Published in Blood on March 01, 2005
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A (2006) 2.39
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood (2006) 1.41
G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation. Immunol Lett (2007) 1.33
Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. Blood (2008) 1.33
Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem (2010) 1.27
Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. J Exp Med (2010) 1.19
Mast cell chemotaxis - chemoattractants and signaling pathways. Front Immunol (2012) 1.07
The role of sphingosine-1-phosphate and its receptors in asthma. Drug News Perspect (2008) 0.97
Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions. PLoS One (2011) 0.94
Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model. Prostaglandins Other Lipid Mediat (2008) 0.92
IgE-dependent signaling as a therapeutic target for allergies. Trends Pharmacol Sci (2012) 0.92
An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival. BMC Cell Biol (2010) 0.90
Novel identified receptors on mast cells. Front Immunol (2012) 0.88
FcepsilonRI-mediated mast cell migration: signaling pathways and dependence on cytosolic free Ca2+ concentration. Cell Signal (2009) 0.88
Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond. Anticancer Agents Med Chem (2011) 0.88
High-resolution three-dimensional imaging of the rich membrane structures of bone marrow-derived mast cells. Ultramicroscopy (2008) 0.86
Growth Conditions and Cell Cycle Phase Modulate Phase Transition Temperatures in RBL-2H3 Derived Plasma Membrane Vesicles. PLoS One (2015) 0.86
Sphingosine-1-phosphate synthesis and functions in mast cells. Future Lipidol (2008) 0.84
Implication of sphingosin-1-phosphate in cardiovascular regulation. Front Biosci (Landmark Ed) (2016) 0.77
Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells. Neurochem Res (2014) 0.76
Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. J Immunol (2013) 0.76
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature (2004) 12.72
Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol (2003) 9.29
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science (2002) 8.63
The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem (2002) 6.96
Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer (2004) 5.63
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature (1996) 5.48
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol (2005) 5.10
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol (2004) 3.65
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature (1993) 3.58
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO J (2003) 2.93
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol (1999) 2.87
An oncogenic role of sphingosine kinase. Curr Biol (2000) 2.59
Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med (2004) 2.44
beta-arrestins: traffic cops of cell signaling. Curr Opin Cell Biol (2004) 2.40
Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res (2004) 2.15
Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. Nature (1996) 2.15
PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem (2002) 2.11
Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J Biol Chem (2001) 1.97
Lysophospholipid G protein-coupled receptors. J Biol Chem (2004) 1.88
Purification and characterization of rat kidney sphingosine kinase. J Biol Chem (1998) 1.76
Enzymatic measurement of sphingosine 1-phosphate. Anal Biochem (1999) 1.69
Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase. J Biol Chem (2000) 1.56
EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. FASEB J (2001) 1.55
Retracted Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. J Biol Chem (2002) 1.54
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J Neurochem (2001) 1.47
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem (2003) 1.47
The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering. J Exp Med (1999) 1.32
Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. J Biol Chem (2002) 1.28
Pleiotropic actions of sphingosine-1-phosphate. Prog Lipid Res (2003) 1.27
Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. Am J Physiol Cell Physiol (2004) 1.15
The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction. Semin Cell Dev Biol (2004) 1.13
Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. Cancer Res (1999) 1.09
Sphingosine 1-phosphate receptors. Prostaglandins Other Lipid Mediat (2001) 1.05
Quercetin sensitizes RBL-2H3 cells to polybasic mast cell secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway. J Immunol (1998) 0.93
Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes. J Leukoc Biol (2004) 0.90
Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol (2003) 9.29
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science (2009) 4.45
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev (2008) 3.80
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature (2010) 3.59
Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol (2005) 3.59
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell (2012) 3.24
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem (2004) 3.22
The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol (2011) 3.07
Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol (2011) 2.97
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol Ther (2008) 2.96
Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. Nature (2003) 2.77
Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies. Biochem J (2008) 2.71
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem (2005) 2.64
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim Biophys Acta (2006) 2.62
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta (2002) 2.53
Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med (2004) 2.44
Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem (2002) 2.42
Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol (2005) 2.39
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A (2006) 2.39
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem (2003) 2.36
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood (2008) 2.22
International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev (2010) 2.10
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci (2005) 2.07
Autocrine and paracrine roles of sphingosine-1-phosphate. Trends Endocrinol Metab (2007) 2.00
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett (2003) 1.98
Targeting SphK1 as a new strategy against cancer. Curr Drug Targets (2008) 1.91
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res (2007) 1.82
Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression. Hepatology (2015) 1.81
Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta (2009) 1.76
Functions of the multifaceted family of sphingosine kinases and some close relatives. J Biol Chem (2006) 1.76
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem (2010) 1.74
Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem (2002) 1.73
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res (2012) 1.71
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp Cell Res (2002) 1.69
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett (2005) 1.69
Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. J Biol Chem (2005) 1.67
Extracellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol (2010) 1.67
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov (2013) 1.66
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Development (2003) 1.57
Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ Res (2003) 1.54
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res (2009) 1.54
Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. J Biol Chem (2007) 1.54
OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells. Mol Pharmacol (2008) 1.52
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J Cell Biol (2002) 1.51
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J (2010) 1.49
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Mol Cancer Ther (2008) 1.48
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem (2003) 1.47
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem (2003) 1.47
Sphingosine-1-phosphate: dual messenger functions. FEBS Lett (2002) 1.44
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. FASEB J (2008) 1.43
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Res (2010) 1.43
Sphingosine kinases: a novel family of lipid kinases. Prog Nucleic Acid Res Mol Biol (2002) 1.43
Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med (2003) 1.42
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood (2006) 1.41
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. J Cell Biol (2005) 1.40