 1.38
Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy. Genome Biol (2008) 1.38
LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol (2012) 1.37
Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. J Exp Med (2003) 1.37
PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP. J Biol Chem (2001) 1.37
Hemozoin induces macrophage chemokine expression through oxidative stress-dependent and -independent mechanisms. J Immunol (2005) 1.36
Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice. Glia (2010) 1.36
Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta. J Neurosci (2006) 1.33
Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling. Mol Cell Biol (2003) 1.32
The two faces of PTP1B in cancer. Biochim Biophys Acta (2009) 1.31
Role of host protein tyrosine phosphatase SHP-1 in Leishmania donovani-induced inhibition of nitric oxide production. Infect Immun (2006) 1.29
Hemozoin increases IFN-gamma-inducible macrophage nitric oxide generation through extracellular signal-regulated kinase- and NF-kappa B-dependent pathways. J Immunol (2003) 1.29
Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol Cell Biol (2002) 1.27
Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS One (2012) 1.26
T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease. Immunol Rev (2009) 1.25
Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species. Nucleic Acids Res (2011) 1.23
The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation. J Biol Chem (2008) 1.22
Host-pathogen interactions of Actinobacillus pleuropneumoniae with porcine lung and tracheal epithelial cells. Infect Immun (2009) 1.22
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. J Clin Invest (2011) 1.20
Redox regulation of interleukin-4 signaling. Immunity (2008) 1.20
Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS. Mol Cell Neurosci (2005) 1.20
Encapsulated Streptococcus suis inhibits activation of signaling pathways involved in phagocytosis. Infect Immun (2004) 1.20
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood (2004) 1.20
Phosphatases in cell-matrix adhesion and migration. Nat Rev Mol Cell Biol (2003) 1.19
Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer. Biochim Biophys Acta (2005) 1.19
Signalling events involved in interferon-gamma-inducible macrophage nitric oxide generation. Immunology (2003) 1.19
Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2. J Virol (2007) 1.17
Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J Biol Chem (2008) 1.15
PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP. J Biol Chem (2006) 1.14
Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J Exp Med (2013) 1.14
Host cell signalling and leishmania mechanisms of evasion. J Trop Med (2011) 1.13
Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone. Circ Res (2009) 1.13
Leishmania-induced inactivation of the macrophage transcription factor AP-1 is mediated by the parasite metalloprotease GP63. PLoS Pathog (2010) 1.12
A novel form of NF-kappaB is induced by Leishmania infection: involvement in macrophage gene expression. Eur J Immunol (2008) 1.11
PTP1B and TC-PTP: novel roles in immune-cell signaling. Can J Physiol Pharmacol (2006) 1.11
Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. Cancer Res (2005) 1.11
PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Cancer Res (2012) 1.10
Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif. PLoS Negl Trop Dis (2008) 1.10
Synthetic Plasmodium-like hemozoin activates the immune response: a morphology - function study. PLoS One (2009) 1.10
Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Mech Dev (2006) 1.08
Coordinated action of protein tyrosine phosphatases in insulin signal transduction. Eur J Biochem (2002) 1.08
Innate inflammatory response to the malarial pigment hemozoin. Microbes Infect (2010) 1.07
PTP1B and TC-PTP: regulators of transformation and tumorigenesis. Cancer Metastasis Rev (2008) 1.07
Proinflammatory cytokine and chemokine modulation by Streptococcus suis in a whole-blood culture system. FEMS Immunol Med Microbiol (2006) 1.07
Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models. J Endocrinol (2010) 1.07
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol (2004) 1.06
In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis. Trends Cell Biol (2010) 1.06
PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446. J Biol Chem (2008) 1.06
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. J Cell Sci (2005) 1.05
Myeloid-related proteins rapidly modulate macrophage nitric oxide production during innate immune response. J Immunol (2008) 1.05
Comparison of the effects of Leishmania major or Leishmania donovani infection on macrophage gene expression. Infect Immun (2007) 1.04
T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis. Diabetes (2010) 1.03
Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PLoS One (2010) 1.03
Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling. Proc Natl Acad Sci U S A (2006) 1.02
Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure. J Biol Chem (2005) 1.02
T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. Mol Cell Biol (2006) 1.02
Proteasome-mediated degradation of STAT1alpha following infection of macrophages with Leishmania donovani. J Biol Chem (2005) 1.02
Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8. Cell Host Microbe (2013) 1.02
Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse. PLoS One (2010) 1.01
Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases. J Clin Invest (2009) 1.01
Induction of nitric oxide synthase and activation of signaling proteins in Anopheles mosquitoes by the malaria pigment, hemozoin. Infect Immun (2007) 1.01
Cerebral malaria: human versus mouse studies. Trends Parasitol (2010) 1.01
The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase. J Biol Chem (2006) 1.00
A sulfated carbohydrate epitope inhibits axon regeneration after injury. Proc Natl Acad Sci U S A (2012) 1.00
Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination. Infect Immun (2002) 1.00
Modulation of leptin resistance by protein tyrosine phosphatases. Cell Metab (2012) 0.99
Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1. Eur J Immunol (2005) 0.99
Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. Cancer Res (2010) 0.98
Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia. J Cell Sci (2012) 0.98