Published in Cancer Sci on February 01, 2005
Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50
Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med (2008) 8.77
Modulation of microRNA processing by p53. Nature (2009) 7.88
MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol (2009) 5.92
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med (2012) 5.46
Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proc Natl Acad Sci U S A (2008) 4.79
MicroRNAs in cancer. Annu Rev Pathol (2009) 4.47
Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. RNA (2007) 3.91
Retracted A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2009) 3.88
MiRNAs and cancer. Am J Pathol (2009) 3.42
Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. Am J Pathol (2006) 3.30
microRNA involvement in human cancer. Carcinogenesis (2012) 2.98
MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer (2012) 2.78
MicroRNA biogenesis pathways in cancer. Nat Rev Cancer (2015) 2.67
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms. Cell Commun Signal (2009) 2.27
MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol Immunol (2007) 2.24
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A (2011) 2.21
Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Clin Cancer Res (2008) 2.11
MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis. J Cancer Res Clin Oncol (2010) 2.05
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev (2010) 2.05
MicroRNA in lung cancer. Br J Cancer (2010) 1.97
Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1. Proc Natl Acad Sci U S A (2009) 1.94
Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo. Cell Death Differ (2009) 1.92
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. Nat Cell Biol (2012) 1.89
A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis. PLoS One (2011) 1.87
Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. Br J Cancer (2009) 1.85
microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Res (2010) 1.76
MicroRNAs in gene regulation: when the smallest governs it all. J Biomed Biotechnol (2006) 1.76
Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications. J Clin Invest (2007) 1.72
Aberrant regulation and function of microRNAs in cancer. Curr Biol (2014) 1.72
Dicer is regulated by cellular stresses and interferons. Mol Immunol (2008) 1.69
The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex. PLoS One (2010) 1.63
Characterization of Epstein-Barr virus miRNAome in nasopharyngeal carcinoma by deep sequencing. PLoS One (2010) 1.63
Integrated miRNA and mRNA expression profiling of the inflammatory breast cancer subtype. Br J Cancer (2010) 1.54
Causes and consequences of microRNA dysregulation. Cancer J (2012) 1.51
Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. Carcinogenesis (2010) 1.50
Systematic evaluation of three microRNA profiling platforms: microarray, beads array, and quantitative real-time PCR array. PLoS One (2011) 1.49
Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA (2009) 1.48
Mechanisms of control of microRNA biogenesis. J Biochem (2010) 1.48
miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol Cancer (2011) 1.46
Development of the human cancer microRNA network. Silence (2010) 1.43
Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC. Nat Commun (2012) 1.41
mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer. Genome Biol (2009) 1.34
Protein interactions and complexes in human microRNA biogenesis and function. Front Biosci (2008) 1.33
MicroRNAs: molecular features and role in cancer. Front Biosci (Landmark Ed) (2012) 1.32
Genetic variation in MicroRNA genes and risk of oral premalignant lesions. Mol Carcinog (2010) 1.32
Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells. Genes Chromosomes Cancer (2010) 1.27
Identification of rat lung-specific microRNAs by micoRNA microarray: valuable discoveries for the facilitation of lung research. BMC Genomics (2007) 1.27
Regulation of microRNA processing in development, differentiation and cancer. J Cell Mol Med (2008) 1.25
Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression. Virchows Arch (2008) 1.22
Dicer-independent, Ago2-mediated microRNA biogenesis in vertebrates. Cell Cycle (2010) 1.21
miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner. Mol Cancer (2011) 1.19
Up-regulated Dicer expression in patients with cutaneous melanoma. PLoS One (2011) 1.18
SNPing cancer in the bud: microRNA and microRNA-target site polymorphisms as diagnostic and prognostic biomarkers in cancer. Pharmacol Ther (2012) 1.18
MicroRNAs in the pathogenesis of Lung Cancer. J Thorac Oncol (2009) 1.17
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat Commun (2014) 1.17
MicroRNAs: key modulators of posttranscriptional gene expression. Gastroenterology (2008) 1.16
The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease. RNA (2013) 1.16
Absence of DICER in monocytes and its regulation by HIV-1. J Biol Chem (2010) 1.15
miRNA biogenesis: biological impact in the development of cancer. Cancer Biol Ther (2014) 1.13
The dicey role of Dicer: implications for RNAi therapy. Cancer Res (2010) 1.13
Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives. Cancer Manag Res (2014) 1.13
Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nat Commun (2014) 1.10
Therapeutic microRNA strategies in human cancer. AAPS J (2009) 1.10
MicroRNAs in mutagenesis, genomic instability, and DNA repair. Semin Oncol (2011) 1.09
Evidence for X-chromosomal schizophrenia associated with microRNA alterations. PLoS One (2009) 1.08
Impact of tiny miRNAs on cancers. World J Gastroenterol (2007) 1.08
Protein components of the microRNA pathway and human diseases. Methods Mol Biol (2009) 1.07
Sox4-mediated Dicer expression is critical for suppression of melanoma cell invasion. Oncogene (2012) 1.06
Dicer-independent processing of short hairpin RNAs. Nucleic Acids Res (2013) 1.06
Epigenetics, miRNAs, and human cancer: a new chapter in human gene regulation. Mamm Genome (2009) 1.05
Impaired MicroRNA Processing Facilitates Breast Cancer Cell Invasion by Upregulating Urokinase-Type Plasminogen Activator Expression. Genes Cancer (2011) 1.05
MetastamiRs: non-coding MicroRNAs driving cancer invasion and metastasis. Int J Mol Sci (2012) 1.04
Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs. Oncogene (2012) 1.04
A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis. Oncogene (2013) 1.04
miRNA Deregulation in Cancer Cells and the Tumor Microenvironment. Cancer Discov (2016) 1.03
Regulatory RNAs: future perspectives in diagnosis, prognosis, and individualized therapy. Methods Mol Biol (2007) 1.03
The roles of microRNAs in tumorigenesis and angiogenesis. Int J Physiol Pathophysiol Pharmacol (2010) 1.03
Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications. Genet Res Int (2012) 1.03
Repurposing metformin: an old drug with new tricks in its binding pockets. Biochem J (2015) 1.03
Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proc Natl Acad Sci U S A (2005) 1.02
Emerging roles of competing endogenous RNAs in cancer: insights from the regulation of PTEN. Mol Cell Biol (2013) 1.01
miRNAs in human cancer. Methods Mol Biol (2012) 1.01
Proteomic consequences of a single gene mutation in a colorectal cancer model. J Proteome Res (2011) 1.01
Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients. BMC Cancer (2011) 1.00
A precursor microRNA in a cancer cell nucleus: get me out of here! Cell Cycle (2011) 0.97
DICER1 expression and outcomes in endometrioid endometrial adenocarcinoma. Cancer (2010) 0.97
MicroRNA expression in lymphoid malignancies: new hope for diagnosis and therapy? J Cell Mol Med (2008) 0.97
Role of MicroRNAs in lung disease. Arch Bronconeumol (2012) 0.96
Investigation of miRNA biology by bioinformatic tools and impact of miRNAs in colorectal cancer--regulatory relationship of c-Myc and p53 with miRNAs. Cancer Inform (2007) 0.96
Involvement of microRNAs in lung cancer biology and therapy. Transl Res (2011) 0.96
MiRNAs, epigenetics, and cancer. Mamm Genome (2008) 0.96
Transcriptome and small RNA deep sequencing reveals deregulation of miRNA biogenesis in human glioma. J Pathol (2013) 0.96
Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer. Tumour Biol (2011) 0.96
Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of Play. Prostate Cancer (2013) 0.96
RNA-binding protein AUF1 represses Dicer expression. Nucleic Acids Res (2012) 0.96
Signaling by p38 MAPK stimulates nuclear localization of the microprocessor component p68 for processing of selected primary microRNAs. Sci Signal (2013) 0.94
Clinical and functional impact of TARBP2 over-expression in adrenocortical carcinoma. Endocr Relat Cancer (2013) 0.93
MicroRNA as tools and therapeutics in lung cancer. Respir Med (2015) 0.93
Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol (2013) 0.92
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science (2007) 32.68
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol (2009) 21.94
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol (2011) 21.49
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res (2004) 18.86
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res (2005) 10.46
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med (2010) 8.59
Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res (2004) 7.76
Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol (2005) 5.63
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat Med (2012) 4.90
Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res (2006) 4.62
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res (2008) 4.30
Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res (2005) 3.98
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Clinical spectrum of mediastinal cysts. Chest (2003) 3.69
Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci (2007) 3.52
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst (2002) 3.44
Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol (2013) 3.32
Encouragement to submit data of clinical response to EGFR-TKIs in patients with uncommon EGFR mutations. J Thorac Oncol (2012) 3.10
A prospective radiological study of thin-section computed tomography to predict pathological noninvasiveness in peripheral clinical IA lung cancer (Japan Clinical Oncology Group 0201). J Thorac Oncol (2011) 2.78
let-7 regulates Dicer expression and constitutes a negative feedback loop. Carcinogenesis (2008) 2.75
Diagnostic utility of EUS-guided FNA in patients with gastric submucosal tumors. Gastrointest Endosc (2010) 2.67
Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res (2007) 2.59
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res (2005) 2.48
Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer. FEBS J (2009) 2.42
International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary. Proc Am Thorac Soc (2011) 2.39
Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. J Clin Oncol (2006) 2.37
Heterogeneous distribution of EGFR mutations is extremely rare in lung adenocarcinoma. J Clin Oncol (2011) 2.34
Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenocarcinoma who showed initial good response to gefitinib. J Thorac Oncol (2009) 2.33
TTF-1 expression in pulmonary adenocarcinomas. Am J Surg Pathol (2002) 2.32
Predictors of survival in patients with bone metastasis of lung cancer. Clin Orthop Relat Res (2008) 2.30
Primary germ cell tumors in the mediastinum: a 50-year experience at a single Japanese institution. Cancer (2003) 2.27
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
MicroRNAs in biological processes and carcinogenesis. Carcinogenesis (2006) 2.14
Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res (2008) 2.08
Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib. J Thorac Oncol (2011) 2.07
Senile EBV+ B-cell lymphoproliferative disorders: a clinicopathologic study of 22 patients. Am J Surg Pathol (2003) 2.06
Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer. Clin Cancer Res (2010) 2.05
Reproducibility of histopathological diagnosis in poorly differentiated NSCLC: an international multiobserver study. J Thorac Oncol (2014) 2.04
Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proc Natl Acad Sci U S A (2011) 2.01
Diagnosis of lung cancer in small biopsies and cytology: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Arch Pathol Lab Med (2012) 1.98
An international interpretation study using the ALK IHC antibody D5F3 and a sensitive detection kit demonstrates high concordance between ALK IHC and ALK FISH and between evaluators. J Thorac Oncol (2014) 1.97
Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia. J Infect Chemother (2010) 1.92
Hepatocyte growth factor stimulates proliferation of respiratory epithelial cells during postpneumonectomy compensatory lung growth in mice. Am J Respir Cell Mol Biol (2002) 1.91
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet (2010) 1.90
Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction. J Clin Oncol (2004) 1.89
Epidermal growth factor receptor mutations in small cell lung cancer. Clin Cancer Res (2008) 1.88
Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis. Gastroenterology (2010) 1.86
Highly sensitive detection of EGFR T790M mutation using colony hybridization predicts favorable prognosis of patients with lung cancer harboring activating EGFR mutation. J Thorac Oncol (2012) 1.85
Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma. J Thorac Oncol (2009) 1.85
Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol (2009) 1.81
Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis. J Clin Oncol (2009) 1.78
Surgical resection for lung cancer with infiltration of the thoracic aorta. J Thorac Cardiovasc Surg (2005) 1.75
How long should small lung lesions of ground-glass opacity be followed? J Thorac Oncol (2013) 1.75