Published in Crit Care Med on August 01, 2011
Statin Therapy in the Treatment of Sepsis | NCT00676897
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Statins and prevention of infections: systematic review and meta-analysis of data from large randomised placebo controlled trials. BMJ (2011) 1.72
Statins and associated risk of pneumonia: a systematic review and meta-analysis of observational studies. Eur J Clin Pharmacol (2011) 1.46
The impact of statin use on pneumonia risk and outcome: a combined population-based case-control and cohort study. Crit Care (2012) 0.99
The role of statins in prevention and treatment of community acquired pneumonia: a systematic review and meta-analysis. PLoS One (2013) 0.96
Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality. PLoS One (2012) 0.95
Effect of statin therapy on mortality from infection and sepsis: a meta-analysis of randomized and observational studies. Crit Care (2014) 0.92
Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia. BMC Microbiol (2012) 0.90
Statins in the critically ill. Ann Intensive Care (2012) 0.90
Effects of Aging on Inflammation and Hemostasis through the Continuum of Critical Illness. Aging Dis (2011) 0.86
Chronic Statin Use and Long-Term Rates of Sepsis: A Population-Based Cohort Study. J Intensive Care Med (2014) 0.85
The controversy over H5N1 transmissibility research: an opportunity to define a practical response to a global threat. Hum Vaccin Immunother (2013) 0.82
Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study. Eur J Clin Microbiol Infect Dis (2014) 0.81
Emerging therapeutic targets of sepsis-associated acute kidney injury. Semin Nephrol (2015) 0.81
The association between time to antibiotics and relevant clinical outcomes in emergency department patients with various stages of sepsis: a prospective multi-center study. Crit Care (2015) 0.79
Association of statin use with risk and outcome of acute kidney injury in community-acquired pneumonia. Clin J Am Soc Nephrol (2012) 0.78
Mechanisms of action and efficacy of statins against influenza. Biomed Res Int (2014) 0.78
Novel applications of statins for bone regeneration. Natl Sci Rev (2014) 0.77
What is the real role of statins in community-acquired pneumonia and sepsis? Crit Care Med (2011) 0.75
Year in review 2012: Critical Care--management. Crit Care (2013) 0.75
HDL-c levels predict the presence of pleural effusion and the clinical outcome of community-acquired pneumonia. Springerplus (2016) 0.75
Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia: a pilot study. Univ Louisville J Respir Infect (2017) 0.75
Statins in pneumonia--magic versus science? Crit Care (2012) 0.75
Herpes zoster is associated with prior statin use: a population-based case-control study. PLoS One (2014) 0.75
Mortality benefit of statin use in traumatic spinal cord injury: a retrospective analysis. Spinal Cord (2015) 0.75
Evidence to support continuation of statin therapy in patients with Staphylococcus aureus bacteremia. Antimicrob Agents Chemother (2017) 0.75
Impact of prior statin therapy on the outcome of patients with suspected ventilator-associated pneumonia: an observational study. Crit Care (2014) 0.75
Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target? Intensive Care Med Exp (2014) 0.75
A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis (1987) 174.79
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA (2002) 80.37
Random-effects models for longitudinal data. Biometrics (1982) 54.17
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) Lancet (1994) 40.72
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med (1996) 35.00
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med (1995) 28.35
A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med (1997) 24.87
The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest (1991) 16.06
Sepsis in European intensive care units: results of the SOAP study. Crit Care Med (2006) 11.78
Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med (2001) 9.08
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Rare outcomes, common treatments: analytic strategies using propensity scores. Ann Intern Med (2002) 4.38
Adherence to lipid-lowering therapy and the use of preventive health services: an investigation of the healthy user effect. Am J Epidemiol (2007) 3.82
Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study. BMJ (2006) 3.62
Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia. Ann Emerg Med (2008) 3.44
Surviving intensive care: a report from the 2002 Brussels Roundtable. Intensive Care Med (2003) 3.00
Statin adherence and risk of accidents: a cautionary tale. Circulation (2009) 2.47
Do hospitals provide lower quality of care to black patients for pneumonia? Crit Care Med (2010) 2.07
New strategies for clinical trials in patients with sepsis and septic shock. Crit Care Med (2001) 1.95
The effect of statins on mortality from severe infections and sepsis: a systematic review and meta-analysis. J Crit Care (2010) 1.95
Statins, inflammation, and sepsis: hypothesis. Chest (2003) 1.94
Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor XIII and by enhancing factor Va inactivation. Circulation (2001) 1.61
A tobit variance-component method for linkage analysis of censored trait data. Am J Hum Genet (2003) 1.49
Does statin use improve pneumonia outcomes? Chest (2009) 1.48
Statins for sepsis: a critical and updated review. Clin Microbiol Infect (2009) 1.43
Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial). Crit Care (2012) 1.39
A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis. Intensive Care Med (2008) 1.33
The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies. Thorax (2010) 1.31
Statin use and risk of community acquired pneumonia in older people: population based case-control study. BMJ (2009) 1.30
Prevalence and significance of coagulation abnormalities in community-acquired pneumonia. Mol Med (2009) 1.12
Statin treatment and mortality in bacterial infections--a systematic review and meta-analysis. PLoS One (2010) 1.05
Statins for community-acquired pneumonia: current state of the science. Eur J Clin Microbiol Infect Dis (2009) 0.99
The prevalence of anemia and its association with 90-day mortality in hospitalized community-acquired pneumonia. BMC Pulm Med (2010) 0.92
Statin use does not affect the outcome of acute infection: a prospective cohort study. Presse Med (2010) 0.87
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care (2007) 29.89
Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA (2005) 19.57
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med (2008) 14.40
Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA (2002) 9.89
RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care (2006) 9.29
Use of intensive care at the end of life in the United States: an epidemiologic study. Crit Care Med (2004) 9.06
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Nighttime intensivist staffing and mortality among critically ill patients. N Engl J Med (2012) 5.22
Variation in critical care services across North America and Western Europe. Crit Care Med (2008) 5.00
Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. Crit Care Med (2004) 4.93
Acute kidney injury. Lancet (2012) 4.90
The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med (2002) 4.72
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
The effect of multidisciplinary care teams on intensive care unit mortality. Arch Intern Med (2010) 4.41
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats. Chest (2007) 3.51
A comparison of three methods to estimate baseline creatinine for RIFLE classification. Nephrol Dial Transplant (2010) 3.45
Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia. Ann Emerg Med (2008) 3.44
Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care (2013) 3.40
Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome. Am J Respir Crit Care Med (2012) 3.36
Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte. Ann Surg (2012) 3.36
The epidemiology of mechanical ventilation use in the United States. Crit Care Med (2010) 3.28
Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Crit Care Med (2007) 3.27
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics. Am J Respir Crit Care Med (2007) 3.17
Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol (2007) 3.17
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary team. Crit Care Med (2006) 3.15
Pneumonia: still the old man's friend? Arch Intern Med (2003) 3.12
Diuretics and mortality in acute renal failure. Crit Care Med (2004) 3.12
Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes. Kidney Int (2002) 3.07
Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators. Intensive Care Med (2007) 3.03
Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States. Am J Respir Crit Care Med (2002) 3.02
Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int (2009) 2.97
Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med (2015) 2.97
HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology (2002) 2.95
Prospective meta-analysis using individual patient data in intensive care medicine. Intensive Care Med (2009) 2.93
Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. Am J Respir Crit Care Med (2014) 2.93
Organizational characteristics, outcomes, and resource use in 78 Brazilian intensive care units: the ORCHESTRA study. Intensive Care Med (2015) 2.92
Three-year outcomes for Medicare beneficiaries who survive intensive care. JAMA (2010) 2.87
The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med (2006) 2.84
Psychiatric disorders among bariatric surgery candidates: relationship to obesity and functional health status. Am J Psychiatry (2007) 2.80
The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med (2012) 2.72
Defining acute renal failure: physiological principles. Intensive Care Med (2003) 2.69
External validation of severity scoring systems for acute renal failure using a multinational database. Crit Care Med (2005) 2.68
Trends in the epidemiology of pediatric severe sepsis*. Pediatr Crit Care Med (2013) 2.67
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
Amyloid imaging in mild cognitive impairment subtypes. Ann Neurol (2009) 2.66
Working Party proposal for a revised classification system of renal dysfunction in patients with cirrhosis. Gut (2011) 2.65
Acute kidney injury: an increasing global concern. Lancet (2013) 2.61
End-of-life care for the critically ill: A national intensive care unit survey. Crit Care Med (2006) 2.61
Discontinuation of continuous renal replacement therapy: a post hoc analysis of a prospective multicenter observational study. Crit Care Med (2009) 2.58
A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury. Nephrol Dial Transplant (2009) 2.55
Acute kidney injury: what's the prognosis? Nat Rev Nephrol (2011) 2.51
Disability among elderly survivors of mechanical ventilation. Am J Respir Crit Care Med (2010) 2.50
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med (2003) 2.44
Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Med (2013) 2.44
Prioritizing the organization and management of intensive care services in the United States: the PrOMIS Conference. Crit Care Med (2007) 2.42
Relationship between staff perceptions of hospital norms and hospital-level end-of-life treatment intensity. J Palliat Med (2007) 2.39
Long-term mortality and medical care charges in patients with severe sepsis. Crit Care Med (2003) 2.39
Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med (2008) 2.37
Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury. J Crit Care (2008) 2.36
Is survival better at hospitals with higher "end-of-life" treatment intensity? Med Care (2010) 2.35
Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS database. Liver Transpl (2004) 2.31
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31
Growth of intensive care unit resource use and its estimated cost in Medicare. Crit Care Med (2008) 2.31
Severe sepsis epidemiology: sampling, selection, and society. Crit Care (2004) 2.28
Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA (2010) 2.27
Sodium bicarbonate for prevention of contrast-induced acute kidney injury: a systematic review and meta-analysis. Nephrol Dial Transplant (2009) 2.27
Perceptions of safety culture vary across the intensive care units of a single institution. Crit Care Med (2007) 2.24