PubRank

Warren S Alexander

Author PubWeight™ 112.51‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 2003 4.90
2 Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell 2007 3.39
3 The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 2013 3.15
4 The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol 2008 3.07
5 The SOCS box: a tale of destruction and degradation. Trends Biochem Sci 2002 2.64
6 Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev 2012 2.44
7 SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 2004 2.30
8 NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity 2012 2.14
9 Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol 2005 2.01
10 cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood 2014 1.97
11 SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest 2006 1.92
12 Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A 2004 1.81
13 Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood 2009 1.79
14 Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 2009 1.74
15 Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood 2010 1.71
16 Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood 2011 1.69
17 SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest 2005 1.66
18 Socs2 and elf5 mediate prolactin-induced mammary gland development. Mol Endocrinol 2006 1.65
19 Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity 2003 1.55
20 Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biol 2008 1.53
21 The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling. J Biol Chem 2006 1.45
22 Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol Endocrinol 2002 1.39
23 Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem 2003 1.38
24 A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor". J Immunol 2007 1.34
25 ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev 2011 1.30
26 SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol Cell Biol 2002 1.28
27 Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling. J Biol Chem 2002 1.26
28 Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells. Stem Cells 2005 1.22
29 Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J Clin Invest 2003 1.18
30 Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A 2009 1.18
31 Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects. Mol Endocrinol 2004 1.16
32 Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation. Blood 2005 1.14
33 The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo. Blood 2007 1.13
34 Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Blood 2005 1.13
35 Regulation of hematopoietic stem cells by their mature progeny. Proc Natl Acad Sci U S A 2010 1.09
36 Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation. Proc Natl Acad Sci U S A 2014 1.08
37 Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL. Biochem J 2014 1.07
38 Hematopoietic defects in the Ts1Cje mouse model of Down syndrome. Blood 2008 1.07
39 Development of hydrocephalus in mice lacking SOCS7. Proc Natl Acad Sci U S A 2004 1.07
40 Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis. J Immunol 2003 1.07
41 Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination. Proc Natl Acad Sci U S A 2006 1.06
42 Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation. J Biol Chem 2006 1.05
43 SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential. J Exp Med 2005 1.04
44 Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease. Proc Natl Acad Sci U S A 2005 1.04
45 Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Mol Cell Biol 2007 1.03
46 Suppressors of cytokine signalling and regulation of growth hormone action. Growth Horm IGF Res 2004 1.00
47 Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Proc Natl Acad Sci U S A 2005 1.00
48 c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3. EMBO J 2006 0.97
49 Differential regulation of SOCS genes in normal and transformed erythroid cells. Oncogene 2003 0.97
50 Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc Natl Acad Sci U S A 2002 0.96
51 Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia. Proc Natl Acad Sci U S A 2012 0.95
52 Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27. Blood 2007 0.95
53 Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood 2008 0.95
54 Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals. Nat Commun 2013 0.94
55 SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function. Mol Cell Biol 2004 0.94
56 Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential. Proc Natl Acad Sci U S A 2012 0.93
57 IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3. Immunol Cell Biol 2011 0.93
58 An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets. Am J Pathol 2002 0.91
59 Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation. Exp Hematol 2008 0.91
60 Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells. Blood 2002 0.91
61 Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes. Blood 2014 0.90
62 Epigenetic regulator Smchd1 functions as a tumor suppressor. Cancer Res 2012 0.90
63 Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2. Growth Factors 2009 0.89
64 SOCS3 regulates graft-versus-host disease. Blood 2010 0.89
65 Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor. FEBS J 2013 0.89
66 Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors. Blood 2004 0.88
67 A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. J Immunol 2009 0.88
68 A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia. Proc Natl Acad Sci U S A 2006 0.87
69 Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia. Blood 2009 0.86
70 Reduced bone mineral density in SOCS-2-deficient mice. Pediatr Res 2004 0.86
71 Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha. Growth Factors 2007 0.84
72 Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice. Proc Natl Acad Sci U S A 2010 0.84
73 Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma. Blood 2013 0.84
74 SOCS3 deletion in B cells alters cytokine responses and germinal center output. J Immunol 2011 0.83
75 Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major. J Immunol 2003 0.83
76 More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders. Blood 2006 0.82
77 Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia. Proc Natl Acad Sci U S A 2013 0.82
78 Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3. Mol Immunol 2008 0.81
79 The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients. Proc Natl Acad Sci U S A 2003 0.81
80 Thrombopoietin signalling in physiology and disease. Growth Factors 2004 0.81
81 Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia. Growth Factors 2014 0.79
82 Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency. Endocrinology 2011 0.79
83 Genetic heterogeneity of granulocytes for the JAK2 V617F mutation in essential thrombocythaemia: implications for mutation detection in peripheral blood. Pathology 2006 0.79
84 SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo. J Immunol 2009 0.78
85 The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA. Parasite Immunol 2003 0.78
86 Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis. Arthritis Rheumatol 2014 0.78
87 Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1. Proc Natl Acad Sci U S A 2007 0.78
88 Mice rendered severely deficient in megakaryocytes through targeted gene deletion of the thrombopoietin receptor c-Mpl have a normal skeletal phenotype. Calcif Tissue Int 2007 0.77
89 Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain. Proc Natl Acad Sci U S A 2011 0.75
90 Donald Metcalf (1929-2014). Cell 2015 0.75
91 Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest 2017 0.75
92 Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A 2015 0.75
93 In memoriam: Donald Metcalf (1929-2014)--A historical perspective of his contributions to hematology. Exp Hematol 2015 0.75
94 Special Issue Collection: In Memoriam. Stem Cells 2015 0.75
95 Mouse models of diseases of megakaryocyte and platelet homeostasis. Mamm Genome 2011 0.75