PubRank

Gerd Walz

Author PubWeight™ 139.39‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet 2005 6.67
2 The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet 2006 5.36
3 Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet 2003 5.24
4 The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A 2006 4.56
5 Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Nat Genet 2003 4.14
6 Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol 2010 3.55
7 Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 2010 3.44
8 Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 2011 2.90
9 TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol 2008 2.88
10 Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet 2008 2.74
11 Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol 2003 2.69
12 Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell 2012 2.54
13 Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A 2006 2.16
14 Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J 2005 2.12
15 Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol 2009 1.86
16 Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J Cell Sci 2008 1.86
17 NEPH1 defines a novel family of podocin interacting proteins. FASEB J 2002 1.85
18 Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. J Am Soc Nephrol 2003 1.83
19 Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains. Hum Mol Genet 2003 1.70
20 The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol 2006 1.66
21 Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension. Nat Genet 2012 1.62
22 Wnt signaling in polycystic kidney disease. J Am Soc Nephrol 2007 1.58
23 Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc Natl Acad Sci U S A 2009 1.57
24 On-demand strategy as an alternative to conventionally scheduled post-transplant immunoadsorptions after ABO-incompatible kidney transplantation. Nephrol Dial Transplant 2007 1.47
25 The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly. Nephrol Dial Transplant 2013 1.47
26 Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury. Autophagy 2012 1.44
27 Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem 2008 1.43
28 The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1. J Biol Chem 2003 1.42
29 The retinitis pigmentosa GTPase regulator interacting protein 1 (RPGRIP1) links RPGR to the nephronophthisis protein network. Kidney Int 2010 1.42
30 mTORC2 critically regulates renal potassium handling. J Clin Invest 2016 1.40
31 Unraveling the role of podocyte turnover in glomerular aging and injury. J Am Soc Nephrol 2014 1.36
32 Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. EMBO J 2005 1.35
33 ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nat Genet 2013 1.32
34 mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression. Kidney Int 2010 1.30
35 A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. Biochem Biophys Res Commun 2006 1.29
36 Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2. Br J Haematol 2005 1.26
37 Genetic and physical interaction between the NPHP5 and NPHP6 gene products. Hum Mol Genet 2008 1.26
38 TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum. EMBO J 2009 1.21
39 Cilium-generated signaling: a cellular GPS? Curr Opin Nephrol Hypertens 2006 1.21
40 Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit. Curr Biol 2010 1.20
41 Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels. J Cell Sci 2010 1.20
42 NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. J Am Soc Nephrol 2005 1.19
43 Subcellular localization and trafficking of polycystins. Pflugers Arch 2005 1.16
44 OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. J Biol Chem 2007 1.14
45 The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. J Clin Invest 2002 1.11
46 PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Hum Mol Genet 2010 1.10
47 Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis. J Am Soc Nephrol 2013 1.09
48 Gene profiling of polycystic kidneys. Nephrol Dial Transplant 2006 1.09
49 The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. EMBO J 2006 1.09
50 The German Chronic Kidney Disease (GCKD) study: design and methods. Nephrol Dial Transplant 2011 1.09
51 Long-term outcome of ABO-incompatible living donor kidney transplantation based on antigen-specific desensitization. An observational comparative analysis. Nephrol Dial Transplant 2010 1.08
52 Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish. Hum Mol Genet 2011 1.07
53 A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis. Hum Mol Genet 2010 1.05
54 Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol 2006 1.05
55 Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli. J Biol Chem 2008 1.04
56 Regulation of ciliary polarity by the APC/C. Proc Natl Acad Sci U S A 2009 1.03
57 The subcellular localization of TRPP2 modulates its function. J Am Soc Nephrol 2008 1.02
58 ABO-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab: a single center experience. Xenotransplantation 2006 1.02
59 Inversin relays Frizzled-8 signals to promote proximal pronephros development. Proc Natl Acad Sci U S A 2010 1.02
60 Sensitive cilia set up the kidney. Nat Med 2007 1.00
61 Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development. Cancer Res 2007 1.00
62 Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1). Pflugers Arch 2007 0.98
63 The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing. Nucleus 2012 0.98
64 SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans. Genes Dev 2008 0.98
65 Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha. J Biol Chem 2002 0.98
66 Therapeutic approaches in autosomal dominant polycystic kidney disease (ADPKD): is there light at the end of the tunnel? Nephrol Dial Transplant 2006 0.96
67 Inversin, Wnt signaling and primary cilia. Differentiation 2011 0.95
68 Flow modulates centriole movements in tubular epithelial cells. Pflugers Arch 2008 0.91
69 Role of the polarity protein Scribble for podocyte differentiation and maintenance. PLoS One 2012 0.90
70 Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel. Biochem Biophys Res Commun 2009 0.89
71 Expression profiling on chronically rejected transplant kidneys. Transplantation 2003 0.89
72 Increased expression of secreted frizzled-related protein 4 in polycystic kidneys. J Am Soc Nephrol 2008 0.89
73 Host cell responses induced by hepatitis C virus binding. Hepatology 2006 0.89
74 A complex of BBS1 and NPHP7 is required for cilia motility in zebrafish. PLoS One 2013 0.88
75 N-wasp is required for stabilization of podocyte foot processes. J Am Soc Nephrol 2013 0.87
76 The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. Biochem Biophys Res Commun 2009 0.87
77 Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. J Biol Chem 2011 0.87
78 Monitoring kidney and renal cyst volumes applying MR approaches on a rapamycin treated mouse model of ADPKD. MAGMA 2008 0.85
79 aPKCλ/ι and aPKCζ contribute to podocyte differentiation and glomerular maturation. J Am Soc Nephrol 2013 0.85
80 Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells. PLoS One 2013 0.85
81 YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation. PLoS One 2012 0.85
82 Interaction with the Bardet-Biedl gene product TRIM32/BBS11 modifies the half-life and localization of Glis2/NPHP7. J Biol Chem 2014 0.84
83 Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2. Biochem Biophys Res Commun 2007 0.82
84 ABO-incompatible kidney transplantation-proposal of an intensified apheresis strategy for patients with high initial isoagglutinine titers. J Clin Apher 2007 0.81
85 Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis. PLoS One 2011 0.80
86 The Treatment of Autosomal Dominant Polycystic Kidney Disease. Dtsch Arztebl Int 2015 0.80
87 cDNA microarray analysis of adaptive changes after renal ablation in a sclerosis-resistant mouse strain. Kidney Blood Press Res 2007 0.79
88 A short carboxy-terminal domain of polycystin-1 reorganizes the microtubular network and the endoplasmic reticulum. Exp Cell Res 2009 0.79
89 Successful liver transplantation in a kidney and pancreas allograft recipient with fulminant herpes simplex virus type 2 hepatitis. Nephrol Dial Transplant 2007 0.79
90 Thrombotic microangiopathy associated with unusual viral sequences in HIV-1-positive patients. Nephrol Dial Transplant 2004 0.79
91 TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Dev Biol 2013 0.79
92 Preemptive postoperative antigen-specific immunoadsorption in ABO-incompatible kidney transplantation: necessary or not? Transplantation 2007 0.78
93 Remission of polyomavirus-induced graft nephropathy treated with low-dose leflunomide. Nephrol Dial Transplant 2006 0.78
94 The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. Development 2015 0.78
95 An inwardly rectifying whole cell current induced by Gq-coupled receptors. Biochem Biophys Res Commun 2004 0.77
96 Prime time for polycystic kidney disease: does one shot of roscovitine bring the cure? Nephrol Dial Transplant 2007 0.76
97 Slit or pore? A mutation of the ion channel TRPC6 causes FSGS. Nephrol Dial Transplant 2005 0.76
98 Quiz page December 2007: diarrhea and anuria in a recipient of an en bloc infant kidney transplant. Am J Kidney Dis 2007 0.75
99 Effect of everolimus on polycystic liver volume in autosomal dominant polycystic kidney disease. Clin Exp Nephrol 2014 0.75
100 Quiz page. Minimal change glomerulonephritis associated with secondary syphilis. Am J Kidney Dis 2007 0.75
101 Combination of immunosuppressive drugs leaves specific "fingerprint" on gene expression in vitro. Immunopharmacol Immunotoxicol 2009 0.75
102 Quiz page. Renal AA amyloidosis with vascular predominance, secondary to rheumatoid arthritis. Am J Kidney Dis 2007 0.75