Published in J Biol Chem on May 23, 2008
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol (2010) 3.32
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. EMBO J (2012) 2.72
Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med (2012) 2.56
The many substrates of presenilin/γ-secretase. J Alzheimers Dis (2011) 2.02
Intramembrane proteolysis by gamma-secretase. J Biol Chem (2008) 1.74
Activation and intrinsic gamma-secretase activity of presenilin 1. Proc Natl Acad Sci U S A (2010) 1.62
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease. J Exp Med (2015) 1.58
Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem (2011) 1.50
Intramembrane proteolysis. Chem Rev (2009) 1.32
Glu-333 of nicastrin directly participates in gamma-secretase activity. J Biol Chem (2009) 1.30
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol (2009) 1.25
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J Neurosci (2010) 1.21
Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases. J Biol Chem (2009) 1.20
Intramembrane-cleaving proteases. J Biol Chem (2009) 1.14
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem (2008) 1.09
Toward structural elucidation of the gamma-secretase complex. Structure (2009) 1.07
Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies. Proc Natl Acad Sci U S A (2012) 1.06
Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene (2011) 1.03
Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production. J Biol Chem (2010) 1.00
Complex regulation of γ-secretase: from obligatory to modulatory subunits. Front Aging Neurosci (2015) 0.99
Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain. Proc Natl Acad Sci U S A (2015) 0.98
Allosteric regulation of rhomboid intramembrane proteolysis. EMBO J (2014) 0.96
The dynamic conformational landscape of gamma-secretase Nadav. J Cell Sci (2015) 0.93
Cellular mechanisms of γ-secretase substrate selection, processing and toxicity. Prog Neurobiol (2012) 0.92
Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease. Alzheimers Res Ther (2013) 0.91
Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease. Curr Neuropharmacol (2011) 0.89
Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. J Biol Chem (2010) 0.88
Toward the structure of presenilin/γ-secretase and presenilin homologs. Biochim Biophys Acta (2013) 0.87
Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. J Biol Chem (2009) 0.87
Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping. EMBO J (2016) 0.86
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol Cell Biol (2010) 0.83
Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. J Biol Chem (2010) 0.83
Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin. Neurobiol Aging (2010) 0.82
Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8). Age (Dordr) (2015) 0.82
Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing. J Biol Chem (2011) 0.82
A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase. J Biol Chem (2014) 0.81
An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum. J Cell Sci (2014) 0.79
FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.78
Rip exposed: how ectodomain shedding regulates the proteolytic processing of transmembrane substrates. Proc Natl Acad Sci U S A (2009) 0.78
Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis. Biochemistry (2014) 0.78
Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease. PLoS One (2012) 0.78
Structure of nicastrin unveils secrets of γ-secretase. Proc Natl Acad Sci U S A (2014) 0.77
Physiological and pathological roles of the γ-secretase complex. Brain Res Bull (2016) 0.76
High-efficient production and biophysical characterisation of nicastrin and its interaction with APPC100. Sci Rep (2017) 0.75
Probing γ-secretase-substrate interactions at the single amino acid residue level. EMBO J (2016) 0.75
Analysis of nicastrin gene phylogeny and expression in zebrafish. Dev Genes Evol (2015) 0.75
Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing. J Alzheimers Dis (2017) 0.75
Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach. Chem Sci (2017) 0.75
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet (2002) 4.19
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci U S A (2005) 3.57
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci (2005) 3.23
Human embryonic stem cell lines generated without embryo destruction. Cell Stem Cell (2008) 3.11
Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat Neurosci (2002) 3.09
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. J Neurochem (2006) 3.03
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling. EMBO J (2005) 2.95
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron (2004) 2.94
Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. J Biol Chem (2004) 2.85
Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation (2002) 2.84
The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J Neurosci (2009) 2.80
Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci (2011) 2.47
Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. EMBO J (2007) 2.39
Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci (2007) 2.31
Hydrogen production from formic acid decomposition at room temperature using a Ag-Pd core-shell nanocatalyst. Nat Nanotechnol (2011) 2.21
Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1. J Leukoc Biol (2006) 2.17
Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci U S A (2010) 2.05
Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci (2005) 2.04
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice. Proc Natl Acad Sci U S A (2010) 1.92
St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole. Clin Pharmacol Ther (2004) 1.79
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep (2006) 1.72
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J Clin Invest (2007) 1.68
Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. J Neurosci (2003) 1.58
Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. J Biol Chem (2006) 1.55
An overview of APP processing enzymes and products. Neuromolecular Med (2010) 1.54
Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell (2011) 1.52
Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. J Neurosci (2008) 1.45
Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. J Neurosci (2005) 1.43
A meta-analysis of published literature on waist-to-hip ratio and risk of breast cancer. Nutr Cancer (2002) 1.38
Chemical informatics and target identification in a zebrafish phenotypic screen. Nat Chem Biol (2011) 1.37
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. J Neurochem (2014) 1.37
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. J Biol Chem (2005) 1.37
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem (2008) 1.34
Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PLoS One (2008) 1.34
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. J Biol Chem (2009) 1.33
Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cells. Am J Pathol (2006) 1.33
Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). J Neurosci (2007) 1.29
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice. J Neurochem (2006) 1.27
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J Neurosci (2005) 1.26
BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. J Neurosci (2008) 1.25
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development (2011) 1.25
Rodent models of TDP-43: recent advances. Brain Res (2012) 1.24
Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis (2007) 1.24
AMPK activation stimulates autophagy and ameliorates muscular dystrophy in the mdx mouse diaphragm. Am J Pathol (2012) 1.24
Dysregulated microRNAs in neurodegenerative disorders. Semin Cell Dev Biol (2010) 1.19
Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem (2007) 1.19
Bone morphogenetic protein 2 mediates dentin sialophosphoprotein expression and odontoblast differentiation via NF-Y signaling. J Biol Chem (2008) 1.16
Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice. Mol Neurodegener (2013) 1.13
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J Neurosci (2006) 1.13
Papillomavirus infection requires gamma secretase. J Virol (2010) 1.12
Risk factors for breast cancer associated with mammographic features in Singaporean chinese women. Cancer Epidemiol Biomarkers Prev (2004) 1.12
Phase I study of the effect of gastric acid pH modulators on the bioavailability of oral dasatinib in healthy subjects. J Clin Pharmacol (2009) 1.11
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem (2008) 1.09
Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clin Cancer Res (2005) 1.07
Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system. J Neurosci (2011) 1.06
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. EMBO Mol Med (2012) 1.05
Mutagenesis mapping of the presenilin 1 calcium leak conductance pore. J Biol Chem (2011) 1.05
Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer. Mol Cell Biol (2002) 1.05
Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins. J Neurochem (2003) 1.05
Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients. Antiviral Res (2009) 1.04
miR-20a promotes prostate cancer invasion and migration through targeting ABL2. J Cell Biochem (2014) 1.04
Alzheimer's therapeutics: translation of preclinical science to clinical drug development. Neuropsychopharmacology (2011) 1.02
Reversible binding of recombinant human immunodeficiency virus type 1 gag protein to nucleic acids in virus-like particle assembly in vitro. J Virol (2002) 1.01
Recombinant HoxB4 fusion proteins enhance hematopoietic differentiation of human embryonic stem cells. Stem Cells Dev (2007) 0.99
Tension pneumopericardium leads to cardiac tamponade during hand-assisted ventilation in patients with uremia. J Thorac Cardiovasc Surg (2008) 0.98
[Impact of intensive insulin therapy on surgical critically ill patients]. Zhonghua Wai Ke Za Zhi (2007) 0.98
Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo. Int Immunopharmacol (2007) 0.98
Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex. J Biol Chem (2011) 0.97
Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain (2009) 0.96
Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment-naïve patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma. J Med Virol (2012) 0.96
Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins. Mol Endocrinol (2006) 0.96
Flight performance of the orange wheat blossom midge (Diptera: Cecidomyiidae). J Econ Entomol (2013) 0.96
Frequency of autoimmune diseases in myasthenia gravis: a systematic review. Int J Neurosci (2010) 0.96
Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma. J Gastroenterol (2007) 0.94
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. J Biol Chem (2009) 0.94
Profile of HBV antiviral resistance mutations with distinct evolutionary pathways against nucleoside/nucleotide analogue treatment among Chinese chronic hepatitis B patients. Antivir Ther (2010) 0.92
Immunological features and efficacy of the reconstructed epitope vaccine CtUBE against Helicobacter pylori infection in BALB/c mice model. Appl Microbiol Biotechnol (2012) 0.92
Peroxisome proliferator-activated receptor γ coactivator1- gene α transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post-necrotic mdx mouse skeletal muscle. J Physiol (2012) 0.92
Effect of low-dose omeprazole (20 mg daily) on the pharmacokinetics of multiple-dose atazanavir with ritonavir in healthy subjects. J Clin Pharmacol (2010) 0.92
Clinical features of the retinopathy, globe enlarged (rge) chick phenotype. Vision Res (2003) 0.92
Non-syngas direct steam reforming of methanol to hydrogen and carbon dioxide at low temperature. Nat Commun (2012) 0.92
[Status of perfluorochemicals in adult serum and umbilical blood in Shenyang]. Wei Sheng Yan Jiu (2004) 0.91
LRRK2 expression is enriched in the striosomal compartment of mouse striatum. Neurobiol Dis (2012) 0.90
[A comparison of bispectral index and sedation agitation scale in guiding sedation therapy: a randomized controlled study in patients undergoing short term mechanical ventilation]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue (2011) 0.90
Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. J Biol Chem (2011) 0.89
Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation. J Mol Biol (2012) 0.89
Molecular cloning and characterization of four heat shock protein genes from Macrocentrus cingulum (Hymenoptera: Braconidae). Mol Biol Rep (2009) 0.89
Correlation of hepatitis B virus (HBV) genotypes and mutations in basal core promoter/precore with clinical features of chronic HBV infection. Liver Int (2007) 0.88
Intra-abdominal pressure monitoring in predicting outcome of patients with severe acute pancreatitis. Hepatobiliary Pancreat Dis Int (2007) 0.87
Host-derived pentapeptide affecting adhesion, proliferation, and local pH in biofilm communities composed of Streptococcus and Actinomyces species. Infect Immun (2006) 0.87
Effect of germination on phytochemical profiles and antioxidant activity of mung bean sprouts (Vigna radiata). J Agric Food Chem (2012) 0.87
Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: essential role of bone morphogenetic protein 4. Development (2011) 0.87
Modeling an anti-amyloid combination therapy for Alzheimer's disease. Sci Transl Med (2010) 0.87
Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation. J Neurosci (2004) 0.87