PubRank

Dianqing Wu

Author PubWeight™ 116.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 2002 11.28
2 Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 2003 5.95
3 Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem 2005 5.33
4 Regulation of PTEN by Rho small GTPases. Nat Cell Biol 2005 4.51
5 Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell 2003 3.66
6 Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell 2003 3.06
7 Differential targeting of Gbetagamma-subunit signaling with small molecules. Science 2006 2.96
8 Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet 2005 2.10
9 Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol 2010 2.09
10 Mouse taste buds use serotonin as a neurotransmitter. J Neurosci 2005 1.98
11 Sites of regulated phosphorylation that control K-Cl cotransporter activity. Cell 2009 1.93
12 Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science 2008 1.81
13 Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell 2009 1.78
14 The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol Cell Biol 2004 1.77
15 P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol 2005 1.70
16 PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A 2005 1.67
17 Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. Proc Natl Acad Sci U S A 2002 1.60
18 Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem 2002 1.60
19 Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem 2001 1.57
20 Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 2011 1.56
21 Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum. J Neurosci 2005 1.56
22 Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction. Mol Cell Biol 2006 1.48
23 Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. J Clin Invest 2003 1.47
24 DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA. EMBO J 2005 1.44
25 PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A 2004 1.42
26 Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem 2008 1.35
27 The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol 2008 1.31
28 Characterization and application of a new optical probe for membrane lipid domains. Biophys J 2006 1.31
29 Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway. J Biol Chem 2004 1.27
30 Modulation of cell adhesion and motility in the immune system by Myo1f. Science 2006 1.22
31 Phospholipase cbeta is critical for T cell chemotaxis. J Immunol 2007 1.22
32 Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A 2007 1.20
33 Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway. Proc Natl Acad Sci U S A 2013 1.19
34 Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1. Cell Res 2004 1.19
35 Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. J Leukoc Biol 2007 1.17
36 Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells. Mol Biol Cell 2005 1.17
37 Structural insight into the mechanisms of Wnt signaling antagonism by Dkk. J Biol Chem 2008 1.16
38 Cell stimulation with optically manipulated microsources. Nat Methods 2009 1.15
39 Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity 2010 1.10
40 A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Dev Cell 2011 1.10
41 The relative role of PLCbeta and PI3Kgamma in platelet activation. Blood 2005 1.09
42 Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest 2008 1.09
43 PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nat Cell Biol 2012 1.08
44 Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. J Biol Chem 2010 1.06
45 IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood 2005 1.06
46 Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins Other Lipid Mediat 2005 1.02
47 Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl. J Biol Chem 2009 1.01
48 Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils. J Biol Chem 2010 1.00
49 SRF is required for neutrophil migration in response to inflammation. Blood 2014 0.99
50 GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs. Development 2003 0.99
51 Beta-catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells. Proc Natl Acad Sci U S A 2005 0.98
52 Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype. Am J Pathol 2009 0.96
53 The structural basis of DKK-mediated inhibition of Wnt/LRP signaling. Sci Signal 2012 0.94
54 A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis. Biochem Biophys Res Commun 2004 0.93
55 Important roles of PI3Kgamma in osteoclastogenesis and bone homeostasis. Proc Natl Acad Sci U S A 2010 0.93
56 A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils. Dev Cell 2013 0.93
57 Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes. J Cell Biol 2013 0.92
58 Phospholipase Cbeta3 is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets. Eur J Neurosci 2007 0.91
59 A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability. Circ Res 2012 0.91
60 Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism. Proc Natl Acad Sci U S A 2012 0.89
61 Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem 2009 0.89
62 A model of GAG/MIP-2/CXCR2 interfaces and its functional effects. Biochemistry 2012 0.89
63 Role of thalamic phospholipase C[beta]4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain. J Neurosci 2003 0.87
64 The first inner loop of endothelin receptor type B is necessary for specific coupling to Galpha 13. J Biol Chem 2002 0.86
65 Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice. J Biol Chem 2013 0.85
66 Methods for studying neutrophil chemotaxis. Methods Enzymol 2006 0.85
67 Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1. Immunity 2011 0.82
68 Pathway-selective suppression of chemokine receptor signaling in B cells by LPS through downregulation of PLC-β2. Cell Mol Immunol 2010 0.82
69 Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation. Arterioscler Thromb Vasc Biol 2011 0.81
70 Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis. Prostaglandins Other Lipid Mediat 2008 0.81
71 Analysis of G protein-mediated activation of phospholipase C in cultured cells. Methods Mol Biol 2004 0.80
72 PI3Kγ deletion reduces variability in the in vivo osteolytic response induced by orthopaedic wear particles. J Orthop Res 2011 0.79
73 Different Raf protein kinases mediate different signaling pathways to stimulate E3 ligase RFFL gene expression in cell migration regulation. J Biol Chem 2013 0.77
74 Analysis of the coupling of G12/13 to G protein-coupled receptors using a luciferase reporter assay. Methods Mol Biol 2004 0.77
75 Erratum: Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med 2016 0.75
76 Functional interaction of G alpha 13 with p115RhoGEF determined with transcriptional reporter system. Methods Enzymol 2002 0.75