Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis.

PubWeight™: 1.60‹?› | Rank: Top 4%

🔗 View Article (PMC 122570)

Published in Proc Natl Acad Sci U S A on March 19, 2002

Authors

Michael Hannigan1, Lijun Zhan, Zhong Li, Youxi Ai, Dianqing Wu, Chi-Kuang Huang

Author Affiliations

1: Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

Articles citing this

Chemotaxis in cancer. Nat Rev Cancer (2011) 3.68

Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell (2003) 2.56

PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell (2007) 2.53

NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology. Antioxid Redox Signal (2009) 2.29

Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases. J Cell Biol (2003) 2.14

Calpain regulates neutrophil chemotaxis. Proc Natl Acad Sci U S A (2003) 1.73

Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. J Cell Biol (2004) 1.72

A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med (2007) 1.71

The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol (2009) 1.53

The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood (2005) 1.46

Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood (2006) 1.44

The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gels. PLoS One (2015) 1.38

Mechanisms and consequences of neutrophil interaction with the endothelium. Am J Pathol (2007) 1.38

Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A (2006) 1.22

PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells. J Cell Biol (2007) 1.20

Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase. J Immunol (2011) 1.19

Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. Cell Mol Life Sci (2014) 1.15

iPLA2beta: front and center in human monocyte chemotaxis to MCP-1. J Exp Med (2008) 1.11

Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol (2005) 1.10

Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responses. Exp Hematol (2008) 1.02

Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis. Proc Natl Acad Sci U S A (2012) 1.00

Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis. Blood (2011) 0.99

Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma. Proc Natl Acad Sci U S A (2007) 0.98

The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites. J Leukoc Biol (2008) 0.93

Kinase AKT controls innate immune cell development and function. Immunology (2013) 0.92

The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration. J Biol Chem (2011) 0.91

Enhanced neutrophil motility by granulocyte colony-stimulating factor: the role of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. Immunology (2006) 0.91

Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity. Proc Natl Acad Sci U S A (2009) 0.90

Syk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytes. PLoS One (2007) 0.88

Soluble extract from the nematode Strongyloides stercoralis induces CXCR2 dependent/IL-17 independent neutrophil recruitment. Microbes Infect (2011) 0.87

GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production. Mol Biol Cell (2012) 0.86

Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from Ganoderma lucidum. Br J Pharmacol (2003) 0.86

Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution. J Immunol (2014) 0.85

Crossroads of PI3K and Rac pathways. Small GTPases (2015) 0.83

Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation. Immunology (2008) 0.80

Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo. Nat Commun (2015) 0.79

Exploration of molecular pathways mediating electric field-directed Schwann cell migration by RNA-seq. J Cell Physiol (2015) 0.79

Treponema denticola major outer sheath protein impairs the cellular phosphoinositide balance that regulates neutrophil chemotaxis. PLoS One (2013) 0.78

Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen. Dis Model Mech (2016) 0.76

Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration. Br J Pharmacol (2012) 0.76

Direct binding of a fragment of the Wiskott-Aldrich syndrome protein to the C-terminal end of the anaphylatoxin C5a receptor. Biochem J (2003) 0.76

AKT-mediated regulation of polarization in differentiated human neutrophil-like HL-60 cells. Inflamm Res (2012) 0.76

The C-terminal region of the major outer sheath protein of Treponema denticola inhibits neutrophil chemotaxis. Mol Oral Microbiol (2017) 0.76

Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J Cell Mol Med (2016) 0.75

p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration. Immunol Cell Biol (2015) 0.75

The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils. J Immunol Res (2015) 0.75

Honokiol suppresses formyl peptide-induced human neutrophil activation by blocking formyl peptide receptor 1. Sci Rep (2017) 0.75

Articles cited by this

Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem (2001) 8.47

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93

G protein signaling events are activated at the leading edge of chemotactic cells. Cell (1998) 6.60

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science (2000) 6.26

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science (2000) 5.84

Life at the leading edge: the formation of cell protrusions. Annu Rev Cell Biol (1993) 5.15

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science (2000) 4.61

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J (1999) 4.34

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J (1996) 4.31

Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science (2001) 4.04

A role for Cdc42 in macrophage chemotaxis. J Cell Biol (1998) 3.88

Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium. J Cell Biol (2001) 3.03

Principles of locomotion for simple-shaped cells. Nature (1993) 3.00

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol (1996) 2.96

Structure and function of phosphoinositide 3-kinases. Biochim Biophys Acta (1998) 2.88

Localization of the G protein betagamma complex in living cells during chemotaxis. Science (2000) 2.87

Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol (2000) 2.59

Chemotaxis by polymorphonuclear leukocytes. J Cell Biol (1978) 2.20

The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients. Bioessays (2000) 2.02

Roles of phospholipid signaling in chemoattractant-induced responses. J Cell Sci (2000) 1.34

Perspectives: signal transduction. Signals to move cells. Science (2000) 1.18

Introduction to confocal microscopy and three-dimensional reconstruction. Methods Cell Biol (1993) 1.10

Orientation chamber in chemotaxis. Methods Enzymol (1988) 1.07

Micropore filter methods for leukocyte chemotaxis. Methods Enzymol (1988) 1.01

Molecular basis of localized responses during chemotaxis in amoebae and leukocytes. Cell Mol Life Sci (1999) 0.98

Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. J Biol Chem (1999) 0.97

Leukocyte-specific gene 1 protein (LSP1) is involved in chemokine KC-activated cytoskeletal reorganization in murine neutrophils in vitro. J Leukoc Biol (2001) 0.90

Chemotaxis: an overview. Methods Enzymol (1988) 0.85

A synthetic peptide containing a predominant protein kinase C site within p47phox inhibits the NADPH oxidase in intact neutrophils. J Leukoc Biol (1996) 0.81

Articles by these authors

High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med (2002) 11.28

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell (2003) 5.95

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem (2005) 5.33

Regulation of PTEN by Rho small GTPases. Nat Cell Biol (2005) 4.51

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell (2003) 3.66

Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res (2008) 3.36

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell (2003) 3.06

Differential targeting of Gbetagamma-subunit signaling with small molecules. Science (2006) 2.96

Structure and function of flavivirus NS5 methyltransferase. J Virol (2007) 2.93

Synthesis, insecticidal activity, and QSAR of novel nitromethylene neonicotinoids with tetrahydropyridine fixed cis configuration and exo-ring ether modification. J Agric Food Chem (2007) 2.71

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet (2005) 2.10

Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol (2010) 2.09

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol (2006) 2.04

Mouse taste buds use serotonin as a neurotransmitter. J Neurosci (2005) 1.98

Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat. J Mol Cell Cardiol (2006) 1.94

Angiogenic signal triggered by ischemic stress induces myocardial repair in rat during chronic infarction. J Mol Cell Cardiol (2004) 1.93

Sites of regulated phosphorylation that control K-Cl cotransporter activity. Cell (2009) 1.93

In vivo MR imaging tracking of magnetic iron oxide nanoparticle labeled, engineered, autologous bone marrow mesenchymal stem cells following intra-articular injection. Joint Bone Spine (2008) 1.91

Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Nat Cell Biol (2002) 1.91

Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med (2007) 1.90

Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science (2008) 1.81

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell (2009) 1.78

The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol Cell Biol (2004) 1.77

Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media. Proc Natl Acad Sci U S A (2003) 1.75

Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. Biochem J (2006) 1.72

P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol (2005) 1.70

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.67

Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem (2002) 1.60

Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor. J Mol Cell Cardiol (2005) 1.59

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest (2009) 1.58

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem (2001) 1.57

Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (2011) 1.56

Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum. J Neurosci (2005) 1.56

Materials science: Share corrosion data. Nature (2015) 1.50

Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction. Mol Cell Biol (2006) 1.48

Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. J Clin Invest (2003) 1.47

Sex differences in caspase activation after stroke. Stroke (2009) 1.47

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA. EMBO J (2005) 1.44

PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A (2004) 1.42

Crystallographic and mutational studies of Mycobacterium tuberculosis recA mini-inteins suggest a pivotal role for a highly conserved aspartate residue. J Mol Biol (2006) 1.39

Retracted Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c. Cancer Sci (2014) 1.39

Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem (2008) 1.35

The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. Cancer Res (2005) 1.33

Glycogen synthase kinase-3beta/beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF, Bcl-2 and survivin expression in rat ischemic preconditioned myocardium. J Mol Cell Cardiol (2005) 1.32

CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage. J Neurosci (2014) 1.31

The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol (2008) 1.31

Characterization and application of a new optical probe for membrane lipid domains. Biophys J (2006) 1.31

Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology (2012) 1.30

1-[(6-Chloro-3-pyrid-yl)meth-yl]-5-eth-oxy-8-nitro-1,2,3,5,6,7-hexa-hydro-imidazo[1,2-a]pyridine. Acta Crystallogr Sect E Struct Rep Online (2009) 1.30

Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway. J Biol Chem (2004) 1.27

One family cluster of avian influenza A(H7N9) virus infection in Shandong, China. BMC Infect Dis (2014) 1.26

Phospholipase cbeta is critical for T cell chemotaxis. J Immunol (2007) 1.22

Modulation of cell adhesion and motility in the immune system by Myo1f. Science (2006) 1.22

Design, multicomponent synthesis, and bioactivities of novel neonicotinoid analogues with 1,4-dihydropyridine scaffold. J Agric Food Chem (2010) 1.22

Sildenafil-mediated neovascularization and protection against myocardial ischaemia reperfusion injury in rats: role of VEGF/angiopoietin-1. J Cell Mol Med (2008) 1.21

Experimental acute otitis media due to nontypeable Haemophilus influenzae: comparison of high and low azithromycin doses with placebo. Antimicrob Agents Chemother (2002) 1.20

Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A (2007) 1.20

Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice. Hepatology (2011) 1.20

Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway. Proc Natl Acad Sci U S A (2013) 1.19

Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1. Cell Res (2004) 1.19

Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. J Leukoc Biol (2007) 1.17

Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells. Mol Biol Cell (2005) 1.17

Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression. Hepatology (2012) 1.17

Structural insight into the mechanisms of Wnt signaling antagonism by Dkk. J Biol Chem (2008) 1.16

COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med (2007) 1.16

Thioredoxin-1 gene therapy enhances angiogenic signaling and reduces ventricular remodeling in infarcted myocardium of diabetic rats. Circulation (2010) 1.16

5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. Bioorg Med Chem (2007) 1.16

Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine. J Med Chem (2009) 1.15

Cell stimulation with optically manipulated microsources. Nat Methods (2009) 1.15

cis-Nitromethylene neonicotinoids as new nicotinic family: synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2-alpha]pyridine. Bioorg Med Chem Lett (2008) 1.12

Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1. Cell Biochem Biophys (2006) 1.12

Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects. DNA Cell Biol (2005) 1.11

Redox regulation of ischemic preconditioning is mediated by the differential activation of caveolins and their association with eNOS and GLUT-4. Am J Physiol Heart Circ Physiol (2007) 1.11

Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity (2010) 1.10

A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Dev Cell (2011) 1.10

MicroRNA-21 activates hepatic stellate cells via PTEN/Akt signaling. Biomed Pharmacother (2013) 1.10

The relative role of PLCbeta and PI3Kgamma in platelet activation. Blood (2005) 1.09

Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor. Nat Struct Mol Biol (2004) 1.09

Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest (2008) 1.09

Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1α transcription factor and its target genes in mice. Antioxid Redox Signal (2011) 1.08

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nat Cell Biol (2012) 1.08

Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. J Biol Chem (2010) 1.06

IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood (2005) 1.06

Direct medical cost of influenza-related hospitalizations among severe acute respiratory infections cases in three provinces in China. PLoS One (2013) 1.04

OV6⁺ tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. J Hepatol (2012) 1.04

Feasibility and Acceptability of a Real-Time Adherence Device among HIV-Positive IDU Patients in China. AIDS Res Treat (2013) 1.04

Retracted Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target. J Mol Cell Cardiol (2007) 1.03

Scrub typhus: surveillance, clinical profile and diagnostic issues in Shandong, China. Am J Trop Med Hyg (2012) 1.03

MK2-/- gene knockout mouse hearts carry anti-apoptotic signal and are resistant to ischemia reperfusion injury. J Mol Cell Cardiol (2004) 1.03

Inhibition of active autophagy induces apoptosis and increases chemosensitivity in cholangiocarcinoma. Lab Invest (2011) 1.02

Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins Other Lipid Mediat (2005) 1.02

Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl. J Biol Chem (2009) 1.01

Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase. J Biol Chem (2010) 1.00

Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils. J Biol Chem (2010) 1.00

Syntheses and biological activities of octahydro-1H-cyclopenta[d]pyrimidine derivatives. J Agric Food Chem (2007) 1.00