Published in Antioxid Redox Signal on February 11, 2005
Radical-free biology of oxidative stress. Am J Physiol Cell Physiol (2008) 4.33
Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med (2008) 3.38
Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid Redox Signal (2008) 2.67
Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci U S A (2006) 2.51
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A (2007) 2.11
Thiol-based redox switches in eukaryotic proteins. Antioxid Redox Signal (2009) 1.97
Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status. J Biol Chem (2007) 1.92
Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress. J Biol Chem (2008) 1.91
Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med (2009) 1.61
Gene expression profiling reveals a signaling role of glutathione in redox regulation. Proc Natl Acad Sci U S A (2005) 1.57
Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A (2010) 1.53
Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase. J Biol Chem (2010) 1.52
Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation. Antioxid Redox Signal (2009) 1.50
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48
Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling. Oncogene (2008) 1.31
Posttranslational modification of cysteine in redox signaling and oxidative stress: Focus on s-glutathionylation. Antioxid Redox Signal (2012) 1.30
Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response. Cancer Res (2009) 1.27
Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases. Mol Cells (2008) 1.26
Both Php4 function and subcellular localization are regulated by iron via a multistep mechanism involving the glutaredoxin Grx4 and the exportin Crm1. J Biol Chem (2009) 1.26
Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia. Free Radic Biol Med (2007) 1.25
Modulation of glutaredoxin-1 expression in a mouse model of allergic airway disease. Am J Respir Cell Mol Biol (2006) 1.25
Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. J Biol Chem (2009) 1.25
The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function. Mol Cell Biol (2006) 1.25
S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling. Endocrinology (2008) 1.23
Redox regulatory mechanisms in cellular stress responses. Ann Bot (2006) 1.22
Protein-thiol oxidation and cell death: regulatory role of glutaredoxins. Antioxid Redox Signal (2012) 1.20
Cysteine oxidative posttranslational modifications: emerging regulation in the cardiovascular system. Circ Res (2013) 1.19
Dysregulation of glutathione homeostasis in neurodegenerative diseases. Nutrients (2012) 1.18
Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils. Immunity (2012) 1.17
The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase. J Biol Chem (2006) 1.15
Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid Redox Signal (2010) 1.13
Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment. Am J Hum Genet (2010) 1.11
α-Ketoglutarate dehydrogenase: a mitochondrial redox sensor. Free Radic Res (2010) 1.10
Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles. Biochemistry (2008) 1.10
S-glutathionylation of the Na,K-ATPase catalytic α subunit is a determinant of the enzyme redox sensitivity. J Biol Chem (2012) 1.09
Protein glutathionylation in the regulation of peroxiredoxins: a family of thiol-specific peroxidases that function as antioxidants, molecular chaperones, and signal modulators. Antioxid Redox Signal (2012) 1.09
Reversible and irreversible protein glutathionylation: biological and clinical aspects. Expert Opin Drug Metab Toxicol (2011) 1.07
Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response. Oncogene (2008) 1.05
NADPH oxidase 4 mediates monocyte priming and accelerated chemotaxis induced by metabolic stress. Arterioscler Thromb Vasc Biol (2011) 1.05
CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. J Biol Chem (2009) 1.05
Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment. Proc Natl Acad Sci U S A (2012) 1.04
Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system. Antioxid Redox Signal (2012) 1.03
Glutathionylation of beta-actin via a cysteinyl sulfenic acid intermediary. BMC Biochem (2007) 1.02
S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function. J Biol Chem (2009) 1.02
Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death. Antioxid Redox Signal (2011) 1.01
Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells. J Biol Chem (2008) 1.00
Mechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylation. Antioxid Redox Signal (2012) 1.00
Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination. Mol Cell Endocrinol (2008) 1.00
S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFN beta pathway. EMBO J (2008) 0.99
Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal. Chem Res Toxicol (2009) 0.98
Protocols for the detection of s-glutathionylated and s-nitrosylated proteins in situ. Methods Enzymol (2010) 0.96
A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle. J Biol Chem (2013) 0.96
The redoxome: Proteomic analysis of cellular redox networks. Curr Opin Chem Biol (2010) 0.95
Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. Am J Physiol Lung Cell Mol Physiol (2010) 0.94
Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model. Free Radic Biol Med (2012) 0.94
Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking. Front Cell Neurosci (2015) 0.92
S-Glutathionyl quantification in the attomole range using glutaredoxin-3-catalyzed cysteine derivatization and capillary gel electrophoresis with laser-induced fluorescence detection. Anal Bioanal Chem (2011) 0.92
Glioma pathogenesis-related protein 1: tumor-suppressor activities and therapeutic potential. Yonsei Med J (2010) 0.92
Glutaredoxin-2 is required to control proton leak through uncoupling protein-3. J Biol Chem (2013) 0.92
In situ analysis of protein S-glutathionylation in lung tissue using glutaredoxin-1-catalyzed cysteine derivatization. Am J Pathol (2009) 0.92
An overview of mechanisms of redox signaling. J Mol Cell Cardiol (2014) 0.91
TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System. Antioxid Redox Signal (2015) 0.90
Glutathione synthesis and its role in redox signaling. Semin Cell Dev Biol (2012) 0.90
The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies. Pharmacol Ther (2010) 0.90
Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling. Free Radic Biol Med (2011) 0.90
Redox modulation of endothelial nitric oxide synthase by glutaredoxin-1 through reversible oxidative post-translational modification. Biochemistry (2013) 0.89
Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion. J Biol Chem (2012) 0.89
Protein S-glutathionylation enhances Ca2+-induced Ca2+ release via the IP3 receptor in cultured aortic endothelial cells. J Physiol (2012) 0.89
The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans. Toxicol Sci (2010) 0.88
The effect of oxidant and the non-oxidant alteration of cellular thiol concentration on the formation of protein mixed-disulfides in HEK 293 cells. PLoS One (2008) 0.88
S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity. J Mol Biol (2011) 0.86
Resin-assisted enrichment of thiols as a general strategy for proteomic profiling of cysteine-based reversible modifications. Nat Protoc (2013) 0.86
Attenuated cardiovascular hypertrophy and oxidant generation in response to angiotensin II infusion in glutaredoxin-1 knockout mice. Free Radic Biol Med (2010) 0.86
Glutathionylation of α-ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification. Free Radic Biol Med (2013) 0.86
Annexin A2: the importance of being redox sensitive. Int J Mol Sci (2013) 0.86
Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning. Adv Drug Deliv Rev (2009) 0.85
Pleiotropic functions of glutathione S-transferase P. Adv Cancer Res (2014) 0.84
Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease. Ann N Y Acad Sci (2010) 0.84
Glutaredoxin 2 (Grx2) gene deletion induces early onset of age-dependent cataracts in mice. J Biol Chem (2014) 0.83
Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease. Hum Mol Genet (2014) 0.83
Redox regulation in Bacillus subtilis: The bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-bacillithiolated OhrR and MetE. Antioxid Redox Signal (2014) 0.82
Role of glutaredoxin-mediated protein S-glutathionylation in cellular nitroglycerin tolerance. J Pharmacol Exp Ther (2009) 0.81
Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²⁺-induced apoptosis. Free Radic Biol Med (2014) 0.80
Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target? Br J Pharmacol (2014) 0.80
N-acetylcysteine reverses diastolic dysfunction and hypertrophy in familial hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol (2015) 0.80
S-glutathionylation in monocyte and macrophage (dys)function. Int J Mol Sci (2013) 0.80
Shotgun proteomic analysis of S-thiolation sites of guinea pig lens nuclear crystallins following oxidative stress in vivo. Mol Vis (2013) 0.79
N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFκB pathway. Biomed Pharmacother (2014) 0.79
Protein S-glutathionlyation links energy metabolism to redox signaling in mitochondria. Redox Biol (2015) 0.79
Formation and Reversibility of BiP Protein Cysteine Oxidation Facilitate Cell Survival during and post Oxidative Stress. J Biol Chem (2016) 0.79
The Redox System in C. elegans, a Phylogenetic Approach. J Toxicol (2012) 0.79
Reactive oxygen species as signaling molecules in neutrophil chemotaxis. Commun Integr Biol (2010) 0.79
Oxidative stress in mammalian cells impinges on the cysteines redox state of human XRCC3 protein and on its cellular localization. PLoS One (2013) 0.78
The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function. Front Physiol (2015) 0.78
An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly. Age (Dordr) (2015) 0.78
Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4. Redox Biol (2014) 0.77
Differential alkylation-based redox proteomics - Lessons learnt. Redox Biol (2015) 0.77
Protein cysteine oxidation in redox signaling: Caveats on sulfenic acid detection and quantification. Arch Biochem Biophys (2016) 0.77
Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress. Curr Opin Pharmacol (2007) 3.00
Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases. Arch Toxicol (2015) 2.04
Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. Proc Natl Acad Sci U S A (2004) 1.85
Oxidized messenger RNA induces translation errors. Proc Natl Acad Sci U S A (2006) 1.59
Free radicals and disease. Arch Biochem Biophys (2002) 1.54
Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation. Antioxid Redox Signal (2009) 1.50
Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB. J Biol Chem (2007) 1.44
Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Proc Natl Acad Sci U S A (2006) 1.40
Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin. Proc Natl Acad Sci U S A (2003) 1.36
Posttranslational modification of cysteine in redox signaling and oxidative stress: Focus on s-glutathionylation. Antioxid Redox Signal (2012) 1.30
Implication of phosphatidylinositol 3-kinase membrane recruitment in hydrogen peroxide-induced activation of PI3K and Akt. Biochemistry (2003) 1.28
Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways. J Biol Chem (2006) 1.26
Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases. Mol Cells (2008) 1.26
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6. PLoS Pathog (2011) 1.26
Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia. Free Radic Biol Med (2007) 1.25
Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. J Biol Chem (2009) 1.25
Protein-thiol oxidation and cell death: regulatory role of glutaredoxins. Antioxid Redox Signal (2012) 1.20
Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy. J Biol Chem (2007) 1.19
Dysregulation of glutathione homeostasis in neurodegenerative diseases. Nutrients (2012) 1.18
Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2005) 1.13
Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status. Biochemistry (2003) 1.13
What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria? Antioxid Redox Signal (2007) 1.10
Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles. Biochemistry (2008) 1.10
Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction. J Biol Chem (2003) 1.10
Protein glutathionylation in the regulation of peroxiredoxins: a family of thiol-specific peroxidases that function as antioxidants, molecular chaperones, and signal modulators. Antioxid Redox Signal (2012) 1.09
Computational and mutational analysis of human glutaredoxin (thioltransferase): probing the molecular basis of the low pKa of cysteine 22 and its role in catalysis. Biochemistry (2006) 1.05
Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans. Am J Physiol Endocrinol Metab (2009) 1.05
Glutathionylation of peroxiredoxin I induces decamer to dimers dissociation with concomitant loss of chaperone activity. Biochemistry (2011) 1.02
The roles of thioredoxin in protection against oxidative stress-induced apoptosis in SH-SY5Y cells. J Biol Chem (2001) 1.01
Testis brain ribonucleic acid-binding protein/translin possesses both single-stranded and double-stranded ribonuclease activities. Biochemistry (2004) 1.01
Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells. J Biol Chem (2008) 1.00
Mechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylation. Antioxid Redox Signal (2012) 1.00
Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxin. Free Radic Biol Med (2006) 1.00
Novel protective mechanism against irreversible hyperoxidation of peroxiredoxin: Nalpha-terminal acetylation of human peroxiredoxin II. J Biol Chem (2009) 1.00
Polyubiquitylation of PARP-1 through ubiquitin K48 is modulated by activated DNA, NAD+, and dipeptides. J Cell Biochem (2008) 0.98
Cyclic GMP-dependent protein kinase regulates the expression of thioredoxin and thioredoxin peroxidase-1 during hormesis in response to oxidative stress-induced apoptosis. J Biol Chem (2002) 0.98
Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal. Chem Res Toxicol (2009) 0.98
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. Arch Biochem Biophys (2006) 0.98
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Hum Mol Genet (2012) 0.94
Induction of thioredoxin and mitochondrial survival proteins mediates preconditioning-induced cardioprotection and neuroprotection. Ann N Y Acad Sci (2005) 0.93
FAT10 modifies p53 and upregulates its transcriptional activity. Arch Biochem Biophys (2011) 0.92
Radiation response of cells during altered protein thiol redox. Radiat Res (2003) 0.92
Manganese(II) induces apoptotic cell death in NIH3T3 cells via a caspase-12-dependent pathway. J Biol Chem (2002) 0.91
Levodopa deactivates enzymes that regulate thiol-disulfide homeostasis and promotes neuronal cell death: implications for therapy of Parkinson's disease. Biochemistry (2010) 0.91
Biotin-ubiquitin tagging of mammalian proteins in Escherichia coli. Protein Expr Purif (2003) 0.90
Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging. Antioxid Redox Signal (2010) 0.89
Selective inactivation of glutaredoxin by sporidesmin and other epidithiopiperazinediones. Biochemistry (2006) 0.88
A novel thiol oxidation-based mechanism for adriamycin-induced cell injury in human macrophages. FASEB J (2005) 0.88
Preconditioning-mediated neuroprotection: role of nitric oxide, cGMP, and new protein expression. Ann N Y Acad Sci (2002) 0.85
Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease. Chem Res Toxicol (2011) 0.84
Structural insights into the catalytic mechanism of Escherichia coli selenophosphate synthetase. J Bacteriol (2011) 0.84
Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells. J Biol Chem (2012) 0.83
Multimethylation of Rickettsia OmpB catalyzed by lysine methyltransferases. J Biol Chem (2014) 0.83
Pasteurella multocida toxin (PMT) upregulates CTGF which leads to mTORC1 activation in Swiss 3T3 cells. Cell Signal (2013) 0.83
Role of vicinal protein thiols in radiation and cytotoxic responses. Radiat Res (2006) 0.83
Role of the redox protein thioredoxin in cytoprotective mechanism evoked by (-)-deprenyl. Mol Pharmacol (2005) 0.82
Molecular cloning and characterization of murine caspase-12 gene promoter. Proc Natl Acad Sci U S A (2005) 0.81
Effect of CCS on the accumulation of FALS SOD1 mutant-containing aggregates and on mitochondrial translocation of SOD1 mutants: implication of a free radical hypothesis. Arch Biochem Biophys (2011) 0.80
Effect of bicarbonate on iron-mediated oxidation of low-density lipoprotein. Proc Natl Acad Sci U S A (2005) 0.80
Tyrosine phosphatase CD45 regulates hydrogen peroxide-induced calcium mobilization in B cells. Antioxid Redox Signal (2002) 0.80
SUMOylation of DLX3 by SUMO1 promotes its transcriptional activity. J Cell Biochem (2011) 0.79
Roles of thioredoxin in nitric oxide-dependent preconditioning-induced tolerance against MPTP neurotoxin. Toxicol Appl Pharmacol (2005) 0.78