Published in J Mol Evol on November 01, 2004
The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression. Nucleic Acids Res (2005) 1.01
Comparative induction of 28S ribosomal RNA cleavage by ricin and the trichothecenes deoxynivalenol and T-2 toxin in the macrophage. Toxicol Sci (2008) 0.92
Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. Kidney Int (2014) 0.86
The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement. Biochem J (2016) 0.79
Abundance of RNase4 and RNase5 mRNA and protein in host defence related tissues and secretions in cattle. Biochem Biophys Rep (2016) 0.75
The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol (1987) 266.90
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res (1997) 175.36
A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol (1980) 113.75
MEGA2: molecular evolutionary genetics analysis software. Bioinformatics (2001) 38.50
Comparative analyses of multi-species sequences from targeted genomic regions. Nature (2003) 13.31
Simple methods for testing the molecular evolutionary clock hypothesis. Genetics (1993) 11.26
CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP. Evolution (1985) 10.10
Resolution of the early placental mammal radiation using Bayesian phylogenetics. Science (2001) 8.68
Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol (2003) 6.17
Positive Darwinian selection after gene duplication in primate ribonuclease genes. Proc Natl Acad Sci U S A (1998) 5.54
Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey. Nat Genet (2002) 3.49
Small-sample tests of episodic adaptive evolution: a case study of primate lysozymes. Mol Biol Evol (1997) 1.97
Molecular evolution of the ribonuclease superfamily. Prog Biophys Mol Biol (1988) 1.83
Molecular mimicry and the generation of host defense protein diversity. Cell (1993) 1.78
Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein. J Immunol (1986) 1.65
Rapid evolution of a unique family of primate ribonuclease genes. Nat Genet (1995) 1.62
Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens. J Leukoc Biol (2001) 1.62
Evolution of the rodent eosinophil-associated RNase gene family by rapid gene sorting and positive selection. Proc Natl Acad Sci U S A (2000) 1.37
The angiogenins. Cell Mol Life Sci (1998) 1.29
Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity. Nucleic Acids Res (1998) 1.28
RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. Nucleic Acids Res (2002) 1.28
Human RNase 7: a new cationic ribonuclease of the RNase A superfamily. Nucleic Acids Res (2003) 1.22
Tissue-specific expression of pancreatic-type RNases and RNase inhibitor in humans. DNA Cell Biol (1997) 1.22
Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Proc Natl Acad Sci U S A (1996) 1.19
Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. Nucleic Acids Res (1996) 1.01
Mouse eosinophil-associated ribonucleases: a unique subfamily expressed during hematopoiesis. Mamm Genome (2001) 0.97
Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family. Nucleic Acids Res (1997) 0.97
Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. Nucleic Acids Res (1995) 0.97
Enhanced expression of the eosinophil-derived neurotoxin ribonuclease (RNS2) gene requires interaction between the promoter and intron. J Biol Chem (1996) 0.92
Rapid evolution of the ribonuclease A superfamily: adaptive expansion of independent gene clusters in rats and mice. J Mol Evol (1999) 0.92
Gene structure and enzymatic activity of mouse eosinophil-associated ribonuclease 2. Gene (2001) 0.86
Evolution of antiviral activity in the ribonuclease A gene superfamily: evidence for a specific interaction between eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory syncytial virus. Nucleic Acids Res (1998) 0.85
Molecular evolution of mammalian ribonucleases 1. Mol Phylogenet Evol (2003) 0.84
Intronic enhancer activity of the eosinophil-derived neurotoxin (RNS2) and eosinophil cationic protein (RNS3) genes is mediated by an NFAT-1 consensus binding sequence. J Biol Chem (1997) 0.83
Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated ribonuclease 2 (mEar 2) gene. Mamm Genome (2004) 0.80
Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. Genome Res (1998) 0.79
Phylogeny of ruminants secretory ribonuclease gene sequences of pronghorn (Antilocapra americana). Mol Phylogenet Evol (2003) 0.77
Complete cDNA sequence and amino acid analysis of a bovine ribonuclease K6 gene. DNA Seq (2000) 0.75
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum (2002) 4.98
Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution. Genetics (2005) 3.98
Eosinophils: biological properties and role in health and disease. Clin Exp Allergy (2008) 3.92
Evolutionary conservation of expression profiles between human and mouse orthologous genes. Mol Biol Evol (2005) 3.62
Gene sequence-based criteria for identification of new rickettsia isolates and description of Rickettsia heilongjiangensis sp. nov. J Clin Microbiol (2003) 3.59
The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. Nat Rev Genet (2011) 3.57
Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey. Nat Genet (2002) 3.49
Why do hubs tend to be essential in protein networks? PLoS Genet (2006) 3.29
Gene losses during human origins. PLoS Biol (2006) 3.17
RNA sequencing shows no dosage compensation of the active X-chromosome. Nat Genet (2010) 2.71
Null mutations in human and mouse orthologs frequently result in different phenotypes. Proc Natl Acad Sci U S A (2008) 2.60
Balanced codon usage optimizes eukaryotic translational efficiency. PLoS Genet (2012) 2.32
Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow. J Immunol (2008) 2.22
Impacts of gene essentiality, expression pattern, and gene compactness on the evolutionary rate of mammalian proteins. Mol Biol Evol (2006) 2.22
Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine. Clin Cancer Res (2006) 2.20
Genomic patterns of pleiotropy and the evolution of complexity. Proc Natl Acad Sci U S A (2010) 2.19
Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nat Genet (2010) 2.16
Mouse duplicate genes are as essential as singletons. Trends Genet (2007) 2.12
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J Exp Med (2008) 2.04
More genes underwent positive selection in chimpanzee evolution than in human evolution. Proc Natl Acad Sci U S A (2007) 2.00
Low rates of expression profile divergence in highly expressed genes and tissue-specific genes during mammalian evolution. Mol Biol Evol (2006) 1.97
Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals. Proc Natl Acad Sci U S A (2005) 1.88
Toward a molecular understanding of pleiotropy. Genetics (2006) 1.88
Comparative genomic analysis identifies an evolutionary shift of vomeronasal receptor gene repertoires in the vertebrate transition from water to land. Genome Res (2007) 1.85
Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol (2003) 1.82
Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Mol Biol Evol (2005) 1.77
Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity. Infect Immun (2006) 1.76
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int J Cancer (2006) 1.76
Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice. Blood (2013) 1.72
Animal pneumoviruses: molecular genetics and pathogenesis. Clin Microbiol Rev (2004) 1.67
The hearing gene Prestin unites echolocating bats and whales. Curr Biol (2010) 1.62
Higher duplicability of less important genes in yeast genomes. Mol Biol Evol (2005) 1.57
Animal models of human respiratory syncytial virus disease. Am J Physiol Lung Cell Mol Physiol (2011) 1.57
Activated mouse eosinophils protect against lethal respiratory virus infection. Blood (2013) 1.54
Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dietary switch to bamboo. Mol Biol Evol (2010) 1.53
Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus. Blood (2007) 1.52
Maintenance of duplicate genes and their functional redundancy by reduced expression. Trends Genet (2010) 1.51
Composition and evolution of the V2r vomeronasal receptor gene repertoire in mice and rats. Genomics (2005) 1.47
Impact of gene expression noise on organismal fitness and the efficacy of natural selection. Proc Natl Acad Sci U S A (2011) 1.46
The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Genomics (2005) 1.43
Sex-specific splicing of the honeybee doublesex gene reveals 300 million years of evolution at the bottom of the insect sex-determination pathway. Genetics (2007) 1.43
Chemokine regulation of inflammation during acute viral infection. Curr Opin Allergy Clin Immunol (2003) 1.42
Schistosoma mansoni infection in eosinophil lineage-ablated mice. Blood (2006) 1.42
Gene complexity and gene duplicability. Curr Biol (2005) 1.42
Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes. Hum Mol Genet (2004) 1.38
In search of the biological significance of modular structures in protein networks. PLoS Comput Biol (2007) 1.38
The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep (2012) 1.36
Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates. Proc Natl Acad Sci U S A (2002) 1.36
Evolution of the sweet taste receptor gene Tas1r2 in bats. Mol Biol Evol (2010) 1.36
Impact of translational error-induced and error-free misfolding on the rate of protein evolution. Mol Syst Biol (2010) 1.35
Inflammatory responses to pneumovirus infection in IFN-alpha beta R gene-deleted mice. J Immunol (2005) 1.34
Origin of the genetic components of the vomeronasal system in the common ancestor of all extant vertebrates. Mol Biol Evol (2008) 1.33
Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation. J Immunol (2004) 1.33
Respiratory dysfunction and proinflammatory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitis. Virology (2006) 1.32
Measuring the evolutionary rate of protein-protein interaction. Proc Natl Acad Sci U S A (2011) 1.32
MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3. Cancer Lett (2013) 1.31
Positive selection for elevated gene expression noise in yeast. Mol Syst Biol (2009) 1.30
Protein misinteraction avoidance causes highly expressed proteins to evolve slowly. Proc Natl Acad Sci U S A (2012) 1.29
RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. Nucleic Acids Res (2002) 1.28
Functional antagonism of chemokine receptor CCR1 reduces mortality in acute pneumovirus infection in vivo. J Virol (2004) 1.28
Genomic and genetic evidence for the loss of umami taste in bats. Genome Biol Evol (2011) 1.27
Did brain-specific genes evolve faster in humans than in chimpanzees? Trends Genet (2006) 1.26
Lactobacillus-mediated priming of the respiratory mucosa protects against lethal pneumovirus infection. J Immunol (2010) 1.26
Positive selection on protein-length in the evolution of a primate sperm ion channel. Proc Natl Acad Sci U S A (2003) 1.26
Gene dosage and gene duplicability. Genetics (2008) 1.23
Abundant indispensable redundancies in cellular metabolic networks. Genome Biol Evol (2009) 1.23
Human RNase 7: a new cationic ribonuclease of the RNase A superfamily. Nucleic Acids Res (2003) 1.22
Expression reduction in mammalian X chromosome evolution refutes Ohno's hypothesis of dosage compensation. Proc Natl Acad Sci U S A (2012) 1.22
Rapid turnover and species-specificity of vomeronasal pheromone receptor genes in mice and rats. Gene (2004) 1.21
p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR. Mol Cancer Ther (2008) 1.21
Genomic evidence for elevated mutation rates in highly expressed genes. EMBO Rep (2012) 1.19
Largest vertebrate vomeronasal type 1 receptor gene repertoire in the semiaquatic platypus. Mol Biol Evol (2007) 1.19
Why are some human disease-associated mutations fixed in mice? Trends Genet (2003) 1.19
Why is the correlation between gene importance and gene evolutionary rate so weak? PLoS Genet (2009) 1.16
Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6. Blood (2009) 1.15
On the definition and measurement of pleiotropy. Trends Genet (2013) 1.14
Distinct evolutionary patterns between chemoreceptors of 2 vertebrate olfactory systems and the differential tuning hypothesis. Mol Biol Evol (2008) 1.13
No gene-specific optimization of mutation rate in Escherichia coli. Mol Biol Evol (2013) 1.13
Differential expression of proinflammatory cytokine genes in vivo in response to pathogenic and nonpathogenic pneumovirus infections. J Infect Dis (2002) 1.13
Coexpression of linked genes in Mammalian genomes is generally disadvantageous. Mol Biol Evol (2008) 1.12
Animal models for studying respiratory syncytial virus infection and its long term effects on lung function. Pediatr Infect Dis J (2004) 1.11
Nonneutral evolution of the transcribed pseudogene Makorin1-p1 in mice. Mol Biol Evol (2004) 1.11
Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells. Blood (2003) 1.11
The RNase a superfamily: generation of diversity and innate host defense. Mol Divers (2006) 1.10
Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer. Int J Cancer (2007) 1.10
Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly. Proc Natl Acad Sci U S A (2013) 1.09
Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents. J Virol (2003) 1.08
Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire. Mol Biol Evol (2013) 1.08
Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice. Respir Res (2010) 1.07
Positive selection for indel substitutions in the rodent sperm protein catsper1. Mol Biol Evol (2005) 1.07
Mucosal inoculation with an attenuated mouse pneumovirus strain protects against virulent challenge in wild type and interferon-gamma receptor deficient mice. Vaccine (2006) 1.06
Interferon-gamma coordinates CCL3-mediated neutrophil recruitment in vivo. BMC Immunol (2009) 1.06
Contrasting genetic paths to morphological and physiological evolution. Proc Natl Acad Sci U S A (2010) 1.05
Evolution of the complementary sex-determination gene of honey bees: balancing selection and trans-species polymorphisms. Genome Res (2006) 1.04
Impact of extracellularity on the evolutionary rate of mammalian proteins. Genome Biol Evol (2010) 1.02
Antigen profiles for the quantitative assessment of eosinophils in mouse tissues by flow cytometry. J Immunol Methods (2011) 1.02
The ortholog conjecture is untestable by the current gene ontology but is supported by RNA sequencing data. PLoS Comput Biol (2012) 1.02
Generation of novel monoclonal antibodies and their application for detecting ARD1 expression in colorectal cancer. Cancer Lett (2008) 1.02
High expression hampers horizontal gene transfer. Genome Biol Evol (2012) 1.01