Published in Mol Cancer on February 03, 2005
Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors. Gastroenterology (2008) 3.04
Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. J Clin Oncol (2009) 2.94
Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies. Cancer (2008) 2.11
Gene expression patterns in pancreatic tumors, cells and tissues. PLoS One (2007) 1.61
Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches. Genomics (2009) 1.01
The identification of gut neuroendocrine tumor disease by multiple synchronous transcript analysis in blood. PLoS One (2013) 1.01
Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB. Inflamm Bowel Dis (2010) 0.93
Resistance of Sézary cells to TNF-α-induced apoptosis is mediated in part by a loss of TNFR1 and a high level of the IER3 expression. Exp Dermatol (2012) 0.89
Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia (2007) 0.89
Differentiation of small bowel and pancreatic neuroendocrine tumors by gene-expression profiling. Surgery (2012) 0.87
Uncovering gene regulatory networks during mouse fetal germ cell development. Biol Reprod (2010) 0.86
Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes. Cancer Res (2009) 0.86
Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility. Front Genet (2014) 0.86
Immediate early gene-X1 interferes with 26 S proteasome activity by attenuating expression of the 19 S proteasomal components S5a/Rpn10 and S1/Rpn2. Biochem J (2007) 0.83
Towards a new classification of gastroenteropancreatic neuroendocrine neoplasms. Nat Rev Clin Oncol (2016) 0.78
Identification of single- and multiple-class specific signature genes from gene expression profiles by group marker index. PLoS One (2011) 0.77
Molecular pathogenesis of pancreatic neuroendocrine tumors. Cancers (Basel) (2010) 0.75
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science (1999) 83.27
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci U S A (2001) 68.44
Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays. Proc Natl Acad Sci U S A (1999) 35.16
Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A (1971) 31.05
Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A (2001) 19.30
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biol (2001) 15.02
Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (1997) 7.95
Molecular classification of human carcinomas by use of gene expression signatures. Cancer Res (2001) 6.78
Genetic aspects of adenomatosis of endocrine glands. Am J Med (1954) 4.60
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell (1999) 3.16
A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA. Genes Dev (2000) 2.98
Menin, the product of the MEN1 gene, is a nuclear protein. Proc Natl Acad Sci U S A (1998) 2.39
Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway. Endocrinology (2002) 1.95
Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. Proc Natl Acad Sci U S A (2001) 1.88
Towards a novel classification of human malignancies based on gene expression patterns. J Pathol (2001) 1.87
Smads bind directly to the Jun family of AP-1 transcription factors. Proc Natl Acad Sci U S A (1999) 1.81
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene (2001) 1.69
A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J Biol Chem (2001) 1.60
Analysing gene expression data from DNA microarrays to identify candidate genes. J Pathol (2001) 1.52
Multiple endocrine neoplasia type 1: new clinical and basic findings. Trends Endocrinol Metab (2001) 1.36
Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis. Apoptosis (2003) 1.32
Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias. Recent Prog Horm Res (1999) 1.29
Targeted disruption of the murine junD gene results in multiple defects in male reproductive function. Development (2000) 1.28
Menin induces apoptosis in murine embryonic fibroblasts. J Biol Chem (2003) 1.25
Menin interacts directly with the homeobox-containing protein Pem. Biochem Biophys Res Commun (2001) 1.23
Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes (2002) 1.23
Expression of the NF-kappa B target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells. Oncogene (2001) 1.22
Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter. Proc Natl Acad Sci U S A (2003) 1.21
Genomic imprinting of a human apoptosis gene homologue, TSSC3. Cancer Res (1998) 1.19
Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238. Proc Natl Acad Sci U S A (2000) 1.19
Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays. Clin Cancer Res (2003) 1.18
Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism. Biochim Biophys Acta (1999) 1.15
Interaction and functional cooperation of NF-kappa B with Smads. Transcriptional regulation of the junB promoter. J Biol Chem (2000) 1.15
FGF9 is an autocrine and paracrine prostatic growth factor expressed by prostatic stromal cells. J Cell Physiol (1999) 1.13
Characterization of the mouse Men1 gene and its expression during development. Oncogene (1998) 1.13
Fibroblast growth factor-9 is an endometrial stromal growth factor. Endocrinology (2002) 1.13
IEX-1, an immediate early gene, increases the rate of apoptosis in keratinocytes. Oncogene (2001) 1.13
Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities. Endocrinology (2003) 1.12
Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23. Biochem Biophys Res Commun (2001) 1.08
Differential effects of fibroblast growth factor (FGF) 9 and FGF2 on proliferation, differentiation and terminal differentiation of chondrocytic cells in vitro. Biochem J (1999) 1.04
Somatostatin controls Kaposi's sarcoma tumor growth through inhibition of angiogenesis. FASEB J (1999) 0.99
Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet beta-cells. J Mol Biol (2002) 0.96
Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. Hum Mol Genet (2004) 0.95
Antagonists of growth hormone-releasing hormone and somatostatin analog RC-160 inhibit the growth of the OV-1063 human epithelial ovarian cancer cell line xenografted into nude mice. J Clin Endocrinol Metab (2001) 0.94
Uncovering functionally relevant signaling pathways using microarray-based expression profiling. Oncologist (2000) 0.92
Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol (2003) 0.92
Functional cooperation between JunD and NF-kappaB in rat hepatocytes. Oncogene (2001) 0.92
Retention of imprinting of the human apoptosis-related gene TSSC3 in human brain tumors. Hum Mol Genet (2000) 0.91
Improved method for the isolation and purification of human islets of langerhans using Liberase enzyme blend. Hum Immunol (1999) 0.90
Islet amyloid polypeptide in the islets of Langerhans: friend or foe? Diabetologia (2000) 0.90
The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-6)-dependent and IL-6-independent human multiple myeloma cell lines. Blood (1999) 0.90
Somatostatin analogues in the treatment of endocrine tumors of the gastrointestinal tract. Expert Opin Pharmacother (2002) 0.89
Germline mutations in the multiple endocrine neoplasia type 1 gene: evidence for frequent splicing defects. Hum Mutat (1999) 0.88
Expression of somatostatin receptor subtypes and growth inhibition in human exocrine pancreatic cancers. J Hepatobiliary Pancreat Surg (2000) 0.86
Amylin-induced cytotoxicity is associated with activation of caspase-3 and MAP kinases. Biol Chem (2002) 0.86
Homozygotes for the autosomal dominant neoplasia syndrome (MEN1). Am J Hum Genet (1993) 0.85
The role of radioactive somatostatin and its analogues in the control of tumor growth. Recent Results Cancer Res (2000) 0.85
Pathology of MEN-1: morphology, clinicopathologic correlations and tumour development. J Intern Med (1998) 0.85
Autocrine transformation by fibroblast growth factor 9 (FGF-9) and its possible participation in human oncogenesis. Int J Cancer (1997) 0.83
Somatostatin receptor subtype 1-selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line. Biochem Biophys Res Commun (2002) 0.83
The somatostatin analogue octreotide inhibits neuroblastoma growth in vivo. Pediatr Res (1999) 0.82
Inhibition of growth of MX-1, MCF-7-MIII and MDA-MB-231 human breast cancer xenografts after administration of a targeted cytotoxic analog of somatostatin, AN-238. Int J Cancer (1999) 0.81
Inhibition of human endometrial cancer cell growth in vitro and in vivo by somatostatin analog RC-160. Am J Obstet Gynecol (1999) 0.81
Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice. Int J Cancer (1996) 0.80
A targeted cytotoxic somatostatin (SST) analogue, AN-238, inhibits the growth of H-69 small-cell lung carcinoma (SCLC) and H-157 non-SCLC in nude mice. Eur J Cancer (2001) 0.80
Immunohistochemical and statistical studies on the islets of Langerhans pancreas in autopsied patients after gastrectomy. Hum Pathol (2000) 0.78
Islet amyloid polypeptide promotes beta-cell proliferation in neonatal rat pancreatic islets. Diabetologia (2001) 0.77
Growth inhibitory effects of somatostatin on human leukemia cell lines mediated by somatostatin receptor subtype 1. Peptides (1999) 0.76
Somatostatin analog octreotide inhibits the growth of differentiated thyroid cancer cells in vitro, but not in vivo. J Clin Endocrinol Metab (1996) 0.76
Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74
A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60
A genomic storm in critically injured humans. J Exp Med (2011) 6.67
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet (2007) 5.02
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia. N Engl J Med (2012) 4.26
Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A (2005) 3.49
Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics (2004) 3.22
The surgical intensive care unit optimal mobility score predicts mortality and length of stay. Crit Care Med (2012) 2.30
Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol (2002) 2.25
The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study. BMC Med (2008) 2.10
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07
HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism. Hum Mol Genet (2005) 1.96
Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci U S A (2006) 1.82
Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants. Genet Epidemiol (2011) 1.78
Framingham Heart Study genome-wide association: results for pulmonary function measures. BMC Med Genet (2007) 1.76
A genomic score prognostic of outcome in trauma patients. Mol Med (2009) 1.48
Open source clinical science for emerging infections. Lancet Infect Dis (2014) 1.47
Myocardial transcriptional profiles in a murine model of sepsis: evidence for the importance of age. Pediatr Crit Care Med (2008) 1.43
TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol (2006) 1.41
Challenges and a new vision for academic surgery. J Am Coll Surg (2005) 1.40
Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiol Genomics (2005) 1.40
Robot-assisted posterior retroperitoneoscopic adrenalectomy. J Endourol (2010) 1.40
A novel method for the management of post-thyroidectomy or parathyroidectomy hematoma: a single-institution experience after over 4,000 central neck operations. World J Surg (2014) 1.38
Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A (2010) 1.33
Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiol Genomics (2007) 1.30
Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes (2006) 1.27
Elucidating mechanisms of recurrent laryngeal nerve injury during thyroidectomy and parathyroidectomy. J Am Coll Surg (2007) 1.25
DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. J Exp Med (2005) 1.22
Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram. PLoS One (2008) 1.19
Primary splenic angiosarcoma. JSLS (2011) 1.16
Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med (2010) 1.14
Needle biopsy of incidentally discovered adrenal masses is rarely informative and potentially hazardous. Surgery (2007) 1.13
Gastrointestinal manifestations of multiple endocrine neoplasia type 2. Ann Surg (2002) 1.12
Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms. J Vasc Surg (2006) 1.10
Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood (2005) 1.10
Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease. Am J Cardiol (2011) 1.09
Molecular diagnostics in sepsis: from bedside to bench. J Am Coll Surg (2006) 1.02
Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models. J Cereb Blood Flow Metab (2008) 1.01
The long-term impact of routine intraoperative nerve monitoring during thyroid and parathyroid surgery. Surgery (2013) 1.00
Routine bilateral central lymph node clearance for papillary thyroid cancer. Surgery (2009) 1.00
Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis. J Am Coll Surg (2006) 0.99
Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study. Hypertension (2009) 0.94
Adrenalectomy for familial pheochromocytoma in the laparoscopic era. Ann Surg (2002) 0.93
Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo. Am J Physiol Regul Integr Comp Physiol (2007) 0.92
Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays. Crit Care Med (2002) 0.92
Long-term functionality of cryopreserved parathyroid autografts: a 13-year prospective analysis. Surgery (2005) 0.91
Differences in outcome between obese and nonobese patients following severe blunt trauma are not consistent with an early inflammatory genomic response. Crit Care Med (2010) 0.91
Transcriptional profiles of human epithelial cells in response to heat: computational evidence for novel heat shock proteins. Shock (2008) 0.90
Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma. Mol Cancer Ther (2010) 0.89
That which does not kill you makes you stronger: a molecular mechanism for preconditioning. Sci STKE (2005) 0.88
Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. Brain Res (2007) 0.86
Using systems biology to simplify complex disease: immune cartography. Crit Care Med (2009) 0.86
Gene expression profiles of livers from thermally injured rats. Gene (2004) 0.86
Multiple endocrine neoplasia type 1 parathyroid adenoma development over time. World J Surg (2004) 0.86
Early observational research and registries during the 2009-2010 influenza A pandemic. Crit Care Med (2010) 0.85
Functional genomics of critical illness and injury. Crit Care Med (2002) 0.84
Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis. Mol Cancer Res (2009) 0.84
Global participation in core data sets for emerging pathogens. Am J Respir Crit Care Med (2015) 0.83
Utility of surgeon-performed ultrasound assessment of the lateral neck for metastatic papillary thyroid cancer. J Oncol (2012) 0.82
Surrogate consent for genomics research in intensive care. Am J Crit Care (2009) 0.81
Physiologic genomics. Surgery (2006) 0.80
The murine plasma protein response to polymicrobial intra-abdominal sepsis. Proteomics Clin Appl (2007) 0.80
Academic appointment and the process of promotion and tenure. Clin Colon Rectal Surg (2006) 0.79
Outpatient minimally invasive parathyroidectomy using local/regional anesthesia: a safe and effective operative approach for selected patients. Surgery (2005) 0.79
Ultrasound facilitates minimally invasive parathyroidectomy in patients lacking definitive localization from preoperative sestamibi scan. Am J Surg (2007) 0.79
Assessment of satisfaction with care among family members of survivors in a neuroscience intensive care unit. J Neurosci Nurs (2014) 0.78
Evidence for a novel blood RNA diagnostic for pediatric appendicitis: the riboleukogram. Pediatr Emerg Care (2010) 0.78
Management of the Parathyroid Glands During Preventive Thyroidectomy in Patients With Multiple Endocrine Neoplasia Type 2. Ann Surg (2015) 0.77
Safety evaluation of a Medical Device Data System. Conf Proc IEEE Eng Med Biol Soc (2012) 0.77
Candida infection and colonization in critically ill surgical patients. Virulence (2010) 0.77
Sequence makes a difference: paradoxical effects of stress in vivo. Shock (2004) 0.77
Novel diagnostics for sepsis: a decade of promise for gene expression profiling. Crit Care Med (2011) 0.76
Estimating sparse gene regulatory networks using a bayesian linear regression. IEEE Trans Nanobioscience (2010) 0.76
Preliminary evidence for leukocyte transcriptional signatures for pediatric ventilator-associated pneumonia. J Intensive Care Med (2011) 0.76
United States Critical Illness and Injury Trials Group. Chest (2013) 0.75
Putting the patient first: honoring advance directives prior to surgery. Ann Surg (2012) 0.75
Clustering analysis to identify distinct spectral components of encephalogram burst suppression in critically ill patients. Conf Proc IEEE Eng Med Biol Soc (2015) 0.75
Ten years later, still "gene in a haystack?". Crit Care Med (2011) 0.75
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY DISEASE STATE CLINICAL REVIEW: TIMING OF MULTIPLE ENDOCRINE NEOPLASIA THYROIDECTOMY AND EXTENT OF CENTRAL NECK LYMPHADENECTOMY. Endocr Pract (2015) 0.75
Implementation of 24/7 intensivist presence in the SICU: effect on processes of care. J Trauma Acute Care Surg (2013) 0.75
Tumefactive necrobiotic granulomas (nodulosis) of the pancreas in an adult with long-standing rheumatoid arthritis. Int J Surg Pathol (2005) 0.75
Development of a Core Clinical Dataset to Characterize Serious Illness, Injuries, and Resource Requirements for Acute Medical Responses to Public Health Emergencies. Crit Care Med (2015) 0.75