Published in Blood on December 24, 2008
Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome. Blood (2009) 1.84
Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome. Oncogene (2010) 1.57
Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 1.54
Molecular genetic analysis of Down syndrome. Hum Genet (2009) 1.52
Altered DNA methylation in leukocytes with trisomy 21. PLoS Genet (2010) 1.44
Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis. Blood (2013) 1.39
Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J Clin Invest (2012) 1.29
Down syndrome: searching for the genetic culprits. Dis Model Mech (2011) 1.28
Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood (2010) 1.08
Myeloid leukemia in Down syndrome. Crit Rev Oncog (2011) 0.99
Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down Syndrome screening. PLoS One (2011) 0.91
Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes. Blood (2013) 0.84
Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs (2012) 0.80
Stem and progenitor cell dysfunction in human trisomies. EMBO Rep (2014) 0.79
The use of mouse models for understanding the biology of down syndrome and aging. Curr Gerontol Geriatr Res (2012) 0.77
Early lineage priming by trisomy of erg leads to myeloproliferation in a down syndrome model. PLoS Genet (2015) 0.76
Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies. BMC Med Genet (2013) 0.76
A System to Study Aneuploidy In Vivo. Cold Spring Harb Symp Quant Biol (2016) 0.76
Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21. J Biomed Res (2010) 0.76
The impact of trisomy 21 on foetal haematopoiesis. Blood Cells Mol Dis (2013) 0.76
Down syndrome and leukemia: insights into leukemogenesis and translational targets. Transl Pediatr (2015) 0.75
Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update. Curr Hematol Malig Rep (2016) 0.75
Mouse models of diseases of megakaryocyte and platelet homeostasis. Mamm Genome (2011) 0.75
Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics (2005) 10.64
Programmed anuclear cell death delimits platelet life span. Cell (2007) 5.98
Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol (2007) 5.20
SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90
Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol (2006) 4.53
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol (2006) 3.94
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol (2004) 3.76
Rare and novel epidermal growth factor receptor mutations in non-small-cell lung cancer and lack of clinical response to gefitinib in two cases. J Thorac Oncol (2012) 3.45
Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nat Genet (2011) 3.41
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell (2007) 3.39
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature (2002) 3.15
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity (2013) 3.15
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol (2006) 3.09
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol (2008) 3.07
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med (2007) 2.91
The SOCS box: a tale of destruction and degradation. Trends Biochem Sci (2002) 2.64
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol (2007) 2.61
Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A (2005) 2.56
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev (2012) 2.44
Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J Exp Med (2004) 2.43
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J Exp Med (2005) 2.39
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med (2005) 2.34
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity (2004) 2.30
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood (2011) 2.25
Statistical modeling of sequencing errors in SAGE libraries. Bioinformatics (2004) 2.25
ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity. Nucleic Acids Res (2011) 2.23
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet (2008) 2.19
Integrative analysis of RUNX1 downstream pathways and target genes. BMC Genomics (2008) 2.14
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity (2012) 2.14
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A (2003) 2.12
Inhibitors of cytokine signal transduction. J Biol Chem (2003) 2.10
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity (2008) 2.07
Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. N Engl J Med (2008) 2.01
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol (2005) 2.01
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood (2014) 1.97
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest (2006) 1.92
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol (2002) 1.92
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease. Nat Clin Pract Rheumatol (2006) 1.85
Redefining epithelial progenitor potential in the developing thymus. Eur J Immunol (2007) 1.81
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A (2004) 1.81
Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood (2009) 1.79
Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet (2007) 1.79
Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science (2009) 1.74
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood (2010) 1.71
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood (2011) 1.69
SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest (2005) 1.66
Socs2 and elf5 mediate prolactin-induced mammary gland development. Mol Endocrinol (2006) 1.65
Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol (2009) 1.61
Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells. Genes Dev (2006) 1.61
Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin. Hum Mutat (2004) 1.61
The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells. Proc Natl Acad Sci U S A (2002) 1.59
The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro. Hum Mol Genet (2002) 1.58
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival. Blood (2012) 1.57
Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity (2003) 1.55
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biol (2008) 1.53
A comparative analysis of algorithms for somatic SNV detection in cancer. Bioinformatics (2013) 1.51
A specific anti-Aire antibody reveals aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery. J Immunol (2008) 1.46
The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling. J Biol Chem (2006) 1.45
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1. Biochem J (2013) 1.45
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Mol Cell (2006) 1.41
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance. Blood (2010) 1.41
A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genet (2008) 1.40
Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol Endocrinol (2002) 1.39
Sensitive detection of BCR-ABL1 mutations in patients with chronic myeloid leukemia after imatinib resistance is predictive of outcome during subsequent therapy. J Clin Oncol (2011) 1.38
Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem (2003) 1.38
A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis. Blood (2008) 1.34