|
1
|
Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development.
|
Cell
|
2008
|
10.34
|
|
2
|
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.
|
Cell Stem Cell
|
2011
|
6.71
|
|
3
|
Development of definitive endoderm from embryonic stem cells in culture.
|
Development
|
2004
|
4.61
|
|
4
|
Haemangioblast commitment is initiated in the primitive streak of the mouse embryo.
|
Nature
|
2004
|
4.20
|
|
5
|
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures.
|
Blood
|
2007
|
3.71
|
|
6
|
Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.
|
Cell Stem Cell
|
2012
|
3.66
|
|
7
|
Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation.
|
Development
|
2003
|
3.60
|
|
8
|
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
|
Nat Biotechnol
|
2006
|
3.02
|
|
9
|
SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells.
|
Nat Biotechnol
|
2011
|
2.84
|
|
10
|
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.
|
Development
|
2011
|
2.82
|
|
11
|
A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development.
|
Cell
|
2012
|
2.81
|
|
12
|
Identification and targeting of the ROSA26 locus in human embryonic stem cells.
|
Nat Biotechnol
|
2007
|
2.75
|
|
13
|
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells.
|
Nat Biotechnol
|
2011
|
2.22
|
|
14
|
Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes.
|
Nat Methods
|
2013
|
2.14
|
|
15
|
T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures.
|
Cell Rep
|
2012
|
1.99
|
|
16
|
Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation.
|
Proc Natl Acad Sci U S A
|
2005
|
1.85
|
|
17
|
Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.
|
Stem Cells
|
2010
|
1.75
|
|
18
|
Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro.
|
Blood
|
2002
|
1.72
|
|
19
|
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.
|
Nat Cell Biol
|
2011
|
1.70
|
|
20
|
Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on temozolomide-resistant glioma cells.
|
J Neurosurg
|
2007
|
1.63
|
|
21
|
In vivo gene delivery by embryonic-stem-cell-derived astrocytes for malignant gliomas.
|
Neuro Oncol
|
2008
|
1.62
|
|
22
|
Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo.
|
J Am Soc Nephrol
|
2007
|
1.50
|
|
23
|
Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells.
|
Cardiovasc Res
|
2012
|
1.47
|
|
24
|
Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics.
|
J Gen Physiol
|
2013
|
1.44
|
|
25
|
Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice.
|
Proc Natl Acad Sci U S A
|
2002
|
1.41
|
|
26
|
Hypoxia affects mesoderm and enhances hemangioblast specification during early development.
|
Development
|
2004
|
1.41
|
|
27
|
Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6.
|
Blood
|
2005
|
1.39
|
|
28
|
Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes.
|
Circ Arrhythm Electrophysiol
|
2013
|
1.38
|
|
29
|
SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development.
|
Blood
|
2005
|
1.37
|
|
30
|
Alternative induced pluripotent stem cell characterization criteria for in vitro applications.
|
Cell Stem Cell
|
2009
|
1.36
|
|
31
|
Directed differentiation of mouse embryonic stem cells into thyroid follicular cells.
|
Endocrinology
|
2006
|
1.35
|
|
32
|
Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes.
|
PLoS One
|
2011
|
1.34
|
|
33
|
The expression of Sox17 identifies and regulates haemogenic endothelium.
|
Nat Cell Biol
|
2013
|
1.28
|
|
34
|
Retinoic acid signaling is essential for embryonic hematopoietic stem cell development.
|
Cell
|
2013
|
1.25
|
|
35
|
Committing embryonic stem cells to early endocrine pancreas in vitro.
|
Stem Cells
|
2004
|
1.23
|
|
36
|
Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes.
|
Development
|
2013
|
1.23
|
|
37
|
The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation.
|
Blood
|
2005
|
1.21
|
|
38
|
Notch signaling respecifies the hemangioblast to a cardiac fate.
|
Nat Biotechnol
|
2008
|
1.19
|
|
39
|
Serial in vivo positive contrast MRI of iron oxide-labeled embryonic stem cell-derived cardiac precursor cells in a mouse model of myocardial infarction.
|
Magn Reson Med
|
2008
|
1.14
|
|
40
|
Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine.
|
Semin Cell Dev Biol
|
2012
|
1.12
|
|
41
|
Parthenogenetic stem cells for tissue-engineered heart repair.
|
J Clin Invest
|
2013
|
1.11
|
|
42
|
Defining the path to hematopoietic stem cells.
|
Nat Biotechnol
|
2013
|
1.11
|
|
43
|
Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry.
|
J Physiol
|
2011
|
1.08
|
|
44
|
Smad1 expands the hemangioblast population within a limited developmental window.
|
Blood
|
2006
|
1.05
|
|
45
|
Tracking mesoderm formation and specification to the hemangioblast in vitro.
|
Trends Cardiovasc Med
|
2004
|
1.00
|
|
46
|
Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor.
|
Blood
|
2006
|
0.98
|
|
47
|
Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos.
|
Dev Dyn
|
2003
|
0.97
|
|
48
|
Micro-arrayed human embryonic stem cells-derived cardiomyocytes for in vitro functional assay.
|
PLoS One
|
2012
|
0.96
|
|
49
|
Haploinsufficiency of Runx1 results in the acceleration of mesodermal development and hemangioblast specification upon in vitro differentiation of ES cells.
|
Blood
|
2003
|
0.94
|
|
50
|
Apoptosis in human glioblastoma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand.
|
J Neurosurg
|
2006
|
0.94
|
|
51
|
The homeobox gene Hex regulates hepatocyte differentiation from embryonic stem cell-derived endoderm.
|
Hepatology
|
2010
|
0.94
|
|
52
|
Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair.
|
Stem Cell Reports
|
2015
|
0.93
|
|
53
|
SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis.
|
Development
|
2004
|
0.93
|
|
54
|
Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics.
|
Biotechnol Bioeng
|
2011
|
0.92
|
|
55
|
Primitive erythropoiesis is regulated by miR-126 via nonhematopoietic Vcam-1+ cells.
|
Dev Cell
|
2012
|
0.91
|
|
56
|
Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle.
|
Lab Chip
|
2014
|
0.87
|
|
57
|
Fetal reprogramming and senescence in hypoplastic left heart syndrome and in human pluripotent stem cells during cardiac differentiation.
|
Am J Pathol
|
2013
|
0.86
|
|
58
|
Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: differentiation and transplantion into the mouse brain.
|
J Neurosurg
|
2005
|
0.86
|
|
59
|
Embryonic stem cell-derived astrocytes: a novel gene therapy vector for brain tumors.
|
Neurosurg Focus
|
2005
|
0.86
|
|
60
|
Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population.
|
PLoS One
|
2011
|
0.85
|
|
61
|
The cardiomyocyte lineage is critical for optimization of stem cell therapy in a mouse model of myocardial infarction.
|
FASEB J
|
2009
|
0.84
|
|
62
|
The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family.
|
Mech Dev
|
2002
|
0.82
|
|
63
|
Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope?
|
Cancer Biol Ther
|
2008
|
0.78
|
|
64
|
Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.
|
Proc Natl Acad Sci U S A
|
2003
|
0.78
|
|
65
|
Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells.
|
Circ Res
|
2011
|
0.77
|
|
66
|
Looking inwards: opening a window onto human development.
|
Development
|
2015
|
0.76
|
|
67
|
Stem cells and regeneration: a special issue.
|
Development
|
2013
|
0.75
|
|
68
|
An interview with Gordon Keller. Interview by Eva Amsen.
|
Development
|
2011
|
0.75
|