Published in Lancet Infect Dis on March 01, 2005
Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS Pathog (2006) 3.04
From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet (2009) 2.98
Aspects of immune dysfunction in end-stage renal disease. Clin J Am Soc Nephrol (2008) 2.44
Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev (2009) 2.30
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci U S A (2007) 2.28
Genetic variation in Toll-like receptors and disease susceptibility. Nat Immunol (2012) 2.09
Vaccine immunogenetics: bedside to bench to population. Vaccine (2008) 2.01
Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. Proc Natl Acad Sci U S A (2005) 1.95
Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS One (2007) 1.89
Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis. Arthritis Rheum (2012) 1.79
Functional consequences of toll-like receptor 4 polymorphisms. Mol Med (2008) 1.76
Host innate immune responses to sepsis. Virulence (2013) 1.66
Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results. Vaccine (2008) 1.60
Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better? Lancet Infect Dis (2006) 1.56
Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. Hum Genet (2009) 1.46
Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. Prostate (2009) 1.45
Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent. PLoS One (2015) 1.43
Toll-like receptor responses to Peste des petits ruminants virus in goats and water buffalo. PLoS One (2014) 1.39
Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus. Cell Host Microbe (2008) 1.35
Adaptation and constraint at Toll-like receptors in primates. Mol Biol Evol (2010) 1.34
Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer. BMC Cancer (2007) 1.30
Leprosy and the human genome. Microbiol Mol Biol Rev (2010) 1.27
Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies. Ann Rheum Dis (2007) 1.26
Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. J Infect Dis (2012) 1.23
An information-gain approach to detecting three-way epistatic interactions in genetic association studies. J Am Med Inform Assoc (2013) 1.19
Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice. J Immunol (2008) 1.16
The Toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-negative and haematogenous osteomyelitis. Clin Exp Immunol (2006) 1.15
Single nucleotide polymorphisms in toll-like receptor 6 are associated with altered lipopeptide- and mycobacteria-induced interleukin-6 secretion. Genes Immun (2010) 1.11
Biased distribution of single nucleotide polymorphisms (SNPs) in porcine Toll-like receptor 1 (TLR1), TLR2, TLR4, TLR5, and TLR6 genes. Immunogenetics (2006) 1.11
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis. Fibrogenesis Tissue Repair (2010) 1.09
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Crit Care (2010) 1.08
TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases. J Clin Immunol (2009) 1.08
The host genetic diversity in malaria infection. J Trop Med (2012) 1.08
Comparative genomics of Toll-like receptor signalling in five species. BMC Genomics (2009) 1.06
Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population. Crit Care (2011) 1.05
TLR4 polymorphisms and disease susceptibility. Inflamm Res (2012) 1.05
Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. BMC Med Genet (2009) 1.04
Genetic Susceptibility to Fungal Infections in Humans. Curr Fungal Infect Rep (2011) 1.04
Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection. J Hepatol (2009) 1.02
Host genetics of Bordetella pertussis infection in mice: significance of Toll-like receptor 4 in genetic susceptibility and pathobiology. Infect Immun (2006) 1.02
Polymorphisms within inflammatory genes and colorectal cancer. J Negat Results Biomed (2006) 0.98
Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE). BMC Evol Biol (2013) 0.98
Immunogenomics and systems biology of vaccines. Immunol Rev (2011) 0.97
Nasopharyngeal bacterial colonization and gene polymorphisms of mannose-binding lectin and toll-like receptors 2 and 4 in infants. PLoS One (2011) 0.96
Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients. Malar J (2011) 0.96
Immunogenetic factors associated with severe respiratory illness caused by zoonotic H1N1 and H5N1 influenza viruses. Clin Dev Immunol (2011) 0.96
Association of TLR4-T399I polymorphism with chronic obstructive pulmonary disease in smokers. Clin Dev Immunol (2010) 0.94
Polymorphisms at the innate immune receptor TLR2 are associated with Borrelia infection in a wild rodent population. Proc Biol Sci (2013) 0.94
Polymorphic allele of human MRC1 confer protection against tuberculosis in a Chinese population. Int J Biol Sci (2012) 0.94
The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes. PLoS One (2009) 0.93
International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol Rev (2015) 0.92
Molecular markers of susceptibility to ocular toxoplasmosis, host and guest behaving badly. Clin Ophthalmol (2008) 0.92
Mouse models for human otitis media. Brain Res (2009) 0.92
Frequency of TLR 2, 4, and 9 gene polymorphisms in Chinese population and their susceptibility to type 2 diabetes and coronary artery disease. J Biomed Biotechnol (2012) 0.91
Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon. PLoS One (2013) 0.91
Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. PLoS One (2008) 0.91
Mutational analysis of human CEACAM1: the potential of receptor polymorphism in increasing host susceptibility to bacterial infection. Cell Microbiol (2006) 0.91
Toll-like receptor-4 deficiency enhances repair of UVR-induced cutaneous DNA damage by nucleotide excision repair mechanism. J Invest Dermatol (2013) 0.90
Variation at innate immunity Toll-like receptor genes in a bottlenecked population of a New Zealand robin. PLoS One (2012) 0.90
Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation. Genes Dis (2014) 0.90
Toll-like receptor 4 gene (TLR4), but not TLR2, polymorphisms modify the risk of tonsillar disease due to Streptococcus pyogenes and Haemophilus influenzae. Clin Vaccine Immunol (2010) 0.89
TLR-2 Arg753Gln, TLR-4 Asp299Gly, and TLR-4 Thr399Ile polymorphisms in Henoch Schonlein purpura with and without renal involvement. Rheumatol Int (2009) 0.89
Severe sepsis and Toll-like receptors. Semin Immunopathol (2007) 0.89
A single nucleotide polymorphism in 3'-untranslated region contributes to the regulation of Toll-like receptor 4 translation. J Biol Chem (2012) 0.89
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases. Clin Exp Immunol (2015) 0.89
Polymorphism at position +896 of the toll-like receptor 4 gene interferes with rapid response to treatment in rheumatoid arthritis. Ann Rheum Dis (2006) 0.89
Genetic polymorphisms of TLR3 are associated with Nasopharyngeal carcinoma risk in Cantonese population. BMC Cancer (2007) 0.88
Association between Toll-like receptor 2 (TLR2) polymorphisms and asymptomatic bancroftian filariasis. Parasitol Res (2010) 0.88
An integrated epigenetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines. PLoS One (2008) 0.88
Identification of single nucleotide polymorphisms in bovine CARD15 and their associations with health and production traits in Canadian Holsteins. BMC Genomics (2007) 0.88
Disease and freeways drive genetic change in urban bobcat populations. Evol Appl (2014) 0.87
The role of TLR4 896 A>G and 1196 C>T in susceptibility to infections: a review and meta-analysis of genetic association studies. PLoS One (2013) 0.87
Toll-like receptor 9 polymorphisms are associated with severity variables in a cohort of meningococcal meningitis survivors. BMC Infect Dis (2012) 0.87
Polymorphisms in pattern recognition receptors and their relationship to infectious disease susceptibility in pigs. BMC Proc (2011) 0.87
Association of a common TLR-6 polymorphism with coronary artery disease - implications for healthy ageing? Immun Ageing (2013) 0.87
Gene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis. Front Microbiol (2014) 0.87
Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury. BMC Med Genet (2010) 0.86
TLR signaling modulates side effects of anticancer therapy in the small intestine. J Immunol (2015) 0.86
Malarial fever: hemozoin is involved but Toll-free. Proc Natl Acad Sci U S A (2007) 0.86
Systems biology applied to vaccine and immunotherapy development. BMC Syst Biol (2011) 0.85
Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents. J Reprod Immunol (2012) 0.85
Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling. J Clin Invest (2012) 0.84
Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study. Clin Vaccine Immunol (2007) 0.84
The emerging role of Toll-like receptor 4 in myocardial inflammation. Cell Death Dis (2016) 0.84
Effect of currently approved carriers and adjuvants on the pre-clinical efficacy of a conjugate vaccine against oxycodone in mice and rats. PLoS One (2014) 0.83
R753Q single-nucleotide polymorphism impairs toll-like receptor 2 recognition of hepatitis C virus core and nonstructural 3 proteins. Transplantation (2010) 0.83
Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients. PLoS One (2016) 0.83
Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population. BMC Med Genet (2015) 0.82
Novel mutations in TLR genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection. BMC Genet (2009) 0.82
Analysis of the interleukin-12/interferon-gamma pathway in children with non-tuberculous mycobacterial cervical lymphadenitis. Eur J Pediatr (2006) 0.82
Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment. Breast Cancer (Dove Med Press) (2013) 0.81
Prospective study of effect modification by Toll-like receptor 4 variation on the association between Trichomonas vaginalis serostatus and prostate cancer. Cancer Causes Control (2012) 0.81
[Acute rheumatic fever (ARF) and poststreptococcal reactive arthritis (PSRA)--an update]. Z Rheumatol (2005) 0.81
Toll-like receptor 4 (TLR4) and typhoid fever in Vietnam. PLoS One (2009) 0.80
Cytokine production in patients with cirrhosis and TLR4 polymorphisms. World J Gastroenterol (2014) 0.80
TLR polymorphisms in FMF: association of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly, Thre399Ile) polymorphisms and myeloid cell TLR-2 and TLR-4 expression with the development of secondary amyloidosis in FMF. Inflammation (2011) 0.80
Functional polymorphisms of TLR8 are associated with hepatitis C virus infection. Immunology (2014) 0.80
Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice. PLoS One (2011) 0.79
Functional polymorphisms in toll-like receptor 4 are associated with worse outcome in acute ischemic stroke patients. Neuroreport (2014) 0.79
TLR4 single nucleotide polymorphisms (SNPs) associated with Salmonella shedding in pigs. J Appl Genet (2014) 0.79
Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii. J Immunol (2006) 3.24
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci U S A (2007) 2.28
Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem (2004) 2.18
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J Immunol (2007) 2.14
Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One (2007) 2.05
Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. Proc Natl Acad Sci U S A (2005) 1.95
Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein. Immunity (2003) 1.81
High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. J Mol Med (Berl) (2003) 1.66
Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. J Immunol (2005) 1.49
Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy. J Infect Dis (2006) 1.43
Streptococcal M protein: a multipotent and powerful inducer of inflammation. J Immunol (2006) 1.36
Cytokine induction by purified lipoteichoic acids from various bacterial species--role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-gamma release. Eur J Immunol (2002) 1.34
The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes Infect (2006) 1.32
Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J Immunol (2004) 1.31
Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood. J Infect Dis (2003) 1.28
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A (2009) 1.25
Immune responses induced by spirochetal outer membrane lipoproteins and glycolipids. Immunobiology (2008) 1.23
Triptans reduce the inflammatory response in bacterial meningitis. J Cereb Blood Flow Metab (2002) 1.20
A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. AIDS (2009) 1.18
Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling. Infect Immun (2005) 1.15
Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. J Infect Dis (2009) 1.10
CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual. PLoS One (2008) 1.10
Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto. J Biol Chem (2003) 1.10
Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages. Eur J Neurosci (2002) 1.09
Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc Natl Acad Sci U S A (2004) 1.09
Impaired CD14-dependent and independent response of polymorphonuclear leukocytes in preterm infants. J Perinat Med (2003) 1.08
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Crit Care (2010) 1.08
Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci U S A (2006) 1.08
Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. BMC Med Genet (2009) 1.04
The toll-like receptor 1 variant S248N influences placental malaria. Infect Genet Evol (2010) 1.02
Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis. Clin Chim Acta (2005) 1.00
Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Toll-like receptor -2, -4, and -9 genes. J Immunol Methods (2004) 0.99
Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses. Infect Immun (2004) 0.97
Acylated cholesteryl galactosides are specific antigens of borrelia causing lyme disease and frequently induce antibodies in late stages of disease. J Biol Chem (2009) 0.97
Acute-phase concentrations of lipopolysaccharide (LPS)-binding protein inhibit innate immune cell activation by different LPS chemotypes via different mechanisms. Infect Immun (2005) 0.95
A frequent toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis. J Mol Med (Berl) (2005) 0.93
Genetic variation in innate immunity pathways and their potential contribution to the SIRS/CARS debate: evidence from human studies and animal models. J Innate Immun (2010) 0.90
The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity. Immunity (2013) 0.88
Association of a common TLR-6 polymorphism with coronary artery disease - implications for healthy ageing? Immun Ageing (2013) 0.87
Inhibition of LPS-induced activation of alveolar macrophages by high concentrations of LPS-binding protein. Biochem Biophys Res Commun (2002) 0.87
Non-LPS targets and actions of LPS binding protein (LBP). J Endotoxin Res (2005) 0.85
Inhibition of hepatic transcriptional induction of lipopolysaccharide-binding protein by transforming-growth-factor beta 1. Eur J Immunol (2004) 0.85
A frequent Toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-γ production and is associated with Helicobacter pylori-induced gastric disease. Helicobacter (2012) 0.85
Pre- and postoperative cytokine release after in vitro whole blood lipopolysaccharide stimulation and frequent toll-like receptor 4 polymorphisms. Shock (2006) 0.84
Mannose-binding lectin and Toll-like receptor polymorphisms and Chagas disease in Chile. Am J Trop Med Hyg (2012) 0.84
Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients. Crit Care (2011) 0.84
Genetic influence on bloodstream infections and sepsis. Int J Antimicrob Agents (2008) 0.82
Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis. Hum Immunol (2012) 0.81
A Promoter Polymorphism of the Vitamin D Metabolism Gene Cyp24a1 is Associated with Severe Atopic Dermatitis in Adults. Acta Derm Venereol (2016) 0.79
Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations. Eur Cytokine Netw (2010) 0.78
Use of locked nucleic acid oligonucleotides as hybridization/FRET probes for quantification of 16S rDNA by real-time PCR. Biotechniques (2005) 0.77
Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato. FEMS Immunol Med Microbiol (2011) 0.77
The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level. J Neurochem (2004) 0.77
The course of gastric cancer following surgery is associated with genetic variations of the interleukin-1 receptor antagonist and interleukin-1β. Gastric Cancer (2014) 0.77
Chemoenzymatic synthesis of a glycolipid library and elucidation of the antigenic epitope for construction of a vaccine against Lyme disease. Chemistry (2010) 0.76
The Attenuated Brucella abortus Strain 19 Invades, Persists in, and Activates Human Dendritic Cells, and Induces the Secretion of IL-12p70 but Not IL-23. PLoS One (2013) 0.75
Nocardia farcinica activates human dendritic cells and induces secretion of interleukin-23 (IL-23) rather than IL-12p70. Infect Immun (2012) 0.75
A new Toll-road from environment to genes for rheumatic fever? J Mol Med (Berl) (2005) 0.75
Correction: The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele. J Immunol (2017) 0.75