PubRank

Stuart H Orkin

Author PubWeight™ 348.95‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008 14.64
2 A protein interaction network for pluripotency of embryonic stem cells. Nature 2006 9.63
3 Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 2004 8.16
4 Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 2007 7.55
5 Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 2011 7.41
6 EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell 2008 6.86
7 Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science 2008 6.66
8 A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 2010 6.00
9 Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res 2004 5.81
10 A critical role for eosinophils in allergic airways remodeling. Science 2004 5.53
11 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A 2008 5.27
12 Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med 2002 5.07
13 Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell 2006 5.03
14 Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 2002 4.80
15 Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 2004 4.68
16 The SWI/SNF complex--chromatin and cancer. Nat Rev Cancer 2004 4.59
17 DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A 2008 4.46
18 A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev 2009 4.23
19 The placenta is a niche for hematopoietic stem cells. Dev Cell 2005 3.83
20 Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 2007 3.82
21 Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 2003 3.77
22 Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell 2009 3.75
23 Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood 2002 3.59
24 Developmental and species-divergent globin switching are driven by BCL11A. Nature 2009 3.49
25 Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 2003 3.25
26 Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity 2003 3.17
27 The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell 2008 3.09
28 DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell 2009 3.08
29 Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell 2009 3.05
30 Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell 2008 2.96
31 GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med 2004 2.94
32 Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev 2010 2.93
33 Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell 2010 2.80
34 Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev 2008 2.74
35 The journey of developing hematopoietic stem cells. Development 2006 2.71
36 An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science 2013 2.71
37 ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol 2008 2.70
38 Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. Nat Genet 2010 2.63
39 Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell 2007 2.62
40 Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev 2004 2.56
41 Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science 2005 2.56
42 Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell 2002 2.51
43 Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood 2005 2.47
44 Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet 2005 2.44
45 The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development 2003 2.38
46 PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet 2008 2.37
47 Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science 2011 2.36
48 TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell 2010 2.33
49 A functional element necessary for fetal hemoglobin silencing. N Engl J Med 2011 2.25
50 MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med 2012 2.20
51 Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest 2012 2.15
52 Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proc Natl Acad Sci U S A 2006 2.08
53 Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev 2008 2.05
54 Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res 2011 2.05
55 miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev 2010 2.05
56 MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol 2011 2.00
57 Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc Natl Acad Sci U S A 2004 1.99
58 The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev 2002 1.99
59 GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J Exp Med 2003 1.96
60 A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Sci Transl Med 2012 1.95
61 Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc 2009 1.94
62 Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Mol Cell Biol 2010 1.88
63 MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol 2012 1.88
64 ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev 2013 1.87
65 Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell 2013 1.80
66 Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J Exp Med 2008 1.79
67 TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell 2009 1.77
68 GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A 2002 1.77
69 The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood 2002 1.76
70 MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation 2012 1.75
71 Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol 2013 1.75
72 Advances in the understanding of haemoglobin switching. Br J Haematol 2010 1.74
73 Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol 2004 1.68
74 Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A 2008 1.68
75 Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes Dev 2008 1.68
76 PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev 2012 1.66
77 The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol 2004 1.64
78 Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development 2002 1.64
79 Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Dev Cell 2012 1.63
80 Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature 2005 1.62
81 Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. Proc Natl Acad Sci U S A 2012 1.62
82 Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. Semin Cell Dev Biol 2004 1.59
83 Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders. Blood 2012 1.58
84 Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev 2002 1.57
85 MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci U S A 2011 1.54
86 ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell 2007 1.53
87 Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci U S A 2012 1.52
88 Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A 2013 1.50
89 The switch from fetal to adult hemoglobin. Cold Spring Harb Perspect Med 2013 1.47
90 Networking erythropoiesis. J Exp Med 2010 1.47
91 Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Mol Cell Biol 2002 1.47
92 Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood 2003 1.45
93 GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol 2009 1.44
94 Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood 2005 1.44
95 Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife 2013 1.44
96 Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell 2012 1.43
97 Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev 2010 1.42
98 X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Blood 2002 1.41
99 Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol Cell Biol 2008 1.36
100 Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors. J Immunol 2006 1.29
101 Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A 2011 1.28
102 Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev 2012 1.26
103 Update on fetal hemoglobin gene regulation in hemoglobinopathies. Curr Opin Pediatr 2011 1.24
104 Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev 2012 1.23
105 Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proc Natl Acad Sci U S A 2006 1.22
106 Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood 2010 1.21
107 Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Curr Opin Hematol 2006 1.21
108 Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Mol Cell Biol 2002 1.18
109 A single cis element maintains repression of the key developmental regulator Gata2. PLoS Genet 2010 1.14
110 Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Mol Cell Biol 2005 1.14
111 The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. Blood 2006 1.13
112 Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. Proc Natl Acad Sci U S A 2003 1.12
113 Placenta as a site for hematopoietic stem cell development. Exp Hematol 2005 1.11
114 Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Med 2011 1.11
115 Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. J Biol Chem 2004 1.10
116 Gata4 is necessary for normal pulmonary lobar development. Am J Respir Cell Mol Biol 2006 1.09
117 Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Mol Cell 2013 1.09
118 Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood 2010 1.08
119 Context-dependent function of "GATA switch" sites in vivo. Blood 2011 1.08
120 BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations. J Clin Invest 2015 1.07
121 Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc Natl Acad Sci U S A 2003 1.04
122 Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns. Proc Natl Acad Sci U S A 2014 1.02
123 GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Dev Biol 2008 1.02
124 Site-directed, virus-free, and inducible RNAi in embryonic stem cells. Proc Natl Acad Sci U S A 2007 0.99
125 Unraveling the transcriptional network controlling ES cell pluripotency. Genome Biol 2006 0.98
126 Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells 2011 0.97
127 Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis. Genome Biol 2014 0.97
128 TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest 2014 0.96
129 Dnmt3a silences hematopoietic stem cell self-renewal. Nat Genet 2011 0.95
130 Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis. Curr Opin Genet Dev 2013 0.94
131 The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Mol Cell Biol 2012 0.93
132 Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. Blood 2006 0.92
133 Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol Cell Biol 2004 0.91
134 Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med 2014 0.91
135 Glimpses of the epigenetic landscape. Cell Stem Cell 2009 0.89
136 Musings on genome medicine: genome wide association studies. Genome Med 2009 0.89
137 Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Curr Protoc Stem Cell Biol 2009 0.89
138 Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood 2009 0.88
139 TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Dev Biol 2012 0.87
140 Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP). J Biol Chem 2010 0.87
141 The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell 2016 0.87
142 A protein roadmap to pluripotency and faithful reprogramming. Cells Tissues Organs 2008 0.86
143 Translational isoforms of FOG1 regulate GATA1-interacting complexes. J Biol Chem 2009 0.85
144 Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1. J Biol Chem 2006 0.85
145 Modifier genes in Mendelian disorders: the example of hemoglobin disorders. Ann N Y Acad Sci 2010 0.85
146 Stem-cell competition. Nature 2002 0.84
147 Immunology: changed destiny. Nature 2007 0.82
148 The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep 2005 0.82
149 Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods Mol Med 2005 0.82
150 The search for the hemangioblast. J Hematother Stem Cell Res 2002 0.81
151 Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest 2016 0.80
152 More than blood, a novel gene required for mammalian postimplantation development. Mol Cell Biol 2004 0.80
153 Transcriptional silencing of fetal hemoglobin by BCL11A. Ann N Y Acad Sci 2010 0.80
154 Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1. Stem Cells 2005 0.80
155 Stem cells: the road not taken. Nature 2005 0.79
156 Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. Am J Hematol 2010 0.77
157 Musings on genome medicine: gene therapy. Genome Med 2009 0.77
158 Musings on genome medicine: Hepatitis C. Genome Med 2010 0.75
159 Corrigendum: Failure to replicate the STAP cell phenomenon. Nature 2015 0.75
160 Embryonic stem cells as sources of donor-independent platelets. J Clin Invest 2015 0.75
161 Musings on genome medicine: Crohn's disease. Genome Med 2009 0.75
162 Musings on genome medicine: cancer genetics and the promise of effective treatment. Genome Med 2009 0.75
163 The erythroid/myeloid lineage fate paradigm takes a new player. EMBO J 2011 0.75
164 Musings on genome medicine: enzyme-replacement therapy of the lysosomal storage diseases. Genome Med 2009 0.75
165 Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells. Proc Natl Acad Sci U S A 2013 0.75
166 Musings on genome medicine: cholesterol and coronary artery disease. Genome Med 2009 0.75
167 Musings on genome medicine: the slow but inexorable process of medical care reform in the United States. Genome Med 2009 0.75
168 Systematic tracking of cell fate changes. Nat Biotechnol 2010 0.75
169 Reactions to the Hwang scandal. Science 2006 0.75
170 Corrigendum: LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nat Commun 2016 0.75
171 Musings on genome medicine: the Obama effect redux. Genome Med 2009 0.75
172 The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. Methods 2002 0.75
173 Musings on genome medicine: abuse of genetic tests. Genome Med 2009 0.75
174 Musings on genome medicine: the Obama effect. Genome Med 2009 0.75
175 Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J Biol Chem 2017 0.75