Published in Nat Cell Biol on February 01, 2009
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The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Science (2010) 2.46
A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels. Biochem Biophys Res Commun (2009) 2.28
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S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. J Cell Biol (2010) 1.77
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Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant. J Biol Chem (2009) 1.65
Lipid rafts/caveolae as microdomains of calcium signaling. Cell Calcium (2009) 1.65
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Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A (2012) 1.59
Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration. Am J Physiol Cell Physiol (2010) 1.58
Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis. Nat Cell Biol (2009) 1.51
Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression. Nat Chem Biol (2011) 1.50
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Checking your SOCCs and feet: the molecular mechanisms of Ca2+ entry in skeletal muscle. J Physiol (2009) 1.42
Immunodeficiency due to mutations in ORAI1 and STIM1. Clin Immunol (2010) 1.39
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The short N-terminal domains of STIM1 and STIM2 control the activation kinetics of Orai1 channels. J Biol Chem (2009) 1.37
Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. Gastroenterology (2009) 1.37
Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. J Biol Chem (2009) 1.36
A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels. J Biol Chem (2009) 1.35
A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1. Biochemistry (2010) 1.34
Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency. J Immunol (2011) 1.32
Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. Proc Natl Acad Sci U S A (2011) 1.28
Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP(3) receptors. Curr Biol (2009) 1.26
STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Nat Commun (2013) 1.25
The molecular physiology of CRAC channels. Immunol Rev (2009) 1.24
Initial activation of STIM1, the regulator of store-operated calcium entry. Nat Struct Mol Biol (2013) 1.24
A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating. J Gen Physiol (2010) 1.24
Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proc Natl Acad Sci U S A (2013) 1.23
Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling. J Clin Invest (2012) 1.21
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STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+ release. J Cell Biol (2011) 1.20
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POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc Natl Acad Sci U S A (2011) 1.12
The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels. J Physiol (2013) 1.12
Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems. Trends Cell Biol (2011) 1.12
Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P₂ between distinct membrane pools. J Cell Sci (2011) 1.12
Mitofusin 2 regulates STIM1 migration from the Ca2+ store to the plasma membrane in cells with depolarized mitochondria. J Biol Chem (2011) 1.11
Intracellular Ca2+ signaling and store-operated Ca2+ entry are required in Drosophila neurons for flight. Proc Natl Acad Sci U S A (2009) 1.11
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The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels. J Biol Chem (2009) 1.10
Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. Proc Natl Acad Sci U S A (2014) 1.10
Molecular biophysics of Orai store-operated Ca2+ channels. Biophys J (2015) 1.09
Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel. J Biol Chem (2010) 1.09
Interplay between calcium and reactive oxygen/nitrogen species: an essential paradigm for vascular smooth muscle signaling. Antioxid Redox Signal (2010) 1.09
Pharmacology of store-operated calcium channels. Mol Interv (2010) 1.09
Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry. Proc Natl Acad Sci U S A (2011) 1.09
Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca(2+) influx. Nat Cell Biol (2015) 1.09
The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function. J Cell Biol (2013) 1.07
Contribution of TRPC1 and Orai1 to Ca(2+) entry activated by store depletion. Adv Exp Med Biol (2011) 1.06
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Orai1-NFAT signalling pathway triggered by T cell receptor stimulation. Mol Cells (2013) 1.05
The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells. J Cell Sci (2009) 1.05
The physiological function of store-operated calcium entry. Neurochem Res (2011) 1.05
Bombyx mori homologs of STIM1 and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production. J Biol Chem (2009) 1.05
STIM/Orai signalling complexes in vascular smooth muscle. J Physiol (2012) 1.05
Calcium signaling by STIM and Orai: intimate coupling details revealed. Sci Signal (2010) 1.04
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STIM1-dependent and STIM1-independent function of transient receptor potential canonical (TRPC) channels tunes their store-operated mode. J Biol Chem (2010) 1.03
Contribution and regulation of TRPC channels in store-operated Ca2+ entry. Curr Top Membr (2013) 1.03
Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis. J Cell Biol (2010) 1.03
Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions. Mol Biol Cell (2014) 1.02
Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex. J Biol Chem (2011) 1.02
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TRPC channels in smooth muscle cells. Front Biosci (Landmark Ed) (2010) 1.00
STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry. Sci Signal (2013) 0.99
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