Published in Am J Physiol Endocrinol Metab on January 30, 2007
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev (2013) 1.50
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev (2010) 1.44
Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci (2009) 1.35
Growth hormone regulates the balance between bone formation and bone marrow adiposity. J Bone Miner Res (2010) 1.20
Overview of animal models of obesity. Curr Protoc Pharmacol (2012) 1.06
Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue. J Physiol (2009) 0.90
Does adiposity status influence femoral cortical strength in rodent models of growth hormone deficiency? Am J Physiol Endocrinol Metab (2008) 0.82
Disrupted mitochondrial function in the Opa3L122P mouse model for Costeff Syndrome impairs skeletal integrity. Hum Mol Genet (2016) 0.79
The effect of different patterns of growth hormone administration on the IGF axis and somatic and skeletal growth of the dwarf rat. Am J Physiol Endocrinol Metab (2009) 0.79
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology (2003) 3.59
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08
Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res (2004) 1.96
Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol Endocrinol Metab (2004) 1.92
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest (2004) 1.82
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm IGF Res (2008) 1.72
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem (2009) 1.69
Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One (2009) 1.67
Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors. Proc Natl Acad Sci U S A (2010) 1.62
Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol Endocrinol (2002) 1.61
Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology (2003) 1.60
The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. J Exp Med (2008) 1.45
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev (2010) 1.44
Reversal of experimental Laron Syndrome by xenotransplantation of microencapsulated porcine Sertoli cells. J Control Release (2012) 1.40
Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance. Diabetes (2007) 1.36
Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci (2009) 1.35
Insertional gene activation by lentiviral and gammaretroviral vectors. J Virol (2008) 1.35
Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32
Differentially expressed proteins in the pancreas of diet-induced diabetic mice. Mol Cell Proteomics (2005) 1.28
Human osteoblast precursors produce extracellular adenosine, which modulates their secretion of IL-6 and osteoprotegerin. J Bone Miner Res (2005) 1.27
Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids (2002) 1.25
Age-related changes in body composition of bovine growth hormone transgenic mice. Endocrinology (2008) 1.25
Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem Biophys Res Commun (2005) 1.20
Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes. J Bone Miner Res (2011) 1.19
Effect of growth hormone on susceptibility to diet-induced obesity. Endocrinology (2006) 1.18
Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention. Mol Endocrinol (2009) 1.14
Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: evidence from pubertal mouse models. J Bone Miner Res (2010) 1.13
Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol (2006) 1.13
Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation. Proc Natl Acad Sci U S A (2006) 1.12
Development of pure prolactin receptor antagonists. J Biol Chem (2003) 1.11
The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol (2013) 1.11
The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs). Age (Dordr) (2012) 1.10
The role of prolactin and growth hormone in mammary gland development. Mol Cell Endocrinol (2002) 1.09
Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. J Nutr (2002) 1.08
Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. Am J Physiol Endocrinol Metab (2005) 1.06
Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty. J Bone Miner Res (2007) 1.06
Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology (2014) 1.02
Analysis of mouse skin reveals proteins that are altered in a diet-induced diabetic state: a new method for detection of type 2 diabetes. Proteomics (2007) 1.01
Growth hormone is required for ovarian follicular growth. Endocrinology (2002) 1.01
Dynamic regulation of estrogen receptor-alpha isoform expression in the mouse fallopian tube: mechanistic insight into estrogen-dependent production and secretion of insulin-like growth factors. Am J Physiol Endocrinol Metab (2007) 1.01
Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice. Exp Biol Med (Maywood) (2003) 1.01
Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2005) 1.00
Heterogeneity among white adipose tissue depots in male C57BL/6J mice. Obesity (Silver Spring) (2011) 1.00
Growth hormone and adipose tissue: beyond the adipocyte. Growth Horm IGF Res (2011) 1.00
Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity. J Pharmacol Exp Ther (2011) 0.99
Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? J Endocrinol (2013) 0.99
Growth hormone receptor antagonists. Neuroendocrinology (2006) 0.97
Role of growth hormone (GH) in liver regeneration. Endocrinology (2004) 0.97
Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle. J Gerontol A Biol Sci Med Sci (2007) 0.97
Increased adipogenesis in bone marrow but decreased bone mineral density in mice devoid of thyroid hormone receptors. Bone (2005) 0.96
Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res (2009) 0.96
Constitutive expression of peroxisome proliferator-activated receptor alpha-regulated genes in dwarf mice. Mol Pharmacol (2004) 0.96
Low bone mineral density in men with chronic obstructive pulmonary disease. Respir Res (2011) 0.96
Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse. Endocrinology (2005) 0.95
Age-related alterations in pituitary and testicular functions in long-lived growth hormone receptor gene-disrupted mice. Endocrinology (2007) 0.95
CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis. Comp Hepatol (2007) 0.95
Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice. Endocrinology (2005) 0.94
Identification of the glomerular podocyte as a target for growth hormone action. Endocrinology (2007) 0.94
Novel serum biomarkers for erythropoietin use in humans: a proteomic approach. J Appl Physiol (1985) (2010) 0.94
Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice. Mech Ageing Dev (2009) 0.93
Puberty is delayed in male growth hormone receptor gene-disrupted mice. J Androl (2002) 0.93
Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice. Aging Cell (2011) 0.92
The aging population--is there a role for endocrine interventions? Growth Horm IGF Res (2008) 0.92
A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts. Am J Physiol Cell Physiol (2009) 0.92
Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays. J Med Chem (2005) 0.91
A novel long-range enhancer regulates postnatal expression of Zeb2: implications for Mowat-Wilson syndrome phenotypes. Hum Mol Genet (2012) 0.90
Plasma biomarkers of mouse aging. Age (Dordr) (2010) 0.90
Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon proliferation, differentiation and hormone sensitivity. J Endocrinol (2006) 0.90
Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1. J Ovarian Res (2012) 0.89
Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression. Physiol Genomics (2007) 0.88
Growth without growth hormone receptor: estradiol is a major growth hormone-independent regulator of hepatic IGF-I synthesis. J Bone Miner Res (2005) 0.88
Age-dependent maintenance of motor control and corticostriatal innervation by death receptor 3. J Neurosci (2010) 0.88
Plasma proteomic profiles of bovine growth hormone transgenic mice as they age. Transgenic Res (2011) 0.88
Perspective: proteomic approach to detect biomarkers of human growth hormone. Growth Horm IGF Res (2009) 0.88
Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice. Am J Physiol Endocrinol Metab (2006) 0.87
Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency. Growth Horm IGF Res (2009) 0.87
Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling. Carcinogenesis (2006) 0.87
Efficacy and safety of oxandrolone in growth hormone-treated girls with turner syndrome. J Clin Endocrinol Metab (2010) 0.86
Clinical review 166: Growth hormone receptor antagonists. J Clin Endocrinol Metab (2004) 0.86
Growth hormone action in the developing neural retina: a proteomic analysis. Proteomics (2008) 0.86
GH receptor plays a major role in liver regeneration through the control of EGFR and ERK1/2 activation. Endocrinology (2011) 0.86
Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma. J Endocrinol (2006) 0.86
Serum proteome changes in acromegalic patients following transsphenoidal surgery: novel biomarkers of disease activity. Eur J Endocrinol (2010) 0.86
Cardiovascular and musculskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency. Respir Res (2010) 0.86
Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases. Biochem Biophys Res Commun (2010) 0.85
An emerging role for adenosine and its receptors in bone homeostasis. Front Endocrinol (Lausanne) (2012) 0.85
Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice. Age (Dordr) (2011) 0.85