Published in Biochemistry on February 22, 2005
The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes. Proc Natl Acad Sci U S A (2006) 1.64
Electronic and nuclear magnetic resonance spectroscopic features of the 1',4'-iminopyrimidine tautomeric form of thiamin diphosphate, a novel intermediate on enzymes requiring this coenzyme. Biochemistry (2006) 1.08
Saturation mutagenesis of putative catalytic residues of benzoylformate decarboxylase provides a challenge to the accepted mechanism. Proc Natl Acad Sci U S A (2008) 0.95
Determination of pre-steady-state rate constants on the Escherichia coli pyruvate dehydrogenase complex reveals that loop movement controls the rate-limiting step. J Am Chem Soc (2012) 0.87
A thiamin-utilizing ribozyme decarboxylates a pyruvate-like substrate. Nat Chem (2013) 0.86
Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase. Biochemistry (2009) 0.81
Catalysis in Enzymatic Decarboxylations: Comparison of Selected Cofactor-dependent and Cofactor-independent Examples. ACS Catal (2013) 0.78
A prospective natural-history study of coronary atherosclerosis. N Engl J Med (2011) 10.66
Accuracy of ICD-9-CM codes for identifying cardiovascular and stroke risk factors. Med Care (2005) 7.73
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87
Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer. Clin Chem (2002) 4.42
A general multilevel SEM framework for assessing multilevel mediation. Psychol Methods (2010) 3.67
Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens. Cancer Prev Res (Phila) (2011) 3.33
Clostridium difficile--associated disease in a setting of endemicity: identification of novel risk factors. Clin Infect Dis (2007) 3.21
Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF). Am Heart J (2006) 3.05
A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer. Cancer Prev Res (Phila) (2011) 3.03
Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease. N Engl J Med (2015) 2.97
Structures from anomalous diffraction of native biological macromolecules. Science (2012) 2.83
Notch3 gene amplification in ovarian cancer. Cancer Res (2006) 2.66
Performance of the American College of Obstetricians and Gynecologists' ovarian tumor referral guidelines with a multivariate index assay. Obstet Gynecol (2011) 2.38
SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer. Clin Chem (2007) 2.38
A prospective, multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness. Cancer Epidemiol Biomarkers Prev (2010) 2.36
Selection of reliable reference genes for gene expression studies in peach using real-time PCR. BMC Mol Biol (2009) 2.35
Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions. J Clin Oncol (2004) 2.32
Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A (2003) 2.24
Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: sources of sample bias. Clin Chem (2007) 2.23
Clinical and economic outcomes of the electronic intensive care unit: results from two community hospitals. Crit Care Med (2010) 2.22
Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation. Blood (2010) 2.19
The effect of adverse housing and neighborhood conditions on the development of diabetes mellitus among middle-aged African Americans. Am J Epidemiol (2007) 2.17
Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood (2010) 2.15
Independent validation of candidate breast cancer serum biomarkers identified by mass spectrometry. Clin Chem (2005) 2.13
Long-term followup after laparoscopic radical nephrectomy. J Urol (2002) 2.07
Serum markers in patients with resectable pancreatic adenocarcinoma: macrophage inhibitory cytokine 1 versus CA19-9. Clin Cancer Res (2006) 1.93
Assessment of plasma DNA levels, allelic imbalance, and CA 125 as diagnostic tests for cancer. J Natl Cancer Inst (2002) 1.90
Pulmonary Lophomonas blattarum infection in patients with kidney allograft transplantation. Transpl Int (2006) 1.85
Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur J Immunol (2006) 1.84
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res (2006) 1.78
Identifying tumor origin using a gene expression-based classification map. Cancer Res (2003) 1.78
Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol (2006) 1.77
Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur J Immunol (2006) 1.75
The magnitude of fetal renal pelvic dilatation can identify obstructive postnatal hydronephrosis, and direct postnatal evaluation and management. J Urol (2006) 1.73
Proteomic approaches to tumor marker discovery. Arch Pathol Lab Med (2002) 1.72
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits. Nat Neurosci (2006) 1.70
Are racial disparities in pancreatic cancer explained by smoking and overweight/obesity? Cancer Epidemiol Biomarkers Prev (2009) 1.70
Hand-assisted laparoscopic vs. laparoscopic colorectal surgery: a multicenter, prospective, randomized trial. Dis Colon Rectum (2008) 1.67
Optimal vaccination strategies for 2009 pandemic H1N1 and seasonal influenza vaccines in humans. Vaccine (2010) 1.65
The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes. Proc Natl Acad Sci U S A (2006) 1.64
(E)-N'-(2,5-Dimethoxy-benzyl-idene)-2-(8-quinol-yloxy)acetohydrazide methanol solvate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.64
Combination therapy with desmopressin and an anticholinergic medication for nonresponders to desmopressin for monosymptomatic nocturnal enuresis: a randomized, double-blind, placebo-controlled trial. Pediatrics (2008) 1.64
Serum diagnosis of pancreatic adenocarcinoma using surface-enhanced laser desorption and ionization mass spectrometry. Clin Cancer Res (2004) 1.63
Differential dependency network analysis to identify condition-specific topological changes in biological networks. Bioinformatics (2008) 1.56
Region of interest reconstruction from truncated data in circular cone-beam CT. IEEE Trans Med Imaging (2006) 1.55
Characterization of renal allograft rejection by urinary proteomic analysis. Ann Surg (2003) 1.54
Enuresis is a common and persistent problem among children and young adults with sickle cell anemia. Urology (2008) 1.53
Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients. Aging Cell (2008) 1.52
Long-term results of an RTOG Phase II trial (00-19) of external-beam radiation therapy combined with permanent source brachytherapy for intermediate-risk clinically localized adenocarcinoma of the prostate. Int J Radiat Oncol Biol Phys (2012) 1.52
The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proc Natl Acad Sci U S A (2006) 1.51
Effect of hyperthyroidism on the hypercoagulable state and thromboembolic events in patients with atrial fibrillation. Cardiology (2014) 1.50
FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs. Mol Cell (2009) 1.49
The efficacy of oral midazolam for decreasing anxiety in children undergoing voiding cystourethrogram: a randomized, double-blind, placebo controlled study. J Urol (2011) 1.48
NMR analysis of covalent intermediates in thiamin diphosphate enzymes. Biochemistry (2003) 1.48
An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene (2005) 1.47
Matched pair analysis of shock wave lithotripsy effectiveness for comparison of lithotriptors. J Urol (2003) 1.47
Image reconstruction in peripheral and central regions-of-interest and data redundancy. Med Phys (2005) 1.46
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
Early detection of ovarian cancer: promise and reality. Cancer Treat Res (2002) 1.45
Quantification of fragments of human serum inter-alpha-trypsin inhibitor heavy chain 4 by a surface-enhanced laser desorption/ionization-based immunoassay. Clin Chem (2006) 1.45
The XIENCE nano everolimus eluting coronary stent system for the treatment of small coronary arteries: the SPIRIT Small Vessel trial. Catheter Cardiovasc Interv (2012) 1.44
Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. J Biol Chem (2006) 1.43
Tetrahedral intermediates in thiamin diphosphate-dependent decarboxylations exist as a 1',4'-imino tautomeric form of the coenzyme, unlike the michaelis complex or the free coenzyme. Biochemistry (2004) 1.42
Genome-wide analysis of the AP2/ERF gene family in Populus trichocarpa. Biochem Biophys Res Commun (2008) 1.42
Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China. Curr Eye Res (2005) 1.41
Socioeconomic, family, and pediatric practice factors that affect level of asthma control. Pediatrics (2009) 1.41
Effects of breast cancer surgery and surgical side effects on body image over time. Breast Cancer Res Treat (2010) 1.41
Prostate-specific antigen cutoff of 2.6 ng/mL for prostate cancer screening is associated with favorable pathologic tumor features. Urology (2002) 1.41
X-linked amelogenesis imperfecta may result from decreased formation of tyrosine rich amelogenin peptide (TRAP). Arch Oral Biol (2003) 1.40
Preliminary toxicity analysis of 3-dimensional conformal radiation therapy versus intensity modulated radiation therapy on the high-dose arm of the Radiation Therapy Oncology Group 0126 prostate cancer trial. Int J Radiat Oncol Biol Phys (2013) 1.40
Asymmetric somatic stem cells division plays a critical role in cell senescence. Med Hypotheses (2006) 1.38
MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways. Cancer Lett (2013) 1.38
Positional accuracy and geographic bias of four methods of geocoding in epidemiologic research. Ann Epidemiol (2007) 1.37
Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states. Biochemistry (2007) 1.37
Classification of cancer types by measuring variants of host response proteins using SELDI serum assays. Int J Cancer (2005) 1.35
Half-time image reconstruction in thermoacoustic tomography. IEEE Trans Med Imaging (2005) 1.34
Trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland china from 1979 to 2012. Int J Endocrinol (2013) 1.32
Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet (2009) 1.31
Effectiveness of a multivariate index assay in the preoperative assessment of ovarian tumors. Obstet Gynecol (2011) 1.30
Glycoproteomics for prostate cancer detection: changes in serum PSA glycosylation patterns. J Proteome Res (2009) 1.30
Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice. Circulation (2009) 1.30
Dual catalytic apparatus of the thiamin diphosphate coenzyme: acid-base via the 1',4'-iminopyrimidine tautomer along with its electrophilic role. J Am Chem Soc (2003) 1.29
Multi-crystal anomalous diffraction for low-resolution macromolecular phasing. Acta Crystallogr D Biol Crystallogr (2010) 1.29
In vitro susceptibilities of yeast species to fluconazole and voriconazole as determined by the 2010 National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) study. J Clin Microbiol (2012) 1.28
Response of Tomicus yunnanensis (Coleoptera: Scolytinae) to infested and uninfested Pinus yunnanensis bolts. J Econ Entomol (2010) 1.28
Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps. FEBS J (2009) 1.28
ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. Am J Physiol Renal Physiol (2006) 1.27
Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes. J Allergy Clin Immunol (2004) 1.27
Life expectancy and disparity: an international comparison of life table data. BMJ Open (2011) 1.27
Characterization of the H5N1 highly pathogenic avian influenza virus derived from wild pikas in China. J Virol (2009) 1.27
Tannin extracts from immature fruits of Terminalia chebula Fructus Retz. promote cutaneous wound healing in rats. BMC Complement Altern Med (2011) 1.26
Smoking relapse during the first year after treatment for early-stage non-small-cell lung cancer. Cancer Epidemiol Biomarkers Prev (2006) 1.26
Laparoscopic pyeloplasty for secondary ureteropelvic junction obstruction. J Urol (2003) 1.26
Novel structures and superconductivity of silane under pressure. Phys Rev Lett (2009) 1.25
Plaque composition and clinical outcomes in acute coronary syndrome patients with metabolic syndrome or diabetes. JACC Cardiovasc Imaging (2012) 1.24