Published in Endocrinology on February 24, 2005
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev (2010) 1.44
Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci (2009) 1.35
Metabolic characteristics of long-lived mice. Front Genet (2012) 1.04
Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes. PLoS One (2011) 0.98
The intricate role of growth hormone in metabolism. Front Endocrinol (Lausanne) (2011) 0.89
Lifetime congenital isolated GH deficiency does not protect from the development of diabetes. Endocr Connect (2013) 0.82
Mouse models of growth hormone action and aging: a proteomic perspective. Proteomics (2012) 0.82
Age- and sex-associated plasma proteomic changes in growth hormone receptor gene-disrupted mice. J Gerontol A Biol Sci Med Sci (2011) 0.81
Preservation of blood glucose homeostasis in slow-senescing somatotrophism-deficient mice subjected to intermittent fasting begun at middle or old age. Age (Dordr) (2014) 0.79
Aging-related characteristics of growth hormone receptor/binding protein gene-disrupted mice. Age (Dordr) (2006) 0.79
Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging. Aging Cell (2014) 0.77
Glucose lowering effect of transgenic human insulin-like growth factor-I from rice: in vitro and in vivo studies. BMC Biotechnol (2011) 0.77
Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice. Am J Physiol Endocrinol Metab (2014) 0.77
Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence. Gerontology (2015) 0.76
The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies. Clin Proteomics (2017) 0.75
Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest (2002) 3.86
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology (2003) 3.59
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08
Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res (2004) 1.96
Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol Endocrinol Metab (2004) 1.92
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest (2004) 1.82
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm IGF Res (2008) 1.72
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem (2009) 1.69
Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One (2009) 1.67
Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors. Proc Natl Acad Sci U S A (2010) 1.62
Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol Endocrinol (2002) 1.61
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev (2010) 1.44
Basal area growth of sugar maple in relation to acid deposition, stand health, and soil nutrients. J Environ Qual (2002) 1.42
Reversal of experimental Laron Syndrome by xenotransplantation of microencapsulated porcine Sertoli cells. J Control Release (2012) 1.40
Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance. Diabetes (2007) 1.36
Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes. Diabetes (2004) 1.36
Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci (2009) 1.35
Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32
Differentially expressed proteins in the pancreas of diet-induced diabetic mice. Mol Cell Proteomics (2005) 1.28
Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids (2002) 1.25
Age-related changes in body composition of bovine growth hormone transgenic mice. Endocrinology (2008) 1.25
Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem Biophys Res Commun (2005) 1.20
Effect of growth hormone on susceptibility to diet-induced obesity. Endocrinology (2006) 1.18
Effects of liver-derived insulin-like growth factor I on bone metabolism in mice. J Bone Miner Res (2002) 1.18
Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: evidence from pubertal mouse models. J Bone Miner Res (2010) 1.13
Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol (2006) 1.13
Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation. Proc Natl Acad Sci U S A (2006) 1.12
The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol (2013) 1.11
Development of pure prolactin receptor antagonists. J Biol Chem (2003) 1.11
The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs). Age (Dordr) (2012) 1.10
The role of prolactin and growth hormone in mammary gland development. Mol Cell Endocrinol (2002) 1.09
Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats. J Neurochem (2009) 1.08
Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. Am J Physiol Endocrinol Metab (2005) 1.06
Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty. J Bone Miner Res (2007) 1.06
Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology (2014) 1.02
Dynamic regulation of estrogen receptor-alpha isoform expression in the mouse fallopian tube: mechanistic insight into estrogen-dependent production and secretion of insulin-like growth factors. Am J Physiol Endocrinol Metab (2007) 1.01
Growth hormone is required for ovarian follicular growth. Endocrinology (2002) 1.01
Analysis of mouse skin reveals proteins that are altered in a diet-induced diabetic state: a new method for detection of type 2 diabetes. Proteomics (2007) 1.01
Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice. Exp Biol Med (Maywood) (2003) 1.01
Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2005) 1.00
Heterogeneity among white adipose tissue depots in male C57BL/6J mice. Obesity (Silver Spring) (2011) 1.00
Growth hormone and adipose tissue: beyond the adipocyte. Growth Horm IGF Res (2011) 1.00
Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity. J Pharmacol Exp Ther (2011) 0.99
Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? J Endocrinol (2013) 0.99
Growth hormone receptor antagonists. Neuroendocrinology (2006) 0.97
Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle. J Gerontol A Biol Sci Med Sci (2007) 0.97
Role of growth hormone (GH) in liver regeneration. Endocrinology (2004) 0.97
Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res (2009) 0.96
Constitutive expression of peroxisome proliferator-activated receptor alpha-regulated genes in dwarf mice. Mol Pharmacol (2004) 0.96
Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse. Endocrinology (2005) 0.95
Age-related alterations in pituitary and testicular functions in long-lived growth hormone receptor gene-disrupted mice. Endocrinology (2007) 0.95
CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis. Comp Hepatol (2007) 0.95
Identification of the glomerular podocyte as a target for growth hormone action. Endocrinology (2007) 0.94
Novel serum biomarkers for erythropoietin use in humans: a proteomic approach. J Appl Physiol (1985) (2010) 0.94
Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice. Mech Ageing Dev (2009) 0.93
A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia, and significant resistance to experimental diabetes. Am J Physiol Endocrinol Metab (2008) 0.93
Puberty is delayed in male growth hormone receptor gene-disrupted mice. J Androl (2002) 0.93
RET proto-oncogene mutations are restricted to codons 634 and 918 in mainland Chinese families with MEN2A and MEN2B. Clin Endocrinol (Oxf) (2007) 0.92
Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice. Aging Cell (2011) 0.92
Soil solution and sugar maple response to NH(4)NO (3) additions in a base-poor northern hardwood forest of Québec, Canada. Environ Monit Assess (2008) 0.92
The aging population--is there a role for endocrine interventions? Growth Horm IGF Res (2008) 0.92
Plasma biomarkers of mouse aging. Age (Dordr) (2010) 0.90
Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon proliferation, differentiation and hormone sensitivity. J Endocrinol (2006) 0.90
Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1. J Ovarian Res (2012) 0.89
Growth without growth hormone receptor: estradiol is a major growth hormone-independent regulator of hepatic IGF-I synthesis. J Bone Miner Res (2005) 0.88
Age-dependent onset of liver-specific IGF-I gene deficiency and its persistence in old age: implications for postnatal growth and insulin resistance in LID mice. Am J Physiol Endocrinol Metab (2005) 0.88
Liver-derived insulin-like growth factor-I is involved in the regulation of blood pressure in mice. Endocrinology (2002) 0.88
Possible roles of reg family proteins in pancreatic islet cell growth. Endocr Metab Immune Disord Drug Targets (2008) 0.88
Plasma proteomic profiles of bovine growth hormone transgenic mice as they age. Transgenic Res (2011) 0.88
Perspective: proteomic approach to detect biomarkers of human growth hormone. Growth Horm IGF Res (2009) 0.88
Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice. Am J Physiol Endocrinol Metab (2006) 0.87
Increases of dissolved organic carbon in temperate and boreal lakes in Quebec, Canada. Environ Sci Pollut Res Int (2011) 0.87
Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency. Growth Horm IGF Res (2009) 0.87
Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling. Carcinogenesis (2006) 0.87
Adiposity profile in the dwarf rat: an unusually lean model of profound growth hormone deficiency. Am J Physiol Endocrinol Metab (2007) 0.86
Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas. Am J Physiol Endocrinol Metab (2006) 0.86
Clinical review 166: Growth hormone receptor antagonists. J Clin Endocrinol Metab (2004) 0.86
Growth hormone action in the developing neural retina: a proteomic analysis. Proteomics (2008) 0.86
GH receptor plays a major role in liver regeneration through the control of EGFR and ERK1/2 activation. Endocrinology (2011) 0.86
Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma. J Endocrinol (2006) 0.86
Serum proteome changes in acromegalic patients following transsphenoidal surgery: novel biomarkers of disease activity. Eur J Endocrinol (2010) 0.86
Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases. Biochem Biophys Res Commun (2010) 0.85
Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice. Age (Dordr) (2011) 0.85
Growth hormone signaling is necessary for lifespan extension by dietary methionine. Aging Cell (2014) 0.85
Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects. PLoS One (2012) 0.85
Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice. J Gerontol A Biol Sci Med Sci (2013) 0.84
Pancreatic islet-specific overexpression of Reg3β protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus. Am J Physiol Endocrinol Metab (2011) 0.84
Effects of growth hormone overexpression vs. growth hormone receptor gene disruption on mouse hindlimb muscle fiber type composition. Growth Horm IGF Res (2008) 0.84
Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice. Endocrinology (2014) 0.84
The cardiovascular phenotype of a mouse model of acromegaly. Growth Horm IGF Res (2009) 0.84
Effects of growth hormone and insulin-like growth factor I on muscle in mouse models of human growth disorders. Horm Res (2006) 0.84
Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet. Endocrinology (2014) 0.84