PubRank

Jean-Louis Reymond

Author PubWeight™ 89.45‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 An efficient one-step site-directed and site-saturation mutagenesis protocol. Nucleic Acids Res 2004 6.42
2 Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discovery. J Chem Inf Model 2007 1.81
3 970 million druglike small molecules for virtual screening in the chemical universe database GDB-13. J Am Chem Soc 2009 1.64
4 Virtual exploration of the small-molecule chemical universe below 160 Daltons. Angew Chem Int Ed Engl 2005 1.57
5 Multivalent glycoconjugates as anti-pathogenic agents. Chem Soc Rev 2012 1.41
6 Enumeration of 166 billion organic small molecules in the chemical universe database GDB-17. J Chem Inf Model 2012 1.39
7 Inhibition and dispersion of Pseudomonas aeruginosa biofilms by glycopeptide dendrimers targeting the fucose-specific lectin LecB. Chem Biol 2008 1.34
8 Production of a functional catalytic antibody ScFv-NusA fusion protein in bacterial cytoplasm. J Biochem 2003 1.29
9 Expression improvement and mechanistic study of the retro-Diels-Alderase catalytic antibody 10F11 by site-directed mutagenesis. J Mol Biol 2004 1.26
10 Enzyme assays for high-throughput screening. Curr Opin Biotechnol 2004 1.25
11 Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9. Proc Natl Acad Sci U S A 2004 1.25
12 Recent advances in enzyme assays. Trends Biotechnol 2004 1.25
13 Mechanism of bacterial oligosaccharyltransferase: in vitro quantification of sequon binding and catalysis. J Biol Chem 2013 1.05
14 Prebiotic carbohydrate synthesis: zinc-proline catalyzes direct aqueous aldol reactions of alpha-hydroxy aldehydes and ketones. Org Biomol Chem 2005 1.03
15 Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. J Invest Dermatol 2006 1.00
16 A searchable map of PubChem. J Chem Inf Model 2010 0.97
17 A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of Pseudomonas aeruginosa biofilms. Angew Chem Int Ed Engl 2011 0.93
18 Classification of organic molecules by molecular quantum numbers. ChemMedChem 2009 0.92
19 Peptide dendrimers as artificial enzymes, receptors, and drug-delivery agents. Acc Chem Res 2006 0.92
20 A high-throughput, low-volume enzyme assay on solid support. Anal Chem 2005 0.90
21 MQN-mapplet: visualization of chemical space with interactive maps of DrugBank, ChEMBL, PubChem, GDB-11, and GDB-13. J Chem Inf Model 2013 0.90
22 Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation. Nat Commun 2013 0.89
23 Chemical space travel. ChemMedChem 2007 0.89
24 Visualization and virtual screening of the chemical universe database GDB-17. J Chem Inf Model 2013 0.88
25 SMIfp (SMILES fingerprint) chemical space for virtual screening and visualization of large databases of organic molecules. J Chem Inf Model 2013 0.87
26 Discovery of α7-nicotinic receptor ligands by virtual screening of the chemical universe database GDB-13. J Chem Inf Model 2011 0.87
27 Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711). J Med Chem 2012 0.86
28 Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB). J Med Chem 2010 0.85
29 Glycopeptide dendrimers with high affinity for the fucose-binding lectin LecB from Pseudomonas aeruginosa. ChemMedChem 2009 0.84
30 Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL. ACS Chem Neurosci 2014 0.84
31 Visualisation of the chemical space of fragments, lead-like and drug-like molecules in PubChem. J Comput Aided Mol Des 2011 0.84
32 Visualisation and subsets of the chemical universe database GDB-13 for virtual screening. J Comput Aided Mol Des 2011 0.84
33 Neoglycopeptide dendrimer libraries as a source of lectin binding ligands. Org Lett 2007 0.83
34 Inhibition of mitosis by glycopeptide dendrimer conjugates of colchicine. Chemistry 2005 0.83
35 Discovery of NMDA glycine site inhibitors from the chemical universe database GDB. ChemMedChem 2008 0.83
36 Low background FRET-substrates for lipases and esterases suitable for high-throughput screening under basic (pH 11) conditions. Org Biomol Chem 2006 0.83
37 A combinatorial approach to catalytic peptide dendrimers. Angew Chem Int Ed Engl 2004 0.82
38 Atom pair 2D-fingerprints perceive 3D-molecular shape and pharmacophores for very fast virtual screening of ZINC and GDB-17. J Chem Inf Model 2014 0.82
39 Structural and functional analyses reveal that Staphylococcus aureus antibiotic resistance factor HmrA is a zinc-dependent endopeptidase. J Biol Chem 2011 0.82
40 Electrostatics and flexibility drive membrane recognition and early penetration by the antimicrobial peptide dendrimer bH1. Chem Commun (Camb) 2013 0.82
41 Enzyme activity fingerprinting with substrate cocktails. J Am Chem Soc 2004 0.82
42 A catalytically essential motif in external loop 5 of the bacterial oligosaccharyltransferase PglB. J Biol Chem 2013 0.81
43 A structural basis for the activity of retro-Diels-Alder catalytic antibodies: evidence for a catalytic aromatic residue. Proc Natl Acad Sci U S A 2002 0.81
44 A general method for designing combinatorial peptide libraries decodable by amino acid analysis. J Comb Chem 2007 0.81
45 On-bead cyclization in a combinatorial library of 15,625 octapeptides. Bioorg Med Chem 2008 0.81
46 A strong positive dendritic effect in a peptide dendrimer-catalyzed ester hydrolysis reaction. J Am Chem Soc 2004 0.81
47 Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells. Chem Commun (Camb) 2014 0.81
48 Peptide dendrimer/lipid hybrid systems are efficient DNA transfection reagents: structure--activity relationships highlight the role of charge distribution across dendrimer generations. ACS Nano 2013 0.81
49 Dual mechanism of zinc-proline catalyzed aldol reactions in water. Chem Commun (Camb) 2006 0.81
50 Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease. Biol Chem 2007 0.81
51 OMA and OPA--software-supported mass spectra analysis of native and modified nucleic acids. J Am Soc Mass Spectrom 2012 0.81
52 Cluster analysis of the DrugBank chemical space using molecular quantum numbers. Bioorg Med Chem 2012 0.80
53 Remote control of bipyridine-metal coordination within a peptide dendrimer. Chem Commun (Camb) 2009 0.80
54 Combining topology and sequence design for the discovery of potent antimicrobial peptide dendrimers against multidrug-resistant Pseudomonas aeruginosa. Angew Chem Int Ed Engl 2014 0.80
55 Aldehyde detection by chromogenic/fluorogenic oxime bond fragmentation. Org Biomol Chem 2004 0.80
56 Alpha-helix stabilization within a peptide dendrimer. J Am Chem Soc 2008 0.80
57 Bead diffusion assay for discovering antimicrobial cyclic peptides. Chem Commun (Camb) 2010 0.80
58 Artificial aldolases from peptide dendrimer combinatorial libraries. Org Biomol Chem 2006 0.80
59 Fluorogenic substrates for lipases, esterases, and acylases using a TIM-mechanism for signal release. Biotechnol J 2007 0.80
60 The adrenaline test for enzymes. Angew Chem Int Ed Engl 2002 0.80
61 Combinatorial synthesis, selection, and properties of esterase peptide dendrimers. Biopolymers 2006 0.80
62 3-(aminomethyl)piperazine-2,5-dione as a novel NMDA glycine site inhibitor from the chemical universe database GDB. Bioorg Med Chem Lett 2009 0.79
63 Glycopeptide dendrimers for biomedical applications. Curr Top Med Chem 2008 0.79
64 Convergent synthesis and cellular uptake of multivalent cell penetrating peptides derived from Tat, Antp, pVEC, TP10 and SAP. Org Biomol Chem 2013 0.79
65 Structure-based optimization of the terminal tripeptide in glycopeptide dendrimer inhibitors of Pseudomonas aeruginosa biofilms targeting LecA. Chemistry 2013 0.79
66 A peptide dendrimer enzyme model with a single catalytic site at the core. J Am Chem Soc 2007 0.79
67 Synthesis and activity of histidine-containing catalytic peptide dendrimers. J Org Chem 2006 0.79
68 Enzyme fingerprints of activity, and stereo- and enantioselectivity from fluorogenic and chromogenic substrate arrays. Chemistry 2002 0.79
69 CH-π "T-shape" interaction with histidine explains binding of aromatic galactosides to Pseudomonas aeruginosa lectin LecA. ACS Chem Biol 2013 0.79
70 Theoretical investigation of the origins of catalysis of a retro-Diels-Alder reaction by antibody 10F11. J Org Chem 2004 0.79
71 Catalytic peptide dendrimers. Angew Chem Int Ed Engl 2003 0.78
72 Selective catalysis with peptide dendrimers. J Am Chem Soc 2004 0.78
73 pH-tuned metal coordination and peroxidase activity of a peptide dendrimer enzyme model with a Fe(II)bipyridine at its core. Org Biomol Chem 2012 0.78
74 Iterative oxime bond chemistry leads to protease inhibitors. Org Lett 2003 0.78
75 A peptide dendrimer model for vitamin B12 transport proteins. Chembiochem 2008 0.78
76 Classifying enzymes from selectivity fingerprints. Chembiochem 2004 0.78
77 Identification of protease substrates by combinatorial profiling on TentaGel beads. Chem Commun (Camb) 2007 0.77
78 Enzyme assay and activity fingerprinting of hydrolases with the red-chromogenic adrenaline test. Nat Protoc 2008 0.77
79 Protease profiling using a fluorescent domino peptide cocktail. Mol Biosyst 2005 0.77
80 Synthesis and esterolytic activity of catalytic peptide dendrimers. Chemistry 2004 0.77
81 Mechanistic study of proton transfer and hysteresis in catalytic antibody 16E7 by site-directed mutagenesis and homology modeling. Bioorg Med Chem 2005 0.77
82 Proteolysis of peptide dendrimers. Chembiochem 2009 0.77
83 Multivalency effects on Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA. Org Biomol Chem 2015 0.77
84 Dendrimers as artificial enzymes. Curr Opin Chem Biol 2005 0.77
85 Combinatorial libraries of peptide dendrimers: design, synthesis, on-bead high-throughput screening, bead decoding and characterization. Nat Protoc 2009 0.77
86 Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides. Chem Commun (Camb) 2011 0.77
87 Discovery of new peptide-based catalysts for the direct asymmetric aldol reaction. Bioorg Med Chem Lett 2003 0.77
88 Comparing dendritic with linear esterase peptides by screening SPOT arrays for catalysis. Chem Commun (Camb) 2010 0.76
89 Zinc-proline catalyzed pathway for the formation of sugars. Chem Commun (Camb) 2004 0.76
90 A green fluorescent chemosensor for amino acids provides a versatile high-throughput screening (HTS) assay for proteases. Bioorg Med Chem Lett 2003 0.76
91 Synthesis of ether oligomers. Org Lett 2004 0.76
92 Glycopeptide dendrimer colchicine conjugates targeting cancer cells. Bioorg Med Chem 2010 0.76
93 Identification of catalytic Peptide dendrimers by "off-bead" in silica high-throughput screening of combinatorial libraries. J Comb Chem 2010 0.76
94 Fluorogenic stereochemical probes for transaldolases. Chemistry 2003 0.76
95 Molecular dynamics and docking studies of single site esterase peptide dendrimers. J Org Chem 2009 0.76
96 Analytical chemistry: a dendritic signal amplifier. Nat Chem 2009 0.75
97 Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin A. Bioorg Med Chem 2011 0.75
98 Future turnovers in enzyme catalysis. Curr Opin Chem Biol 2010 0.75
99 Corrigendum: Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages. Sci Rep 2016 0.75
100 Peptide dendrimer enzyme models for ester hydrolysis and aldolization prepared by convergent thioether ligation. Org Biomol Chem 2011 0.75
101 Virtual Exploration of the Ring Systems Chemical Universe. J Chem Inf Model 2017 0.75
102 Combinatorial discovery of peptide dendrimer enzyme models hydrolyzing isobutyryl fluorescein. ACS Comb Sci 2011 0.75
103 Structure and binding of peptide-dendrimer ligands to vitamin B12. Chembiochem 2010 0.75
104 A red-fluorescent substrate microarray for lipase fingerprinting. Mol Biosyst 2006 0.75
105 Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro. Chembiochem 2009 0.75
106 STM vizualization of thiol-containing peptide dendrimers on Au(111). Macromol Biosci 2007 0.75
107 "Social" network of isomers based on bond count distance: algorithms. J Chem Inf Model 2014 0.75
108 Five-substrate cocktail as a sensor array for measuring enzyme activity fingerprints of lipases and esterases. Anal Chem 2011 0.75
109 Lipidated Peptide Dendrimers Killing Multidrug Resistant Bacteria. J Am Chem Soc 2017 0.75
110 A cyclodecapeptide ligand to vitamin B12. Org Biomol Chem 2008 0.75
111 A catalytic antibody against a tocopherol cyclase inhibitor. Chemistry 2004 0.75
112 Glycopeptide dendrimers: tuning carbohydrate-lectin interactions with amino acids. Mol Biosyst 2010 0.75
113 Structure-activity relationships in aminocyclopentitol glycosidase inhibitors. Org Biomol Chem 2004 0.75