Published in J Infect Dis on June 13, 2006
Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 4.55
Into the eye of the cytokine storm. Microbiol Mol Biol Rev (2012) 2.58
Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function. Proc Natl Acad Sci U S A (2009) 1.70
Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria. Proc Natl Acad Sci U S A (2007) 1.55
Detection and clinical manifestation of placental malaria in southern Ghana. Malar J (2006) 1.52
The impact of malaria parasitism: from corpuscles to communities. J Clin Invest (2009) 1.37
Genetic polymorphisms linked to susceptibility to malaria. Malar J (2011) 1.29
The host genetic diversity in malaria infection. J Trop Med (2012) 1.08
TLR4 polymorphisms and disease susceptibility. Inflamm Res (2012) 1.05
Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. BMC Med Genet (2009) 1.04
Interethnic differences in antigen-presenting cell activation and TLR responses in Malian children during Plasmodium falciparum malaria. PLoS One (2011) 1.03
TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria. Am J Trop Med Hyg (2010) 1.00
Candidate human genetic polymorphisms and severe malaria in a Tanzanian population. PLoS One (2012) 0.99
Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients. Malar J (2011) 0.96
Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria. Semin Immunopathol (2007) 0.94
The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes. PLoS One (2009) 0.93
Candidate polymorphisms and severe malaria in a Malian population. PLoS One (2012) 0.92
Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon. PLoS One (2013) 0.91
Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1. Exp Parasitol (2011) 0.90
Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome. PLoS One (2008) 0.88
Toll-like receptor polymorphisms in malaria-endemic populations. Malar J (2009) 0.87
Malarial fever: hemozoin is involved but Toll-free. Proc Natl Acad Sci U S A (2007) 0.86
TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression. Malar J (2009) 0.86
Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population. BMC Infect Dis (2013) 0.86
Toll-like receptor 9 (TLR9) polymorphism associated with symptomatic malaria: a cohort study. Malar J (2012) 0.86
SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis? Eur J Clin Microbiol Infect Dis (2012) 0.83
Immunomodulation in Plasmodium falciparum malaria: experiments in nature and their conflicting implications for potential therapeutic agents. Expert Rev Anti Infect Ther (2012) 0.83
Do the placental barrier, parasite genotype and Toll-like receptor polymorphisms contribute to the course of primary infection with various Toxoplasma gondii genotypes in pregnant women? Eur J Clin Microbiol Infect Dis (2013) 0.82
Investigation of host candidate malaria-associated risk/protective SNPs in a Brazilian Amazonian population. PLoS One (2012) 0.81
Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria. Malar J (2012) 0.81
Polysaccharides from the Chinese medicinal herb Achyranthes bidentata enhance anti-malarial immunity during Plasmodium yoelii 17XL infection in mice. Malar J (2012) 0.80
Pre-existing Schistosoma japonicum infection alters the immune response to Plasmodium berghei infection in C57BL/6 mice. Malar J (2013) 0.79
Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice. PLoS One (2011) 0.79
TLR9 -1486T/C and 2848C/T SNPs Are Associated with Human Cytomegalovirus Infection in Infants. PLoS One (2016) 0.78
Possible role of TLR4 and TLR9 SNPs in protection against congenital toxoplasmosis. Eur J Clin Microbiol Infect Dis (2015) 0.78
Polymorphisms in the Fc gamma receptor IIIA and Toll-like receptor 9 are associated with protection against severe malarial anemia and changes in circulating gamma interferon levels. Infect Immun (2012) 0.77
Interferons and interferon regulatory factors in malaria. Mediators Inflamm (2014) 0.77
Divergent roles of IRAK4-mediated innate immune responses in two experimental models of severe malaria. Am J Trop Med Hyg (2010) 0.76
Toll-like receptor (TLR4) Asp299Gly and Thr399Ile polymorphisms in relation to clinical falciparum malaria among Nigerian children: a multisite cross-sectional immunogenetic study in Lagos. Genes Environ (2015) 0.75
Risk factors for placental malaria and associated adverse pregnancy outcomes in Rufiji, Tanzania: a hospital based cross sectional study. Afr Health Sci (2015) 0.75
Association of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil. PLoS One (2017) 0.75
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis (2005) 3.39
Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii. J Immunol (2006) 3.24
Evaluating health research capacity building: an evidence-based tool. PLoS Med (2006) 2.58
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci U S A (2007) 2.28
Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem (2004) 2.18
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J Immunol (2007) 2.14
Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One (2007) 2.05
Evaluation of a learner-designed course for teaching health research skills in Ghana. BMC Med Educ (2007) 2.02
Diagnosis of placental malaria. J Clin Microbiol (2002) 1.97
Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. Proc Natl Acad Sci U S A (2005) 1.95
A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management. Clin Infect Dis (2003) 1.93
Malaria, anemia, and malnutrition in african children--defining intervention priorities. J Infect Dis (2006) 1.90
Intermittent preventive treatment in infants as a means of malaria control: a randomized, double-blind, placebo-controlled trial in northern Ghana. Antimicrob Agents Chemother (2007) 1.82
Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein. Immunity (2003) 1.81
Manifestation and outcome of severe malaria in children in northern Ghana. Am J Trop Med Hyg (2004) 1.71
High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. J Mol Med (Berl) (2003) 1.66
Decline of placental malaria in southern Ghana after the implementation of intermittent preventive treatment in pregnancy. Malar J (2007) 1.66
Laboratory use in Ghana: physician perception and practice. Am J Trop Med Hyg (2006) 1.60
Rapid increase in the prevalence of sulfadoxine-pyrimethamine resistance among Plasmodium falciparum isolated from pregnant women in Ghana. J Infect Dis (2008) 1.58
Detection and clinical manifestation of placental malaria in southern Ghana. Malar J (2006) 1.52
Alpha(+)-thalassemia protects African children from severe malaria. Blood (2004) 1.52
Measures of general and central obesity and risk of type 2 diabetes in a Ghanaian population. Trop Med Int Health (2012) 1.52
Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. J Immunol (2005) 1.49
Plasmodium falciparum dhfr but not dhps mutations associated with sulphadoxine-pyrimethamine treatment failure and gametocyte carriage in northern Ghana. Trop Med Int Health (2005) 1.46
Streptococcal M protein: a multipotent and powerful inducer of inflammation. J Immunol (2006) 1.36
Cytokine induction by purified lipoteichoic acids from various bacterial species--role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-gamma release. Eur J Immunol (2002) 1.34
Diabetes mellitus type 2 in urban Ghana: characteristics and associated factors. BMC Public Health (2012) 1.33
The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes Infect (2006) 1.32
A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria. Trop Med Int Health (2005) 1.31
Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J Immunol (2004) 1.31
Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood. J Infect Dis (2003) 1.28
High prevalence of drug-resistance mutations in Plasmodium falciparum and Plasmodium vivax in southern Ethiopia. Malar J (2006) 1.27
Antiplasmodial activity of naphthoquinones and one anthraquinone from Stereospermum kunthianum. Phytochemistry (2002) 1.26
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A (2009) 1.25
Immune responses induced by spirochetal outer membrane lipoproteins and glycolipids. Immunobiology (2008) 1.23
Triptans reduce the inflammatory response in bacterial meningitis. J Cereb Blood Flow Metab (2002) 1.20
Hemoglobin C and resistance to severe malaria in Ghanaian children. J Infect Dis (2004) 1.20
Acute childhood diarrhoea in northern Ghana: epidemiological, clinical and microbiological characteristics. BMC Infect Dis (2007) 1.20
Type 2 diabetes mellitus and increased risk for malaria infection. Emerg Infect Dis (2010) 1.18
A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. AIDS (2009) 1.18
Diagnosis of red cell G6PD deficiency in rural Burkina Faso: comparison of a rapid fluorescent enzyme test on filter paper with polymerase chain reaction based genotyping. Br J Haematol (2005) 1.17
High rate of resistance to locally used antibiotics among enteric bacteria from children in Northern Ghana. J Antimicrob Chemother (2008) 1.16
Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling. Infect Immun (2005) 1.15
Markers of sulfadoxine-pyrimethamine-resistant Plasmodium falciparum in placenta and circulation of pregnant women. Antimicrob Agents Chemother (2006) 1.14
Reduced prevalence of Plasmodium falciparum infection and of concomitant anaemia in pregnant women with heterozygous G6PD deficiency. Trop Med Int Health (2003) 1.10
CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual. PLoS One (2008) 1.10
Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. J Infect Dis (2009) 1.10
Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto. J Biol Chem (2003) 1.10
Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages. Eur J Neurosci (2002) 1.09
Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc Natl Acad Sci U S A (2004) 1.09
Impaired CD14-dependent and independent response of polymorphonuclear leukocytes in preterm infants. J Perinat Med (2003) 1.08
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Crit Care (2010) 1.08
Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci U S A (2006) 1.08
In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe. Phytother Res (2003) 1.08
Field-based evidence for linkage of mutations associated with chloroquine (pfcrt/pfmdr1) and sulfadoxine-pyrimethamine (pfdhfr/pfdhps) resistance and for the fitness cost of multiple mutations in P. falciparum. Infect Genet Evol (2006) 1.07
Sustained immunological responses to highly active antiretroviral therapy at 36 months in a Ghanaian HIV cohort. Clin Infect Dis (2009) 1.06
Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children. J Clin Pharmacol (2003) 1.05
Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. BMC Med Genet (2009) 1.04
The toll-like receptor 1 variant S248N influences placental malaria. Infect Genet Evol (2010) 1.02
High levels of circulating cardiac proteins indicate cardiac impairment in African children with severe Plasmodium falciparum malaria. Microbes Infect (2005) 1.02
Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis. Clin Chim Acta (2005) 1.00
Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Toll-like receptor -2, -4, and -9 genes. J Immunol Methods (2004) 0.99
Short communication: high prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana. Trop Med Int Health (2005) 0.98
Molecular characterization of enteric viral agents from children in northern region of Ghana. J Med Virol (2008) 0.97
Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses. Infect Immun (2004) 0.97
Acylated cholesteryl galactosides are specific antigens of borrelia causing lyme disease and frequently induce antibodies in late stages of disease. J Biol Chem (2009) 0.97
Acute-phase concentrations of lipopolysaccharide (LPS)-binding protein inhibit innate immune cell activation by different LPS chemotypes via different mechanisms. Infect Immun (2005) 0.95
In vitro antiplasmodial investigation of medicinal plants from El Salvador. Z Naturforsch C (2002) 0.93
A frequent toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis. J Mol Med (Berl) (2005) 0.93
Accumulation of inhibitory kappaB-alpha as a mechanism contributing to the anti-inflammatory effects of surfactant protein-A. Am J Respir Cell Mol Biol (2004) 0.93
Field evaluation of a rota- and adenovirus immunochromatographic assay using stool samples from children with acute diarrhea in Ghana. J Clin Microbiol (2007) 0.92
Limited influence of haemoglobin variants on Plasmodium falciparum msp1 and msp2 alleles in symptomatic malaria. Trans R Soc Trop Med Hyg (2004) 0.92
Surfactant protein a inhibits lipopolysaccharide-induced immune cell activation by preventing the interaction of lipopolysaccharide with lipopolysaccharide-binding protein. Am J Respir Cell Mol Biol (2002) 0.91
Genetic variation in innate immunity pathways and their potential contribution to the SIRS/CARS debate: evidence from human studies and animal models. J Innate Immun (2010) 0.90
Reduced efficacy of intermittent preventive treatment of malaria in malnourished children. Antimicrob Agents Chemother (2009) 0.89
UK-based real-time lymphoproliferative disorder diagnostic service to improve the management of patients in Ghana. J Hematop (2009) 0.89