Published in Trends Biochem Sci on May 01, 2002
Cytokine signaling modules in inflammatory responses. Immunity (2008) 4.09
Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines. Genes Dev (2004) 3.39
Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. Genes Dev (2004) 3.28
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J (2004) 3.07
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev (2009) 2.76
SOCS regulation of the JAK/STAT signalling pathway. Semin Cell Dev Biol (2008) 2.72
Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G. Proc Natl Acad Sci U S A (2005) 2.42
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell (2009) 1.98
Foamy virus Bet proteins function as novel inhibitors of the APOBEC3 family of innate antiretroviral defense factors. J Virol (2005) 1.84
Getting into position: the catalytic mechanisms of protein ubiquitylation. Biochem J (2004) 1.83
Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation. Nature (2003) 1.69
Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase. J Virol (2007) 1.67
SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest (2005) 1.66
Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. Proc Natl Acad Sci U S A (2006) 1.57
The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron (2008) 1.48
IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity. Cancer Biol Ther (2008) 1.45
The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase. J Mol Biol (2008) 1.39
Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. Structure (2007) 1.35
The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression. J Mol Biol (2009) 1.35
Suppression of cytokine signaling: the SOCS perspective. Cytokine Growth Factor Rev (2013) 1.20
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. Mol Cell Biol (2007) 1.17
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. J Clin Invest (2005) 1.14
Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor. EMBO J (2007) 1.14
A novel locus for adolescent idiopathic scoliosis on chromosome 12p. J Orthop Res (2009) 1.13
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo. Blood (2007) 1.13
Kaposi's sarcoma-associated herpesvirus K7 protein targets a ubiquitin-like/ubiquitin-associated domain-containing protein to promote protein degradation. Mol Cell Biol (2004) 1.10
Retracted Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med (2008) 1.09
The tubby family proteins. Genome Biol (2011) 1.07
ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function. BMC Biol (2010) 1.06
The Role of Elongin BC-Containing Ubiquitin Ligases. Front Oncol (2012) 1.04
Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. J Mol Biol (2010) 1.03
Regulation of the M-cadherin-beta-catenin complex by calpain 3 during terminal stages of myogenic differentiation. Mol Cell Biol (2006) 1.03
Advances in the structural understanding of Vif proteins. Curr HIV Res (2008) 1.03
Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation. Infect Immun (2003) 1.01
Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. Mol Cell Proteomics (2012) 1.00
SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. Cell Signal (2008) 0.98
Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase. J Biol Chem (2010) 0.98
Inflammatory mediators and insulin resistance in obesity: role of nuclear receptor signaling in macrophages. Mediators Inflamm (2010) 0.97
Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. Cell Signal (2007) 0.96
Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity. Protein Sci (2013) 0.96
Sepsis-induced SOCS-3 expression is immunologically restricted to phagocytes. J Leukoc Biol (2003) 0.95
XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway. EMBO J (2007) 0.94
Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases. J Mol Biol (2013) 0.94
Enforced SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation. Int J Oncol (2010) 0.93
Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. J Biol Chem (2011) 0.92
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation. J Biol Chem (2009) 0.90
Disruption of RAB40AL function leads to Martin--Probst syndrome, a rare X-linked multisystem neurodevelopmental human disorder. J Med Genet (2012) 0.90
Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation. BMC Neurosci (2011) 0.89
The novel gene asb11: a regulator of the size of the neural progenitor compartment. J Cell Biol (2006) 0.89
Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells. Mol Vis (2013) 0.87
Evolution of the JAK-STAT pathway. JAKSTAT (2013) 0.86
SOCS2 influences LPS induced human monocyte-derived dendritic cell maturation. PLoS One (2009) 0.86
Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation. Biochem J (2015) 0.85
Molecular structure and biochemical properties of the HCCH-Zn2+ site in HIV-1 Vif. Biochemistry (2009) 0.85
PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. J Cell Biol (2015) 0.85
Molecular characterisation of the early response in pigs to experimental infection with Actinobacillus pleuropneumoniae using cDNA microarrays. Acta Vet Scand (2007) 0.85
Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor. Eur Biophys J (2009) 0.84
Anchoring skeletal muscle development and disease: the role of ankyrin repeat domain containing proteins in muscle physiology. Crit Rev Biochem Mol Biol (2010) 0.84
Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (Asb-4) in proopiomelanocortin neurons of the arcuate nucleus of mice produces a hyperphagic, lean phenotype. Endocrinology (2009) 0.83
Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkappaB activation in glioblastoma. Neuro Oncol (2008) 0.83
Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2). J Biomol NMR (2005) 0.83
CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling. J Biol Chem (2011) 0.83
SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor. J Biol Chem (2015) 0.82
Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary. Dev Biol (2013) 0.82
SOCS-3 inhibits E2F/DP-1 transcriptional activity and cell cycle progression via interaction with DP-1. J Biol Chem (2008) 0.82
Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo. PLoS One (2010) 0.81
Tumor necrosis factor-a augments lipopolysaccharide-induced suppressor of cytokine signalling 3 (SOCS-3) protein expression by preventing the degradation. Immunology (2010) 0.81
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Gastroenterology (2016) 0.80
Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Nutr Metab (Lond) (2015) 0.80
Microarray analysis of Aeromonas hydrophila cytotoxic enterotoxin-treated murine primary macrophages. Infect Immun (2004) 0.80
Mechanism of up-regulation of immunoglobulin A production in the intestine of mice unresponsive to lipopolysaccharide. Immunology (2005) 0.79
Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis. J Pharmacol Exp Ther (2015) 0.79
Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation. J Cell Sci (2013) 0.79
Contrasting effects of IFNα on MHC class II expression in professional vs. nonprofessional APCs: Role of CIITA type IV promoter. Results Immunol (2012) 0.78
A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein. Nucleic Acids Res (2007) 0.78
SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts. J Interferon Cytokine Res (2012) 0.78
E3 ubiquitin ligases and their control of T cell autoreactivity. Arthritis Res Ther (2005) 0.78
Working your SOCS off: The role of ASB10 and protein degradation pathways in glaucoma. Exp Eye Res (2016) 0.77
Transcriptional profiling of swine lung tissue after experimental infection with Actinobacillus pleuropneumoniae. Int J Mol Sci (2013) 0.77
Suppressor of cytokine signalling protein SOCS1 and UBP43 regulate the expression of type I interferon-stimulated genes in human microvascular endothelial cells infected with Rickettsia conorii. J Med Microbiol (2013) 0.77
Cell regulation by phosphotyrosine-targeted ubiquitin ligases. Mol Cell Biol (2015) 0.77
Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock. Proc Natl Acad Sci U S A (2015) 0.77
Genome-Wide Identification and Expression Analysis of the Tubby-Like Protein Family in the Malus domestica Genome. Front Plant Sci (2016) 0.76
GH/STAT5 signaling during the growth period in livers of mice overexpressing GH. J Mol Endocrinol (2015) 0.76
Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3. Mol Cell Endocrinol (2014) 0.76
Evolution of the long terminal repeat and accessory genes of feline immunodeficiency virus genomes from naturally infected cougars. Virology (2007) 0.76
Regulation of ankyrin repeat and suppressor of cytokine signalling box protein 4 expression in the immortalized murine endothelial cell lines MS1 and SVR: a role for tumour necrosis factor alpha and oxygen. Cell Biochem Funct (2011) 0.76
Protein degradation machinery is present broadly during early development in the sea urchin. Gene Expr Patterns (2014) 0.75
ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. J Cell Biol (2016) 0.75
SOCS-1 rescues IL-1β-mediated suppression of epithelial sodium channel in mouse lung epithelial cells via ASK-1. Oncotarget (2016) 0.75
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells. Cell Commun Signal (2017) 0.75
Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases. PLoS One (2017) 0.75
In human monocyte derived dendritic cells SOCS1 interacting with CYTIP induces the degradation of CYTIP by the proteasome. PLoS One (2013) 0.75
Putative mechanism of hemorrhage-induced leukocyte hyporesponsiveness: induction of suppressor of cytokine signaling-3. J Trauma (2004) 0.75
A Naturally Generated Decoy of the Prostate Apoptosis Response-4 Protein Overcomes Therapy Resistance in Tumors. Cancer Res (2017) 0.75
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med (2009) 10.54
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell (2008) 6.07
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell (2003) 5.31
JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2009) 4.98
SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol (2006) 3.94
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol (2004) 3.76
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell (2007) 3.39
The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. Proc Natl Acad Sci U S A (2004) 3.16
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity (2013) 3.15
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol (2008) 3.07
Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Nature (2007) 3.05
Structural mechanisms underlying posttranslational modification by ubiquitin-like proteins. Annu Rev Biophys Biomol Struct (2007) 2.98
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell (2009) 2.84
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell (2005) 2.75
Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol Cell (2009) 2.58
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev (2012) 2.44
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. Nature (2003) 2.39
E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer. Nat Struct Mol Biol (2005) 2.33
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity. Immunity (2012) 2.30
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity (2004) 2.30
Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. Mol Cell (2005) 2.26
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol Cell (2003) 2.25
ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity. Nucleic Acids Res (2011) 2.23
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet (2008) 2.19
Structural assembly of cullin-RING ubiquitin ligase complexes. Curr Opin Struct Biol (2010) 2.17
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity (2012) 2.14
Inhibitors of cytokine signal transduction. J Biol Chem (2003) 2.10
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity. Nat Immunol (2005) 2.01
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell (2009) 1.98
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood (2014) 1.97
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest (2006) 1.92
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol (2002) 1.92
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
Structural complexity in ubiquitin recognition. Cell (2006) 1.89
Structural regulation of cullin-RING ubiquitin ligase complexes. Curr Opin Struct Biol (2011) 1.89
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity (2012) 1.89
Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem (2010) 1.85
Identification of a multifunctional binding site on Ubc9p required for Smt3p conjugation. J Biol Chem (2002) 1.84
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A (2004) 1.81
Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood (2009) 1.79
N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science (2011) 1.78
Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science (2009) 1.74
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. Nat Struct Mol Biol (2004) 1.72
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood (2010) 1.71
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood (2011) 1.69
SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest (2005) 1.66
Socs2 and elf5 mediate prolactin-induced mammary gland development. Mol Endocrinol (2006) 1.65
Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol (2009) 1.61
Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity (2003) 1.55
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biol (2008) 1.53
A dual E3 mechanism for Rub1 ligation to Cdc53. Mol Cell (2010) 1.49
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism. Structure (2013) 1.48
Building and remodelling Cullin-RING E3 ubiquitin ligases. EMBO Rep (2013) 1.47
Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2. Nat Struct Mol Biol (2008) 1.46
The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling. J Biol Chem (2006) 1.45
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1. Biochem J (2013) 1.45
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Mol Cell (2006) 1.41
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nat Struct Mol Biol (2012) 1.40
A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis. PLoS Genet (2008) 1.40
Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol Endocrinol (2002) 1.39
The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase. J Mol Biol (2008) 1.39
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Mol Cell (2011) 1.38
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat Struct Mol Biol (2013) 1.38
How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic. EMBO J (2009) 1.38
Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem (2003) 1.38
The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression. J Mol Biol (2009) 1.35
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor". J Immunol (2007) 1.34
ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev (2011) 1.30
DEC-205 is a cell surface receptor for CpG oligonucleotides. Proc Natl Acad Sci U S A (2012) 1.29
Structural analysis of Escherichia coli ThiF. J Mol Biol (2005) 1.28
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol Cell Biol (2002) 1.28