PubRank

Sheldon Milstien

Author PubWeight™ 140.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 2003 9.29
2 Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 2009 4.45
3 "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev 2008 3.80
4 Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 2010 3.59
5 Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 2012 3.24
6 The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol 2011 3.07
7 Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol 2011 2.97
8 SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem 2005 2.64
9 Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim Biophys Acta 2006 2.62
10 Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta 2002 2.53
11 Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med 2004 2.44
12 Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem 2002 2.42
13 Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol 2005 2.39
14 Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A 2006 2.39
15 Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem 2003 2.36
16 A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood 2008 2.22
17 Autocrine and paracrine roles of sphingosine-1-phosphate. Trends Endocrinol Metab 2007 2.00
18 The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett 2003 1.98
19 Targeting SphK1 as a new strategy against cancer. Curr Drug Targets 2008 1.91
20 Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res 2007 1.82
21 Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta 2009 1.76
22 Functions of the multifaceted family of sphingosine kinases and some close relatives. J Biol Chem 2006 1.76
23 Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem 2010 1.74
24 Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res 2012 1.71
25 Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp Cell Res 2002 1.69
26 Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett 2005 1.69
27 Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. J Biol Chem 2005 1.67
28 Extracellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol 2010 1.67
29 Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov 2013 1.66
30 Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res 2009 1.54
31 Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ Res 2003 1.54
32 Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. J Biol Chem 2007 1.54
33 Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J Cell Biol 2002 1.51
34 Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J 2010 1.49
35 Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem 2003 1.47
36 Sphingosine-1-phosphate: dual messenger functions. FEBS Lett 2002 1.44
37 Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. FASEB J 2008 1.43
38 Sphingosine kinases: a novel family of lipid kinases. Prog Nucleic Acid Res Mol Biol 2002 1.43
39 The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood 2006 1.41
40 A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. J Cell Biol 2005 1.40
41 The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Mol Cell Biol 2005 1.38
42 Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Res 2008 1.34
43 Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. Blood 2008 1.33
44 Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. J Lipid Res 2008 1.30
45 Generation and metabolism of bioactive sphingosine-1-phosphate. J Cell Biochem 2004 1.28
46 Pleiotropic actions of sphingosine-1-phosphate. Prog Lipid Res 2003 1.27
47 Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration. Mol Cell Biol 2008 1.22
48 Sphingosine-1-phosphate and lipid phosphohydrolases. Biochim Biophys Acta 2002 1.20
49 Sphingosine 1-phosphate signaling: providing cells with a sense of direction. Trends Cell Biol 2002 1.20
50 Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. J Biol Chem 2007 1.19
51 Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. J Exp Med 2010 1.19
52 A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. J Allergy Clin Immunol 2012 1.15
53 EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells. FASEB J 2007 1.11
54 Regulation and functions of sphingosine kinases in the brain. Biochim Biophys Acta 2008 1.11
55 Is tail vein injection a relevant breast cancer lung metastasis model? J Thorac Dis 2013 1.11
56 Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension. J Cell Biol 2004 1.10
57 Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. FASEB J 2012 1.09
58 Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells. J Biol Chem 2008 1.08
59 Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol Cell Biol 2006 1.07
60 Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. J Biol Chem 2004 1.06
61 Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Blood 2005 1.05
62 Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells. FEBS Lett 2007 1.04
63 Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacol Ther 2007 1.04
64 Characterization of murine sphingosine-1-phosphate phosphohydrolase. J Biol Chem 2001 1.04
65 A rapid and sensitive method to measure secretion of sphingosine-1-phosphate. Methods Enzymol 2007 1.04
66 An improved syngeneic orthotopic murine model of human breast cancer progression. Breast Cancer Res Treat 2014 1.03
67 Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. J Biol Chem 2002 1.01
68 The roles of sphingosine-1-phosphate in asthma. Mol Immunol 2002 1.01
69 Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor. Mol Pharmacol 2006 0.99
70 Aminoacylase 1 is a sphingosine kinase 1-interacting protein. FEBS Lett 2004 0.99
71 Development of small-molecule inhibitors of sphingosine-1-phosphate signaling. Pharmacol Ther 2011 0.98
72 Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells. J Biol Chem 2002 0.97
73 Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. Prostaglandins Other Lipid Mediat 2005 0.96
74 Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. J Neurochem 2009 0.94
75 Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription. FEBS Lett 2010 0.94
76 Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. J Neurosci Res 2002 0.93
77 Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. J Biol Chem 2011 0.93
78 Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness. Mol Cancer Res 2008 0.91
79 The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. Biochemistry 2003 0.90
80 Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. FASEB J 2009 0.89
81 Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo. Methods Enzymol 2007 0.87
82 Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone. FASEB J 2007 0.86
83 Targeting sphingosine-1-phosphate in hematologic malignancies. Anticancer Agents Med Chem 2011 0.85
84 Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. Circ Res 2007 0.85
85 Bacterial translocation up-regulates GTP-cyclohydrolase I in mesenteric vasculature of cirrhotic rats. Hepatology 2003 0.85
86 Sphingosine-1-phosphate synthesis and functions in mast cells. Future Lipidol 2008 0.84
87 The fate of intravenously administered tetrahydrobiopterin and its implications for heterologous gene therapy of phenylketonuria. Mol Genet Metab 2004 0.84
88 A specific ceramide kinase assay to measure cellular levels of ceramide. Anal Biochem 2003 0.83
89 The potential of histone deacetylase inhibitors in Niemann - Pick type C disease. FEBS J 2013 0.80
90 Modulation of adaptive immune responses by sphingosine-1-phosphate. Semin Cell Dev Biol 2004 0.80