Published in Can J Physiol Pharmacol on July 01, 2006
Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol (2007) 1.66
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes (2009) 1.63
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood (2008) 1.32
PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim. Diabetes (2011) 1.26
Small molecule tools for functional interrogation of protein tyrosine phosphatases. FEBS J (2012) 1.17
Phosphoinositide 3-kinase signaling in the vertebrate retina. J Lipid Res (2010) 1.15
Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene. J Biol Chem (2010) 1.13
Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity. Invest Ophthalmol Vis Sci (2008) 1.10
Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates. Proc Natl Acad Sci U S A (2011) 0.93
Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance. Mol Cancer Res (2011) 0.89
PTP1B dephosphorylates N-ethylmaleimide-sensitive factor and elicits SNARE complex disassembly during human sperm exocytosis. J Biol Chem (2009) 0.89
Protein tyrosine phosphatase 1B deficiency ameliorates murine experimental colitis via the expansion of myeloid-derived suppressor cells. PLoS One (2013) 0.88
Mechanism of attenuation of leptin signaling under chronic ligand stimulation. BMC Biochem (2010) 0.86
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background. PLoS One (2012) 0.85
PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo. J Immunol (2011) 0.85
An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol Biol Cell (2008) 0.84
The novel protein PTPIP51 is expressed in human keratinocyte carcinomas and their surrounding stroma. J Cell Mol Med (2008) 0.80
The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development. Immunology (2009) 0.78
Sustained high protein-tyrosine phosphatase 1B activity in the sperm of obese males impairs the sperm acrosome reaction. J Biol Chem (2014) 0.76
A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2). Sci Rep (2015) 0.75
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol (2002) 4.89
Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis. Nature (2002) 3.22
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell (2002) 2.99
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem (2003) 2.94
Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A (2003) 2.89
Inside the human cancer tyrosine phosphatome. Nat Rev Cancer (2011) 2.38
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS One (2009) 2.11
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol (2002) 2.02
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nat Genet (2007) 1.98
Numb regulates post-endocytic trafficking and degradation of Notch1. J Biol Chem (2009) 1.89
aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. EMBO J (2007) 1.81
Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle (2011) 1.79
Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. Circulation (2009) 1.70
The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size. Dev Cell (2006) 1.67
Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP. Curr Opin Cell Biol (2005) 1.61
Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer. Mol Cell Biol (2010) 1.53
Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice. Diabetologia (2014) 1.49
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J Biol Chem (2004) 1.49
Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat Immunol (2005) 1.49
A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. Curr Biol (2002) 1.49
Problems with co-funding in Canada. Science (2005) 1.48
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell (2009) 1.47
T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice. Arthritis Rheum (2012) 1.46
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics (2008) 1.46
Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genet (2005) 1.44
The role of protein tyrosine phosphatase 1B in Ras signaling. Proc Natl Acad Sci U S A (2004) 1.43
Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases. Biochem Cell Biol (2004) 1.38
LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol (2012) 1.37
Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. J Exp Med (2003) 1.37
PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP. J Biol Chem (2001) 1.37
Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice. Glia (2010) 1.36
Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins. Nature (2009) 1.35
The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol Biol Cell (2004) 1.34
Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta. J Neurosci (2006) 1.33
Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases. Sci Signal (2009) 1.32
Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling. Mol Cell Biol (2003) 1.32
LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J (2002) 1.31
The two faces of PTP1B in cancer. Biochim Biophys Acta (2009) 1.31
Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol Cell Biol (2002) 1.27
T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease. Immunol Rev (2009) 1.25
Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition. Mol Cell (2003) 1.24
The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation. J Biol Chem (2008) 1.22
The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo. Development (2007) 1.21
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. J Clin Invest (2011) 1.20
Redox regulation of interleukin-4 signaling. Immunity (2008) 1.20
Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS. Mol Cell Neurosci (2005) 1.20
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood (2004) 1.20
Phosphatases in cell-matrix adhesion and migration. Nat Rev Mol Cell Biol (2003) 1.19
Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer. Biochim Biophys Acta (2005) 1.19
Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J Biol Chem (2008) 1.15
PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP. J Biol Chem (2006) 1.14
Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone. Circ Res (2009) 1.13
A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. J Exp Med (2011) 1.13
Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. Cancer Res (2005) 1.11
PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Cancer Res (2012) 1.10
Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Mech Dev (2006) 1.08
Coordinated action of protein tyrosine phosphatases in insulin signal transduction. Eur J Biochem (2002) 1.08
PTP1B and TC-PTP: regulators of transformation and tumorigenesis. Cancer Metastasis Rev (2008) 1.07
Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models. J Endocrinol (2010) 1.07
PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446. J Biol Chem (2008) 1.06
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol (2004) 1.06
In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis. Trends Cell Biol (2010) 1.06
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. J Cell Sci (2005) 1.05
The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades. J Exp Med (2004) 1.05
Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell (2006) 1.04
T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis. Diabetes (2010) 1.03
Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PLoS One (2010) 1.03
Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling. Proc Natl Acad Sci U S A (2006) 1.02
Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure. J Biol Chem (2005) 1.02
T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. Mol Cell Biol (2006) 1.02
Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse. PLoS One (2010) 1.01
Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases. J Clin Invest (2009) 1.01
The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase. J Biol Chem (2006) 1.00
A sulfated carbohydrate epitope inhibits axon regeneration after injury. Proc Natl Acad Sci U S A (2012) 1.00
Modulation of leptin resistance by protein tyrosine phosphatases. Cell Metab (2012) 0.99
Transgenic expression of numb inhibits notch signaling in immature thymocytes but does not alter T cell fate specification. J Immunol (2002) 0.98
Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. Cancer Res (2010) 0.98
Cluster analysis of protein array results via similarity of Gene Ontology annotation. BMC Bioinformatics (2006) 0.98
Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia. J Cell Sci (2012) 0.98
Organization of the Sec61 translocon, studied by high resolution native electrophoresis. J Proteome Res (2010) 0.97
Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins. Mol Endocrinol (2006) 0.96
Identification of PTPsigma as an autophagic phosphatase. J Cell Sci (2011) 0.95
PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J Biol Chem (2010) 0.95
The DNA damage response pathway regulates the alternative splicing of the apoptotic mediator Bcl-x. J Biol Chem (2010) 0.95
Protein tyrosine phosphatases: emerging regulators of apoptosis. Cell Cycle (2007) 0.94
TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}. Blood (2007) 0.93
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif. EMBO J (2007) 0.93
Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors. J Biol Chem (2011) 0.92
Beyond the metabolic function of PTP1B. Cell Cycle (2004) 0.92
The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. J Cell Sci (2013) 0.92
HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. PLoS One (2009) 0.92
Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives. Chembiochem (2007) 0.91
Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb. Mol Cell Proteomics (2012) 0.91
PTP1B: a simple enzyme for a complex world. Crit Rev Biochem Mol Biol (2013) 0.91
Numb regulates Notch1, but not Notch3, during myogenesis. Mech Dev (2011) 0.90
Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells. Mol Cell Biol (2003) 0.90