Published in Mol Endocrinol on February 17, 2005
Human ATP-binding cassette (ABC) transporter family. Hum Genomics (2009) 1.61
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest (2014) 1.55
The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol (2006) 1.54
Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites. Mol Pharmacol (2007) 1.39
Bile salts of vertebrates: structural variation and possible evolutionary significance. J Lipid Res (2009) 1.37
Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds. Curr Drug Metab (2006) 1.32
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics. Pharmacogenomics (2008) 1.27
The importance of discerning shape in molecular pharmacology. Trends Pharmacol Sci (2009) 1.17
Functional evolution of the vitamin D and pregnane X receptors. BMC Evol Biol (2007) 1.17
Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). Nucl Recept (2005) 1.17
Evolution of pharmacologic specificity in the pregnane X receptor. BMC Evol Biol (2008) 1.14
Active nuclear receptors exhibit highly correlated AF-2 domain motions. PLoS Comput Biol (2008) 1.12
Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation. Curr Pharmacogenomics Person Med (2009) 1.10
Evolution of hormone signaling in elasmobranchs by exploitation of promiscuous receptors. Mol Biol Evol (2008) 1.09
Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists. Pharm Res (2009) 1.09
Evolution of the bile salt nuclear receptor FXR in vertebrates. J Lipid Res (2008) 1.08
Ligand specificity and evolution of liver X receptors. J Steroid Biochem Mol Biol (2008) 1.06
Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway. Physiol Biochem Zool (2010) 1.04
Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR. PLoS Comput Biol (2009) 1.01
Machine learning methods and docking for predicting human pregnane X receptor activation. Chem Res Toxicol (2008) 0.99
Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR. Mol Cell Endocrinol (2010) 0.97
Orphan nuclear receptors as targets for drug development. Pharm Res (2010) 0.97
Functional evolution of the pregnane X receptor. Expert Opin Drug Metab Toxicol (2006) 0.96
Intrinsic disorder in nuclear hormone receptors. J Proteome Res (2008) 0.92
The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. BMC Biochem (2011) 0.89
The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation. Drug Metab Dispos (2009) 0.87
Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites. BMC Evol Biol (2010) 0.87
Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR. World J Gastroenterol (2007) 0.85
Modulation of xenobiotic receptors by steroids. Molecules (2013) 0.82
Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio). Aquat Toxicol (2013) 0.80
Understanding nuclear receptors using computational methods. Drug Discov Today (2009) 0.80
Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database. Environ Health Perspect (2010) 0.80
Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons. Hum Genomics (2005) 0.79
Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish. Toxicol Sci (2014) 0.78
COMPLEX EVOLUTION OF BILE SALTS IN BIRDS. Auk (2010) 0.77
Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection. Drug Metab Dispos (2009) 0.77
Marine invertebrate xenobiotic-activated nuclear receptors: their application as sensor elements in high-throughput bioassays for marine bioactive compounds. Mar Drugs (2014) 0.77
Molecular adaptation and resilience of the insect's nuclear receptor USP. BMC Evol Biol (2012) 0.76
PXR variants: the impact on drug metabolism and therapeutic responses. Acta Pharm Sin B (2016) 0.75
MicroRNA-30c-1-3p is a silencer of the pregnane X receptor by targeting the 3'-untranslated region and alters the expression of its target gene cytochrome P450 3A4. Biochim Biophys Acta (2016) 0.75
Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Toxicol Appl Pharmacol (2015) 0.75
Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership. PLoS One (2016) 0.75
Annotation of the Nuclear Receptors in an Estuarine Fish species, Fundulus heteroclitus. Nucl Receptor Res (2017) 0.75
PAML: a program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci (1997) 45.07
Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics (2000) 14.84
The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins. Science (2002) 11.11
Statistical methods for detecting molecular adaptation. Trends Ecol Evol (2000) 10.10
Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science (2003) 9.20
Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Mol Biol Evol (1998) 8.74
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature (1998) 8.33
Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages. Mol Biol Evol (2002) 7.21
The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem (2003) 6.35
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell (1998) 5.97
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest (1998) 4.76
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A (2001) 4.58
SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev (1998) 4.19
Accuracy and power of the likelihood ratio test in detecting adaptive molecular evolution. Mol Biol Evol (2001) 4.03
Vitamin D receptor as an intestinal bile acid sensor. Science (2002) 3.64
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science (2001) 3.27
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A (1998) 3.24
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature (1998) 3.23
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem (2000) 3.23
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol (2002) 2.94
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A (2001) 2.83
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol (2000) 2.74
Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J Biol Chem (1991) 2.70
Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling. Science (2003) 2.49
Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. Proc Natl Acad Sci U S A (2001) 2.38
The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. Pharmacogenetics (2001) 2.29
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J Biol Chem (2003) 2.04
Comparative studies of bile salts, myxinol disulphate, the principal bile salt of hagfish (Myxinidae). Biochem J (1966) 1.81
Bile acid content of human serum. II. The binding of cholanic acids by human plasma proteins. J Clin Invest (1957) 1.71
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metab Dispos (2001) 1.70
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. Mol Endocrinol (2002) 1.67
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J Biol Chem (2001) 1.67
Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. Drug Metab Rev (2004) 1.64
Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems. Mol Biol Evol (2004) 1.58
Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. J Mol Biol (2003) 1.57
2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. Biochemistry (2003) 1.55
The sodium bile salt cotransport family SLC10. Pflugers Arch (2003) 1.50
Comparative studies of bile salts. Bile salts of the lamprey Petromyzon marinus L. Biochem J (1969) 1.42
The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem (2004) 1.38
Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome. Genome Res (2004) 1.38
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci U S A (2002) 1.28
The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily. Nucleic Acids Res (2003) 1.20
Hepatic levels of bile acids in end-stage chronic cholestatic liver disease. Clin Chim Acta (1996) 1.18
Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors. J Biol Chem (2002) 1.11
BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. Genes Dev (1998) 1.10
Ichthyotoxic ARF after fish gallbladder ingestion: a large case series from Vietnam. Am J Kidney Dis (2003) 1.07
Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teeth. Endocrinology (2003) 1.04
Structural insights into the promiscuity and function of the human pregnane X receptor. Curr Opin Drug Discov Devel (2002) 1.03
Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos (2003) 1.03
Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. Proc Natl Acad Sci U S A (2003) 1.01
Physicochemical and physiological properties of 5alpha-cyprinol sulfate, the toxic bile salt of cyprinid fish. J Lipid Res (2003) 0.99
Bile acid composition of bile from germ-free rabbits. Biochim Biophys Acta (1969) 0.98
Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression. Mol Pharmacol (2004) 0.96
Natural occurrence and chemical synthesis of bile alcohols, higher bile acids, and short side chain bile acids. Hiroshima J Med Sci (1994) 0.96
CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proc Natl Acad Sci U S A (2000) 0.95
Comparative binding of bile acids to serum lipoproteins and albumin. J Lipid Res (1993) 0.95
Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria. Gastroenterology (1999) 0.94
The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals. Nucl Recept (2004) 0.93
Metabolism of lithocholate in healthy man. III. Plasma disappearance of radioactivity after intravenous injection of labeled lithocholate and its derivatives. Gastroenterology (1975) 0.91
Urinary bile acid profile in children with inborn errors of bile acid metabolism and chronic cholestasis; screening technique using electrospray tandem mass-spectrometry (ES/MS/MS). Med Sci Monit (2003) 0.89
Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid. Hepatology (2000) 0.88
Biliary, fecal and plasma deoxycholic acid in rabbit, hamster, guinea pig, and rat: comparative study and implication in colon cancer. Biol Pharm Bull (2002) 0.83
Urinary bile alcohol profiles in healthy and cholestatic children. Clin Chim Acta (2001) 0.80
Short-term toxicity of grass carp bile powder, 5alpha-cyprinol and 5alpha-cyprinol sulfate in rats. Comp Biochem Physiol C Toxicol Pharmacol (2002) 0.79
Elevated bile acids in the plasma of laying hens fed rapeseed meal. Res Vet Sci (1985) 0.77
Significance of bile alcohol in urine of a patient with cholestasis: identification of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,26,27-pentol ( beta-cyprinol) and 5 beta-cholestane-3 alpha,7 alpha,12 alpha,26-tetrol (27-deoxy-5 beta-cyprinol). Chem Pharm Bull (Tokyo) (1984) 0.77
Reduced blood-to-tissue albumin movement after plasmapheresis. Shock (2003) 0.77
Urinary bile alcohol profile in infants with intrahepatic cholestasis: identification of 5beta-cholestane-3alpha,7alpha,24,25-tetrol. Acta Paediatr (1999) 0.76
Changes in circulating blood and plasma volume after hemoglobin-based oxygen carrier infusion and additional infusion of colloid solutions. Am J Ther (2002) 0.76
Genetic contribution to variable human CYP3A-mediated metabolism. Adv Drug Deliv Rev (2002) 3.73
Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther (2003) 1.94
Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism. Mol Pharmacol (2002) 1.91
The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nat Med (2003) 1.81
Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J Clin Invest (2006) 1.75
Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. Hepatology (2003) 1.51
Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. Pharmacogenetics (2003) 1.51
Expression of the pregnane X receptor in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein profile. Arterioscler Thromb Vasc Biol (2005) 1.49
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem (2004) 1.46
Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo. Clin Pharmacol Ther (2003) 1.42
PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators. Toxicol Appl Pharmacol (2004) 1.37
Bile salts of vertebrates: structural variation and possible evolutionary significance. J Lipid Res (2009) 1.37
Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5. Clin Pharmacol Ther (2005) 1.35
Human cecal bile acids: concentration and spectrum. Am J Physiol Gastrointest Liver Physiol (2007) 1.35
Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants. J Pharmacol Exp Ther (2007) 1.34
Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol (2005) 1.33
Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. Pharmacogenetics (2002) 1.30
Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology (2010) 1.26
Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients. J Pediatr Gastroenterol Nutr (2008) 1.21
Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences. J Pharmacol Exp Ther (2004) 1.18
Functional evolution of the vitamin D and pregnane X receptors. BMC Evol Biol (2007) 1.17
Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). Nucl Recept (2005) 1.17
Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons. Hum Mol Genet (2003) 1.16
Evolution of pharmacologic specificity in the pregnane X receptor. BMC Evol Biol (2008) 1.14
CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults. J Appl Physiol (1985) (2003) 1.11
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther (2002) 1.11
A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among related species. Cell Rep (2012) 1.10
A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta. Pharm Res (2002) 1.10
Accurate enzymatic measurement of fecal bile acids in patients with malabsorption. J Lab Clin Med (2003) 1.09
A phylogenetic survey of biliary lipids in vertebrates. J Lipid Res (2005) 1.08
Evolution of the bile salt nuclear receptor FXR in vertebrates. J Lipid Res (2008) 1.08
A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor. Drug Metab Dispos (2009) 1.07
Ligand specificity and evolution of liver X receptors. J Steroid Biochem Mol Biol (2008) 1.06
Genetic predictors of interindividual variability in hepatic CYP3A4 expression. J Pharmacol Exp Ther (2009) 1.05
Detection of Δ4-3-oxo-steroid 5β-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids. J Chromatogr B Analyt Technol Biomed Life Sci (2012) 1.05
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol (2002) 1.04
Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates. Mol Pharmacol (2002) 1.02
Single nucleotide polymorphisms of thrifty genes for energy metabolism: evolutionary origins and prospects for intervention to prevent obesity-related diseases. Biochem Biophys Res Commun (2002) 1.01
Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res (2003) 1.00
Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships. Am J Physiol Gastrointest Liver Physiol (2006) 0.99
Functional characterization of the promoter of human carbonyl reductase 1 (CBR1). Role of XRE elements in mediating the induction of CBR1 by ligands of the aryl hydrocarbon receptor. Mol Pharmacol (2007) 0.98
Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR. Mol Cell Endocrinol (2010) 0.97
Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors. Pharmacogenetics (2003) 0.95
A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression. Mol Endocrinol (2007) 0.94
The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation. Drug Metab Dispos (2007) 0.92
Ontogeny and sorafenib metabolism. Clin Cancer Res (2012) 0.92
Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity. Drug Metab Dispos (2005) 0.92
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Am J Physiol Gastrointest Liver Physiol (2012) 0.91
Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology (2005) 0.91
CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose. J Pharmacol Exp Ther (2009) 0.91
Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol (2012) 0.91
The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor. Am J Med Genet A (2012) 0.89
Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction. Mol Cell Proteomics (2011) 0.89
The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. BMC Biochem (2011) 0.89
Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation. Biochem Pharmacol (2012) 0.88
Induction of CYP3A4 by vinblastine: Role of the nuclear receptor NR1I2. Ann Pharmacother (2010) 0.88
Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1. Toxicol Appl Pharmacol (2013) 0.87
The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation. Drug Metab Dispos (2009) 0.87
PharmGKB summary: very important pharmacogene information for CYP3A5. Pharmacogenet Genomics (2012) 0.87
CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Drug Metab Dispos (2004) 0.86
Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s. Drug Metab Dispos (2013) 0.85
Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes. Pharmacogenet Genomics (2006) 0.84
Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells. Biochem Pharmacol (2012) 0.84
Exploration of CYP450 and drug transporter genotypes and correlations with nevirapine exposure in Malawians. Pharmacogenomics (2011) 0.84
Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen. Mol Pharmacol (2009) 0.84
Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1. Hepatology (2010) 0.83
Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents. Mol Pharmacol (2002) 0.83
Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier. Drug Metab Dispos (2013) 0.83
Etoposide pathway. Pharmacogenet Genomics (2009) 0.82
Identification of a novel bile acid in swans, tree ducks, and geese: 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid. J Lipid Res (2006) 0.81
Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15alpha-hydroxylithocholic acid. J Lipid Res (2007) 0.81
Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro. Aquat Toxicol (2010) 0.81
Gene-nutrient and gene-gene interactions of controlled folate intake by Japanese women. Biochem Biophys Res Commun (2004) 0.80
[A case of small-cell lung cancer effectively treated by bi-weekly administration of amrubicin]. Gan To Kagaku Ryoho (2006) 0.80
Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis. Hepatology (2011) 0.80
Potential bile acid metabolites. 25. Synthesis and chemical properties of stereoisomeric 3alpha,7alpha,16- and 3alpha,7alpha,15-trihydroxy-5beta-cholan-24-oic acids. Chem Pharm Bull (Tokyo) (2002) 0.80
Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability. Endocrinology (2014) 0.80
The effect of dietary prebiotics and probiotics on body weight, large intestine indices, and fecal bile acid profile in wild type and IL10-/- mice. PLoS One (2013) 0.80
Sex, age, and family differences in the chemical composition of owl monkey (Aotus nancymaae) subcaudal scent secretions. Am J Primatol (2008) 0.79
Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo[a]pyrene. Toxicol Lett (2012) 0.79
Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. Am J Physiol Gastrointest Liver Physiol (2013) 0.78
Chemical synthesis of (22E)-3 alpha,6 beta,7 beta-trihydroxy-5 beta-chol-22-en-24-oic acid and its taurine and glycine conjugates: a major bile acid in the rat. J Lipid Res (2003) 0.78
Bromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells. Jpn J Cancer Res (2002) 0.78
Treatment of irritable bowel syndrome-diarrhea with pancrealipase or colesevelam and association with steatorrhea. Pancreas (2009) 0.78
The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans. Drug Metab Dispos (2012) 0.77
Why do most human liver cytosol preparations lack xanthine oxidase activity? Drug Metab Dispos (2014) 0.77
Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: I. Expression and role of cytochromes P450. J Pharmacol Exp Ther (2006) 0.77