PubRank

O C Uhlenbeck

Author PubWeight™ 397.27‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Improved estimation of secondary structure in ribonucleic acids. Nat New Biol 1973 46.33
2 Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates. Nucleic Acids Res 1987 25.34
3 Estimation of secondary structure in ribonucleic acids. Nature 1971 20.52
4 Stability of ribonucleic acid double-stranded helices. J Mol Biol 1974 16.35
5 Synthesis of small RNAs using T7 RNA polymerase. Methods Enzymol 1989 10.82
6 3'-terminal labelling of RNA with T4 RNA ligase. Nature 1978 10.69
7 A small catalytic oligoribonucleotide. Nature 1987 8.73
8 Stability of RNA hairpin loops: A 6 -C m -U 6 . J Mol Biol 1973 8.39
9 Biochemical and physical characterization of an unmodified yeast phenylalanine transfer RNA transcribed in vitro. Proc Natl Acad Sci U S A 1988 7.76
10 Specific labeling of 3' termini of RNA with T4 RNA ligase. Methods Enzymol 1980 7.55
11 Reactions at the termini of tRNA with T4 RNA ligase. Nucleic Acids Res 1978 5.93
12 CUUCGG hairpins: extraordinarily stable RNA secondary structures associated with various biochemical processes. Proc Natl Acad Sci U S A 1988 5.50
13 Self-complementary oligoribonucleotides: effects of helix defects and guanylic acid-cytidylic acid base pairs. J Mol Biol 1971 4.54
14 RNA binding site of R17 coat protein. Biochemistry 1987 4.20
15 Sequence-specific interaction of R17 coat protein with its ribonucleic acid binding site. Biochemistry 1983 4.09
16 Enzymatic oligoribonucleotide synthesis with T4 RNA ligase. Biochemistry 1978 3.99
17 3'-Phosphatase activity in T4 polynucleotide kinase. Biochemistry 1977 3.86
18 Sequence requirements of the hammerhead RNA self-cleavage reaction. Biochemistry 1990 3.64
19 Uniform binding of aminoacyl-tRNAs to elongation factor Tu by thermodynamic compensation. Science 2001 3.54
20 Role of divalent metal ions in the hammerhead RNA cleavage reaction. Biochemistry 1991 3.31
21 Characterization of RNA hairpin loop stability. Nucleic Acids Res 1988 3.10
22 Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism. Biochemistry 1993 2.91
23 Specific interaction between RNA phage coat proteins and RNA. Prog Nucleic Acid Res Mol Biol 1991 2.84
24 T4-induced RNA ligase joins single-stranded oligoribonucleotides. Proc Natl Acad Sci U S A 1975 2.84
25 Substrate sequence effects on "hammerhead" RNA catalytic efficiency. Proc Natl Acad Sci U S A 1990 2.81
26 Kinetics of intermolecular cleavage by hammerhead ribozymes. Biochemistry 1992 2.79
27 Self-complementary oligoribonucleotides: adenylic acid-uridylic acid block copolymers. J Mol Biol 1971 2.78
28 Numbering system for the hammerhead. Nucleic Acids Res 1992 2.74
29 In vitro selection of RNAs that undergo autolytic cleavage with Pb2+. Biochemistry 1992 2.60
30 Role of a bulged A residue in a specific RNA-protein interaction. Biochemistry 1987 2.52
31 A kinetic and thermodynamic framework for the hammerhead ribozyme reaction. Biochemistry 1994 2.39
32 T7 RNA polymerase produces 5' end heterogeneity during in vitro transcription from certain templates. RNA 1998 2.39
33 Nucleotides in yeast tRNAPhe required for the specific recognition by its cognate synthetase. Science 1989 2.36
34 Equimolar addition of oligoribonucleotides with T4 RNA ligase. Nucleic Acids Res 1977 2.32
35 Interaction of R17 coat protein with synthetic variants of its ribonucleic acid binding site. Biochemistry 1983 2.30
36 An RNA mutation that increases the affinity of an RNA-protein interaction. Nucleic Acids Res 1987 2.25
37 Quantitative in situ hybridization of ribosomal RNA species to polytene chromosomes of Drosophila melanogaster. J Mol Biol 1977 2.18
38 Folding of circularly permuted transfer RNAs. Science 1991 2.14
39 Complementary oligonucleotide binding to the anticodon loop of fMet-transfer RNA. Nature 1970 2.13
40 Hammerhead ribozyme kinetics. RNA 1998 2.08
41 Kinetic and thermodynamic characterization of the R17 coat protein-ribonucleic acid interaction. Biochemistry 1983 2.07
42 Ribonucleoprotein complexes of R17 coat protein and a translational operator analog. J Mol Biol 1988 1.99
43 RNA template-directed RNA synthesis by T7 RNA polymerase. Proc Natl Acad Sci U S A 1994 1.98
44 Dinucleoside pyrophosphate are substrates for T4-induced RNA ligase. Proc Natl Acad Sci U S A 1977 1.94
45 Enzymatic replacement of the anticodon of yeast phenylalanine transfer ribonucleic acid. Biochemistry 1982 1.94
46 Lead-catalyzed cleavage of yeast tRNAPhe mutants. Biochemistry 1990 1.87
47 Tetraloops and RNA folding. Nature 1990 1.87
48 Chemical and enzymatic synthesis of tRNAs for high-throughput crystallization. RNA 2001 1.81
49 Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction. Nucleic Acids Res 1990 1.76
50 Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins. Science 1993 1.73
51 Mutants of the bacteriophage MS2 coat protein that alter its cooperative binding to RNA. Biochemistry 1995 1.72
52 Structure of an unmodified tRNA molecule. Biochemistry 1989 1.71
53 Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb. Science 1998 1.66
54 Synthesis of modified nucleoside 3',5'-bisphosphates and their incorporation into oligoribonucleotides with T4 RNA ligase. Biochemistry 1978 1.62
55 Joining of RNA molecules with RNA ligase. Methods Enzymol 1983 1.62
56 Nucleoside and nucleotide inactivation of R17 coat protein: evidence for a transient covalent RNA-protein bond. Biochemistry 1985 1.62
57 Role of the tertiary nucleotides in the interaction of yeast phenylalanine tRNA with its cognate synthetase. Biochemistry 1990 1.60
58 Determination of RNA-protein contacts using thiophosphate substitutions. Biochemistry 1989 1.60
59 The self-splicing RNA of Tetrahymena is trapped in a less active conformation by gel purification. Biochemistry 1990 1.58
60 Escherichia coli DbpA is an RNA helicase that requires hairpin 92 of 23S rRNA. EMBO J 2001 1.58
61 Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation. J Biol Chem 1997 1.55
62 Studies on the hammerhead RNA self-cleaving domain. Gene 1989 1.52
63 Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations. RNA 2001 1.51
64 Specificity of hammerhead ribozyme cleavage. EMBO J 1996 1.49
65 Complementary oligonucleotide binding to transfer RNA. J Mol Biol 1972 1.49
66 Sequence-dependent structural variations of hammerhead RNA enzymes. Nucleic Acids Res 1990 1.47
67 Proton NMR and structural features of a 24-nucleotide RNA hairpin. Biochemistry 1995 1.47
68 Intact aminoacyl-tRNA is required to trigger GTP hydrolysis by elongation factor Tu on the ribosome. Biochemistry 2000 1.47
69 A small metalloribozyme with a two-step mechanism. Nature 1992 1.46
70 Specific RNA binding by Q beta coat protein. Biochemistry 1989 1.45
71 Kinetic characterization of intramolecular and intermolecular hammerhead RNAs with stem II deletions. Proc Natl Acad Sci U S A 1994 1.42
72 Roles of operator and non-operator RNA sequences in bacteriophage R17 capsid assembly. J Mol Biol 1988 1.41
73 The Escherichia coli DEAD protein DbpA recognizes a small RNA hairpin in 23S rRNA. RNA 2001 1.40
74 In vitro analysis of translational rate and accuracy with an unmodified tRNA. Biochemistry 1993 1.40
75 A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein. Proc Natl Acad Sci U S A 1998 1.40
76 The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis. Nucleic Acids Res 1995 1.39
77 Self-cleaving catalytic RNA. FASEB J 1993 1.39
78 Cloning and biochemical characterization of Bacillus subtilis YxiN, a DEAD protein specifically activated by 23S rRNA: delineation of a novel sub-family of bacterial DEAD proteins. Nucleic Acids Res 1999 1.35
79 A specific, UV-induced RNA-protein cross-link using 5-bromouridine-substituted RNA. Biochemistry 1991 1.34
80 Specific interaction of anticodon loop residues with yeast phenylalanyl-tRNA synthetase. Biochemistry 1982 1.32
81 Determination of recognition nucleotides for Escherichia coli phenylalanyl-tRNA synthetase. Biochemistry 1992 1.31
82 Enzymatic synthesis of a 21-nucleotide coat protein binding fragment of R17 ribonucleic acid. Biochemistry 1982 1.31
83 Inhibition of the hammerhead ribozyme by neomycin. RNA 1995 1.31
84 Cooperative binding of R17 coat protein to RNA. Biochemistry 1990 1.30
85 Quantitative assessment of EF-1alpha.GTP binding to aminoacyl-tRNAs, aminoacyl-viral RNA, and tRNA shows close correspondence to the RNA binding properties of EF-Tu. J Biol Chem 1999 1.29
86 Kinetic analysis of the RNA-dependent adenosinetriphosphatase activity of DbpA, an Escherichia coli DEAD protein specific for 23S ribosomal RNA. Biochemistry 1998 1.28
87 Binding of yeast tRNAPhe anticodon arm to Escherichia coli 30 S ribosomes. J Mol Biol 1983 1.27
88 Polynucleotide kinase from a T4 mutant which lacks the 3' phosphatase activity. Nucleic Acids Res 1978 1.27
89 Properties of an in vitro selected Pb2+ cleavage motif. Biochemistry 1994 1.27
90 Guanosine modifications in runoff transcripts of synthetic transfer RNA-Phe genes microinjected into Xenopus oocytes. Biochim Biophys Acta 1990 1.25
91 Hammerhead ribozymes with a faster cleavage rate. Biochemistry 1997 1.25
92 Many of the conserved nucleotides of tRNA(Phe) are not essential for ternary complex formation and peptide elongation. EMBO J 1994 1.24
93 Interaction of Escherichia coli host factor protein with oligoriboadenylates. Biochemistry 1980 1.21
94 Aminoacylation of anticodon loop substituted yeast tyrosine transfer RNA. Biochemistry 1985 1.20
95 A re-investigation of the thio effect at the hammerhead cleavage site. Nucleic Acids Res 1999 1.20
96 A new assay for tRNA aminoacylation kinetics. RNA 1998 1.19
97 Interactions of Escherichia coli RNA with bacteriophage MS2 coat protein: genomic SELEX. Nucleic Acids Res 2000 1.19
98 Effect of replacing uridine 33 in yeast tRNAPhe on the reaction with ribosomes. J Biol Chem 1986 1.17
99 The role of 2'-hydroxyl groups in an RNA-protein interaction. Biochemistry 1995 1.15
100 Identification of thermodynamically relevant interactions between EF-Tu and backbone elements of tRNA. J Mol Biol 2001 1.13
101 Recognition of yeast tRNA(Phe) by its cognate yeast phenylalanyl-tRNA synthetase: an analysis of specificity. Biochemistry 1992 1.12
102 Mutagenesis of a stacking contact in the MS2 coat protein-RNA complex. EMBO J 1996 1.10
103 Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 1986 1.09
104 Hammerhead cleavage of the phosphorodithioate linkage. Biochemistry 2000 1.09
105 A covalent crosslink converts the hammerhead ribozyme from a ribonuclease to an RNA ligase. Nat Struct Biol 2001 1.08
106 Selection for active E. coli tRNA(Phe) variants from a randomized library using two proteins. EMBO J 1993 1.08
107 Circularly permuted DNA, RNA and proteins--a review. Gene 1993 1.07
108 An RNA-protein contact determined by 5-bromouridine substitution, photocrosslinking and sequencing. Nucleic Acids Res 1994 1.07
109 Use of T4 RNA ligase to construct model substrates for a ribosomal RNA maturation endonuclease. Proc Natl Acad Sci U S A 1978 1.06
110 Characterization of two RNA-catalyzed RNA cleavage reactions. Cold Spring Harb Symp Quant Biol 1987 1.06
111 Use of intrinsic binding energy for catalysis by an RNA enzyme. Proc Natl Acad Sci U S A 1997 1.06
112 Probing the binding of Tb(III) and Eu(III) to the hammerhead ribozyme using luminescence spectroscopy. Chem Biol 1999 1.06
113 The hammerhead ribozyme. Biochem Soc Trans 2002 1.06
114 Kinetic characterization of two I/II format hammerhead ribozymes. RNA 1996 1.03
115 Circular dichroism study of nine species of transfer ribonucleic acid. Biochemistry 1972 1.00
116 Interaction of Escherichia coli host factor protein with Q beta ribonucleic acid. Biochemistry 1980 0.99
117 The internal equilibrium of the hammerhead ribozyme reaction. Biochemistry 1995 0.99
118 Neomycin inhibition of the hammerhead ribozyme involves ionic interactions. Biochemistry 1995 0.98
119 An ultraviolet light-induced crosslink in yeast tRNA(Phe). Nucleic Acids Res 1992 0.98
120 PMR or the self-complementary oligoribonucleotide CpCpGpG. Biochem Biophys Res Commun 1974 0.98
121 Role of the constant uridine in binding of yeast tRNAPhe anticodon arm to 30S ribosomes. Nucleic Acids Res 1982 0.97
122 Circular dichroism of double-helical oligoribonucleotides. J Mol Biol 1973 0.97
123 Using phosphorothioate-substituted RNA to investigate the thermodynamic role of phosphates in a sequence specific RNA-protein complex. Biochemistry 2000 0.96
124 RNA aptamers as pathway-specific MAP kinase inhibitors. Chem Biol 2000 0.96
125 Thermal stability of RNA hairpins containing a four-membered loop and a bulge nucleotide. Biochemistry 1989 0.96
126 Removal of Y-37 from tRNA phe yeast alters oligomer binding to two loops. Biochem Biophys Res Commun 1973 0.95
127 Characterization of deoxy- and ribo-containing oligonucleotide substrates in the hammerhead self-cleavage reaction. Biochimie 1990 0.95
128 Mapping contacts between Escherichia coli alanyl tRNA synthetase and 2' hydroxyls using a complete tRNA molecule. Biochemistry 2000 0.94
129 In situ hybridization of three transfer RNAs to the polytene chromosomes of Drosophila melanogaster. J Mol Biol 1980 0.94
130 Specific replacement of functional groups of uridine-33 in yeast phenylalanine transfer ribonucleic acid. Biochemistry 1985 0.93
131 Replacement of RNA hairpins by in vitro selected tetranucleotides. Nucleic Acids Res 1993 0.93
132 Reversal of T4 RNA ligase. Biochemistry 1982 0.93
133 A kinetic and thermodynamic analysis of cleavage site mutations in the hammerhead ribozyme. Biochemistry 1997 0.93
134 Recognition nucleotides for human phenylalanyl-tRNA synthetase. Nucleic Acids Res 1992 0.92
135 Chromosomal sites of integration of simian virus 40 DNA sequences mapped by in situ hybridization in two transformed hybrid cell lines. J Virol 1984 0.92
136 In vitro selection of small RNAs that bind to Escherichia coli phenylalanyl-tRNA synthetase. J Mol Biol 1994 0.91
137 Recognition of tertiary structure in tRNAs by Rh(phen)2phi3+, a new reagent for RNA structure-function mapping. Biochemistry 1992 0.91
138 Uridine-33 in yeast tRNA not essential for amber suppression. Nature 1983 0.91
139 Binding of complementary oligonucleotides to free and aminoacyl transfer ribonucleic acid synthetase bound transfer ribonucleic acid. Biochemistry 1972 0.91
140 Isolation and characterization of two mutant forms of T4 polynucleotide kinase. J Biol Chem 1982 0.90
141 Using circular permutation analysis to redefine the R17 coat protein binding site. Biochemistry 1993 0.90
142 T4 RNA ligase as a nucleic acid synthesis and modification reagent. Gene Amplif Anal 1981 0.90
143 Functional groups on the cleavage site pyrimidine nucleotide are required for stabilization of the hammerhead transition state. RNA 1997 0.89
144 Defining a smaller RNA substrate for elongation factor Tu. Biochemistry 1995 0.88
145 Evaluation of methylphosphonates as analogs for detecting phosphate contacts in RNA-protein complexes. RNA 2001 0.88
146 tRNA conformity. Cold Spring Harb Symp Quant Biol 2001 0.88
147 A comparison of two phage coat protein-RNA interactions. Nucleic Acids Res 1988 0.87
148 Independent locations of kinase and 3'-phosphatase activities on T4 polynucleotide kinase. J Biol Chem 1982 0.87
149 Stepwise enzymatic oligoribonucleotide synthesis including modified nucleotides. Biochemistry 1975 0.86
150 RNA binding properties of the coat protein from bacteriophage GA. Nucleic Acids Res 1991 0.86
151 Oligonucleotide binding to the native and denatured conformers of yeast transfer RNA-3 Lea. J Mol Biol 1974 0.86
152 Structural variation induced by different nucleotides at the cleavage site of the hammerhead ribozyme. Biochemistry 1998 0.86
153 Cryoenzymology of the hammerhead ribozyme. RNA 1998 0.84
154 Thermodynamic dissection of the substrate-ribozyme interaction in the hammerhead ribozyme. Biochemistry 1998 0.84
155 Ribozymes. Hammerhead nailed down. Nature 1994 0.82
156 Divalent metal ions and the internal equilibrium of the hammerhead ribozyme. Biochemistry 1995 0.82
157 A coat for all sequences. Nat Struct Biol 1998 0.82
158 Circular substrates of the hammerhead ribozyme shift the internal equilibrium further toward cleavage. Biochemistry 1998 0.78
159 Failure of translational repression in the phage f2 op3 mutant is not due to an altered coat protein-RNA interaction. J Biol Chem 1984 0.78
160 Hammerhead: Part 2. Nat Struct Biol 1995 0.77
161 Modifying the specificity of an RNA backbone contact. J Mol Biol 2001 0.76
162 Quantitation of in situ hybridization of ribosomal ribonucleic acids to human diploid cells. Chromosoma 1980 0.75