1
|
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
Nat Genet
|
2010
|
23.08
|
2
|
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
Nature
|
2010
|
20.01
|
3
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
4
|
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
|
Nature
|
2011
|
13.25
|
5
|
Genome-wide association study identifies eight loci associated with blood pressure.
|
Nat Genet
|
2009
|
12.44
|
6
|
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|
Nat Genet
|
2008
|
12.07
|
7
|
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
|
Lancet
|
2010
|
8.89
|
8
|
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
|
Nat Genet
|
2010
|
7.94
|
9
|
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
Nat Genet
|
2010
|
6.49
|
10
|
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
|
Nat Genet
|
2009
|
6.39
|
11
|
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.
|
Nat Genet
|
2008
|
5.49
|
12
|
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.
|
Science
|
2008
|
4.38
|
13
|
Genome-wide association study identifies five loci associated with lung function.
|
Nat Genet
|
2009
|
4.10
|
14
|
Identification of seven loci affecting mean telomere length and their association with disease.
|
Nat Genet
|
2013
|
3.87
|
15
|
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
Nat Genet
|
2013
|
3.25
|
16
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
17
|
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
|
PLoS Genet
|
2010
|
3.21
|
18
|
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
|
Nat Genet
|
2011
|
3.18
|
19
|
New gene functions in megakaryopoiesis and platelet formation.
|
Nature
|
2011
|
3.14
|
20
|
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
|
Nat Genet
|
2011
|
3.03
|
21
|
Common variants associated with plasma triglycerides and risk for coronary artery disease.
|
Nat Genet
|
2013
|
2.92
|
22
|
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
|
PLoS Genet
|
2013
|
2.83
|
23
|
Seventy-five genetic loci influencing the human red blood cell.
|
Nature
|
2012
|
2.77
|
24
|
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.
|
PLoS Med
|
2013
|
2.73
|
25
|
Neonatal outcome and congenital malformations in children born after in-vitro fertilization.
|
Hum Reprod
|
2002
|
2.70
|
26
|
A genome-wide association meta-analysis identifies new childhood obesity loci.
|
Nat Genet
|
2012
|
2.60
|
27
|
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.
|
Nature
|
2011
|
2.59
|
28
|
Elevated blood pressure in pregnancy and subsequent chronic disease risk.
|
Circulation
|
2013
|
2.33
|
29
|
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
|
Nat Genet
|
2010
|
2.30
|
30
|
Infant vitamin d supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966.
|
Ann N Y Acad Sci
|
2004
|
2.28
|
31
|
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
|
J Allergy Clin Immunol
|
2011
|
2.24
|
32
|
Early life factors and blood pressure at age 31 years in the 1966 northern Finland birth cohort.
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Hypertension
|
2004
|
2.14
|
33
|
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
|
Diabetes
|
2011
|
2.09
|
34
|
Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.
|
PLoS One
|
2009
|
2.03
|
35
|
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.
|
Proc Natl Acad Sci U S A
|
2011
|
2.01
|
36
|
Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.
|
PLoS Genet
|
2009
|
1.89
|
37
|
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
|
Nat Genet
|
2013
|
1.72
|
38
|
Relationship between birthweight and blood lipid concentrations in later life: evidence from the existing literature.
|
Int J Epidemiol
|
2003
|
1.72
|
39
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
40
|
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.
|
PLoS Med
|
2013
|
1.70
|
41
|
Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study.
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J Clin Endocrinol Metab
|
2008
|
1.69
|
42
|
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.
|
J Mol Med (Berl)
|
2009
|
1.62
|
43
|
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
Circ Cardiovasc Genet
|
2012
|
1.60
|
44
|
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
|
Nat Genet
|
2011
|
1.60
|
45
|
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
|
PLoS Genet
|
2012
|
1.52
|
46
|
Common variants at 6q22 and 17q21 are associated with intracranial volume.
|
Nat Genet
|
2012
|
1.51
|
47
|
Maternal smoking and hyperactivity in 8-year-old children.
|
J Am Acad Child Adolesc Psychiatry
|
2003
|
1.43
|
48
|
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.
|
PLoS Genet
|
2010
|
1.40
|
49
|
Thyroid dysfunction and autoantibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life.
|
J Clin Endocrinol Metab
|
2010
|
1.38
|
50
|
Distinct variants at LIN28B influence growth in height from birth to adulthood.
|
Am J Hum Genet
|
2010
|
1.37
|
51
|
Early growth and adult respiratory function in men and women followed from the fetal period to adulthood.
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Thorax
|
2006
|
1.36
|
52
|
Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts.
|
PLoS One
|
2012
|
1.35
|
53
|
Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 Birth Cohort study.
|
Eur Heart J
|
2008
|
1.32
|
54
|
Risks of overweight and abdominal obesity at age 16 years associated with prenatal exposures to maternal prepregnancy overweight and gestational diabetes mellitus.
|
Diabetes Care
|
2010
|
1.30
|
55
|
Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study.
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J Clin Endocrinol Metab
|
2004
|
1.30
|
56
|
The effect of freezing, thawing, and short- and long-term storage on serum thyrotropin, thyroid hormones, and thyroid autoantibodies: implications for analyzing samples stored in serum banks.
|
Clin Chem
|
2007
|
1.29
|
57
|
Manifestations of metabolic syndrome after hypertensive pregnancy.
|
Hypertension
|
2004
|
1.26
|
58
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Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study.
|
Am J Epidemiol
|
2010
|
1.26
|
59
|
Adolescent manifestations of metabolic syndrome among children born to women with gestational diabetes in a general-population birth cohort.
|
Am J Epidemiol
|
2009
|
1.26
|
60
|
Variations in prenatal sociodemographic factors associated with intellectual disability: a study of the 20-year interval between two birth cohorts in northern Finland.
|
Am J Epidemiol
|
2007
|
1.24
|
61
|
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
|
PLoS Genet
|
2012
|
1.23
|
62
|
Hormonal profile of women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study.
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J Clin Endocrinol Metab
|
2003
|
1.21
|
63
|
TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood.
|
Biol Psychiatry
|
2010
|
1.21
|
64
|
Gestational diabetes identifies women at risk for permanent type 1 and type 2 diabetes in fertile age: predictive role of autoantibodies.
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Diabetes Care
|
2006
|
1.16
|
65
|
Evidence of inbreeding depression on human height.
|
PLoS Genet
|
2012
|
1.16
|
66
|
Early pregnancy reference intervals of thyroid hormone concentrations in a thyroid antibody-negative pregnant population.
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Thyroid
|
2011
|
1.14
|
67
|
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample.
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PLoS One
|
2011
|
1.13
|
68
|
Comparison of metabolic and inflammatory outcomes in women who used oral contraceptives and the levonorgestrel-releasing intrauterine device in a general population.
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Am J Obstet Gynecol
|
2008
|
1.10
|
69
|
Pubertal timing and growth influences cardiometabolic risk factors in adult males and females.
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Diabetes Care
|
2012
|
1.04
|
70
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Associations between pre-pregnancy obesity and asthma symptoms in adolescents.
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J Epidemiol Community Health
|
2011
|
1.04
|
71
|
Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling.
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Am J Epidemiol
|
2010
|
1.02
|
72
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Prepregnancy overweight and gestational diabetes as determinants of subsequent diabetes and hypertension after 20-year follow-up.
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J Clin Endocrinol Metab
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2009
|
1.02
|
73
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Large-scale analysis of the relationship between CYP11A promoter variation, polycystic ovarian syndrome, and serum testosterone.
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J Clin Endocrinol Metab
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2004
|
1.01
|
74
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Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight.
|
Hum Mol Genet
|
2012
|
1.01
|
75
|
Does in utero exposure to synthetic glucocorticoids influence birthweight, head circumference and birth length? A systematic review of current evidence in humans.
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Paediatr Perinat Epidemiol
|
2010
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0.99
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76
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Low-grade, systemic inflammation in adolescents: association with early-life factors, gender, and lifestyle.
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Am J Epidemiol
|
2009
|
0.99
|
77
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Genetic variants of TSLP and asthma in an admixed urban population.
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PLoS One
|
2011
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0.98
|
78
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Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits.
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J Clin Endocrinol Metab
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2005
|
0.96
|
79
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Smoking and early pregnancy thyroid hormone and anti-thyroid antibody levels in euthyroid mothers of the Northern Finland Birth Cohort 1986.
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Thyroid
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2012
|
0.95
|
80
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Variation at the insulin gene VNTR (variable number tandem repeat) polymorphism and early growth: studies in a large Finnish birth cohort.
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Diabetes
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2004
|
0.91
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81
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European lactase persistence genotype shows evidence of association with increase in body mass index.
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Hum Mol Genet
|
2009
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0.91
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82
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Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents.
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Addict Biol
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2010
|
0.90
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83
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Offspring's blood pressure and metabolic phenotype after exposure to gestational hypertension in utero.
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Eur J Epidemiol
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2013
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0.90
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84
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Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity.
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PLoS One
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2013
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0.88
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85
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Mothers and daughters: intergenerational patterns of reproduction.
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Eur J Public Health
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2005
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0.88
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86
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Phenotype mining in CNV carriers from a population cohort.
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Hum Mol Genet
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2011
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0.87
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87
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Analyzing atopic and non-atopic asthma.
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Eur J Epidemiol
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2012
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0.87
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88
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Full-length visfatin levels are associated with inflammation in women with polycystic ovary syndrome.
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Eur J Clin Invest
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2011
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0.87
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89
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The course of pregnancy and delivery and the use of maternal healthcare services after standard IVF in Northern Finland 1990-1995.
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Hum Reprod
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2002
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0.86
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90
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Early-life origins of schizotypal traits in adulthood.
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Br J Psychiatry
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2009
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0.85
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91
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Deviant intrauterine growth and risk of schizophrenia: a 34-year follow-up of the Northern Finland 1966 Birth Cohort.
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Schizophr Res
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2010
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0.83
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92
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The impact of gestational thyroid hormone concentrations on ADHD symptoms of the child.
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J Clin Endocrinol Metab
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2013
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0.83
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93
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Weight at birth and infancy in relation to adult leukocyte count: a population-based study of 5619 men and women followed from the fetal period to adulthood.
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J Clin Endocrinol Metab
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2009
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0.83
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94
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Detailed analysis of variation at and around mitochondrial position 16189 in a large Finnish cohort reveals no significant associations with early growth or metabolic phenotypes at age 31 years.
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J Clin Endocrinol Metab
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2007
|
0.83
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95
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Post-neonatal hospitalization and health care costs among IVF children: a 7-year follow-up study.
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Hum Reprod
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2007
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0.82
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96
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Maternal Hb during pregnancy and offspring's educational achievement: a prospective cohort study over 30 years.
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Br J Nutr
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2010
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0.82
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97
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Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels.
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Eur J Hum Genet
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2007
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0.81
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98
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Maternal serum Chlamydia pneumoniae antibodies and CRP levels in women with preeclampsia and gestational hypertension.
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Hypertens Pregnancy
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2008
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0.80
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99
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Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traits.
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Circ Cardiovasc Genet
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2012
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0.79
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100
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Are recurrent pregnancies a risk in Type 1 diabetes?
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Acta Obstet Gynecol Scand
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2002
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0.79
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101
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Serum C-reactive protein and Chlamydia trachomatis antibodies in preterm delivery.
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Obstet Gynecol
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2005
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0.79
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102
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Temporal changes in incidence and prevalence of intellectual disability between two birth cohorts in Northern Finland.
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Am J Ment Retard
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2003
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0.78
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103
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High-dose vitamin D supplements are not associated with linear growth in a large Finnish cohort.
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J Nutr
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2011
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0.78
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104
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Infant locomotive development and its association with adult blood pressure.
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Eur J Pediatr
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2014
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0.77
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105
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Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response.
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PLoS One
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2013
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0.77
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106
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False discovery rate estimation for stability selection: application to genome-wide association studies.
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Stat Appl Genet Mol Biol
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2011
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0.77
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107
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Preeclampsia, gestational hypertension and subsequent hypothyroidism.
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Pregnancy Hypertens
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2012
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0.77
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108
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Placental size is associated with mental health in children and adolescents.
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PLoS One
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2012
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0.77
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109
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Maternal thyroid dysfunction during pregnancy and thyroid function of her child in adolescence.
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J Clin Endocrinol Metab
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2013
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0.77
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110
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Maternal hypertensive disorders during pregnancy and mild cognitive limitations in the offspring.
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Paediatr Perinat Epidemiol
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2012
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0.77
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111
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Etiological survey on intellectual disability in the northern Finland birth cohort 1986.
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Am J Ment Retard
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2005
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0.76
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112
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The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size.
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PLoS One
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2012
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0.76
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113
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Metabolic and reproductive characteristics of first-degree relatives of women with self-reported oligo-amenorrhoea and hirsutism.
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Gynecol Endocrinol
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2010
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0.75
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114
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Body size and violent offending among males in the Northern Finland 1966 birth cohort.
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Soc Psychiatry Psychiatr Epidemiol
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2007
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0.75
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