Published in Immunol Rev on April 01, 2005
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med (2007) 2.86
Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. Diabetes (2015) 2.21
Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J (2009) 1.70
Quantification and three-dimensional imaging of the insulitis-induced destruction of beta-cells in murine type 1 diabetes. Diabetes (2010) 1.50
Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. Proc Natl Acad Sci U S A (2008) 1.49
Contribution of antibodies against IA-2β and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age. Diabetes Care (2011) 1.12
TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. J Clin Invest (2006) 1.09
Dysregulated Toll-like receptor-induced interleukin-1β and interleukin-6 responses in subjects at risk for the development of type 1 diabetes. Diabetes (2012) 1.05
C-peptide response and HLA genotypes in subjects with recent-onset type 1 diabetes after immunotherapy with DiaPep277: an exploratory study. Diabetes (2011) 0.95
ZnT8-Specific CD4+ T cells display distinct cytokine expression profiles between type 1 diabetes patients and healthy adults. PLoS One (2013) 0.91
Rotavirus-specific T cell responses and cytokine mRNA expression in children with diabetes-associated autoantibodies and type 1 diabetes. Clin Exp Immunol (2006) 0.85
The immunotherapeutic potential of dendritic cells in type 1 diabetes. Clin Exp Immunol (2010) 0.84
Immunosuppression in islet transplantation. J Clin Invest (2008) 0.83
Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes. Diabetes (2010) 0.82
Relapsing and remitting severe hypoglycemia due to a monoclonal anti-insulin antibody heralding a case of multiple myeloma. J Clin Endocrinol Metab (2012) 0.80
α1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1β responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes. J Clin Endocrinol Metab (2014) 0.80
New potential treatments for protection of pancreatic B-cell function in Type 1 diabetes. Diabet Med (2008) 0.79
Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect. Int Immunol (2010) 0.77
Teplizumab therapy for type 1 diabetes. Expert Opin Biol Ther (2010) 0.76
Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes. PLoS One (2017) 0.75
β-cell preservation and regeneration for diabetes treatment: where are we now? Diabetes Manag (Lond) (2012) 0.75
2α-Methyl-19-nor-(20S)-1,25-dihydroxyvitamin D(3) protects the insulin 2 knockout non-obese diabetic mouse from developing type 1 diabetes without hypercalcaemia. Clin Exp Immunol (2011) 0.75
Bioengineered stem cells as an alternative for islet cell transplantation. World J Transplant (2015) 0.75
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet (2004) 12.25
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A (2007) 6.44
Risk of pediatric celiac disease according to HLA haplotype and country. N Engl J Med (2014) 5.44
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature (2005) 5.39
Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA (2003) 4.00
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA (2013) 3.65
Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA (2005) 3.61
Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol (2006) 3.55
A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity (2005) 3.07
Infant exposures and development of type 1 diabetes mellitus: The Diabetes Autoimmunity Study in the Young (DAISY). JAMA Pediatr (2013) 2.92
Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia. J Clin Endocrinol Metab (2010) 2.70
Type 1 diabetes: recent developments. BMJ (2004) 2.66
The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results. Pediatr Diabetes (2008) 2.60
A prospective study of the incidence of childhood celiac disease. J Pediatr (2003) 2.50
Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice. Nat Med (2002) 2.29
Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab (2004) 2.19
A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes (2008) 2.09
Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes. JAMA (2007) 2.04
Insulin as an autoantigen in NOD/human diabetes. Curr Opin Immunol (2008) 1.95
Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screening. Diabetes (2008) 1.90
Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci U S A (2006) 1.90
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci U S A (2010) 1.87
Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young. Diabetes Care (2011) 1.86
Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex. Diabetes (2007) 1.84
Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc Natl Acad Sci U S A (2003) 1.75
Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays. Clin Immunol (2007) 1.75
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes (2011) 1.74
Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes (2010) 1.67
Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up. Diabetes Care (2004) 1.65
Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J Clin Endocrinol Metab (2003) 1.55
Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay. Diabetes (2011) 1.53
Concordance for islet autoimmunity among monozygotic twins. N Engl J Med (2008) 1.53
In utero dietary exposures and risk of islet autoimmunity in children. Diabetes Care (2003) 1.49
Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study. Diabetes (2006) 1.49
Persistently autoantibody negative (PAN) type 1 diabetes mellitus in children. Pediatr Diabetes (2010) 1.48
Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity. J Clin Endocrinol Metab (2006) 1.47
Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies. Diabetes Care (2012) 1.45
Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J Clin Invest (2007) 1.44
Autoantibody "subspecificity" in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups. Diabetes Care (2005) 1.43
Analysis of pathogenesis of juvenile new-onset diabetes. J Diabetes (2011) 1.42
SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes. Ann N Y Acad Sci (2008) 1.42
Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc Natl Acad Sci U S A (2002) 1.40
Multi-SNP analysis of MHC region: remarkable conservation of HLA-A1-B8-DR3 haplotype. Diabetes (2006) 1.38
Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). Pediatr Diabetes (2006) 1.33
Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes (2006) 1.30
Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease. J Pediatr Gastroenterol Nutr (2007) 1.30
Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates. Pediatr Diabetes (2005) 1.28
Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23. J Clin Invest (2002) 1.26
Association of the PTPN22/LYP gene with type 1 diabetes. Pediatr Diabetes (2006) 1.25
Additional autoimmune disease found in 33% of patients at type 1 diabetes onset. Diabetes Care (2011) 1.25
Rituximab selectively suppresses specific islet antibodies. Diabetes (2011) 1.23
Timing of initial exposure to cereal grains and the risk of wheat allergy. Pediatrics (2006) 1.22
New reagents on the horizon for immune tolerance. Annu Rev Med (2007) 1.22
Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population. J Clin Endocrinol Metab (2004) 1.20
GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes. Diabetes (2013) 1.19
Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes. Diabetes (2005) 1.18
Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic mice. Diabetes (2003) 1.15
Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes. Clin Immunol (2009) 1.14
In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice. J Immunol (2008) 1.14
Need for quantitative assessment of transglutaminase autoantibodies for celiac disease in screening-identified children. J Pediatr (2005) 1.14
Stepwise or linear decrease in penetrance of type 1 diabetes with lower-risk HLA genotypes over the past 40 years. Diabetes (2011) 1.13
Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol (2011) 1.10
Conserved T cell receptor alpha-chain induces insulin autoantibodies. Proc Natl Acad Sci U S A (2008) 1.10
Molecular targeting of islet autoantigens. Immunity (2010) 1.10
Prospective study of enteroviral infections and development of beta-cell autoimmunity. Diabetes autoimmunity study in the young (DAISY). Diabetes Res Clin Pract (2003) 1.09
Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice. Diabetes (2012) 1.09
Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells. J Immunol (2010) 1.07
Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodies. Clin Immunol (2002) 1.07
Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing. J Pediatr (2007) 1.06
Prediction and prevention of Type 1 diabetes mellitus. J Diabetes (2011) 1.05
Type 1A diabetes mellitus-associated autoimmunity. Endocrinol Metab Clin North Am (2002) 1.04
Clinical features of children with screening-identified evidence of celiac disease. Pediatrics (2004) 1.04
A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clin Immunol (2007) 1.03
Immunotherapeutic approaches to prevent, ameliorate, and cure type 1 diabetes. Am J Ther (2005) 1.02
Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes? Diabetes (2009) 1.02
Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes. Diabetes (2012) 1.01
Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes. Cold Spring Harb Perspect Med (2012) 1.01
Extreme genetic risk for type 1A diabetes in the post-genome era. J Autoimmun (2008) 1.00
HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population. Diabetes (2007) 1.00
Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes. Diabetes (2012) 1.00
Role of autoantibodies in type 1 diabetes. Front Biosci (2007) 0.99
17. Immunologic endocrine disorders. J Allergy Clin Immunol (2003) 0.98
Perinatal factors and development of islet autoimmunity in early childhood: the diabetes autoimmunity study in the young. Am J Epidemiol (2004) 0.97
Early and quantal (by litter) expression of insulin autoantibodies in the nonobese diabetic mice predict early diabetes onset. J Immunol (2004) 0.97
Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes. J Clin Endocrinol Metab (2006) 0.97
Genome-wide analysis of copy number variation in type 1 diabetes. PLoS One (2010) 0.96
Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23. J Autoimmun (2010) 0.96
Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assays. Diabetes Metab Res Rev (2009) 0.96
The stages of type 1A diabetes. Ann N Y Acad Sci (2005) 0.95
The genetics of autoimmune polyendocrine syndrome type II. Endocrinol Metab Clin North Am (2002) 0.95
Anti-dsDNA antibody assay: high specificity and sensitivity with a filtration radioassay in comparison to low specificity with the standard ELISA. J Rheumatol (2007) 0.95
Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains. J Autoimmun (2009) 0.94
Immune intervention in type 1 diabetes. Semin Immunol (2011) 0.94
Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene. Ann N Y Acad Sci (2004) 0.94
Genetic determinants of type 1 diabetes across populations. Ann N Y Acad Sci (2006) 0.94
Type 1 diabetes mellitus of man: genetic susceptibility and resistance. Adv Exp Med Biol (2004) 0.94
Fluctuating transglutaminase autoantibodies are related to histologic features of celiac disease. Clin Gastroenterol Hepatol (2003) 0.93
Induction of insulin autoantibodies and protection from diabetes with subcutaneous insulin B:9-23 peptide without adjuvant. Ann N Y Acad Sci (2002) 0.93
Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice. Diabetes Metab Res Rev (2011) 0.93
Association of non-HLA genes with type 1 diabetes autoimmunity. Diabetes (2005) 0.93