Published in Endocrinology on March 24, 2005
Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci (2010) 2.24
Growth and aging: a common molecular mechanism. Aging (Albany NY) (2009) 2.13
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm IGF Res (2008) 1.72
Insulin sensitivity as a key mediator of growth hormone actions on longevity. J Gerontol A Biol Sci Med Sci (2009) 1.69
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev (2013) 1.50
Mitochondria and cardiovascular aging. Circ Res (2012) 1.46
Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. FASEB J (2010) 1.33
Iron accumulation with age, oxidative stress and functional decline. PLoS One (2008) 1.24
Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. J Gerontol A Biol Sci Med Sci (2011) 1.24
Protein hormones and immunity. Brain Behav Immun (2007) 1.24
Aging, atherosclerosis, and IGF-1. J Gerontol A Biol Sci Med Sci (2012) 1.16
Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation. J Endocrinol (2009) 1.15
The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances. J Gerontol A Biol Sci Med Sci (2012) 1.14
Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity. J Gerontol A Biol Sci Med Sci (2009) 1.08
Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats. J Gerontol A Biol Sci Med Sci (2010) 1.07
Hormonal control of aging in rodents: the somatotropic axis. Mol Cell Endocrinol (2008) 1.07
Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment. J Gerontol A Biol Sci Med Sci (2011) 1.03
Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. J Gerontol A Biol Sci Med Sci (2012) 1.02
Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging. J Gerontol A Biol Sci Med Sci (2011) 0.99
Growth hormone and aging: a challenging controversy. Clin Interv Aging (2008) 0.98
Reduced susceptibility to azoxymethane-induced aberrant crypt foci formation and colon cancer in growth hormone deficient rats. Growth Horm IGF Res (2009) 0.94
Reductions in serum IGF-1 during aging impair health span. Aging Cell (2013) 0.93
Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence. J Endocrinol (2011) 0.92
IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice. J Cereb Blood Flow Metab (2014) 0.91
Sex Differences in Lifespan. Cell Metab (2016) 0.90
Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span. J Gerontol A Biol Sci Med Sci (2013) 0.89
The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling. J Biol Chem (2010) 0.88
Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand. Neurobiol Aging (2013) 0.88
Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I. Growth Factors (2009) 0.87
Growth hormone, insulin-like growth factor-1 and the aging brain. Exp Gerontol (2014) 0.86
Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice. Growth Horm IGF Res (2011) 0.86
Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats. Age (Dordr) (2012) 0.85
Embryonic exposure to maternal testosterone influences age-specific mortality patterns in a captive passerine bird. Age (Dordr) (2011) 0.83
Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats. PLoS One (2010) 0.82
Links between growth hormone and aging. Endokrynol Pol (2013) 0.82
IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms. J Bone Miner Res (2015) 0.81
Growth hormone in the aging male. Best Pract Res Clin Endocrinol Metab (2013) 0.80
Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats. Biogerontology (2013) 0.80
Longevity is impacted by growth hormone action during early postnatal period. Elife (2017) 0.79
Climacteric in untreated isolated growth hormone deficiency. Menopause (2008) 0.79
Growth hormone actions during development influence adult phenotype and longevity. Exp Gerontol (2016) 0.76
Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat. J Gerontol A Biol Sci Med Sci (2014) 0.76
Functional Vascular Contributions to Cognitive Impairment and Dementia (VCID): Mechanisms and Consequences of Cerebral Microvascular Dysfunction in Aging. Am J Physiol Heart Circ Physiol (2016) 0.76
Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation. Growth Horm IGF Res (2011) 0.76
Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats. Oxid Med Cell Longev (2016) 0.75
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum (2004) 6.46
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics (2003) 3.84
The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc (2012) 3.45
Is the oxidative stress theory of aging dead? Biochim Biophys Acta (2009) 2.86
Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci (2003) 2.67
Transplant nephrectomy improves survival following a failed renal allograft. J Am Soc Nephrol (2009) 2.56
Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. Am J Clin Nutr (2004) 2.37
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08
Effects of short daily versus conventional hemodialysis on left ventricular hypertrophy and inflammatory markers: a prospective, controlled study. J Am Soc Nephrol (2005) 2.04
Lifespan extension in genetically modified mice. Aging Cell (2009) 1.98
Nitric oxide levels and nitric oxide synthase expression in uterine samples from mares susceptible and resistant to persistent breeding-induced endometritis. Am J Reprod Immunol (2005) 1.98
Overexpression of Mn superoxide dismutase does not increase life span in mice. J Gerontol A Biol Sci Med Sci (2009) 1.98
Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum (2012) 1.91
Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci (2013) 1.87
Housing density does not influence the longevity effect of calorie restriction. J Gerontol A Biol Sci Med Sci (2005) 1.85
Wear analysis of the Bryan Cervical Disc prosthesis. Spine (Phila Pa 1976) (2003) 1.82
Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes. Arthritis Rheum (2002) 1.81
Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. J Biol Chem (2003) 1.78
Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis. Obesity (Silver Spring) (2006) 1.72
Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide. Arthritis Rheum (2006) 1.71
NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol (2005) 1.68
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. J Gerontol A Biol Sci Med Sci (2009) 1.65
Prognostic utility of erectile dysfunction for cardiovascular disease in younger men and those with diabetes. Am Heart J (2012) 1.65
Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Arthritis Rheum (2006) 1.65
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum (2005) 1.65
Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem (2010) 1.64
Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis Rheum (2002) 1.63
Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem (2009) 1.60
Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res Rev (2005) 1.57
Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation. J Biol Chem (2007) 1.55
Depression and comorbid illness in elderly primary care patients: impact on multiple domains of health status and well-being. Ann Fam Med (2004) 1.53
IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. Biochem J (2005) 1.51
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Arthritis Rheum (2002) 1.49
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J Gerontol A Biol Sci Med Sci (2007) 1.47
Caspase-2 deficiency enhances aging-related traits in mice. Mech Ageing Dev (2006) 1.46
Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev (2002) 1.46
The mammalian twisted gastrulation gene functions in foregut and craniofacial development. Dev Biol (2004) 1.45
The Bryan Cervical Disc: wear properties and early clinical results. Spine J (2004) 1.41
Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels. Arthritis Rheum (2003) 1.41
Effects of aging on articular cartilage homeostasis. Bone (2012) 1.40
Bone loss following hypogonadism in men with prostate cancer treated with GnRH analogs. J Clin Endocrinol Metab (2002) 1.40
Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol (2010) 1.40
Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? PLoS One (2011) 1.39
Primary care attributes, health care system hassles, and chronic illness. Med Care (2005) 1.39
MRG15 regulates embryonic development and cell proliferation. Mol Cell Biol (2005) 1.35
Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy. Biochim Biophys Acta (2009) 1.31
Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiat Res (2006) 1.31
Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy. Ageing Res Rev (2010) 1.31
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med (2004) 1.30
Pathology is a critical aspect of preclinical aging studies. Pathobiol Aging Age Relat Dis (2013) 1.30
Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo. Cancer Lett (2007) 1.30
The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale. BMC Musculoskelet Disord (2009) 1.29
Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes. J Cell Biochem (2010) 1.28
Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability. Exp Neurol (2008) 1.27
Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system. Mol Ther (2009) 1.24
Iron accumulation with age, oxidative stress and functional decline. PLoS One (2008) 1.24
Cell death in osteoarthritis. Curr Rheumatol Rep (2008) 1.22
Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress. Free Radic Biol Med (2007) 1.22
Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors. Aging (Albany NY) (2013) 1.22
Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13. Arthritis Res Ther (2008) 1.22
The alpha5beta1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro. Arthritis Rheum (2002) 1.17
Focal changes in blood supply during normal epiphyseal growth are central in the pathogenesis of osteochondrosis in pigs. Bone (2004) 1.15
Prediction of GFR in liver transplant candidates. Am J Kidney Dis (2003) 1.14
Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction. Mech Ageing Dev (2009) 1.14
Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin. Matrix Biol (2002) 1.14
The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline results. Control Clin Trials (2003) 1.13
Plasma glucose and the action of calorie restriction on aging. J Gerontol A Biol Sci Med Sci (2007) 1.13
Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli. J Gerontol A Biol Sci Med Sci (2005) 1.13
Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats. J Gerontol A Biol Sci Med Sci (2006) 1.13
Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys. Arthritis Rheum (2002) 1.10
Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc. J Orthop Res (2007) 1.09
Battery of behavioral tests in mice that models age-associated changes in human motor function. Age (Dordr) (2014) 1.09
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Cancer Res (2006) 1.08
Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. Am J Physiol Regul Integr Comp Physiol (2007) 1.06
Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems. Physiol Genomics (2005) 1.06
Detection of vulnerable plaque in a murine model of atherosclerosis with optical coherence tomography. Catheter Cardiovasc Interv (2006) 1.06
Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy. J Am Geriatr Soc (2008) 1.05
Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments. Free Radic Biol Med (2007) 1.04
Integrin-mediated adhesion of human articular chondrocytes to cartilage. Arthritis Rheum (2003) 1.03
Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum (2009) 1.03
Physical exercise and comorbidity. Results from the Fitness and Arthritis in Seniors Trial (FAST). Aging Clin Exp Res (2006) 1.02
Mortality of first-time amputees in diabetics: a 10-year observation. Diabetes Res Clin Pract (2008) 1.02
Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis. PLoS One (2013) 1.02
Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging. Aging Cell (2009) 1.02
Alterations in mineral composition observed in osteoarthritic joints of cynomolgus monkeys. Bone (2004) 1.01
Laboratory markers of tumor burden in nasopharyngeal carcinoma: a comparison of viral load and serologic tests for Epstein-Barr virus. Int J Cancer (2004) 1.01
Differential correlations between inflammatory cytokines and psychopathology in veterans with schizophrenia: potential role for IL-17 pathway. Schizophr Res (2013) 0.99
Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice. J Gerontol A Biol Sci Med Sci (2011) 0.99
Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum (2009) 0.99
Adherence to mental health treatment in a primary care clinic. J Am Board Fam Pract (2005) 0.99