Published in Nature on January 19, 2003
Hematopoiesis: an evolving paradigm for stem cell biology. Cell (2008) 11.95
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med (2008) 4.76
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18
Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol Cell Biol (2003) 3.45
Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell (2007) 3.41
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood (2005) 3.32
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol (2008) 2.70
E and ID proteins branch out. Nat Rev Immunol (2009) 2.68
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood (2005) 2.64
Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells. Genome Res (2010) 2.64
Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev (2004) 2.56
GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol (2005) 2.55
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med (2005) 2.34
Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell (2011) 2.30
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood (2008) 2.19
The role of JNK in the development of hepatocellular carcinoma. Genes Dev (2011) 2.07
Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation. Mol Cell Biol (2003) 1.92
SCL assembles a multifactorial complex that determines glycophorin A expression. Mol Cell Biol (2004) 1.89
E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors. Proc Natl Acad Sci U S A (2009) 1.81
Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 1.79
Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell (2012) 1.71
ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Mol Cell Biol (2005) 1.70
25 years of epidermal stem cell research. J Invest Dermatol (2011) 1.70
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell (2009) 1.69
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. EMBO J (2006) 1.63
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell (2009) 1.61
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc Natl Acad Sci U S A (2009) 1.58
Novel role for EKLF in megakaryocyte lineage commitment. Blood (2007) 1.53
Coordination of erythropoiesis by the transcription factor c-Myb. Blood (2006) 1.52
Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation. Blood (2011) 1.50
Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation. Proc Natl Acad Sci U S A (2009) 1.48
Networking erythropoiesis. J Exp Med (2010) 1.47
Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells. PLoS One (2013) 1.43
Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell (2012) 1.43
Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis. Proc Natl Acad Sci U S A (2003) 1.42
Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res (2012) 1.38
Effect of transcription-factor concentrations on leukemic stem cells. Blood (2005) 1.33
Lack of alpha4 integrin expression in stem cells restricts competitive function and self-renewal activity. Blood (2005) 1.32
Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development. Mol Cell Biol (2009) 1.31
ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev (2011) 1.30
Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol Cell Biol (2008) 1.29
Transcription factor networks in erythroid cell and megakaryocyte development. Blood (2011) 1.29
Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis. PLoS Biol (2007) 1.29
Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling. Blood (2008) 1.27
Runx1 function in hematopoiesis is required in cells that express Tek. Blood (2005) 1.25
c-Kit-mediated functional positioning of stem cells to their niches is essential for maintenance and regeneration of adult hematopoiesis. PLoS One (2011) 1.24
Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proc Natl Acad Sci U S A (2006) 1.22
The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Mol Cell Biol (2004) 1.22
Regulation of endothelial cell differentiation and specification. Circ Res (2013) 1.20
Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells. Blood (2011) 1.18
TAL-1/SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells. Mol Cell Biol (2007) 1.17
Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo. Mol Cell Biol (2005) 1.16
The SCL +40 enhancer targets the midbrain together with primitive and definitive hematopoiesis and is regulated by SCL and GATA proteins. Mol Cell Biol (2007) 1.13
Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+ alpha4(f/f) mice are hematopoietic cell autonomous. Blood (2006) 1.12
Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood (2007) 1.10
FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood (2010) 1.09
Measuring stem cell frequency in epidermis: a quantitative in vivo functional assay for long-term repopulating cells. Proc Natl Acad Sci U S A (2003) 1.06
Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150. Stem Cells (2009) 1.06
Combinatorial regulation of tissue specification by GATA and FOG factors. Development (2012) 1.06
The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy. Leukemia (2007) 1.04
Functional but abnormal adult erythropoiesis in the absence of the stem cell leukemia gene. Mol Cell Biol (2005) 1.02
The biochemistry of hematopoietic stem cell development. Biochim Biophys Acta (2012) 1.01
Common features of megakaryocytes and hematopoietic stem cells: what's the connection? J Cell Biochem (2009) 0.99
Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. PLoS One (2010) 0.99
Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo. J Exp Med (2013) 0.99
The effect of erythropoietin on normal and neoplastic cells. Biologics (2012) 0.98
Ldb1 complexes: the new master regulators of erythroid gene transcription. Trends Genet (2013) 0.96
Parsing the niche code: the molecular mechanisms governing hematopoietic stem cell adhesion and differentiation. Haematologica (2009) 0.96
VCAM-1 ablation in nonhematopoietic cells in MxCre+ VCAM-1f/f mice is variable and dictates their phenotype. Exp Hematol (2007) 0.96
Building multifunctionality into a complex containing master regulators of hematopoiesis. Proc Natl Acad Sci U S A (2010) 0.96
Erythro-megakaryocytic transcription factors associated with hereditary anemia. Blood (2014) 0.95
A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood (2006) 0.94
Rb and hematopoiesis: stem cells to anemia. Cell Div (2008) 0.93
Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol Cell Biol (2004) 0.91
Hematopoiesis. Cold Spring Harb Perspect Biol (2012) 0.91
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med (2014) 0.91
Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking. Nat Commun (2013) 0.91
Induced pluripotent stem cell-derived human platelets: one step closer to the clinic. J Exp Med (2010) 0.90
Role of helix-loop-helix proteins during differentiation of erythroid cells. Mol Cell Biol (2011) 0.90
The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells. Mol Cell Biol (2011) 0.88
Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma. Clin Cancer Res (2015) 0.88
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood (2009) 0.88
Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells. Blood (2011) 0.87
Gene expression fluctuations in murine hematopoietic stem cells with cell cycle progression. J Cell Physiol (2008) 0.86
Plasticity and maintenance of hematopoietic stem cells during development. Recent Pat Biotechnol (2011) 0.85
Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function. Stem Cells Int (2015) 0.84
Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points. Exp Hematol (2014) 0.84
Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. J Biol Chem (2009) 0.83
The ERGonomics of hematopoietic stem cell self-renewal. Genes Dev (2011) 0.82
The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors. Mol Cell Biol (2010) 0.81
Genetic interaction between Kit and Scl. Blood (2013) 0.80
Interferon regulatory factor-2 drives megakaryocytic differentiation. Biochem J (2004) 0.80
Vasculogenic and hematopoietic cellular progenitors are scattered within the prenatal mouse heart. Histochem Cell Biol (2014) 0.79
Impaired in vitro erythropoiesis following deletion of the Scl (Tal1) +40 enhancer is largely compensated for in vivo despite a significant reduction in expression. Mol Cell Biol (2013) 0.79
Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis. Proc Natl Acad Sci U S A (2003) 0.78
The c-Myb target gene neuromedin U functions as a novel cofactor during the early stages of erythropoiesis. Blood (2011) 0.78
Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages. Exp Hematol (2012) 0.78
SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. Mol Ther (2014) 0.77
An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability. Elife (2016) 0.77
Establishment of an ES cell-derived murine megakaryocytic cell line, MKD1, with features of primary megakaryocyte progenitors. PLoS One (2012) 0.76
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18
A protein interaction network for pluripotency of embryonic stem cells. Nature (2006) 9.63
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell (2004) 8.16
Bidirectional transport of amino acids regulates mTOR and autophagy. Cell (2009) 7.88
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat Biotechnol (2009) 6.76
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (2008) 6.66
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell (2010) 6.00
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res (2004) 5.81
A critical role for eosinophils in allergic airways remodeling. Science (2004) 5.53
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat Genet (2010) 5.37
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med (2002) 5.07
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell (2006) 5.03
Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene (2002) 4.80
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature (2004) 4.68
The SWI/SNF complex--chromatin and cancer. Nat Rev Cancer (2004) 4.59
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A (2008) 4.46
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol (2008) 4.41
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet (2009) 4.28
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev (2009) 4.23
The placenta is a niche for hematopoietic stem cells. Dev Cell (2005) 3.83
Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell (2007) 3.82
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature (2003) 3.77
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell (2009) 3.75
Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood (2002) 3.59
Developmental and species-divergent globin switching are driven by BCL11A. Nature (2009) 3.49
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet (2005) 3.28
Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity (2003) 3.17
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell (2008) 3.09
Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nat Genet (2007) 3.08
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell (2009) 3.08
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell (2009) 3.05
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell (2008) 2.96
GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med (2004) 2.94
Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev (2010) 2.93
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell (2010) 2.80
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
The journey of developing hematopoietic stem cells. Development (2006) 2.71
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (2013) 2.71
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol (2008) 2.70
Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. Nat Genet (2010) 2.63
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell (2007) 2.62
Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera. Cell Stem Cell (2007) 2.56
Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev (2004) 2.56
Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science (2005) 2.56
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell (2002) 2.51
A call for standardized naming and reporting of human ESC and iPSC lines. Cell Stem Cell (2011) 2.48
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood (2005) 2.47
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest (2005) 2.45
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet (2005) 2.44
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development (2003) 2.38
The influence of transcriptional orientation on endogenous switch region function. Nat Immunol (2003) 2.38
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet (2008) 2.37
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science (2011) 2.36
TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell (2010) 2.33
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature (2012) 2.32
A functional element necessary for fetal hemoglobin silencing. N Engl J Med (2011) 2.25
MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med (2012) 2.20
Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest (2012) 2.15
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proc Natl Acad Sci U S A (2006) 2.08
Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev (2008) 2.05
Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res (2011) 2.05
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev (2010) 2.05
MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol (2011) 2.00
Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc Natl Acad Sci U S A (2004) 1.99
The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev (2002) 1.99
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J (2003) 1.98
GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J Exp Med (2003) 1.96
A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Sci Transl Med (2012) 1.95
Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc (2009) 1.94
An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J Biol Chem (2005) 1.89
Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage. Blood (2010) 1.88
Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Mol Cell Biol (2010) 1.88
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol (2012) 1.88
Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem (2002) 1.87
ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev (2013) 1.87
Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell (2013) 1.80
Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. J Exp Med (2008) 1.79
Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions. J Exp Med (2005) 1.79
TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell (2009) 1.77