Published in J Biol Chem on April 27, 2007
Radical-free biology of oxidative stress. Am J Physiol Cell Physiol (2008) 4.33
Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid Redox Signal (2008) 2.67
Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal (2011) 1.82
Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation. Antioxid Redox Signal (2009) 1.50
S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal (2011) 1.49
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48
Causes and consequences of cysteine S-glutathionylation. J Biol Chem (2013) 1.43
Cysteine 111 affects aggregation and cytotoxicity of mutant Cu,Zn-superoxide dismutase associated with familial amyotrophic lateral sclerosis. J Biol Chem (2007) 1.40
Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases. Mol Cells (2008) 1.26
Oxidative stress, redox signaling, and autophagy: cell death versus survival. Antioxid Redox Signal (2014) 1.25
Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. J Clin Invest (2010) 1.22
The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer. Free Radic Biol Med (2011) 1.22
Protein-thiol oxidation and cell death: regulatory role of glutaredoxins. Antioxid Redox Signal (2012) 1.20
Manganese porphyrin, MnTE-2-PyP5+, Acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells. Free Radic Biol Med (2012) 1.12
Redox metabolism and malignancy. Curr Opin Pharmacol (2010) 1.10
Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles. Biochemistry (2008) 1.10
Ablation of glutaredoxin-1 attenuates lipopolysaccharide-induced lung inflammation and alveolar macrophage activation. Am J Respir Cell Mol Biol (2010) 1.10
Reversible and irreversible protein glutathionylation: biological and clinical aspects. Expert Opin Drug Metab Toxicol (2011) 1.07
Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system. Antioxid Redox Signal (2012) 1.03
Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal (2012) 1.01
Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death. Antioxid Redox Signal (2011) 1.01
Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells. J Biol Chem (2008) 1.00
Mechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylation. Antioxid Redox Signal (2012) 1.00
Protein S-glutathiolation: redox-sensitive regulation of protein function. J Mol Cell Cardiol (2011) 0.99
Glutathione efflux and cell death. Antioxid Redox Signal (2012) 0.98
Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. Am J Physiol Lung Cell Mol Physiol (2010) 0.94
S-glutathionylation regulates inflammatory activities of S100A9. J Biol Chem (2010) 0.93
Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival. J Neural Transm (Vienna) (2009) 0.92
Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli. J Bacteriol (2009) 0.91
Levodopa deactivates enzymes that regulate thiol-disulfide homeostasis and promotes neuronal cell death: implications for therapy of Parkinson's disease. Biochemistry (2010) 0.91
Glutathione synthesis and its role in redox signaling. Semin Cell Dev Biol (2012) 0.90
TAK1 targeting by glucocorticoids determines JNK and IkappaB regulation in Toll-like receptor-stimulated macrophages. Blood (2010) 0.90
Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling. Free Radic Biol Med (2011) 0.90
Redox modulation of endothelial nitric oxide synthase by glutaredoxin-1 through reversible oxidative post-translational modification. Biochemistry (2013) 0.89
Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging. Antioxid Redox Signal (2010) 0.89
Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation. PLoS One (2010) 0.89
Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kappa B activity in leukemic cells. Mol Biosyst (2011) 0.89
Glutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularization. J Biol Chem (2014) 0.88
Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease. Am J Physiol Lung Cell Mol Physiol (2012) 0.85
Reduced glutathione: a radioprotector or a modulator of DNA-repair activity? Nutrients (2013) 0.85
Glutaredoxin 1 protects dopaminergic cells by increased protein glutathionylation in experimental Parkinson's disease. Antioxid Redox Signal (2012) 0.85
Beta-mecaptoethanol suppresses inflammation and induces adipogenic differentiation in 3T3-F442A murine preadipocytes. PLoS One (2012) 0.85
Targeting the redox balance in inflammatory skin conditions. Int J Mol Sci (2013) 0.84
Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease. Chem Res Toxicol (2011) 0.84
Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology. Sci Rep (2015) 0.84
Protein glutathionylation in cardiovascular diseases. Int J Mol Sci (2013) 0.83
Glutaredoxin-1 overexpression enhances neovascularization and diminishes ventricular remodeling in chronic myocardial infarction. PLoS One (2012) 0.82
Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²⁺-induced apoptosis. Free Radic Biol Med (2014) 0.80
N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFκB pathway. Biomed Pharmacother (2014) 0.79
Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway. Biochem Soc Trans (2014) 0.77
The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor κB family proteins. Free Radic Biol Med (2014) 0.77
The N-Terminus of the Floral Arabidopsis TGA Transcription Factor PERIANTHIA Mediates Redox-Sensitive DNA-Binding. PLoS One (2016) 0.77
Temporal changes in glutaredoxin 1 and protein s-glutathionylation in allergic airway inflammation. PLoS One (2015) 0.76
Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease. Biochemistry (2016) 0.76
Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol (2016) 0.76
Redox regulation of ischemic limb neovascularization - What we have learned from animal studies. Redox Biol (2017) 0.75
Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation. Oncotarget (2016) 0.75
Mitochondrial calcium and the permeability transition in cell death. Biochim Biophys Acta (2009) 3.10
Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress. Curr Opin Pharmacol (2007) 3.00
Glutaredoxin: role in reversible protein s-glutathionylation and regulation of redox signal transduction and protein translocation. Antioxid Redox Signal (2005) 2.48
Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases. Arch Toxicol (2015) 2.04
Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation. Antioxid Redox Signal (2009) 1.50
Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin. Proc Natl Acad Sci U S A (2003) 1.36
Fluorescence resonance energy transfer reveals a binding site of a photosensitizer for photodynamic therapy. Cancer Res (2003) 1.35
Structural factors and mechanisms underlying the improved photodynamic cell killing with silicon phthalocyanine photosensitizers directed to lysosomes versus mitochondria. Photochem Photobiol (2009) 1.31
Posttranslational modification of cysteine in redox signaling and oxidative stress: Focus on s-glutathionylation. Antioxid Redox Signal (2012) 1.30
Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases. Mol Cells (2008) 1.26
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6. PLoS Pathog (2011) 1.26
Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia. Free Radic Biol Med (2007) 1.25
Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. J Biol Chem (2009) 1.25
The pros and cons of apoptosis assays for use in the study of cells, tissues, and organs. Microsc Microanal (2002) 1.23
Protein-thiol oxidation and cell death: regulatory role of glutaredoxins. Antioxid Redox Signal (2012) 1.20
Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy. J Biol Chem (2007) 1.19
Dysregulation of glutathione homeostasis in neurodegenerative diseases. Nutrients (2012) 1.18
Domain-dependent photodamage to Bcl-2. A membrane anchorage region is needed to form the target of phthalocyanine photosensitization. J Biol Chem (2002) 1.17
Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei. FEBS Lett (2005) 1.15
Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status. Biochemistry (2003) 1.13
Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles. Biochemistry (2008) 1.10
What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria? Antioxid Redox Signal (2007) 1.10
Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction. J Biol Chem (2003) 1.10
Computational and mutational analysis of human glutaredoxin (thioltransferase): probing the molecular basis of the low pKa of cysteine 22 and its role in catalysis. Biochemistry (2006) 1.05
Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans. Am J Physiol Endocrinol Metab (2009) 1.05
N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts. J Biol Chem (2004) 1.02
Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis. Mol Endocrinol (2006) 1.02
Mechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylation. Antioxid Redox Signal (2012) 1.00
Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells. J Biol Chem (2008) 1.00
Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxin. Free Radic Biol Med (2006) 1.00
Promotion of photodynamic therapy-induced apoptosis by the mitochondrial protein Smac/DIABLO: dependence on Bax. Photochem Photobiol (2002) 0.98
Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal. Chem Res Toxicol (2009) 0.98
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Hum Mol Genet (2012) 0.94
Radiation response of cells during altered protein thiol redox. Radiat Res (2003) 0.92
Levodopa deactivates enzymes that regulate thiol-disulfide homeostasis and promotes neuronal cell death: implications for therapy of Parkinson's disease. Biochemistry (2010) 0.91
Lysosomal signaling enhances mitochondria-mediated photodynamic therapy in A431 cancer cells: role of iron. Photochem Photobiol (2012) 0.90
Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging. Antioxid Redox Signal (2010) 0.89
Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy. J Biol Chem (2012) 0.89
A novel thiol oxidation-based mechanism for adriamycin-induced cell injury in human macrophages. FASEB J (2005) 0.88
Selective inactivation of glutaredoxin by sporidesmin and other epidithiopiperazinediones. Biochemistry (2006) 0.88
A requirement for bid for induction of apoptosis by photodynamic therapy with a lysosome- but not a mitochondrion-targeted photosensitizer. Photochem Photobiol (2010) 0.87
Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain. Brain Res Mol Brain Res (2002) 0.86
Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease. Chem Res Toxicol (2011) 0.84
Toxicological consequences of differential regulation of cytochrome p450 isoforms in rat brain regions by phenobarbital. Arch Biochem Biophys (2002) 0.83
Role of vicinal protein thiols in radiation and cytotoxic responses. Radiat Res (2006) 0.83
Signaling From Lysosomes Enhances Mitochondria-Mediated Photodynamic Therapy In Cancer Cells. Proc SPIE Int Soc Opt Eng (2009) 0.81
Presence of splice variant forms of cytochrome P4502D1 in rat brain but not in liver. Brain Res Mol Brain Res (2005) 0.76