Published in Curr Opin Microbiol on April 01, 2005
Evolution of sensory complexity recorded in a myxobacterial genome. Proc Natl Acad Sci U S A (2006) 3.35
Natural products version 2.0: connecting genes to molecules. J Am Chem Soc (2010) 3.06
Global phenotypic characterization of bacteria. FEMS Microbiol Rev (2008) 2.97
Molecular regulation of antibiotic biosynthesis in streptomyces. Microbiol Mol Biol Rev (2013) 2.24
Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO Rep (2008) 2.07
Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters. Microb Biotechnol (2010) 2.02
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A (2014) 1.78
The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2). Genome Biol (2007) 1.60
New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters. Appl Microbiol Biotechnol (2012) 1.50
Response of RNA polymerase to ppGpp: requirement for the omega subunit and relief of this requirement by DksA. Genes Dev (2005) 1.45
Structuring Microbial Metabolic Responses to Multiplexed Stimuli via Self-Organizing Metabolomics Maps. Chem Biol (2015) 1.45
Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2). J Bacteriol (2007) 1.39
Taxonomy, Physiology, and Natural Products of Actinobacteria. Microbiol Mol Biol Rev (2015) 1.36
Recent functional insights into the role of (p)ppGpp in bacterial physiology. Nat Rev Microbiol (2015) 1.35
Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters. J Ind Microbiol Biotechnol (2010) 1.28
Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters. J Am Chem Soc (2012) 1.25
The multifaceted roles of antibiotics and antibiotic resistance in nature. Front Microbiol (2013) 1.21
Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus. J Bacteriol (2007) 1.19
Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Appl Microbiol Biotechnol (2010) 1.19
High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system. ACS Synth Biol (2014) 1.17
2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proc Natl Acad Sci U S A (2008) 1.16
Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity. Nat Prod Rep (2010) 1.15
Triggers and cues that activate antibiotic production by actinomycetes. J Ind Microbiol Biotechnol (2013) 1.14
"Pseudo" gamma-butyrolactone receptors respond to antibiotic signals to coordinate antibiotic biosynthesis. J Biol Chem (2010) 1.14
Phosphorylated AbsA2 negatively regulates antibiotic production in Streptomyces coelicolor through interactions with pathway-specific regulatory gene promoters. J Bacteriol (2007) 1.12
Strain improvement in actinomycetes in the postgenomic era. J Ind Microbiol Biotechnol (2011) 1.07
Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts. J Bacteriol (2008) 1.07
Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes. Appl Environ Microbiol (2011) 1.03
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074. Microb Biotechnol (2014) 1.03
Small RNA-dependent expression of secondary metabolism is controlled by Krebs cycle function in Pseudomonas fluorescens. J Biol Chem (2009) 1.03
Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold. ACS Synth Biol (2013) 1.02
Regulation of ppk expression and in vivo function of Ppk in Streptomyces lividans TK24. J Bacteriol (2006) 1.01
Crp is a global regulator of antibiotic production in streptomyces. MBio (2012) 1.00
Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements. J Ind Microbiol Biotechnol (2013) 1.00
Genetic factors that influence moenomycin production in streptomycetes. J Ind Microbiol Biotechnol (2010) 1.00
Functional analysis of the N-acetylglucosamine metabolic genes of Streptomyces coelicolor and role in control of development and antibiotic production. J Bacteriol (2011) 0.98
The gene encoding RNase III in Streptomyces coelicolor is transcribed during exponential phase and is required for antibiotic production and for proper sporulation. J Bacteriol (2008) 0.97
Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon. Genome Biol (2009) 0.97
FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis. BMC Microbiol (2012) 0.96
Metabolic switches and adaptations deduced from the proteomes of Streptomyces coelicolor wild type and phoP mutant grown in batch culture. Mol Cell Proteomics (2011) 0.96
The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis. Mol Genet Genomics (2009) 0.96
A comparison of key aspects of gene regulation in Streptomyces coelicolor and Escherichia coli using nucleotide-resolution transcription maps produced in parallel by global and differential RNA sequencing. Mol Microbiol (2014) 0.95
RNA-Seq and RNA immunoprecipitation analyses of the transcriptome of Streptomyces coelicolor identify substrates for RNase III. J Bacteriol (2012) 0.94
Characterization of rrdA, a TetR family protein gene involved in the regulation of secondary metabolism in Streptomyces coelicolor. Appl Environ Microbiol (2009) 0.94
Two-component systems in Streptomyces: key regulators of antibiotic complex pathways. Microb Cell Fact (2013) 0.93
Manipulating and understanding antibiotic production in Streptomyces coelicolor A3(2) with decoy oligonucleotides. Proc Natl Acad Sci U S A (2008) 0.93
Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor. Appl Environ Microbiol (2010) 0.92
The broad-spectrum antibiotic, zeamine, kills the nematode worm Caenorhabditis elegans. Front Microbiol (2015) 0.92
Biosynthesis and regulation of grisemycin, a new member of the linaridin family of ribosomally synthesized peptides produced by Streptomyces griseus IFO 13350. J Bacteriol (2011) 0.92
Mycelium development in Streptomyces antibioticus ATCC11891 occurs in an orderly pattern which determines multiphase growth curves. BMC Microbiol (2005) 0.92
Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027. BMC Microbiol (2009) 0.91
Genome plasticity and systems evolution in Streptomyces. BMC Bioinformatics (2012) 0.91
Saccharopolyspora erythraea's genome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch. BMC Genomics (2013) 0.90
Novel links between antibiotic resistance and antibiotic production. J Bacteriol (2007) 0.89
Optimal Conditions for Antimicrobial Metabolites Production from a New Streptomyces sp. RUPA-08PR Isolated from Bangladeshi Soil. Mycobiology (2009) 0.89
An indigoidine biosynthetic gene cluster from Streptomyces chromofuscus ATCC 49982 contains an unusual IndB homologue. J Ind Microbiol Biotechnol (2012) 0.87
Antibiotic production by actinomycetes: the Janus faces of regulation. J Ind Microbiol Biotechnol (2006) 0.87
The antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba. Proc Natl Acad Sci U S A (2013) 0.87
Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners. J Nat Prod (2012) 0.87
Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol (2013) 0.87
Regulation of a novel gene cluster involved in secondary metabolite production in Streptomyces coelicolor. J Bacteriol (2010) 0.87
Genome engineering and direct cloning of antibiotic gene clusters via phage ϕBT1 integrase-mediated site-specific recombination in Streptomyces. Sci Rep (2015) 0.87
Decoding and engineering tetracycline biosynthesis. Metab Eng (2008) 0.87
Production of bioactive compounds by actinomycetes and their antioxidant properties. Biotechnol Res Int (2014) 0.86
Transcriptome analysis of an antibiotic downregulator mutant and synergistic Actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor. Appl Environ Microbiol (2011) 0.86
Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor. J Bacteriol (2008) 0.86
Regulation of the biosynthesis of the macrolide antibiotic spiramycin in Streptomyces ambofaciens. J Bacteriol (2010) 0.86
PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis. Microb Cell Fact (2009) 0.86
Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP. Appl Environ Microbiol (2012) 0.85
Repression of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor. Appl Environ Microbiol (2013) 0.85
Synthetic promoter library for modulation of actinorhodin production in Streptomyces coelicolor A3(2). PLoS One (2014) 0.85
Bacterial competition reveals differential regulation of the pks genes by Bacillus subtilis. J Bacteriol (2013) 0.85
The -omics Era- Toward a Systems-Level Understanding of Streptomyces. Curr Genomics (2011) 0.85
An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor. J Bacteriol (2011) 0.85
Complex transcriptional control of the antibiotic regulator afsS in Streptomyces: PhoP and AfsR are overlapping, competitive activators. J Bacteriol (2011) 0.84
EshA accentuates ppGpp accumulation and is conditionally required for antibiotic production in Streptomyces coelicolor A3(2). J Bacteriol (2006) 0.84
Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. BMC Microbiol (2009) 0.84
LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor. PLoS One (2012) 0.83
A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. PLoS One (2013) 0.83
Evolution of High Cellulolytic Activity in Symbiotic Streptomyces through Selection of Expanded Gene Content and Coordinated Gene Expression. PLoS Biol (2016) 0.83
Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis. J Bacteriol (2013) 0.83
Comparative Proteomic Analysis of saccharopolyspora spinosa SP06081 and PR2 strains reveals the differentially expressed proteins correlated with the increase of spinosad yield. Proteome Sci (2011) 0.82
Natural Products and the Gene Cluster Revolution. Trends Microbiol (2016) 0.81
Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis. PLoS One (2014) 0.81
Engineering microbial hosts for production of bacterial natural products. Nat Prod Rep (2016) 0.80
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites. Nat Prod Rep (2016) 0.80
Crosstalk between ROS homeostasis and secondary metabolism in S. natalensis ATCC 27448: modulation of pimaricin production by intracellular ROS. PLoS One (2011) 0.80
SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea. Microb Cell Fact (2013) 0.80
A relA-dependent regulatory cascade for auto-induction of microbisporicin production in Microbispora corallina. Mol Microbiol (2015) 0.80
Subinhibitory antibiotic concentrations mediate nutrient use and competition among soil streptomyces. PLoS One (2013) 0.80
Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects. J Antibiot (Tokyo) (2016) 0.80
Increasing Avermectin Production in Streptomyces avermitilis by Manipulating the Expression of a Novel TetR-Family Regulator and Its Target Gene Product. Appl Environ Microbiol (2015) 0.79
Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins. Appl Microbiol Biotechnol (2015) 0.79
In vivo DNase I sensitivity of the Streptomyces coelicolor chromosome correlates with gene expression: implications for bacterial chromosome structure. Nucleic Acids Res (2006) 0.79
Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis. J Bacteriol (2008) 0.79
Metabolic profiling as a tool for prioritizing antimicrobial compounds. J Ind Microbiol Biotechnol (2015) 0.78
Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412. J Ind Microbiol Biotechnol (2009) 0.78
Pleiotropic control of secondary metabolism and morphological development by KsbC, a butyrolactone autoregulator receptor homologue in Kitasatospora setae. Appl Environ Microbiol (2012) 0.78
A flexible mathematical model platform for studying branching networks: experimentally validated using the model actinomycete, Streptomyces coelicolor. PLoS One (2013) 0.78