PubRank

Rafael Radi

Author PubWeight™ 124.34‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov 2007 5.65
2 Chemical biology of peroxynitrite: kinetics, diffusion, and radicals. ACS Chem Biol 2009 1.99
3 Nitro-fatty acid reaction with glutathione and cysteine. Kinetic analysis of thiol alkylation by a Michael addition reaction. J Biol Chem 2007 1.78
4 Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci 2008 1.72
5 Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. Free Radic Biol Med 2008 1.65
6 Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion. J Biol Chem 2003 1.64
7 Protein tyrosine nitration--functional alteration or just a biomarker? Free Radic Biol Med 2008 1.61
8 Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. Biochem J 2007 1.55
9 Biochemistry of protein tyrosine nitration in cardiovascular pathology. Cardiovasc Res 2007 1.48
10 Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite. Biochemistry 2003 1.46
11 Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis. J Neurosci 2007 1.40
12 Reactivity of sulfenic acid in human serum albumin. Biochemistry 2007 1.37
13 Factors affecting protein thiol reactivity and specificity in peroxide reduction. Chem Res Toxicol 2011 1.28
14 Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis. Arch Biochem Biophys 2004 1.25
15 Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite. Free Radic Biol Med 2006 1.24
16 Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite. Subcell Biochem 2007 1.23
17 Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest. Free Radic Biol Med 2010 1.19
18 The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radic Biol Med 2013 1.18
19 Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity. J Biol Chem 2010 1.17
20 Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite. Am J Physiol Heart Circ Physiol 2007 1.15
21 Macrophage-derived peroxynitrite diffusion and toxicity to Trypanosoma cruzi. Arch Biochem Biophys 2004 1.14
22 Inactivation of human Cu,Zn superoxide dismutase by peroxynitrite and formation of histidinyl radical. Free Radic Biol Med 2004 1.13
23 Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics. Biochemistry 2009 1.12
24 Inactivation and nitration of human superoxide dismutase (SOD) by fluxes of nitric oxide and superoxide. Free Radic Biol Med 2007 1.12
25 Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production. Free Radic Biol Med 2011 1.09
26 Binding of xanthine oxidase to glycosaminoglycans limits inhibition by oxypurinol. J Biol Chem 2004 1.09
27 Direct measurement of nitric oxide and oxygen partitioning into liposomes and low density lipoprotein. J Biol Chem 2005 1.09
28 Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration. Arch Biochem Biophys 2004 1.08
29 Trypanosoma brucei and Trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols. J Biol Chem 2004 1.08
30 Pre-steady state kinetic characterization of human peroxiredoxin 5: taking advantage of Trp84 fluorescence increase upon oxidation. Arch Biochem Biophys 2007 1.08
31 Fighting the oxidative assault: the Trypanosoma cruzi journey to infection. Curr Opin Microbiol 2009 1.07
32 Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione, and peroxynitrite: mechanisms and relative contributions to aconitase inactivation. Free Radic Biol Med 2007 1.05
33 Peroxynitrite and drug-dependent toxicity. Toxicology 2005 1.04
34 Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: modeling the impact of superoxide dismutase and nitric oxide diffusion. Free Radic Biol Med 2005 1.04
35 Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radic Biol Med 2008 1.03
36 Protein and lipid nitration: role in redox signaling and injury. Biochim Biophys Acta 2008 1.02
37 Mitochondrial protein tyrosine nitration. Free Radic Res 2010 1.02
38 Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers. Am J Physiol Heart Circ Physiol 2009 1.02
39 Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides. J Biol Chem 2007 1.02
40 Reactions of manganese porphyrins and manganese-superoxide dismutase with peroxynitrite. Methods Enzymol 2002 1.01
41 Peroxynitrite reaction with the reduced and the oxidized forms of lipoic acid: new insights into the reaction of peroxynitrite with thiols. Arch Biochem Biophys 2002 1.01
42 Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite. Biochem J 2008 1.01
43 Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells. Proc Natl Acad Sci U S A 2009 1.00
44 Time course and site(s) of cytochrome c tyrosine nitration by peroxynitrite. Biochemistry 2005 1.00
45 Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals. J Biol Chem 2003 0.99
46 Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi. Biochem J 2009 0.99
47 Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition. Intensive Care Med 2004 0.98
48 Albumin and hydroxyethyl starch modulate oxidative inflammatory injury to vascular endothelium. Anesthesiology 2004 0.98
49 Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification. Free Radic Biol Med 2008 0.97
50 Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester. Biochemistry 2006 0.96
51 Nitration of solvent-exposed tyrosine 74 on cytochrome c triggers heme iron-methionine 80 bond disruption. Nuclear magnetic resonance and optical spectroscopy studies. J Biol Chem 2008 0.95
52 Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease. Antioxid Redox Signal 2012 0.95
53 Sulfenic acid--a key intermediate in albumin thiol oxidation. J Chromatogr B Analyt Technol Biomed Life Sci 2009 0.95
54 Peroxynitrite detoxification and its biologic implications. Antioxid Redox Signal 2008 0.94
55 Kinetic studies on peroxynitrite reduction by peroxiredoxins. Methods Enzymol 2008 0.94
56 Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress. Free Radic Biol Med 2012 0.94
57 Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase. Biochemistry 2008 0.93
58 Peroxynitrite flux-mediated LDL oxidation is inhibited by manganese porphyrins in the presence of uric acid. Free Radic Biol Med 2003 0.93
59 Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide. Cardiovasc Res 2010 0.93
60 Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical. J Biol Chem 2004 0.93
61 Diffusion of nitric oxide into low density lipoprotein. J Biol Chem 2001 0.93
62 Peroxynitrite-mediated alpha-tocopherol oxidation in low-density lipoprotein: a mechanistic approach. Free Radic Biol Med 2004 0.91
63 Kinetic and mechanistic considerations to assess the biological fate of peroxynitrite. Biochim Biophys Acta 2013 0.91
64 Nitroarachidonic acid, a novel peroxidase inhibitor of prostaglandin endoperoxide H synthases 1 and 2. J Biol Chem 2011 0.90
65 Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis. PLoS One 2012 0.90
66 Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes. Chem Res Toxicol 2010 0.90
67 Peroxynitrite and reactive nitrogen species: the contribution of ABB in two decades of research. Arch Biochem Biophys 2009 0.89
68 Intragastric nitration by dietary nitrite: implications for modulation of protein and lipid signaling. Free Radic Biol Med 2011 0.89
69 Kinetics of reduction of tyrosine phenoxyl radicals by glutathione. Arch Biochem Biophys 2010 0.89
70 The mycobacterial thioredoxin peroxidase can act as a one-cysteine peroxiredoxin. J Biol Chem 2006 0.89
71 The trypanothione-thiol system in Trypanosoma cruzi as a key antioxidant mechanism against peroxynitrite-mediated cytotoxicity. Arch Biochem Biophys 2003 0.89
72 Peroxynitrite formation from biochemical and cellular fluxes of nitric oxide and superoxide. Methods Enzymol 2002 0.88
73 L-arginine metabolism during interaction of Trypanosoma cruzi with host cells. Trends Parasitol 2004 0.88
74 Nitroarachidonic acid prevents NADPH oxidase assembly and superoxide radical production in activated macrophages. Free Radic Biol Med 2013 0.88
75 Molecular basis of intramolecular electron transfer in proteins during radical-mediated oxidations: computer simulation studies in model tyrosine-cysteine peptides in solution. Arch Biochem Biophys 2012 0.87
76 Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: a free radical mechanism of inactivation. Free Radic Biol Med 2007 0.86
77 Tryparedoxin peroxidases from Trypanosoma cruzi: high efficiency in the catalytic elimination of hydrogen peroxide and peroxynitrite. Arch Biochem Biophys 2010 0.85
78 Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration. Arch Biochem Biophys 2010 0.85
79 Modulation of the reactivity of the thiol of human serum albumin and its sulfenic derivative by fatty acids. Arch Biochem Biophys 2012 0.85
80 The extraordinary catalytic ability of peroxiredoxins: a combined experimental and QM/MM study on the fast thiol oxidation step. Chem Commun (Camb) 2014 0.85
81 Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite. Biol Chem 2005 0.85
82 Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through intramolecular electron transfer. J Biol Chem 2014 0.84
83 Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins. Arch Biochem Biophys 2012 0.84
84 Formation and reactions of sulfenic acid in human serum albumin. Methods Enzymol 2010 0.84
85 Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents. Inorg Chem 2014 0.84
86 Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes. Biochim Biophys Acta 2011 0.83
87 Reactions of desferrioxamine with peroxynitrite-derived carbonate and nitrogen dioxide radicals. Free Radic Biol Med 2004 0.83
88 Peroxynitrite, a potent macrophage-derived oxidizing cytotoxin to combat invading pathogens. Biofactors 2013 0.82
89 Antioxidant activity of uruguayan propolis. In vitro and cellular assays. J Agric Food Chem 2011 0.82
90 Hydroperoxide and peroxynitrite reductase activity of poplar thioredoxin-dependent glutathione peroxidase 5: kinetics, catalytic mechanism and oxidative inactivation. Biochem J 2012 0.82
91 Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids. Biochim Biophys Acta 2013 0.82
92 Oxidizing substrate specificity of Mycobacterium tuberculosis alkyl hydroperoxide reductase E: kinetics and mechanisms of oxidation and overoxidation. Free Radic Biol Med 2011 0.81
93 Dietary nitrite in nitric oxide biology: a redox interplay with implications for pathophysiology and therapeutics. Curr Drug Targets 2011 0.81
94 NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection. PLoS Negl Trop Dis 2012 0.81
95 Mechanism of cysteine oxidation by peroxynitrite: An integrated experimental and theoretical study. Arch Biochem Biophys 2013 0.81
96 Mycothiol/mycoredoxin 1-dependent reduction of the peroxiredoxin AhpE from Mycobacterium tuberculosis. J Biol Chem 2013 0.80
97 Leghemoglobin is nitrated in functional legume nodules in a tyrosine residue within the heme cavity by a nitrite/peroxide-dependent mechanism. Plant J 2015 0.80
98 Nitrocytochrome c: synthesis, purification, and functional studies. Methods Enzymol 2008 0.80
99 Cyclic guanosine 5' monophosphate (GMP) prevents expression of neuronal nitric oxide synthase and apoptosis in motor neurons deprived of trophic factors in rats. Neurosci Lett 2002 0.80
100 Red blood cells in the metabolism of nitric oxide-derived peroxynitrite. IUBMB Life 2006 0.80
101 EPR detection of glutathiyl and hemoglobin-cysteinyl radicals during the interaction of peroxynitrite with human erythrocytes. Biochemistry 2002 0.80
102 Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity. Radiat Res 2010 0.80
103 Distance-dependent diffusion-controlled reaction of •NO and O2•- at chemical equilibrium with ONOO-. J Phys Chem B 2010 0.80
104 Reaction of the carbonate radical with the spin-trap 5,5-dimethyl-1-pyrroline-N-oxide in chemical and cellular systems: pulse radiolysis, electron paramagnetic resonance, and kinetic-competition studies. Free Radic Biol Med 2007 0.79
105 Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: a novel interaction between dietary nitrate and gut proteins. Free Radic Biol Med 2012 0.79
106 Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid. Free Radic Biol Med 2005 0.79
107 Kinetics of oxidation of tyrosine by a model alkoxyl radical. Free Radic Res 2012 0.79
108 pH-sensitive binding of cytochrome c to the inner mitochondrial membrane. Implications for the participation of the protein in cell respiration and apoptosis. Biochemistry 2009 0.79
109 Tyrosine-lipid peroxide adducts from radical termination: para coupling and intramolecular Diels-Alder cyclization. J Am Chem Soc 2010 0.79
110 Molecular basis of the mechanism of thiol oxidation by hydrogen peroxide in aqueous solution: challenging the SN2 paradigm. Chem Res Toxicol 2012 0.79
111 Kinetic studies of peroxiredoxin 6 from Arenicola marina: rapid oxidation by hydrogen peroxide and peroxynitrite but lack of reduction by hydrogen sulfide. Arch Biochem Biophys 2011 0.78
112 Hemoglobin and red blood cells as tools for studying peroxynitrite biochemistry. Methods Enzymol 2005 0.78
113 Incorporation of the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester to red blood cell membranes to study peroxynitrite-dependent reactions. Chem Res Toxicol 2007 0.78
114 Peroxynitrite inhibits electron transport on the acceptor side of higher plant photosystem II. Arch Biochem Biophys 2008 0.78
115 Tyrosine nitration, dimerization, and hydroxylation by peroxynitrite in membranes as studied by the hydrophobic probe N-t-BOC-l-tyrosine tert-butyl ester. Methods Enzymol 2008 0.78
116 Protective effect of diphenyl diselenide against peroxynitrite-mediated endothelial cell death: a comparison with ebselen. Nitric Oxide 2013 0.77
117 Thiol-sensitive mutant forms of human SOD2, L60F, and I58T: the role of Cys140. Free Radic Biol Med 2010 0.77
118 Redox pioneer: professor Helmut Sies. Antioxid Redox Signal 2014 0.76
119 Metal-catalyzed protein tyrosine nitration in biological systems. Redox Rep 2014 0.76
120 Structural basis of redox-dependent modulation of galectin-1 dynamics and function. Glycobiology 2014 0.75
121 Electrostatically driven second-sphere ligand switch between high and low reorganization energy forms of native cytochrome c. J Am Chem Soc 2013 0.75
122 Homolytic pathways drive peroxynitrite-dependent Trolox C oxidation. Chem Res Toxicol 2004 0.75
123 Correction: Nitro-Arachidonic Acid Prevents Angiotensin II Induced Mitochondrial Dysfunction in Kidney Proximal Tubular Cells. PLoS One 2016 0.75
124 Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs. Bioorg Med Chem 2005 0.75
125 Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c. Chem Commun (Camb) 2014 0.75
126 L-arginine metabolism in Trypanosoma cruzi in the regulation of programmed cell death. Methods Enzymol 2002 0.75
127 Exploring the Catalytic Mechanism of Human Glutamine Synthetase by Computer Simulations. Biochemistry 2016 0.75
128 Antioxidant and diffusion properties of nitric oxide in low-density lipoprotein. Methods Enzymol 2002 0.75
129 Correction to Alternative Conformations of Cytochrome c: Structure, Function, and Detection. Biochemistry 2016 0.75
130 Addition and Correction to Multifunctional Cytochrome c: Learning New Tricks from an Old Dog. Chem Rev 2017 0.75