A critical role for eosinophils in allergic airways remodeling.

PubWeight™: 5.53‹?› | Rank: Top 1%

🔗 View Article (PMID 15375268)

Published in Science on September 17, 2004

Authors

Alison A Humbles1, Clare M Lloyd, Sarah J McMillan, Daniel S Friend, Georgina Xanthou, Erin E McKenna, Sorina Ghiran, Norma P Gerard, Channing Yu, Stuart H Orkin, Craig Gerard

Author Affiliations

1: Department of Pediatrics, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. alison.humbles@childrens.harvard.edu

Articles citing this

(truncated to the top 100)

Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med (2012) 6.15

Diversity and dialogue in immunity to helminths. Nat Rev Immunol (2011) 3.72

Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol (2009) 3.13

Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med (2010) 2.91

Anatomical profiling of G protein-coupled receptor expression. Cell (2008) 2.88

The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol (2010) 2.74

Eosinophils: changing perspectives in health and disease. Nat Rev Immunol (2012) 2.69

CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature (2009) 2.39

IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways. Am J Respir Crit Care Med (2010) 2.36

Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest (2006) 2.12

The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med (2011) 2.12

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J Exp Med (2008) 2.11

Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nat Med (2007) 2.08

CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Nat Med (2010) 2.07

Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry. J Immunol Methods (2007) 2.04

Innate cells and T helper 2 cell immunity in airway inflammation. Immunity (2009) 1.94

Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A (2005) 1.87

Importance of cytokines in murine allergic airway disease and human asthma. J Immunol (2010) 1.86

Mouse models of allergic asthma: acute and chronic allergen challenge. Dis Model Mech (2008) 1.86

Airway hyperresponsiveness is dissociated from airway wall structural remodeling. J Allergy Clin Immunol (2008) 1.76

Biology of the eosinophil. Adv Immunol (2009) 1.74

Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am J Respir Crit Care Med (2009) 1.72

Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology (2007) 1.71

A Holy Grail of asthma management: toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids. Br J Pharmacol (2007) 1.71

Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol (2008) 1.71

Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood (2010) 1.69

Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol (2009) 1.65

Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma. J Exp Med (2008) 1.59

Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. J Exp Med (2014) 1.59

Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils. Traffic (2005) 1.56

A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc Natl Acad Sci U S A (2006) 1.55

Pivotal advance: eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production. J Leukoc Biol (2008) 1.55

Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proc Natl Acad Sci U S A (2006) 1.54

CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol (2008) 1.51

Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis. Immunol Allergy Clin North Am (2009) 1.51

Allergic airway responses in obese mice. Am J Respir Crit Care Med (2007) 1.50

Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation. Am J Respir Crit Care Med (2015) 1.49

Persistent effects induced by IL-13 in the lung. Am J Respir Cell Mol Biol (2006) 1.47

Targeting eosinophils in allergy, inflammation and beyond. Nat Rev Drug Discov (2013) 1.47

Asthma exacerbations in children immediately following stressful life events: a Cox's hierarchical regression. Thorax (2004) 1.45

Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge. J Allergy Clin Immunol (2014) 1.43

Schistosoma mansoni infection in eosinophil lineage-ablated mice. Blood (2006) 1.42

Eosinophils in health and disease: the LIAR hypothesis. Clin Exp Allergy (2010) 1.41

Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness. Am J Respir Crit Care Med (2008) 1.40

Dishing the dirt on asthma: What we can learn from poor hygiene. Biologics (2007) 1.40

Mechanisms of eosinophilia in the pathogenesis of hypereosinophilic disorders. Immunol Allergy Clin North Am (2007) 1.37

The expanding role(s) of eosinophils in health and disease. Blood (2012) 1.35

Eosinophils in innate immunity: an evolving story. Cell Tissue Res (2010) 1.34

EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression. Blood (2007) 1.33

What targeting eosinophils has taught us about their role in diseases. J Allergy Clin Immunol (2010) 1.33

The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat Immunol (2009) 1.29

Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis. J Clin Invest (2008) 1.28

Biomedicine. Eosinophils in asthma: remodeling a tangled tale. Science (2004) 1.28

A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils. Blood (2008) 1.26

Eosinophils in the pathogenesis of allergic airways disease. Cell Mol Life Sci (2007) 1.26

Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling. Am J Pathol (2006) 1.25

Pathology of asthma. Front Microbiol (2013) 1.25

Eosinophils in vasculitis: characteristics and roles in pathogenesis. Nat Rev Rheumatol (2014) 1.24

Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling. Mucosal Immunol (2012) 1.22

Chronic inflammation and asthma. Mutat Res (2009) 1.22

Eosinophils and Th2 immunity: contemporary insights. Immunol Cell Biol (2010) 1.22

Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction. J Clin Invest (2005) 1.20

No audible wheezing: nuggets and conundrums from mouse asthma models. J Exp Med (2005) 1.18

Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Am J Pathol (2005) 1.18

Airway and lung pathology due to mucosal surface dehydration in {beta}-epithelial Na+ channel-overexpressing mice: role of TNF-{alpha} and IL-4R{alpha} signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment. J Immunol (2009) 1.17

Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir Res (2007) 1.15

Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease. Am J Respir Cell Mol Biol (2009) 1.15

Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice. Infect Immun (2011) 1.14

Allergic rhinitis and asthma: inflammation in a one-airway condition. BMC Pulm Med (2006) 1.13

CD137-mediated immunotherapy for allergic asthma. J Clin Invest (2006) 1.13

Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD). J Allergy Clin Immunol (2012) 1.12

Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma. J Immunol (2011) 1.11

Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses. J Immunol (2008) 1.11

Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils. J Leukoc Biol (2013) 1.11

Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice. PLoS One (2009) 1.11

Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol (2011) 1.11

Eosinophil granule proteins: form and function. J Biol Chem (2014) 1.10

Esophageal functional impairments in experimental eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol (2012) 1.09

CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling. Am J Physiol Lung Cell Mol Physiol (2008) 1.07

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med (2009) 1.07

Allergen-induced airway remodeling is impaired in galectin-3-deficient mice. J Immunol (2010) 1.07

A role for airway remodeling during respiratory syncytial virus infection. Respir Res (2005) 1.06

Respiratory viruses and eosinophils: exploring the connections. Antiviral Res (2009) 1.06

Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease. J Exp Med (2009) 1.06

Eosinophils and disease pathogenesis. Semin Hematol (2012) 1.05

Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood (2009) 1.05

Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. PLoS One (2013) 1.04

Eosinophils preserve parasitic nematode larvae by regulating local immunity. J Immunol (2011) 1.03

Importance of myeloid dendritic cells in persistent airway disease after repeated allergen exposure. Am J Respir Crit Care Med (2005) 1.02

Murine lung eosinophil activation and chemokine production in allergic airway inflammation. Cell Mol Immunol (2010) 1.01

Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation. Clin Exp Allergy (2008) 1.01

Virally delivered cytokines alter the immune response to future lung infections. J Virol (2007) 1.01

Eosinophil development, regulation of eosinophil-specific genes, and role of eosinophils in the pathogenesis of asthma. Allergy Asthma Immunol Res (2011) 1.01

Separate endocytic pathways regulate IL-5 receptor internalization and signaling. J Leukoc Biol (2008) 1.01

Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice. Am J Pathol (2009) 1.00

Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem (2013) 0.99

Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling. Clin Exp Allergy (2005) 0.99

Maternal transmission of resistance to development of allergic airway disease. J Immunol (2007) 0.99

Allergen-induced airway remodelling. Eur Respir J (2007) 0.98

GATA-1 regulates the generation and function of basophils. Proc Natl Acad Sci U S A (2013) 0.98

Articles by these authors

An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64

A protein interaction network for pluripotency of embryonic stem cells. Nature (2006) 9.63

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell (2004) 8.16

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (2008) 6.66

A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell (2010) 6.00

Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science (2002) 5.82

Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res (2004) 5.81

Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol (2004) 5.80

Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27

Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med (2002) 5.07

Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell (2006) 5.03

Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene (2002) 4.80

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature (2004) 4.68

The SWI/SNF complex--chromatin and cancer. Nat Rev Cancer (2004) 4.59

Modulation of the antitumor immune response by complement. Nat Immunol (2008) 4.53

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A (2008) 4.46

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev (2009) 4.23

CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature (2009) 4.03

The placenta is a niche for hematopoietic stem cells. Dev Cell (2005) 3.83

Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell (2007) 3.82

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature (2003) 3.77

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell (2009) 3.75

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev (2009) 3.65

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood (2002) 3.59

Developmental and species-divergent globin switching are driven by BCL11A. Nature (2009) 3.49

Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med (2005) 3.48

Functional roles for C5a receptors in sepsis. Nat Med (2008) 3.33

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature (2003) 3.25

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity (2003) 3.17

The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell (2008) 3.09

DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell (2009) 3.08

Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell (2009) 3.05

Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. Immunity (2002) 2.99

Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell (2008) 2.96

GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med (2004) 2.94

Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev (2010) 2.93

The Th17 pathway in cystic fibrosis lung disease. Am J Respir Crit Care Med (2011) 2.87

Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol (2007) 2.81

Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell (2010) 2.80

Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proc Natl Acad Sci U S A (2009) 2.76

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74

The journey of developing hematopoietic stem cells. Development (2006) 2.71

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (2013) 2.71

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol (2008) 2.70

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. Nat Genet (2010) 2.63

Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell (2007) 2.62

Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science (2005) 2.56

Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev (2004) 2.56

Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell (2002) 2.51

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood (2005) 2.47

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat Med (2008) 2.44

Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet (2005) 2.44

The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development (2003) 2.38

PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet (2008) 2.37

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science (2011) 2.36

SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J Biol Chem (2005) 2.36

IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways. Am J Respir Crit Care Med (2010) 2.36

TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell (2010) 2.33

A functional element necessary for fetal hemoglobin silencing. N Engl J Med (2011) 2.25

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci U S A (2002) 2.24

C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity (2005) 2.24

Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs. J Exp Med (2005) 2.23

Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. J Immunol (2005) 2.22

MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med (2012) 2.20

Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med (2002) 2.17

Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest (2012) 2.15

A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest (2006) 2.15

The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Immunity (2008) 2.13

Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J Clin Invest (2004) 2.10

Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nat Med (2007) 2.08

Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proc Natl Acad Sci U S A (2006) 2.08

Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev (2008) 2.05

Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res (2011) 2.05

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev (2010) 2.05

Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A (2007) 2.02

MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol (2011) 2.00

Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc Natl Acad Sci U S A (2004) 1.99

The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev (2002) 1.99

Activin A and TGF-β promote T(H)9 cell-mediated pulmonary allergic pathology. J Allergy Clin Immunol (2012) 1.98

Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology (2008) 1.98

GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J Exp Med (2003) 1.96

A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Sci Transl Med (2012) 1.95

Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc (2009) 1.94

Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in mice. J Leukoc Biol (2004) 1.92

C5L2, a nonsignaling C5A binding protein. Biochemistry (2003) 1.90

An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J Biol Chem (2005) 1.89

Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax (2012) 1.88

Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Mol Cell Biol (2010) 1.88

MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol (2012) 1.88